Measuring social desirability amongst men with intellectual disabilities: The psychometric properties of the Self- and Other-Deception Questionnaire—Intellectual Disabilities

Background Social desirability has been construed as either inaccurately attributing positive characteristics to oneself (self-deception), or inaccurately denying that one possesses undesirable characteristics to others (other-deception or impression management). These conceptualisations of social desirability have not been considered in relation to people with intellectual disabilities (IDs), but they are important constructs to consider when undertaking a psychological assessment of an individual, especially within forensic contexts. Therefore, we revised two existing measures of self- and other-deception and considered their psychometric properties. Methods Thirty-two men with mild IDs and 28 men without IDs completed the Self- and Other-Deception Questionnaires—Intellectual Disabilities (SDQ-ID and ODQ-ID) on two occasions, two weeks apart. Results Men with IDs scored significantly higher on the SDQ-ID and the ODQ-ID than men without IDs. However, these differences disappeared when Full Scale IQ, Verbal IQ and Performance IQ were controlled in relation to the SDQ-ID, and partially disappeared in relation to the ODQ-ID. The SDQ-ID and the ODQ-ID had substantial internal consistency in relation to men with IDs (k = 0.82 and 0.84 respectively). The test-retest reliability of the SDQ-ID was good (ri = 0.68), while the test-retest reliability of the ODQ-ID was moderate (ri = 0.56), for men with IDs. The SDQ-ID had moderate (k = 0.60) and the ODQ-ID had substantial (k = 0.70) internal consistency in relation to men without IDs, while the test-retest reliability of the SDQ-ID was excellent (ri = 0.87) as was the case for the ODQ-ID (ri = 0.85). Conclusions The SDQ-ID and the ODQ-ID have satisfactory psychometric properties in relation to men with and without IDs. Future research using these instruments is propose

A low-cost head and eye tracking system for realistic eye movements in virtual avatars

A virtual avatar or autonomous agent is a digital representation of a human being that can be controlled by either a human or an artificially intelligent computer system. Increasingly avatars are becoming realistic virtual human characters that exhibit human behavioral traits, body language and eye and head movements. As the interpretation of eye and head movements represents an important part of nonverbal human communication it is extremely important to accurately reproduce these movements in virtual avatars to avoid falling into the well-known ``uncanny valley''. In this paper we present a cheap hybrid real-time head and eye tracking system based on existing open source software and commonly available hardware. Our evaluation indicates that the system of head and eye tracking is stable and accurate and can allow a human user to robustly puppet a virtual avatar, potentially allowing us to train an A.I. system to learn realistic human head and eye movements

Membrane dissolution and division in P

Membrane systems with dividing and dissolving membranes are known to solve PSPACE problems in polynomial time. However, we give a P upperbound on an important restriction of such systems. In particular we examine systems with dissolution, elementary division and where each membrane initially has at most one child membrane. Even though such systems may create exponentially many membranes, each with di erent contents, we show that their power is upperbounded by PJunta de Andalucía TIC-581Ministerio de Educación y Ciencia TIN2006-1342

Understanding and responding to challenging behaviour: from theory to practice

While the concept of "challenging behaviour" is socially defined, it often involves persistent behaviour with serious physical and social consequences for the person and others. Challenging behaviour is relatively common amongst people with learning disabilities and often poorly dealt with. Models for understanding such behaviour have developed over time and can now provide a relatively sophisticated account. Such models are of immense use in understanding the behaviour of individuals and have clear implications for the development of individualised interventions. They also have implications for the design and organisation of services which will more competently support people with challenging behaviour and, as far as possible, prevent its emergence in those at risk

Insulin-like growth factor-1 receptor inhibitor, AMG-479, in cetuximab-refractory head and neck squamous cell carcinoma

Background Recurrent head and neck squamous cell carcinoma (HNSCC) remains a difficult cancer to treat. Here, we describe a patient with HNSCC who had complete response to methotrexate (MTX) after progressing on multiple cytotoxic agents, cetuximab, and AMG-479 (monoclonal antibody against insulin-like growth factor-1 receptor [IGF-1R]). Methods The clinical information was collected by a retrospective medical record review under an Institutional Review Board-approved protocol. From 4 tumors and 2 normal mucosal epithelia, global gene expression, and IGF-1R and dihydrofolate reductase (DHFR) protein levels were determined. Results Effective target inhibition in the tumor was confirmed by the decreased protein levels of total and phospho-IGF-1R after treatment with AMG-479. Decreased level of DHFR and conversion of a gene expression profile associated with cetuximab-resistance to cetuximab-sensitivity were also observed. Conclusion This suggests that the combination of AMG-479 and MTX or cetuximab may be a promising therapeutic approach in refractory HNSCC

