54 research outputs found
Validation and calibration of next-generation sequencing to identify Epstein-Barr virus-positive gastric cancer in The Cancer Genome Atlas
- Author
- Publication venue
- Publication date
- 01/01/2016
- Field of study
The Epstein-Barr virus (EBV)-positive subtype of gastric adenocarcinoma is conventionally identified by in situ hybridization (ISH) for viral nucleic acids, but next-generation sequencing represents a potential alternative. We therefore determined normalized EBV read counts by whole genome, whole exome, mRNA and miRNA sequencing for 295 fresh-frozen gastric tumor samples. Formalin-fixed, paraffin-embedded tissue sections were retrieved for ISH confirmation of 13 high-EBV and 11 low-EBV cases. In pairwise comparisons, individual samples were either concordantly high or concordantly low by all genomic methods for which data were available. Empiric cut-offs of sequencing counts identified 26 (9%) tumors as EBV-positive. EBV-positivity or negativity by molecular testing was confirmed by EBER-ISH in all but one tumor evaluated by both approaches (kappa=0.91). EBV-positive gastric tumors may be accurately identified by quantifying viral sequences in genomic data. Simultaneous analyses of human and viral DNA, mRNA and miRNA could streamline tumor profiling for clinical care and research
Comprehensive molecular characterization of gastric adenocarcinoma
- Author
- Akbani Rehan
- Bass Adam J.
- Bernard Brady
- Bowlby Reanne
- Cherniack Andrew
- Chu Andy
- Curtis Christina
- Getz Gad
- Gordon Robertson A.
- Hinoue Toshinori
- Kasaian Katayoon
- Kelsen David P.
- Laird Peter W.
- Lee Ju-Seog
- Liu Wenbin
- Liu Yingchun
- Miller Michael
- Mills Gordon B.
- Mungall Andrew J.
- Noble Michael S.
- Pedamallu Chandra
- Reynolds Sheila M.
- Schultz Nikolaus
- Shen Hui
- Shen Ronglai
- Shmulevich Ilya
- Sipahimalani Payal
- Sougnez Carrie
- Taylor-Weiner Amaro
- Thorsson Vesteinn
- Weinhold Nils
- Weisenberger Daniel J.
- Publication venue
- Publication date
- 01/01/2014
- Field of study
Gastric cancer is a leading cause of cancer deaths, but analysis of its molecular and clinical characteristics has been complicated by histological and aetiological heterogeneity. Here we describe a comprehensive molecular evaluation of 295 primary gastric adenocarcinomas as part of The Cancer Genome Atlas (TCGA) project. We propose a molecular classification dividing gastric cancer into four subtypes: tumours positive for Epstein–Barr virus, which display recurrent PIK3CA mutations, extreme DNA hypermethylation, and amplification of JAK2, CD274 (also known as PD-L1) and PDCD1LG2 (also knownasPD-L2); microsatellite unstable tumours, which show elevated mutation rates, including mutations of genes encoding targetable oncogenic signalling proteins; genomically stable tumours, which are enriched for the diffuse histological variant and mutations of RHOA or fusions involving RHO-family GTPase-activating proteins; and tumours with chromosomal instability, which show marked aneuploidy and focal amplification of receptor tyrosine kinases. Identification of these subtypes provides a roadmap for patient stratification and trials of targeted therapies
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Comprehensive molecular characterization of gastric adenocarcinoma
- Author
- Abdel-Misih Raafat
- Ajani Jaffer
- Akbani Rehan
- Albert Monique
- Alexopoulou Iakovina
- Ally Adrian
- Alonso Shelley
- Askoy B. Arman
- Ayala Brenda
- Balasundaram Miruna
- Bartlett John
- Bass Adam J.
- Baylin Stephen B.
- Beer David G.
- Belyaev Smitry
- Bennett Joseph
- Benz Christopher
- Bernard Brady
- Beroukhim Rameen
- Birol Inanc
- Black Aaron D.
- Bootwalla Moiz S.
- Boussioutas Alex
- Bowen Jay
- Bowlby Reanne
- Bristow Christopher A.
- Brooks Denise
- Brown Jennifer
- Brzezinski Jakub
- Burton Robert
- Butterfield Yaron S. N.
- Camargo M. Constanza
- Carlsen Rebecca
- Carney Julie Ann
- Carter Scott L.
- Cheong Jae-Ho
- Cherniack Andrew
- Cherniack Andrew D.
- Chin Lynda
- Cho Eunjung
- Cho Juok
- Chu Andy
- Chu Justin
- Chuah Eric
- Chudamani Sudha
- Chun Hye-Jung E.
- Cibulskis Kristian
- Ciriello Giovanni
- Clarke Amanda
- Crain Daniel
- Curely Erin
- Curley Erin
- Curtis Christina
- Davidsen Tanja
- Demchok John A.
- Dhalla Noreen
- Dhir Rajiv
- DiCara Daniel
- Ding Li
- Dolzhansky Oleg
- Dresdner Gideon
- Eley Greg
- Engel Jay
- Fedosenko Konstantin
- Fisher Sheila
- Frazer Scott
- Gabriel Stacey B.
- Gao Jianjiong
- Gardner Johanna
- Garman Katherine
- Gastier-Foster Julie M.
- Gehlenborg Nils
- Getz Gad
- Gross Benjamin
- Guin Ranabir
- Gulley Margaret
- Hadjipanayis Angela
- Haussler David
- Heiman David I.
- Helsel Carmen
- Herman James G.
- Hinoue Toshinori
- Holt Robert A.
- Hutter Carolyn M.
- Iacocca Mary
- Ibbs Matthew
- Iype Lisa
- Jacobsen Anders
- Janjigian Yelena Y.
- Jensen Mark A.
- Jones Steven J.M.
- Jung Joonil
- Kasaian Katayoon
- Kelsen David P.
- Kemkes Ariane
- Kim Hark K.
- Kim Jaegil
- Kim Jihun
- Kim Sang-Bae
- Korski Konstanty
- Kramer Roger W.
- Kreisberg Richard
- Kucherlapati Raju
- Kwon Sun-Young
- Kycler Witold
- Ladanyi Marc
- Lai Phillip H.
- Laird Peter W.
- Lander Eric S.
- Landreneau Rodney
- Lau Kevin
- Lawrence Michael S.
- Lee Darlene
- Lee Jae-Hyuk
- Lee Ju-Seog
- Lee Semin
- Lee William
- Leiserson Mark D. M.
- Leporowska Ewa
- Leraas Kristen M.
- Li Haiyan A.
- Lichtenberg Tara M.
- Lichtenstein Lee
- Lim Emilia
- Lin Pei
- Ling Shiyun
- Liu Jia
- Liu Wenbin
- Liu Yingchun
- Lu Yiling
- Luketich James
- Ma Yussanne
- Mackiewicz Andrzej
- Mahadeshwar Harshad S.
- Mallery David
- Manikhas Georgy
- Marra Marco A.
- Mayo Michael
- McAllister Cynthia
- McCall Shannon J.
- McLellan Michael
- Meyerson Matthew
- Miller Michael
- Mills Shaw Kenna R.
- Mills Gordon
- Mills Gordon B.
- Moore Richard A.
- Morris Scott
- Mungall Andrew J.
- Mungall Karen L.
- Murawa Dawid
- Murawa Pawel
- Murray Bradley A.
- Ng Sam
- Ng Santa Cruz Sam
- Nip Ka Ming
- Niu Beifang
- Noble Michael S.
- Odze Robert
- Ojesina Akinyemi I.
- Pantazi Angeliki
- Parfenov Michael
- Park Do-Youn
- Park Peter J.
- Park Young S.
- Paulauskis Joseph
- Pedamallu Chandra
- Pedamallu Chandra Sekhar
- Pennathur Arjun
- Penny Robert
- Piazuelo M. Blanca
- Pihl Todd
- Potapova Olga
- Protopopov Alexei
- Rabeno Brenda
- Rabkin Charles S.
- Raman Rohini
- Ramirez Nilsa C.
- Ramirez Ricardo
- Rao Arvind
- Raphael Benjamin J.
