Synthesis, Structural Analysis, and Biological Activities of Some Imidazolium Salts

Four newly synthesized imidazolium salts were characterized by nuclear magnetic resonance, vibrational spectra, and mass spectra. Then, the density functional theory calculations were performed to obtain the molecular configurations on which the theoretical nuclear magnetic resonance and infrared spectra were consequently obtained. The comparison of calculated spectra with the experimental spectra for each molecule leads to the conclusion that the theoretical results can be assumed to be a good approach to their molecular configurations. The in vitro biological activities of the salts on the selected bacteria and cancer cell lines were determined by using the broth dilution method according to Clinical and Laboratory Standards Institute guidelines. The 1,3-bis(2-hydroxyethyl) imidazolidinium bromide and 3-(2-ethoxy-2-oxoethly)-1-(3-aminopropyl)-1H-imidazol-3-ium bromide showed efficiency on Bacillus cereus ATCC 11778. The 3-bis(2-carboxyethyl)-4-methyl-1-H-imidazol-3-ium bromide was effective on HeLa while a similar effect was observed on Hep G2 with 3-(2-carboxyethyl)-1-(3-aminopropyl)-1H-imidazol-3-ium bromide

Multistep Synthesis of Phosphazene Derivative of Chenodeoxycholicacid (CDCA)

<div><p>GRAPHICAL ABSTRACT</p><p></p></div

Mean platelet volume in Henoch-Schonlein purpura: relationship to gastrointestinal bleeding

Henoch-Schonlein purpura (HSP) is the most common systemic vasculitis in children. Gastrointestinal (GI) bleeding is one of the major complications affecting one third of the cases which may cause serious morbidity. Platelet volume directly correlates with the platelet function and activation. Small platelets have lower functional capabilities than larger ones. The aim of this retrospective study was to evaluate levels of mean platelet volume (MPV) in patients with HSP compared with healthy controls and to investigate the relationship between MPV and gastrointestinal bleeding. The study consisted of 43 HSP patients (male/female = 25/18, mean age = 6.2 +/- 2.6 years) and 27 age-matched healthy children (male/female = 14/13, mean age = 6.9 +/- 2 years) as control group. HSP patients had significantly lower MPV levels than healthy controls (7.5 +/- 0.8 vs. 7.9 +/- 0.5, p = 0.027). Thirteen of 43 patients had gastrointestinal bleeding. MPV was significantly lower in patients with GI bleeding than patients without bleeding (7.0 +/- 0.8 vs. 7.7 +/- 0.6, p = 0.01). Platelet counts, white blood cell counts, and C-reactive protein levels were significantly higher in patients with GI bleeding when compared to patients without GI bleeding (p = 0.03, p = 0.004, and p = 0.03, respectively). This study suggests that low MPV may contribute to GI bleeding in HSP

The Relationship Between Bone Formation and Functional Status in Symptomatic Lumbar Spinal Stenosis

WOS: 000346139300007Objective: the aim of the present study was to investigate the relationship between bone formation and functional status in patients with symptomatic lumbar spinal stenosis (LSS). Material and Methods: Sixty patients (range 45 to 65 years) diagnosed with symptomatic lumbar spinal stenosis and 30 age-and gender-matched healthy controls were included in this study. Bone mineral density (BMD) of the subjects included in the study was measured from the lumbar vertebra and proximal femur. Bone-specific alkaline phosphatase, osteocalcin, and 24-hour urinary calcium (Ca) and phosphorus (P) levels were tested to assess bone metabolism. the functional status of patients was evaluated with the modified Oswestry disability index (mODI) and Swiss spinal stenosis questionnaire (SSSQ). Results: the mean age of the patient and control groups was different but not significant. No statistically significant difference was found between the patient and the control groups in bone-specific alkaline phosphatase, osteocalcin, and 24-hour urinary Ca and P values. Mean BMD values measured from the lumbar vertebra and proximal femur were significantly lower in patients with LSS. in the patient group, the mean mODI score was 42.28 +/- 3.1. Mean SSSQ pain scale score was 3.34 +/- 0.2, whereas the mean functional status score was 2.35 +/- 0.2. There was no statistically significant relationship of mODI with bone-specific alkaline phosphatase and osteocalcin levels. the pain and functional status scales of the SSSQ had no significant correlation with bone-specific alkaline phosphatase and osteocalcin. Conclusion: in this study, we determined that LSS has a negative impact on the functional status of patients, does not influence bone metabolism, and decreases BMD