Curvature in causal BD-type inflationary cosmology

We study a closed model of the universe filled with viscous fluid and quintessence matter components in a Brans-Dicke type cosmological model. The dynamical equations imply that the universe may look like an accelerated flat Friedmann-Robertson-Walker universe at low redshift. We consider here dissipative processes which follow a causal thermodynamics. The theory is applied to viscous fluid inflation, where accepted values for the total entropy in the observable universe is obtained.Comment: 11 pages, revtex 4. For a festschrift honoring Alberto Garcia. To be publishen in Gen. Rel. Gra

Extended Gari-Krumpelmann model fits to nucleon electromagnetic form factors

Nucleon electromagnetic form factor data (including recent data) is fitted with models that respect the confinement and asymptotic freedom properties of QCD. Gari-Krumpelmann (GK) type models, which include the major vector meson pole contributions and at high momentum transfer conform to the predictions of perturbative QCD, are combined with Hohler-Pietarinen (HP) models, which also include the width of the rho meson and the addition of higher mass vector meson exchanges, but do not evolve into the explicit form of PQCD at high momentum transfer. Different parameterizations of the GK model's hadronic form factors, the effect of including the width of the rho meson and the addition of the next (in mass) isospin 1 vector meson are considered. The quality of fit and the consistency of the parameters select three of the combined HP/GK type models. Projections are made to the higher momentum transfers which are relevant to electron-deuteron experiments. The projections vary little for the preferred models, removing much of the ambiguity in electron-nucleus scattering predictions.Comment: 18pp, 7 figures, using RevTeX with BoxedEPS macros; 1 new figure, minor textual changes; email correspondence to [email protected]

Effect of recent R_p and R_n measurements on extended Gari-Krumpelmann model fits to nucleon electromagnetic form factors

The Gari-Krumpelmann (GK) models of nucleon electromagnetic form factors, in which the rho, omega, and phi vector meson pole contributions evolve at high momentum transfer to conform to the predictions of perturbative QCD (pQCD), was recently extended to include the width of the rho meson by substituting the result of dispersion relations for the pole and the addition of rho' (1450) isovector vector meson pole. This extended model was shown to produce a good overall fit to all the available nucleon electromagnetic form factor (emff) data. Since then new polarization data shows that the electric to magnetic ratios R_p and R_n obtained are not consistent with the older G_{Ep} and G_{En} data in their range of momentum transfer. The model is further extended to include the omega' (1419) isoscalar vector meson pole. It is found that while this GKex cannot simultaneously fit the new R_p and the old G_{En} data, it can fit the new R_p and R_n well simultaneously. An excellent fit to all the remaining data is obtained when the inconsistent G_{Ep} and G_{En} is omitted. The model predictions are shown up to momentum transfer squared, Q^2, of 8 GeV^2/c^2.Comment: 14 pages, 8 figures, using RevTeX4; email correspondence to [email protected] ; minor typos corrected, figures added, conclusions extende

Memory Th1 Cells Are Protective in Invasive Staphylococcus aureus Infection

Mechanisms of protective immunity to Staphylococcus aureus infection in humans remain elusive. While the importance of cellular immunity has been shown in mice, T cell responses in humans have not been characterised. Using a murine model of recurrent S. aureus peritonitis, we demonstrated that prior exposure to S. aureus enhanced IFNγ responses upon subsequent infection, while adoptive transfer of S. aureus antigen-specific Th1 cells was protective in naïve mice. Translating these findings, we found that S. aureus antigen-specific Th1 cells were also significantly expanded during human S. aureus bloodstream infection (BSI). These Th1 cells were CD45RO+, indicative of a memory phenotype. Thus, exposure to S. aureus induces memory Th1 cells in mice and humans, identifying Th1 cells as potential S. aureus vaccine targets. Consequently, we developed a model vaccine comprising staphylococcal clumping factor A, which we demonstrate to be an effective human T cell antigen, combined with the Th1-driving adjuvant CpG. This novel Th1-inducing vaccine conferred significant protection during S. aureus infection in mice. This study notably advances our understanding of S. aureus cellular immunity, and demonstrates for the first time that a correlate of S. aureus protective immunity identified in mice may be relevant in humans

Evaluating the provision of flexible learning for children at risk of primary school dropout in Malawi

Communities in Malawi selected 15 children deemed "at-risk" - predominantly orphans - in Class 6 of each of 20 intervention schools to receive learning materials, support from the community and a school "buddy." An experimental evaluation found that dropout was reduced by 45% across intervention schools compared to 20 control schools. The program had spillover effects, indirectly reducing dropout among older pupils in the class not deemed at-risk. These findings imply that age, and not orphanhood, was the main indicator of dropout risk and that when targeting criteria are considered carefully, flexible learning programs can reduce dropout substantially among vulnerable children. (C) 2014 Elsevier Ltd. All rights reserved