- Rathmell W. Kimryn
- Ren Xiaojia
- Reynolds Sheila M.
- Robertson A. Gordon
- Rosenberg Mara
- Rovira Hector
- Sakai Ryo
- Saksena Gordon
- Sander Chris
- Santoso Netty
- Schein Jacqueline E.
- Schneider Barbara G.
- Schultz Nikolaus
- Schumacher Steven E.
- Seidman Jonathan
- Senbabaoglu Yasin
- Seth Sahil
- Shelton Candace
- Shelton Troy
- Shen Hui
- Shen Ronglai
- Sherman Mark
- Sheth Margi
- Shmulevich Ilya
- Sinha Rileen
- Sipahimalani Payal
- Sofia Heidi J.
- Song Xingzhi
- Sougnez Carrie
- Spychała Arkadiusz
- Stojanov Petar
- Stuart Josh M.
- Suchorska Wiktoria M.
- Sumer S. Onur
- Sun Yichao
- Tabak Barbara
- Tabler Teresa R.
- Tam Angela
- Tang Jiabin
- Tang Laura
- Tarnuzzer Roy
- Tasman Natalie
- Tatka Honorata
- Taylor Barry S.
- Taylor-Weiner Amaro
- Teresiak Marek
- Thiessen Nina
- Thorsson Vesteinn
- Thorsson Vésteinn
- Triche Timothy
- Van Den Berg David J.
- Verhaak Roeland G.W.
- Voet Doug
- Voronina Olga
- Walton Jessica
- Wan Yunhu
- Wang Zhining
- Weaver Stephanie
- Weinhold Nils
- Weinstein John N.
- Weisenberger Daniel J.
- Willis Joseph E.
- Wise Lisa
- Wiznerowicz Maciej
- Wu Hsin-Ta
- Xi Ruibin
- Xu Andrew W.
- Yang Da
- Yang Liming
- Yang Lixing
- Zack Travis I.
- Zenklusen Jean Claude
- Zhang Hailei
- Zhang Jianhua
- Zhang Wei
- Zmuda Erik
- Zou Lihua
- ŁaŸniak Radoslaw
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/10/2014
- Field of study
Gastric cancer is a leading cause of cancer deaths, but analysis of its molecular and clinical characteristics has been complicated by histological and aetiological heterogeneity. Here we describe a comprehensive molecular evaluation of 295 primary gastric adenocarcinomas as part of The Cancer Genome Atlas (TCGA) project. We propose a molecular classification dividing gastric cancer into four subtypes: tumours positive for Epstein–Barr virus, which display recurrent PIK3CA mutations, extreme DNA hypermethylation, and amplification of JAK2, CD274 (also known as PD-L1) and PDCD1LG2 (also knownasPD-L2); microsatellite unstable tumours, which show elevated mutation rates, including mutations of genes encoding targetable oncogenic signalling proteins; genomically stable tumours, which are enriched for the diffuse histological variant and mutations of RHOA or fusions involving RHO-family GTPase-activating proteins; and tumours with chromosomal instability, which show marked aneuploidy and focal amplification of receptor tyrosine kinases. Identification of these subtypes provides a roadmap for patient stratification and trials of targeted therapies
Comprehensive molecular portraits of human breast tumours
- Author
- Ally Adrian
- Balasundaram Miruna
- Butterfield Yaron S. N.
- Carlsen Rebecca
- Carter Candace
- Chu Andy
- Chuah Eric
- Chun Hye-Jung E.
- Coope Robin J. N.
- Dhalla Noreen
- Ding Li
- Dooling David J.
- Fulton Lucinda L.
- Fulton Robert S.
- Gordon Robertson A.
- Guin Ranabir
- Hirst Carrie
- Hirst Martin
- Holt Robert A.
- Kalicki-Veizer Joelle
- Koboldt Daniel C.
- Lee Darlene
- Li Haiyan I.
- Mardis Elaine R.
- Mayo Michael
- McLellan Michael D.
- McMichael Joshua F.
- Moore Richard A.
- Mungall Andrew J.
- Pleasance Erin
- Schmidt Heather
- Wilson Richard K.
- Publication venue
- Publication date
- 01/01/2012
- Field of study
This Article from the Cancer Genome Atlas consortium describes a multifaceted analysis of primary breast cancers in 825 people. Exome sequencing, copy number variation, DNA methylation, messenger RNA arrays, microRNA sequencing and proteomic analyses were performed and integrated to shed light on breast-cancer heterogeneity. Just three genes — TP53, PIK3CA and GATA3 — are mutated at greater than 10% frequency across all breast cancers. Many subtype-associated and novel mutations were identified, as well as two breast-cancer subgroups with specific signalling-pathway signatures. The analyses also suggest that much of the clinically observable plasticity and heterogeneity occurs within, and not across, the major subtypes of breast cancer
Integrated genomic characterization of pancreatic ductal adenocarcinoma
- Author
- Adsay Volkan
- Aguirre Andrew J.
- Akbani Rehan
- Albert Monique
- Ally Adrian
- Amundadottir Laufey T.
- Auman J. Todd
- Bahary Nathan
- Bailey Peter
- Balasundaram Miruna
- Balu Saianand
- Bardeesy Nabeel
- Bartlett John
- Bathe Oliver
- Baylin Stephen B.
- Becker Karl-Friedrich
- Behera Madhusmita
- Bennett Joseph
- Bergelson Louis
- Beroukhim Rameen
- Berrios Mario
- Biankin Andrew
- Birol Inanc
- Bodenheimer Tom
- Boice Lori
- Bootwalla Moiz S.
- Bowen Jay
- Bowlby Reanne
- Breggia Anne
- Brooks Denise
- Burch Patrick
- Burks Eric
- Cancer Genome Initiative (APGI Australian Pancreatic
- Carlotti Junior Carlos Gilberto
- Carlsen Rebecca
- Chabot John
- Chaffee Kari
- Chang David
- Cherniack Andrew D.
- Chin Lynda
- Chin Lynda
- Cho Juok
- Chu Andy
- Chuah Eric
- Chudamani Sudha
- Cibulskis Carrie
- Clarke Amanda
- Collisson Eric
- Crain Daniel
- Curley Erin
- Defreitas Timothy
- Demchok John A.
- Dhalla Noreen
- Dhir Rajiv
- Dubina Michael
- Eschbacher Jennifer
- Fei Suzanne S.
- Felau Ina
- Ferguson Martin L.
- Frazer Scott
- Frick Jessica
- Furth Emma
- Gabriel Stacey B.
- Gardner Johanna
- Gastier-Foster Julie M.
- Gehlenborg Nils
- Gerken Mark
- Getz Gad
- Gibb Ewan A.
- Gill Anthony
- Gingras Marie-Claude
- Goldenberg Anna
- Grimmond Sean
- Gupta Manaswi
- Han Sung-Sik
- Hayes D. Neil
- Heiman David I.
- Hess Julian
- Hibshoosh Hanina
- Hinoue Toshinori
- Hoadley Katherine A.
- Holbrook Andrea
- Holt Robert A.
- Howard Zaren
- Hoyle Alan P.
- Hruban Ralph H.
- Huang Mei
- Huelsenbeck-Dill Lori
- Hutter Carolyn M.
- Hwang Rosa F.
- Janssen Klaus-Peter
- Jefferys Stuart R.
- Jenkins Roger
- Jennifer Smith
- Johns Amber
- Johns Amber
- Jones Corbin D.
- Jones Steven J.M.
- Judy Miller
- Kamburov Atanas
- Karpov Alexey
- Kasaian Katayoon
- Kemp Rafael
- Kench James
- Kim Hark
- Kim Jaegil
- Kim Jaegil
- Kim Paula
- Kim Seong Hoon
- Kim Yong Hoon
- Klimstra David
- Korkut Anil
- Kucherlapati Melanie
- Kucherlapati Raju
- Kwon Sun Young
- Lai Phillip H.
- Laird Peter W.
- Lander Eric
- Lau Kevin
- Lawrence Michael S.
- Lee Darlene
- Leiserson Mark D.M.
- Leraas Kristen M.
