Are Two z~6 Quasars Gravitationally Lensed ?

Several high-z (z > 5.7) quasars have been found in the course of Sloan Digital Sky Survey. The presence of such very high-z quasars is expected to give constraints on early structure formation. On one hand, it is suggested that these most luminous objects at high redshift are biased toward the highly magnified objects by gravitational lensing. To clarify the effect of gravitational lensing on the high-z quasars, we began the imaging survey of intervening lensing galaxies. Indeed our previous optical image showed that SDSSp J104433.04+012502.2 at z=5.74 is gravitationally magnified by a factor 2. In this paper, we report our new optical imaging of other two high-z quasars, SDSSp J103027.10+052455.0 at z=6.28 and SDSSp J130608.26+035626.3 at z=5.99. Since we find neither intervening galaxy nor counter image with i^{\prime} < 25.4-25.8 around each quasar, we conclude that they are not strongly magnified regardless that a lens galaxy is dusty.Comment: 10 pages, 8 figures, Accepted for PAS

SDSSp J104433.04−-012502.2 at z=5.74z=5.74 is Gravitationally Magnified by an Intervening Galaxy

During the course of our optical deep survey program on L$\alpha$ emitters at $z \approx 5.7$ in the sky area surrounding the quasar SDSSp J104433.04$-$012502.2 at $z=5.74$, we found that a faint galaxy with $m_B$(AB) $\approx 25$ is located at \timeform{1".9} southwest of the quasar. Its broad-band color properties from $B$ to $z^\prime$ suggest that the galaxy is located at a redshift of $z \sim 1.5$ -- 2.5. This is consistent with no strong emission line in our optical spectroscopy. Since the counter image of the quasar cannot be seen in our deep optical images, the magnification factor seems not to be very high. Our modest estimate is that this quasar is gravitationally magnified by a factor of 2.Comment: 11 pages, 5 figures, PASJ, in pres

The Discovery of a Very Narrow-Line Star Forming Obat a Redshift of 5.66ject

We report on the discovery of a very narrow-line star forming object beyond redshift of 5. Using the prime-focus camera, Suprime-Cam, on the 8.2 m Subaru telescope together with a narrow-passband filter centered at $\lambda_{\rm c}$ = 8150 \AA with passband of $\Delta\lambda$ = 120 \AA, we have obtained a very deep image of the field surrounding the quasar SDSSp J104433.04$-$012502.2 at a redshift of 5.74. Comparing this image with optical broad-band images, we have found an object with a very strong emission line. Our follow-up optical spectroscopy has revealed that this source is at a redshift of $z=5.655\pm0.002$, forming stars at a rate $\sim 13 ~ h_{0.7}^{-2} ~ M_\odot$ yr$^{-1}$. Remarkably, the velocity dispersion of Ly$\alpha$-emitting gas is only 22 km s$^{-1}$. Since a blue half of the Ly$\alpha$ emission could be absorbed by neutral hydrogen gas, perhaps in the system, a modest estimate of the velocity dispersion may be $\gtrsim$ 44 km s$^{-1}$. Together with a linear size of 7.7 $h_{0.7}^{-1}$ kpc, we estimate a lower limit of the dynamical mass of this object to be $\sim 2 \times 10^9 M_\odot$. It is thus suggested that LAE J1044$-$0123 is a star-forming dwarf galaxy (i.e., a subgalactic object or a building block) beyond redshift 5 although we cannot exclude a possibility that most Ly$\alpha$ emission is absorbed by the red damping wing of neutral intergalactic matter.Comment: 6 pages, 2 figures. ApJ Letters, in pres

The Subaru Deep Field Project: Lymanα\alpha Emitters at Redshift of 6.6

We present new results of a deep optical imaging survey using a narrowband filter ($NB921$) centered at $\lambda =$ 9196 \AA ~ together with $B$, $V$, $R$, $i^\prime$, and $z^\prime$ broadband filters in the sky area of the Subaru Deep Field which has been promoted as one of legacy programs of the 8.2m Subaru Telescope. We obtained a photometric sample of 58 Ly$\alpha$ emitter candidates at $z \approx$ 6.5 -- 6.6 among $\sim 180$ strong $NB921$-excess ($z^\prime - NB921 > 1.0$) objects together with a color criterion of $i^\prime - z^\prime > 1.3$. We then obtained optical spectra of 20 objects in our $NB921$-excess sample and identified at least nine Ly$\alpha$ emitters at $z \sim 6.5$ -- 6.6 including the two emitters reported by Kodaira et al. (2003). Since our Ly$\alpha$ emitter candidates are free from strong amplification of gravitational lensing, we are able to discuss their observational properties from a statistical point of view. Based on these new results, we obtain a lower limit of the star formation rate density of $\rho_{\rm SFR} \simeq 5.5 \times 10^{-4}$ $h_{0.7}$ $M_\odot$ yr$^{-1}$ Mpc$^{-3}$ at $z \approx 6.6$, being consistent with our previous estimate. We discuss the nature of star-formation activity in galaxies beyond $z=6$.Comment: 49 pages, 16 figures, PASJ, Vol. 57, No. 1, in pres