Mega Hpv laboratories for cervical cancer control

Cervical cancer is the fourth most common cancer among women in the world. It is estimated that one woman dies every 2 min from cervical cancer. Nearly all cervical cancers are preventable by early detection and treatment through screening or HPV vaccination. In 2018, World Health Organization (WHO) made a global call for action toward the elimination of cervical cancer. Cervical cancer screening involves a complex organized program, which begins with a call/recall system based on personal invitation of eligible women, followed by participation in screening, and leading to diagnosis, treatment, and management as appropriate. An effective cervical screening program with high coverage is dependent on each country's infrastructure and human resource capacity. Efforts to develop an effective program is particularly challenging in low and middle income countries (LMIC) where resources are limited. For an effective strategy, Turkey redesigned the country's cervical screening program. The local call/recall system and centralized monitoring system of individual women were re-vamped with an automated evaluation system. The revised screening program includes the use of primary HPV testing with a well-defined protocol outlining the algorithms of management (i.e., screening intervals and referral), a single nationwide centralized diagnostic laboratory, and a sustainable agreement with the HPV diagnostics industry. This system allows for traceable, real-time monitoring of screening visits and specimens. Turkey reports on the first four years of this re-vamped organized program and shares lessons learnt from the implementation of this new program.PubMedWoSScopu

Reliability of electrode materials for supercapacitors and batteries in energy storage applications: a review

Supercapacitors and batteries are among the most promising electrochemical energy storage technologies available today. Indeed, high demands in energy storage devices require cost-effective fabrication and robust electroactive materials. In this review, we summarized recent progress and challenges made in the development of mostly nanostructured materials as well as fabrication routes for energy storage devices. Indeed, we systematically sorted out the design principles of electrode materials such as lithium-ion, lead-acid, lithium-sulfur, nickel-cadmium, nickel-metal hydride, and sodium-ion for rechargeable batteries electrode and supercapacitors (SCs) electrode materials following by systematic discussions on electric double-layer capacitors, pseudocapacitors, and hybrid SCs behavior. © 2021, The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature

Complexation, thermal and catalytic studies of N-substituted piperazine, morpholine and thiomorpholine with some metal ions

Several Cu(II), Pt(II) and Ni(II) complexes of N-substituted, piperazine (NN donor), morpholine (NO donor) and thiomorpholine (NS donor) derivatives were synthesized and their thermal behavior and catalytic activity in epoxidation reaction of cis-diphenylethylene were studied using oxygen sources NaOCl. The coordination compounds of Cu(II), Pt(II) and Ni(II) having general formula [MLCl]Cl, [ML2l]Cl2 or [ML]Cl2 with tetra coordinated geometry around metal ions have been isolated as solid. All the ligands and complexes were identified by spectroscopic methods and elemental analysis, magnetic measurements, electrical conductance and thermal analysis. A square planer structures have been proposed for all complexes. The thermal stability of the complexes discussed in terms of ligands donor atoms, geometry and central metal ions. The complexes have a similar thermal behavior for the selected metal ions. The thermogravimetric analyses suggest high thermal stability for most complexes followed by thermal decomposition in different steps. The decomposition processes were observed as water elimination, chloride anion removal and degradation of the organic ligands. Catalytic ability of the complexes were examined and found that all the complexes can effectively catalyze the epoxidation of cis-stilbene with NaOCl

Spontaneous Superficial Femoral Artery Pseudoaneurysm in Behcet's Disease

Behcet’s disease is an autoimmune multisystemic disorder on vasculitis base. Cardiovascular involvement is the most important predictor of morbidity and mortality. The treatment should be planned carefully for pathologies requiring interventions. In our report, we present a 45-year-old patient with spontaneous superficial femoral artery pseudoaneurysm, our treatment strategy, and circumstances we faced