- Leshchiner Ignaty
- Lichtenberg Tara M.
- Lin Pei
- Ling Shiyun
- Liu Jia
- Liu Yuexin
- Livitz Dimitri
- Loher Phillipe
- Lolla Laxmi
- Londin Eric R.
- Lu Yiling
- Lyadov Vladimir
- Ma Yussanne
- Maglinte Dennis T.
- Mahurkar Swapna
- Maithel Shishir
- Mallery David
- Manikhas Georgy
- Marra Marco A.
- Mayo Michael
- McWilliams Robert
- Meier Sam
- Meng Shaowu
- Meyerson Matthew
- Mezlini Aziz M.
- Mieczkowski Piotr A.
- Mills Shaw Kenna R.
- Mills Gordon B.
- Moffitt Richard A.
- Montgomery Eric
- Moore Richard A.
- Morris Scott
- Mose Lisle E.
- Mungall Andrew J.
- Mungall Karen L.
- Murray Bradley A.
- Naresh Rashi
- Noble Michael S.
- Noushmehr Houtan
- Oberg Ann
- Osunkoya Adeboye
- Owonikoko Taofeek
- Paklina Oxana
- Pantazi Angeliki
- Park Peter
- Park Sang-Jae
- Parker Joel S.
- Paul Drwiega
- Paulauskis Joseph
- Penny Robert
- Perou Amy H.
- Perou Charles M.
- Petersen Gloria
- Pihl Todd
- Postier Russell
- Potapova Olga
- Pretti da Cunha Tirapelli Daniela
- Radenbaugh Amie
- Ramalingam Suresh
- Ramirez Nilsa C.
- Raphael Benjamin J.
- Rathmell W. Kimryn
- Reardon Brendan
- Renkel Jeremy
- Rieger-Christ Kimberly
- Rigoutsos Isidore
- Roach Jeffrey
- Robertson A. Gordon
- Roggin Kevin
- Rosenberg Mara
- Sadeghi Sara
- Saksena Gordon
- Saksena Gordon
- Saller Charles
- Sander Chris
- Schein Jacqueline E.
- Schumacher Steven E.
- Sebastião dos Santos Jose
- Sekhon Harman
- Senbabaoglu Yasin
- Sepulveda Antonia
- Setdikova Galiya
- Shabunin Alexey
- Shelton Candace
- Shelton Troy
- Shen Hui
- Sherman Mark
- Sheth Margi
- Shi Yan
- Shih Juliann
- Shroff Rachna T.
- Sica Gabriel
- Sicotte Hugues
- Simons Janae V.
- Singhi Aatur D.
- Sipahimalani Payal
- Skelly Tara
- Slotta-Huspenina Julia
- Smyrk Thomas
- Sofia Heidi J.
- Soloway Matthew G.
- Spellman Paul T.
- Stephen Yeager
- Stewart Chip
- Su Tao
- Sullivan Travis
- Sun Qiang
- Swanson Pat
- Tam Angela
- Tan Donghui
- Tarnuzzer Roy
- Tarvin Katherine
- Tavobilov Michael
- Telonis Aristeidis G.
- Tempero Margaret
- Tepper Joel
- Thiessen Nina
- Thorne Leigh B.
- Tiao Grace
- Triche Timothy J.
- Tse Kane
- Urbanski Stefan
- Van Allen Eliezer
- Van Den Berg David J.
- Veluvolu Umadevi
- Voet Doug
- Voronina Olga
- Wan Yunhu
- Wang Timothy
- Wang Zhining
- Weinstein John N.
- Weisenberger Daniel J.
- Wheeler David A.
- Wilkerson Matthew D.
- Wise Lisa
- Wong Tina
- Wu Ye
- Xi Liu
- Yang Liming
- Yeh Jen Jen
- Yena Peggy
- Zenklusen Jean C.
- Zhang Hailei
- Zhang Jiashan (Julia)
- Zhang Lizhi
- Zhang Wei
- Zmuda Erik
- Zuna Rosemary
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/08/2017
- Field of study
We performed integrated genomic, transcriptomic, and proteomic profiling of 150 pancreatic ductal adenocarcinoma (PDAC) specimens, including samples with characteristic low neoplastic cellularity. Deep whole-exome sequencing revealed recurrent somatic mutations in KRAS, TP53, CDKN2A, SMAD4, RNF43, ARID1A, TGFβR2, GNAS, RREB1, and PBRM1. KRAS wild-type tumors harbored alterations in other oncogenic drivers, including GNAS, BRAF, CTNNB1, and additional RAS pathway genes. A subset of tumors harbored multiple KRAS mutations, with some showing evidence of biallelic mutations. Protein profiling identified a favorable prognosis subset with low epithelial-mesenchymal transition and high MTOR pathway scores. Associations of non-coding RNAs with tumor-specific mRNA subtypes were also identified. Our integrated multi-platform analysis reveals a complex molecular landscape of PDAC and provides a roadmap for precision medicine
Finishing the euchromatic sequence of the human genome
- Author
- . Haifeng
- . Magner
- . Yin
- Abbott Scott
- Abbott-Ozersky Amanda
- Abdellah Zahra
- Abouelleil Amr
- Abrajano Anne
- Adachi Tamami
- Adam Catherine
- Adams Charles Q.
- Adamson Aaron
- Adekoya Emmanuel
- Adio-Oduola Babajide
- Aerts Andrea
- Aggarwal Arun
- Ahmadi Alireza
- Ahmed Shahana
- Aimable Matthew
- Ainscough Rachael
- Ait-Zahra Mostafa
- Aizu Tomoyuki
- Alcivare Dana
- Alegria Michelle
- Ali Alla
- Ali Johar
- Allegria-hartmann Michelle
- Alleman Jennifer
- Allen Carlana C.
- Allen Heather
- Allen Nicole R.
- Allen Susan
- Allen Thaddeus
- Almeida Jeff
- Almond Claire
- Alsbrooks Stephen L.
- Altherr Michael R.
- Amaratunge Harshinie C.
- Ambler Andrew
- Ambrose Karen
- Ambrose Kerrie
- Amemiya Chris
- Amico-Keller Gina
- Amin Amita G.
- Anderson Mechele
- Anderson Scott
- Anderson Scott
- Andora Janice
- Andredesz Carol
- Andrew Robert
- Andrews Dan
- Andrews Daniel
- Andrews Neil
- Andrews Stephanie
- Andriese Tim
- Anthouard Véronique
- Antonarakis Stylianos E.
- Anyalebechi Vivian
- Aoki Norie
- Apostolou Sinoula
- Apweiler Eva
- Arachchi Harindra
- Arai Rie
- Arbery Hazel
- Arcaina Marlon
- Arcaina Terisita
- Archer Beth
- Arellano Andre
- Arellano-Jones Perry
- Armbruster Jeff
- Armstrong Jon
- Arredondo Dilrukshi P.
- Arredondo Heather Hope
- Artiguenave François
- Asakawa Shuichi
- Asakawa Teruyo
- Ash Gareth
- Ashcroft Kevin
- Ashurst Jennifer
- Ashwell Robert
- Ashworth Linda K.
- Aslanidis Cara
- Asomugha Chinwe O.
- Asuncion Lawreen
- Atkin Deborah
- Atkinson Andrea
- Atkinson Barry
- Attix Cristina
- Attwood John
- Aubin Keith
- Auger Katherine
- Austin Shannon Michelle
- Avila Aaron
- Avis Terry
- Ayele Mulu
- Babayan Primo
- Babbage Anne
- Babbage Sarah
- Bach Phil
- Bachatsang Pasang
- Bacon Joanne
- Badri Hummy
- Baertsch Robert
- Bagguley Claire
- Bailey Jonathan
- Bajorek Eva
- Baker Andrew
- Baker Dan
- Baker M.
- Baker Richard
- Bakis Michele
- Baldwin Jennifer
- Banda Michael
- Banerjee Ruby
- Bao Jingyue
- Bao Qiyu
- Bao Weidong
- Bao Weidong
- Baptiste Pertrice
- Barbaria Joseph A.