Florbetaben PET imaging to detect amyloid beta plaques in Alzheimer's disease: Phase 3 study

AbstractBackgroundEvaluation of brain β-amyloid by positron emission tomography (PET) imaging can assist in the diagnosis of Alzheimer disease (AD) and other dementias.MethodsOpen-label, nonrandomized, multicenter, phase 3 study to validate the 18F-labeled β-amyloid tracer florbetaben by comparing in vivo PET imaging with post-mortem histopathology.ResultsBrain images and tissue from 74 deceased subjects (of 216 trial participants) were analyzed. Forty-six of 47 neuritic β-amyloid-positive cases were read as PET positive, and 24 of 27 neuritic β-amyloid plaque-negative cases were read as PET negative (sensitivity 97.9% [95% confidence interval or CI 93.8–100%], specificity 88.9% [95% CI 77.0–100%]). In a subgroup, a regional tissue-scan matched analysis was performed. In areas known to strongly accumulate β-amyloid plaques, sensitivity and specificity were 82% to 90%, and 86% to 95%, respectively.ConclusionsFlorbetaben PET shows high sensitivity and specificity for the detection of histopathology-confirmed neuritic β-amyloid plaques and may thus be a valuable adjunct to clinical diagnosis, particularly for the exclusion of AD.Trial registrationClinicalTrials.gov NCT01020838

Clustering of Lyman Break Galaxies at z=4 and 5 in The Subaru Deep Field: Luminosity Dependence of The Correlation Function Slope

We explored the clustering properties of Lyman Break Galaxies (LBGs) at z=4 and 5 with an angular two-point correlation function on the basis of the very deep and wide Subaru Deep Field data. We found an apparent dependence of the correlation function slope on UV luminosity for LBGs at both z=4 and 5. More luminous LBGs have a steeper correlation function. To compare these observational results, we constructed numerical mock LBG catalogs based on a semianalytic model of hierarchical clustering combined with high-resolution N-body simulation, carefully mimicking the observational selection effects. The luminosity functions for LBGs predicted by this mock catalog were found to be almost consistent with the observation. Moreover, the overall correlation functions of LBGs were reproduced reasonably well. The observed dependence of the clustering on UV luminosity was not reproduced by the model, unless subsamples of distinct halo mass were considered. That is, LBGs belonging to more massive dark haloes had steeper and larger-amplitude correlation functions. With this model, we found that LBG multiplicity in massive dark halos amplifies the clustering strength at small scales, which steepens the slope of the correlation function. The hierarchical clustering model could therefore be reconciled with the observed luminosity-dependence of the angular correlation function, if there is a tight correlation between UV luminosity and halo mass. Our finding that the slope of the correlation function depends on luminosity could be an indication that massive dark halos hosted multiple bright LBGs (abridged).Comment: 16 pages, 17 figures, Accepted for publication in ApJ, Full resolution version is available at http://zone.mtk.nao.ac.jp/~kashik/sdf/acf/sdf_lbgacf.pd

DOCK2 is involved in the host genetics and biology of severe COVID-19

「コロナ制圧タスクフォース」COVID-19疾患感受性遺伝子DOCK2の重症化機序を解明 --アジア最大のバイオレポジトリーでCOVID-19の治療標的を発見--. 京都大学プレスリリース. 2022-08-10.Identifying the host genetic factors underlying severe COVID-19 is an emerging challenge. Here we conducted a genome-wide association study (GWAS) involving 2, 393 cases of COVID-19 in a cohort of Japanese individuals collected during the initial waves of the pandemic, with 3, 289 unaffected controls. We identified a variant on chromosome 5 at 5q35 (rs60200309-A), close to the dedicator of cytokinesis 2 gene (DOCK2), which was associated with severe COVID-19 in patients less than 65 years of age. This risk allele was prevalent in East Asian individuals but rare in Europeans, highlighting the value of genome-wide association studies in non-European populations. RNA-sequencing analysis of 473 bulk peripheral blood samples identified decreased expression of DOCK2 associated with the risk allele in these younger patients. DOCK2 expression was suppressed in patients with severe cases of COVID-19. Single-cell RNA-sequencing analysis (n = 61 individuals) identified cell-type-specific downregulation of DOCK2 and a COVID-19-specific decreasing effect of the risk allele on DOCK2 expression in non-classical monocytes. Immunohistochemistry of lung specimens from patients with severe COVID-19 pneumonia showed suppressed DOCK2 expression. Moreover, inhibition of DOCK2 function with CPYPP increased the severity of pneumonia in a Syrian hamster model of SARS-CoV-2 infection, characterized by weight loss, lung oedema, enhanced viral loads, impaired macrophage recruitment and dysregulated type I interferon responses. We conclude that DOCK2 has an important role in the host immune response to SARS-CoV-2 infection and the development of severe COVID-19, and could be further explored as a potential biomarker and/or therapeutic target