Foot protein isoforms are expressed at different times during embryonic chick skeletal muscle development.

We have investigated the time course of expression of the alpha and beta triad junctional foot proteins in embryonic chick pectoral muscle. The level of [3H]ryanodine binding in muscle homogenates is low until day E20 of embryonic development, then increases dramatically at the time of hatching reaching adult levels by day N7 posthatch. The alpha and beta foot protein isoforms increase in abundance concomitantly with [3H]ryanodine binding. Using foot protein isoform-specific antibodies, the alpha foot protein is detected in a majority of fibers in day E10 muscle, while the beta isoform is first observed at low levels in a few fibers in day E15 muscle. A high molecular weight polypeptide, distinct from the alpha and beta proteins, is recognized by antifoot protein antibodies. This polypeptide is observed in day E8 muscle and declines in abundance with continued development. It appears to exist as a monomer and does not bind [3H]ryanodine. In contrast, the alpha isoform present in day E10 muscle and the beta isoform in day E20 muscle are oligomeric and bind [3H]ryanodine suggesting that they may exist as functional calcium channels in differentiating muscle. Comparison of the intracellular distributions of the alpha foot protein, f-actin, the heavy chain of myosin and titin in day E10 muscle indicates that the alpha foot protein is expressed during myofibril assembly and Z line formation. The differential expression of the foot protein isoforms in developing muscle, and their continued expression in mature muscle, is consistent with these proteins making different functional contributions. In addition, the expression of the alpha isoform during the time of organization of a differentiated muscle morphology suggests that foot proteins may participate in events involved in muscle differentiation

Fast ignition driven by quasi-monoenergetic ions: Optimal ion type and reduction of ignition energies with an ion beam array

Fast ignition of inertial fusion targets driven by quasi-monoenergetic ion beams is investigated by means of numerical simulations. Light and intermediate ions such as lithium, carbon, aluminium and vanadium have been considered. Simulations show that the minimum ignition energies of an ideal configuration of compressed Deuterium-Tritium are almost independent on the ion atomic number. However, they are obtained for increasing ion energies, which scale, approximately, as Z^2, where Z is the ion atomic number. Assuming that the ion beam can be focused into 10 {\mu}m spots, a new irradiation scheme is proposed to reduce the ignition energies. The combination of intermediate Z ions, such as 5.5 GeV vanadium, and the new irradiation scheme allows a reduction of the number of ions required for ignition by, roughly, three orders of magnitude when compared with the standard proton fast ignition scheme

ASCA Discovery of an X-ray Pulsar in the Error Box of SGR1900+14

We present a 2 - 10 keV ASCA observation of the field around the soft gamma repeater SGR1900+14. One quiescent X-ray source was detected in this observation, and it was in the SGR error box. In 2 - 10 keV X-rays, its spectrum may be fit by a power law with index -2.2, and its unabsorbed flux is 9.6 x 10^-12 erg cm^-2 s^-1. We also find a clear 5.16 s period. The properties of the three well-studied soft gamma repeaters are remarkably similar to one another, and provide evidence that all of them are associated with young, strongly magnetized neutron stars in supernova remnants.Comment: Accepted for publication in the Astrophysical Journal Letter

Timing Noise in SGR 1806-20

We have phase connected a sequence of RXTE PCA observations of SGR 1806-20 covering 178 days. We find a simple secular spin-down model does not adequately fit the data. The period derivative varies gradually during the observations between 8.1 and 11.7 * 10^-11 s/s (at its highest, ~40% larger than the long term trend), while the average burst rate as seen with BATSE drops throughout the time interval. The phase residuals give no compelling evidence for periodicity, but more closely resemble timing noise as seen in radio pulsars. The magnitude of the timing noise, however, is large relative to the noise level typically found in radio pulsars. Combining these results with the noise levels measured for some AXPs, we find all magnetar candidates have \Delta_8 values larger than those expected from a simple extrapolation of the correlation found in radio pulsars. We find that the timing noise in SGR 1806-20 is greater than or equal to the levels found in some accreting systems (e.g., Vela X-1, 4U 1538-52 and 4U 1626-67), but the spin-down of SGR 1806-20 has thus far maintained coherence over 6 years. Alternatively, an orbital model with a period P_orb = 733 days provides a statistically acceptable fit to the data. If the phase residuals are created by Doppler shifts from a gravitationally bound companion, then the allowed parameter space for the mass function (small) and orbital separation (large) rule out the possibility of accretion from the companion sufficient to power the persistent emission from the SGR.Comment: 11 pages, accepted for publication in ApJ Letter

From the 'cinematic' to the 'anime-ic': Issues of movement in anime

This is the author's accepted manuscript. The final published article is available from the link below.This article explores the way that movement is formally depicted in anime. Drawing on Thomas Lamarre's concepts of the `cinematic' and the `anime-ic', the article interrogates further the differences in movement and action in anime from traditional filmic form. While often considered in terms of `flatness', anime offers spectacle, character development and, ironically, depth through the very form of movement put to use in such texts.The article questions whether the modes of address at work in anime are unique to this form of animation.Taking into account how the terms `cinematic' and `anime-ic' can be understood (and by extension the cinematic and animatic apparatus), the article also begins to explore how viewers might identify with such images

Current-induced spin polarization and the spin Hall effect: a quasiclassical approach

The quasiclassical Green function formalism is used to describe charge and spin dynamics in the presence of spin-orbit coupling. We review the results obtained for the spin Hall effect on restricted geometries. The role of boundaries is discussed in the framework of spin diffusion equations.Comment: 10 pages, 5 figures, Submitted to Solid State Communications Special Issue on "Fundamental Phenomena in Low Dimensional Electron Systems". Special Issue Editors: Marco Polini, Michele Governale, Hermann Grabert, Vittorio Pellegrini, and Mario Tos