- Barbe Valérie
- Bardill Simon
- Barker Daniel
- Barker Darren
- Barker Gary
- Barlow Karen
- Baron Laurent
- Barrett Anika
- Bartlett Rebecca
- Basham Victoria
- Bashman David
- Basu Suba
- Bateman Alex
- Bates Karen
- Battles John
- Batzer Mark
- Baumgart Cornelia
- Baumohl Jason
- Baynes Caroline
- Bayul Tashi
- Beall Keith
- Beard Lisa
- Beard Susan
- Beare David
- Beasley Alastair
- Beasley Helen
- Beasley Oliver
- Beaucham Leslie
- Beaudet Arthur
- Beck Alfred
- Beck Stephen
- Becker Michael
- Bell Emma
- Bell George I.
- Bellard Terell M.
- Bellerby Damian
- Bellerby Tristram
- Belter Edward A., Jr.
- Bemrose Richard
- Benard Michael Anthony
- BenKahla Alia
- Benke J
- Benner William
- Bennett James
- Bensasson Douda
- Bentley Andrew
- Bentley Dan
- Bentley David
- Berardinis Véronique de
- Bercovitz John
- Berghoff Amy
- Bergmann Anne
- Berkowicz Nicolas
- Berks Mary
- Berks Michael
- Bethel Graeme
- Beugelsdijk Tony J.
- Bhakta Rita
- Bhuchar Venita
- Bi Shihua
- Bian Xuemeng
- Bieri Tamberlyn
- Bimage Kesha E.
- Bird Christine
- Birditt Brian
- Birney Ewan
- Birney Ewan
- Birren Bruce
- Bissell Helen
- Biswalo Kaneza
- Bituin Aleksandr
- Black Stacey
- Blackburne-Maze Suzanne
- Blair Jessica Anne
- Blakey Sarah
- Blanks Tia
- Blasiar Darin
- Blazej Robert
- Blitshsteyn Berta
- Blomstrom David B.
- Bloom Scott
- Bloom Toby
- Blumer Heather
- Blye Jason
- Blyth Peter R.
- Blöcker Helmut
- Boatright Elizabeth
- Boehm John
- Boen Juanan
- Boguslavskiy Leonid
- Bolton Christel
- Bolund Lars
- Bondoc Marnel
- Bonfield James
- Bonnett Ralph
- Bonnin David
- Border Richard
- Borowsky Mark
- Borzym Katja
- Boukhgalter Boris
- Bowen Eric
- Bradley Amanda
- Bradshaw-Cordum Holly
- Brady Nicola
- Brandriff Brigitte F.
- Brannon Wade
- Branscomb Elbert
- Bray Jason
- Bray-Allen Sarah
- Brettin Thomas
- Bridgeman Anne
- Bridgers Michael
- Brimhall Angela K.
- Brokstein Peter
- Brook Jonathan
- Brooking Shane
- Brottier Philippe
- Brown Andrew
- Brown Clive
- Brown Jacqui
- Brown Margaret
- Brown Mary
- Brown Mary J.
- Brown Michael
- Brown Nancy C.
- Bruce David D.
- Bruce Robert
- Bruno William J.
- Bruskiewich Richard
- Bryant Jackie
- Bryant Jennifer E.
- Bryant Nathaniel P.
- Brüls Thomas
- Buatsi Delali
- Buck David
- Buckingham Judith M.
- Buckle Veronica
- Buczek Donald
- Budd Claire
- Buhay Christian J.
- Bulbul Kerem
- Buller Sarah
- Bunker Nathan
- Burberry Jill
- Burch Paula Ellen
- Burford Deborah
- Burgess Joanne
- Burgin Matt
- Burkett Carrie E.
- Burkhart-Schultz Karolyn
- Burrell Kevin L.
- Burrill Wayne
- Burrows Christine
- Burton Christine
- Burton John
- Butcher Phil
- Butler Adam
- Butler Jon
- Butler Paul
- Caenepeel Sean
- Cahill Patrick
- Cai Tianjing
- Cai Zhen
- Cairns Murray
- Calderon Eliana
- Callen David F.
- Camarata Jody
- Camire David
- Camm Nick
- Campbell Christopher
- Campbell Connie S.
- Campbell Evelyn W.
- Campbell Mary I.
- Campbell Mary L.
- Campo Kevin
- Canning Bruno
- Cao Ting
- Cao Yuzhu
- Caoile Chenier
- Cardenas Faviola
- Cardenas Lolo
- Cardenas Veronica
- Carder Carol
- Carder Paul
- Carpenter Kelly
- Carrano Anthony V.
- Carriere Jason
- Carter Jason
- Carter Kelvin
- Carter Nigel
- Caruso Lauren
- Casias Kristal
- Cattolico Laurence
- Cavanna Tamara
- Cavazos Iracema
- Cavazos Sandra R.
- Ceasar Heather
- Cedroni Maria
- Cepeda Mario
- Chacko Joseph
- Chain Patrick
- Chalk Shani
- Challacombe Jean F.
- Chan Ka
- Chan Sheryl N.
- Chan Yee Man
- Chang Jean L.
- Chapman Jarrod
- Chapman Joanna
- Chapple Jeffrey
- Charles Rachel
- Chasteen Leslie A.
- Chavarria Simeon
- Chazaro Bruno
- Chen Baoxian
- Chen Bin
- Chen Chira
- Chen Chong
- Chen Chong
- Chen Chun-Nan
- Chen Cong
- Chen Ellson
- Chen Hsiu-Chuan
- Chen Jianlong
- Chen Jie
- Chen Jin
- Chen Junbao
- Chen Lihong
- Chen Lixia
- Chen Ray
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- Cinkowsky Michael J.
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- DeArellano Kurt
- Deaven Larry I.
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- Förste Silke
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- Harbes Brandy A.
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- Krawczyk Marie-Claude
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- Kremmidiotis Gabriel
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- Kruchowski Scott S.
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- Mercado Iracema C.
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- Mistry Dippica
- Mistry Shailesh
- Mitchell Jake
- Mitchell Jeff
- Mitchell Teresa
- Mitina Sophia
- Mitsui Aki
- Mitsuyama Susumu
- Miyazawa Akemi
- Mlenga Val
- Mohabbat Farida
- Mohabbat Khatera
- Mohammadi Maryam
- Mohrenweiser Harvey
- Molina Christophe
- Monforte Joseph
- Montemayor Julie
- Montgomery Baize
- Montgomery Mishelle
- Mooney Paul
- Moore Madeline
- Moore Niki
- Moreland Andrea
- Morgan Jenna
- Morgan Margaret B.
- Morita Hiroko
- Morris Sidney
- Mortimore Beverly
- Morton Jerry
- Motoyama Ayuko
- Mott Richard
- Moyzis Robert K.
- Mu Feng
- Mukherjee Shibani
- Mullenger Ian
- Mullikin Jim
- Mulrain Leon
- Munday Brian
- Munday Elaine
- Mundt Mark O.
- Mungall Andy
- Munidasa Mala
- Munk A. Christine
- Munk Christie A.
- Munson Glen
- Murakami Katsuhiko
- Murayama Yuji
- Murnane Clare
- Murphy Matthew B.
- Murphy Michael
- Murray Christine
- Murray Debra Dianne
- Murray Jennifer
- Murrell Kerry
- Muzny Donna Marie
- Myers Alison
- Myers Richard
- Müller Ines
- Nagamine Kentaro
- Nagao Syunsuke
- Nagaraja R.
- Nair Latha
- Nair Seema R.
- Naka Maho
- Nakagawa Masayo
- Nakagawa Saori
- Nakamura Etsuko
- Nakato Eriko
- Nanavati Amit N.
- Nandkeshwar Richard
- Nankervis Colin E.
- Naranjo Cleo M.
- Nash William
- Naylor Jerome
- Nazareth Lynne V.
- Neal Dearl D.
- Negus David
- Nelson Catherine
- Nelson David O.
- Nelson Deborah A.
- Nelson Joanne
- Nelson Kathryn
- Nelson Ward
- Nesbitt Ryan
- Neunkirch Jennifer
- Newes Christian
- Newman April
- Ng Bee
- Ng Terrance
- Ngo Robin Ngoc
- Nguyen Bao-Viet
- Nguyen Christine
- Nguyen Cindy
- Nguyen Hoa
- Nguyen Le-Thu Dinh
- Nguyen Lisa
- Nguyen Minh
- Nguyen Na
- Nguyen Natalie M.
- Nguyen Ngoc Bich
- Nguyen Thu
- Nhan Mike
- Ni Lin
- Niblett David
- Nicholson Jonathan
- Nickerson Elizabeth
- Nickerson Tim
- Nicol Robert
- Nijjar Sukhjit
- Ning Zemin
- Nisbet James
- Nishida Aki
- Niu Yuxin
- Niu Yuxin
- Nivens Amber
- Noguchi Hideki
- Nolan Matt
- Norbu Chou Dolma
- Norbu Nyima
- Nordsiek Gabriele
- Norris Sarah Louise
- Novik Karen
- Nowlin Larry
- Nusbaum Chad
- Nwaokelemeh Ogechi O.
- Nwokenkwo Stanley
- O\u27Donnell Paula
- O\u27Donovan Daniel
- O\u27Leary Sinead
- O\u27Loughlin Jennifer
- O\u27Neill Keith
- Obayashi Izumi
- Obregon Melissa
- Oddone Paola
- Oddone Pierre
- Oddy Lachlan
- Odell Christopher
- Ogawara Etsuko
- Ogbighele Francess
- Oguh Maryann
- Ohmori Kyoko
- Ohno Saho
- Ohta Nao
- Ohtsubo Masafumi
- Oinn Tom
- Okoawo Ose
- Okui Michiyo
- Okumura Reina
- Okwuonu Geoffrey O.
- Okwuonu Kenneth C.
- Olarnpunsagoon Alisa
- Olivas Jason
- Oliver Hayley
- Oliver Karen
- Olsen Anne S.
- Olson Maynard V.
- Omotosho Bamidele
- Onoda Junko
- Oomori Nobuhiro
- Ooshima Kenshiro
- Oragunye Njideka
- Orantes Jerry
- Orbell Helena
- Osada Misuzu
- Osborn Anthony
- Osborne Joan
- Osman Sahal
- Ovcharenko Ivan
- Overton-Larty Emma
- Oviedo Rodolfo J.
- Ow David
- Ozawa Ritsuko
- Ozersky Philip
- Pace Araceli C.
- Pack Elizabeth
- Padki Anuradha
- Pahlavan Shane
- Palaniappan Krishnaveni
- Palazzolo Michael
- Palmeiri Anthony
- Palmer Sophie
- Pan Jiaofeng
- Pan Sisu
- Panasenko Vladimir
- Pandian Richard
- Parker Adrian
- Parker David Neil
- Parker Stephen
- Parkin Christopher
- Parkin Kim
- Parks Kenya L.
- Parry-Brown Ginny
- Parson-Quintana Beverly
- Pasternak Shiran
- Patel Bella Mayurkumar
- Patel Dina
- Patel Jalpa N.
- Patel Ritesh
- Patel Shripa
- Patel Vishal V.
- Patrick James
- Paul Heidie A.
- Paul Shelia
- Paulson Edward
- Payton Brett A.
- Pearce Alexandra
- Pearman Charlene
- Pearson Danita
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- Peck Anna
- Peck Richard
- Pedan John
- Pelan Sarah
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- Peng Vivian
- Peng Vivian
- Peng Yi
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- Pennacchio Len A.
- Pennacchio Len A.
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- Perez Agapito
- Perez Lesette M.
- Perito Andrew
- Perrault Isabelle
- Perrier Rene
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- Perrin William
- Pesavento Brad
- Peters Anna
- Peters Leonard G.
- Peterson Jane
- Peterson Karl
- Petit Jean-Louis
- Pettett Roger
- Petz Uta
- Pfeiffer Joyce
- Phan Hoan
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- Phillimore Ben
- Phillips Kim
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- Phulchung Tenzin
- Phunkang Pema
- Pickens Adam
- Pieper Natasha
- Pierre Nadia
- Piqani Bruno
- Piscia C.
- Pitesky Maurice
- Pitluck Sam
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- Playford Emma
- Plopper Farah Jo Homsi
- Plumb Bob
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- Pohl Craig
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- Poliakov Alex
- Pollard Martin
- Polman Jos
- Ponting Chris P.
- Porter Aaron
- Porter Keith
- Porter Tarryn
- Posada Martha
- Potter Christopher
- Potter Simon
- Poundstone Pat
- Pourrajabi Nima M.
- Powell Don
- Powell Jason
- Prado Daisy
- Prange Christa
- Prathalingham Radhika
- Predki Paul
- Prigmore Elena
- Primus Eltrick L.
- Primus Jennifer
- Probst Lyle
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- Pruitt Kim
- Pu Ling-Ling
- Puazo Maria
- Putnam Nicholas
- Qasem Osama
- Qi Qiuhui
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- Qi Xiaohua
- Qian Xufang
- Qian Zengmin
- Qiang Boqin
- Qiang Boqin
- Qiao Zhenyong
- Qin Xiang
- Quail Michael
- Quan Glenda
- Quarrie Hannah
- Quiles Miyo M.
- Quince Chris
- Quiroz Juana B.
- Qureshi Matloob
- Rabata Dina
- Rachlin Eric K.
- Rachupka Anthony
- Radionenko Maxim
- Rajagopal Mohan
- Ramasami Umadevi
- Rameau Rayale
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- Ramirez Melissa
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- Ramsay Helen
- Ramsey Yvonne
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- Rand Vikki
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- Randolph David
- Randolph James
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- Rappaport Barry
- Rash Sam
- Ratford Joanne
- Ratford Lewis
- Ratliff Robert I.
- Ray Aditya
- Ray Vernada
- Raymond Chris
- Raymond Christina
- Read Daniel
- Redhead Donald
- Redon Richard
- Rees Christine
- Reeves Kacy
- Regala Warren
- Reichwald Kathrin
- Reid Mary
- Reigh Richard A.
- Reily Amy D.
- Reinhardt Astrid
- Reinhardt Richard
- Reiter Charlie
- Ren Shuangxi
- Ren Shuangxi
- Ren Yanru
- Retterer James
- Rice Alex
- Rice Catherine
- Rice Peter
- Rice Stephen
- Richard Suzzanne
- Richards Stephen
- Richardson Kristi
- Richardson Paul
- Richardson Paul
- Richardson Susan
- Ricke Darryl O.
- Ridler Kerry
- Riethman Harold
- Riethoven Lyn
- Rigby Rachel
- Riley B.E
- Rise Cecil
- Rivera Angel
- Rives Catharine M.
- Road JungShing
- Robert Catherine
- Roberts Simon
- Robinson Chris
- Robinson Dezere
- Robinson Donna I.
- Robinson Donna L.
- Robinson Melanie
- Rochford Rebecca
- Rock Susan M.
- Rodkey Travis L.
- Rodriguez Alex
- Rodriguez Joseph
- Rodriguez Juan
- Rogers Jane
- Rogers Lisa
- Rogers Stephanine
- Rogosin Andrea
- Rogov Peter
- Rohlfing Theresa
- Rojas Alberto
- Rokhsar Daniel
- Rong Li
- Rong Li
- Rosenbloom Kate R.
- Roskin Krishna M.
- Ross Hugh
- Ross Mark
- Ross Stephanie
- Rowen Lee
- Rubenfield Marc
- Rubin Edward M.
- Ruef Barbara
- Ruiz Erica M.
- Ruiz San Juana
- Rule Angela
- Rule James
- Rule Jeffrey
- Russell Ben
- Russell Jayne
- Ryan Andrea
- Sabo Aniko
- Saenphimmachak Channakhone
- Safdar Kamal
- Sakai Ryoko
- Sakaki Yoshiyuki
- Sakaldasis George
- Salamov Azaf
- Salazar Angelica
- Salter Natalie
- Samain Sylvie
- Sana Moazzam Mohammad
- Sanders Brent
- Sanders Christina
- Sanders Wendi
- Santibanez Jireh
- Santoyo-Lopez Javier
- Sanuki Naoko
- Sarmiento R.
- Sasaki Takashi
- Satpathy Suraj
- Saunders David
- Saunders Elizabeth H.
- Saurin William
- Savery Glenford G.
- Sawada Nori
- Sawhill William W.
- Saxman Eric
- Scarpelli Claude
- Scharfe Maren
- Schatzkamer Kyriena L.
- Scherer Steven Edward
- Schilhabel Markus
- Schlessinger David
- Schmeits James
- Schmidt Esther
- Schmoger Siliva
- Schmutz Jeremy
- Schnabl Matthew
- Schuler Gregory
- Schupbach Rebecca
- Schuster Michael
- Schön Oliver
- Scott Carol
- Scott Damian
- Scott Deborah
- Scott Duncan
- Scott Graham
- Scott Ian
- Scott Kelsi
- Scott Paul
- Seager Fiona
- Seaman Christopher
- Seaman Steven
- Searle Margaret
- Searle Paul
- Searle Stephen
- Sehra Harminder
- Seitz Kathleen
- Sekhon Mundeep
- Severin Jessica
- Seymour Burt
- Shah Neha
- Shakespeare Joe
- Shams Saima
- Shao Chunyan
- Shao Yufen
- Shapiro Harris
- Shardelow Jason
- Sharp Greg
- Sharpe Ted
- Shaw Teresa
- Shaw-Smith Charles
- She Xinwei
- Shearing Jennifer
- Shen Fengye
- Shen Hua
- Shen Meishan
- Shen Yan
- Shen Yan
- Shen Yan
- Sheng Haihui
- Sheppard Karen
- Sheridan Andrew
- Sheridan Elizabeth
- Sherpa Ngawang
- Shi Guibin
- Shi Hongfang
- Shibuya Kazunori
- Shiino Noriko
- Shimizu Atsushi
- Shimizu Hidetsugu
- Shimizu Nobuyoshi
- Shimizu Yoshiko
- Shin Maria
- Shindoh Nobuaki
- Shintani Ai
- Shiohama Aiko
- Shoji Minami
- Shotland Yoram
- Shought Timothy
- Shownkeen Ratna
- Shreve Jeff
- Siddiqui Roman
- Siepel Adam C.
- Silk Richard
- Silk Richard
- Sims Matthew
- Sims Matthew
- Sims Sarah
- Sims Sarah
- Sindelar Linda
- Sinha Prashant
- Sisson Ida
- Sivadasan Shanthi
- Sivadasan Shanthi
- Skowronski Evan
- Skuce Carl
- Skuce Carl
- Slater Nathaniel
- Slezak Tom
- Smedley Damian
- Smink Luc
- Smink Luc
- Smith Andrew
- Smith Andrew
- Smith Cherylyn
- Smith Doug
- Smith Douglas R.
- Smith James
- Smith James
- Smith Joel
- Smith Karen
- Smith Laura
- Smith Laura
- Smith Lorraine
- Smith Lorraine
- Smith Michael
- Smith Michelle
- Smith Michelle
- Smith Russell
- Smith Russell
- Smith Stephanie
- Smith Stephanie
- Smith Troy
- Sneath Hannah
- Sneath Hannah
- Sodergren Erica
- Soderlund Cari
- Soderlund Cari
- Soderlund Cari
- Solovyev Victor
- Solovyez Victor
- Sonaike Titilola
- Song Liping
- Song Liping
- Song Shuping
- Song Xing-Zhi
- Sonnhammer Erik
- Sonnhammer Erik
- Sorelle Richard P.
- Sotheran Elizabeth
- Sougnez Carrie
- Spainhower Corey
- Sparks Anastasia L.
- Spencer Brian
- Spieth John
- Spooner William
- Spraggon Lee
- Sqaures Suzanna
- Squares Janet
- Stabenau Arne
- Stables Michael
- Stalker James
- Stalker John
- Stallings Raymond I.
- Stalvey Malinda
- Stamford Steve
- Stammers Melanie
- Standring Lisa
- Stange-Thomann Nicole
- Stavropoulos Sharon
- Steffen David
- Stege Justin T.
- Steingruber Helen
- Stephens Yvonne
- Stephens-Bolds Shaela
- Stetson Kevin
- Stevko Victor
- Steward Charles
- Stewart Aengus
- Stewart Michael
- Still Ian
- Stock Mo
- Stone Casey
- Stone Evan
- Stone Sabrina
- Stoppard Lisa
- Storey Philip
- Storey Roy
- Stowe Sarah
- Strachan Carol
- Strachan Greg
- Strasser Jonathan
- Stribling Claire
- Strong Cynthia
- Stubbs Lisa
- Stubbs Matthew
- Stultz Janet
- Sturdy John
- Su Xiaohu
- Subramanian Sandhya
- Subramanian Sandhya
- Sudbrak Ralf
- Sugnet Charles W.
- Sulston John
- Summers Leslie J.
- Sun Hui
- Sun Jiajia
- Sun Jiandong
- Sun Jiu Qin
- Sun Min
- Sun Tao
- Sun Wei
- Sun Yongqiao
- Sun Yu
- Sun Yue
- Sutherland Grant R.
- Sutherland Robert D.
- Sutton Angelica E.
- Svatek Amanda F.
- Svetz Jessica
- Svetz Leah Anne
- Swainson Chris
- Swann Mark
- Swarbreck David
- Swearengen-Shahid Sharhonda
- Sycamore Neil
- Ségurens Béatrice
- Tabor Paul E.
- Tacey Kristina
- Tagett Beckie
- Tagney Matthew
- Tahara Takashi
- Takahashi Keiko
- Takano Nobuhiro
- Takaoka Tori
- Takayanagi Atsushi
- Takenaka Tracy
- Talamas Jessica
- Tam Serena
- Tamerisa Kavitha S.
- Tamirisa Aparna
- Tan Olivia
- Tan Steven
- Tan Xinyu
- Tan Xinyu
- Tang Hongli
- Tang Xiangjun
- Tansey Jennifer
- Tao Ran
- Tapia Roxanne
- Taring Elizabeth
- Tatsuyama Miho
- Tatum Owatha I.
- Taudien Stefan
- Taylor Amy
- Taylor Christina C.
- Taylor Gillian
- Taylor Kate
- Taylor Ruth
- Taylor Sam
- Taylor Susan
- Taylor Tineace R.
- Taylor Todd Duane
- Tchuinga Pierre
- Tee Louise
- Telford Ethan Brett
- Tenzin Pema
- Terada Yoriko
- Terry Astrid
- Tesfaye Senait
- Tesmer Judith G.
- Tester Julieanne
- Thayer Nina
- Theaker Andrew
- Theil James
- Theodore Joumathe
- Thexton David
- Thies Stephanie
- Thomas Craig
- Thomas Daniel
- Thomas Daryl J.
- Thomas Karen
- Thomas Nicole
- Thomas Paulette
- Thomas Ruth
- Thomas Shereen
- Thommai Roselin
- Thompson Linda S.
- Thorne Rachel Diane
- Thorpe Andrea
- Thorpe Karen
- Thoulutsang Yama
- Threadgold Glen
- Thurston Scott
- Tian Chaoguang
- Tian Chaoguang
- Tian Wei
- Tian Yan
- Tian Yong
- Tian Yuqing
- Tice Hope
- Tighe Damon
- Tin-Wollam Aye M.
- Tinsley Emma
- Tochigi Miwako
- Togashi Naoko
- Tomizawa Iori
- Tomlinson Chad
- Tong Jingli
- Topham Kerri
- Torcaso Bill
- Torney David C.
- Totoki Yasushi
- Towey Sarah
- Toyoda Atsushi
- Tracey Alan
- Tran Ly Thanh
- Tran-Gyamfi Mary
- Trani Lee
- Trankiem Margie
- Trask Barbara J.
- Travers Johnathan
- Trejos Zulma Y.
- Treuhaft Marianne
- Trevino Brenda Kaye
- Tromans Anthony
- Trong Stephan
- Trumbower Heather
- Tsai Ming
- Tsamla Tsamla
- Tsolas Jason
- Tsomo Nawang
- Tsujimoto Susan
- Tsukamoto Yumi
- Tsuruoka Hiromi
- Tsuzuki Rina
- Tu Yuefeng
- Tu Yuefeng
- Tubby Ben
- Tufarelli Cristina
- Turner Heidi
- Turney Kathryn
- Tynan Katherine
- Ueland Stephanie
- Ueng Samantha
- Ukegbu Ogechi Nkemdirim
- Ulanovsky Levy E.
- Un Chun
- Ung Quyen
- Upson Darren
- Urban Jeremy B.
- Ureta-Vidal Abel
- Ureta-Vidal Abel
- Usmani Kamran
- Ustaszewska Anna
- Uyama Nozomi
- Valas Ruben E.
- Valdez Michelle
- Valle Duane
- Valles Yvonne
- Van Brunt Andrew
- Van Dilla Marvin
- Van Helmond Zoe
- Van Luchene Ryan
- Vardanian Zachary
- Vargas Michelle
- Vargo Charles E.
- Vartanian Steffan
- Vasquez Lydia I.
- Vassiliev Helen
- Vastrik Imre
- Vaudin Mark
- Veil Rose
- Veklerov Eugene
- Velasco Nelson
- Velasquez Lisa
- Venkataranan Vijay
- Vera Virginia A.
- Verduzco Daniel
- Vergez Lisa
- Vico Virginie
- Viknaraja Ramya
- Villasana Donna M.
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- Viswanathan Vijay
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- Vo Nu
- Voak Paul
- Vollenhoven David
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- Wagner-McPherson Caryn
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- Walker Keya
- Walker Sarah
- Wall Melanie
- Wall Randy E.
- Wallace John
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- Wallis Michelle
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- Walsham Natalie
- Wan Ma
- Wang Chunyan
- Wang Dong
- Wang Feng
- Wang Guangxin
- Wang Guihai
- Wang Guihai
- Wang Hongjuan
- Wang Hongwei
- Wang Huanjie
- Wang Huifeng
- Wang Huifeng
- Wang Jian
- Wang Jian
- Wang Jian
- Wang Jie
- Wang Jing
- Wang Jingqiang
- Wang Jingqiang
- Wang Jinhua
- Wang Joann
- Wang Juan
- Wang Jun
- Wang Jun
- Wang Jun
- Wang Li
- Wang Lijie
- Wang Lijuan
- Wang Lijun
- Wang Ling
- Wang Liqun
- Wang Mei
- Wang Qiaoyan
- Wang Shifen
- Wang Shu
- Wang Suzhen
- Wang Wenjun
- Wang Xiaoling
- Wang Xiaoning
- Wang Xuefei
- Wang Xuegang
- Wang Yan
- Wang Yimin
- Wang Ying
- Wang Ying
- Wang Yuanyuan
- Wangchuck Tsering
- Wangdi Tsering
- Ward-Moore Stephanie
- Warren Graham
- Warren James T.
- Warry Georgina
- Watanabe Hidemi
- Watanabe Saki
- Waterston Robert H.
- Watson Andy
- Watt Nicola
- Webb Anthony
- Webb Jeannette
- Webber Caleb
- Weber Ryan J.
- Wehri Edward
- Wei Shulin
- Wei Xuehong
- Weidenbach Richard
- Weinstock George
- Weinstock Keith
- Weir John
- Weissenbach Jean
- Wells Alan
- Wells Sarah
- Welton Robert
- Wen Gaiping
- Wendi Mike
- Weng Li
- Wenning Sarah
- Wentz Sara
- Werler Daniela
- Wesley Mary Melissa
- West Paul
- West Tony
- Wetterstrand Kris
- Wheatley Angela
- Wheatley Carl
- Wheeler David A.
- Wheeler Gideon
- Wheeler Jeremy
- Whitaker Hayley
- White Adam
- White Amelia
- White Brian
- White Catherine
- White Flower
- White Jennifer
- White Johnathon
- White P. Scott
- White Scott P.
- White Simon
- Whitehead Sally
- Whiteley Matthew
- Whitmore Scott
- Whittaker Adam
- Whittaker Charles
- Whittaker Pamela
- Wickremasinghe Manosha I.
- Widaa Sara
- Wiegel Sarah
- Wild Anna
- Wilkinson Jane
- Wilkinson Jane
- Wilkinson Paul
- Willey David
- Williams Albert L.
- Williams Andy
- Williams Bill
- Williams Gabrielle A.
- Williams Leanne
- Williamson Angela L.
- Williamson Helen
- Wills Patricia L.
- Wills Richard
- Wilmer Tamsin
- Wilming Laurens
- Wilson Brian
- Wilson Gareth
- Wilson Margaret
- Wilson Nyree
- Wilson Piers
- Wilson Richard K.
- Wilson Siobhan
- Wilson Steve
- Wilson Wendy
- Wincker Patrick
- Window Philip
- Winster Jenny
- Winzar Claire
- Witt James
- Wleczyk Regina
- Wobus Fred
- Woessner Jeffrey
- Wohldmann Patty
- Wollard Jessica
- Womack Andrew W.
- Wong Benjamin
- Wong Gane K-S
- Wood Diane
- Wood Emma
- Wood Joe
- Wooden Hailey S.
- Wooden Steven H.
- Woodeson Sharon
- Woodfine Kathryn
- Woodmansey Rebecca
- Woods Eric
- Woodwark Cara
- Wooster Richard
- Worley Kim Carlyle
- Woyke Tanja
- Wray Matthew
- Wray Paul
- Wright Charmain
- Wright Debbie
- Wright Kathrine
- Wright Kristin
- Wright Rita A.
- Wu Chungen
- Wu Dongying
- Wu Jiaqian
- Wu Jung-Rung
- Wu Kevin
- Wu Qingfa
- Wu Qingfa
- Wu Ruiming
- Wu Xiao
- Wu Xiaojing
- Wu Zaining
- Wyatt Julia
- Wycoff-Montenegro Melissa
- Wylie Kris
- Wyman Dudley
- Wyman Stacia
- Xi Yan
- Xi Yingying
- Xie Fei
- Xie Gary
- Xie Jane
- Xiong Hui
- Xiong Yuqing
- Xu Alex
- Xu Jing
- Xu Jing
- Xu Ruqin
- Xu Shuhua
- Xu Wei
- Xu Xinlai
- Xu Yan
- Xu Yuning
- Xu Zhihong
- Xu Zuyuan
- Xuan Yali
- Xuan Zhenyu
- Xue Rui
- Yada Tetsushi
- Yadav Shailendra
- Yakub Syed
- Yamamoto Lynn
- Yamamoto Noriko
- Yamamoto Yuko
- Yamashita Yasue
- Yamazaki Satoru
- Yang Hao
- Yang Huanming
- Yang Huanming
- Yang Joan
- Yang Shiaw-Pyng
- Yang Shudong
- Yang Xiaonan
- Yang Xiaonan
- Yang Xiaoping
- Yang Yongkui
- Yano Candance
- Yao Zhijian
- Yao Zhijian
- Yaspo Marie-Laure
- Ye Chen
- Yeager Shane
- Yeh Mimi
- Yen Jennifer
- Yeshitela Rahel Retta
- Yoakum Martin
- Yokobata Kathy
- Yokoyama Jennifer
- Yonezawa Miho
- Yoon Lillienne
- Yoon Vivienne
- Yoshida Satoru
- You Bo
- Young Geneva
- Young Louise
- Young Shelia
- Younger Ruth
- Yu Bing
- Yu Charles
- Yu Fuli
- Yu Jun
- Yu Jun
- Yu Jun
- Yuan Kaiwen
- Yuan Ye
- Yuan Yida
- Yue Shujie
- Yumae Brian
- Yun Rui
- Zainoun Joanne
- Zembeck Lisa
- Zeng Yixin
- Zhai Dong
- Zhan Guoping
- Zhang Bo
- Zhang Caimin
- Zhang Fengmei
- Zhang Guangyu
- Zhang Guohua
- Zhang Guohua
- Zhang Haiqing
- Zhang Haiqing
- Zhang Haiqing
- Zhang Hongbo
- Zhang Hongbo
- Zhang Jingjing
- Zhang Jingjing
- Zhang Jingkun
- Zhang Jiuchun
- Zhang Jiuchun
- Zhang Lanzhi
- Zhang Li
- Zhang Li
- Zhang Meihua
- Zhang Meng
- Zhang Ming
- Zhang Qing
- Zhang Ruhua
- Zhang Shaojie
- Zhang Tiezhen
- Zhang Wei
- Zhang Wei
- Zhang Xianglin
- Zhang Xianglin
- Zhang Xiaoliang
- Zhang Xiuqing
- Zhang Yan
- Zhang Yi
- Zhang Yilin
- Zhang Yilin
- Zhang Ying
- Zhang Yuansen
- Zhang Yuzhi
- Zhang Zhengdong
- Zhao Hongmei
- Zhao Lijian
- Zhao Shenru
- Zhao Zhijing
- Zhen Zhicheng
- Zheng Haibo
- Zhong Ming
- Zhou Carol
- Zhou Haixia
- Zhou Jianling
- Zhou Nannan
- Zhou Xinfeng
- Zhou Yan
- Zhou Yang
- Zhou Yi
- Zhu Bingying
- Zhu Bofeng
- Zhu Fenghua
- Zhu Genfeng
- Zhu Genfeng
- Zhu Miao
- Zhu Ning
- Zhu Yongge
- Zhu Zhen
- Zhuang Shitao
- Zierten Deborah
- Zimmer Andrew
- Zody Michael C.
- Zollo Massimo
- Zorrilla Sara E.
- Zuo Lin
- Publication venue
- LSU Digital Commons
- Publication date
- 21/10/2004
- Field of study
The sequence of the human genome encodes the genetic instructions for human physiology, as well as rich information about human evolution. In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human genome. Since then, the international collaboration has worked to convert this draft into a genome sequence with high accuracy and nearly complete coverage. Here, we report the result of this finishing process. The current genome sequence (Build 35) contains 2.85 billion nucleotides interrupted by only 341 gaps. It covers ∼99% of the euchromatic genome and is accurate to an error rate of ∼1 event per 100,000 bases. Many of the remaining euchromatic gaps are associated with segmental duplications and will require focused work with new methods. The near-complete sequence, the first for a vertebrate, greatly improves the precision of biological analyses of the human genome including studies of gene number, birth and death. Notably, the human enome seems to encode only 20,000-25,000 protein-coding genes. The genome sequence reported here should serve as a firm foundation for biomedical research in the decades ahead
Comprehensive miRNA sequence analysis reveals survival differences in diffuse large B-cell lymphoma patients
- Author
- A Gordon Robertson
- A Kozomara
- A Liston
- A Roehle
- AA Alizadeh
- AJ Alencar
- AJA Deutsch
- AL Shaffer 3rd
- Andrew J Mungall
- Andy Chu
- Anja Mottok
- B John
- C Trapnell
- C Xiao
- Cancer Genome Atlas Research Network
- CDC Allen
- CE Ott
- CH Lawrie
- CH Lawrie
- CH Lawrie
- Christian Steidl
- D Lenze
- Daisuke Ennishi
- David W Scott
- DD Jima
- Diane L Trinh
- DM Garcia
- DW Scott
- Emilia L Lim
- F Hsu
- G Teng
- GA Calin
- I Haecker
- J Li
- J Lin
- J Lu
- Jacqueline Schein
- JJ Forman
- Joseph M Connors
- JR Lytle
- K Basso
- L Qin
- L Weng
- L Xu
- LH Sehn
- M Hafner
- M Wang
- MA Shipp
- Marco A Marra
- Martin Krzywinski
- Merrill Boyle
- N Rosenfeld
- Nathalie A Johnson
- PP Medina
- R Bosch
- R Malumbres
- R Shaknovich
- Randy D Gascoyne
- RD Gascoyne
- RD Morin
- RD Morin
- RL Camp
- Ryan D Morin
- S Bauer
- S Caramuta
- S Costinean
- S Ding
- S Montes-Moreno
- SW Chi
- TM Therneau
- V Fulci
- VJ Craig
- W Kwanhian
- W Meng
- W Wang
- W-T Huang
- Yongjun Zhao
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
The Somatic Genomic Landscape of Chromophobe Renal Cell Carcinoma
- Author
- Ahn Jaeil
- Akbani Rehan
- Aldape Kenneth D.
- Ally Adrian
- Atkins Michael B.
- Auman J. Todd
- Ayala Brenda
- Baboud Julien
- Balasundaram Miruna
- Balu Saianand
- Baylin Stephen B.
- Benz Christopher C.
- Beroukhim Rameen
- Bhanot Gyan
- Biehl Michael
- Birol Inanc
- Black Aaron D.
- Bodenheimer Tom
- Boice Lori
- Bootwalla Moiz S.
- Bowen Jay
- Bristow Christopher A.
- Brooks Denise
- Buda Elizabeth
- Buhay Christian
- Butterfield Yaron S.N.
- Carter Scott L.
- Chao Hsu
- Chen Fengju
- Cherniack Andrew D.
- Cheville John
- Chin Lynda
- Cho Juok
- Choi Yoon La
- Choueiri Toni K.
- Chu Andy
- Chuah Eric
- Chudamani Sudha
- Clarke Amanda
- Coarfa Cristian
- Creighton Chad J.
- Czerniak Bogdan A.
- Dahdouli Mike
- Davidsen Tanja
- Davis Caleb F.
- Demchok John A.
- Dhalla Noreen
- Di-Cara Daniel
- Doddapaneni Harsha
- Donehower Lawrence A.
- Downs Brittany
- Drummond Jennifer
- Eley Greg
- English Adam
- Fahey Catherine C.
- Fan Yu
- Fargo David
- Felau Ina
- Frazer Scott
- Gabriel Stacey B.
- Gastier-Foster Julie M.
- Gehlenborg Nils
- Getz Gad
- Gibbs Richard A.
- Gordenin Dmitry A.
- Guin Ranabir
- Gunaratne Preethi H.
- Guyer Mark S.
- Hacker Kathryn E.
- Hadjipanayis Angela
- Hakimi A. Ari
- Hale Walker
- Hall Tracy M.
- Hanf Benjamin
- Haussler David
- Hawes Alicia
- Hayes D. Neil
- Heiman David I.
- Henske Elizabeth P.
- Hoadley Katherine A.
- Holt Robert A.
- Hoyle Alan P.
- Hsieh James J.
- Huang Mei
- Hutter Carolyn M.
- Jefferys Stuart R.
- Jensen Mark A.
- Jones Corbin D.
- Jones Steven J.M.
- Kaelin William G.
- Kaipparettu Benny A.
- Kakkar Nipun
- Kalra Divya
- Kang Hyojin
- Kasaian Katayoon
- Kim Jaegil
- Kim Sang Cheol
- Klimczak Leszek J.
- Kovar Christie
- Kucherlapati Raju
- Kwiatkowski David J.
- Lai Phillip H.
- Laird Peter W.
- Lang Martin
- Lawrence Michael S.
- Lee Darlene
- Lee Eunjung
- Lee June Koo
- Lee Junehawk
- Lee Semin
- Leraas Kristen M.
- Lewis Lora
- Li Haiyan I.
- Lichtenberg Tara M.
- Lim Emilia
- Lin Pei
- Linehan W. Marston
- Liu Jia
- Liu Yingchun
- Luquette Lovelace J.
- Ma Singer
- Ma Yussanne
- Marra Marco A.
- Mayo Michael
- Meng Qingchang
- Meng Shaowu
- Merino Maria
- Meyerson Matthew
- Mieczkowski Piotr A.
- Moore Richard A.
- Morgan Margaret
- Morton Donna
- Mose Lisle E.
- Mungall Andrew J.
- Murray Bradley A.
- Muzny Donna
- Noble Michael S.
- Ozenberger Bradley A.
- Pantazi Angeliki
- Parfenov Michael
- Park Peter J.
- Park Woong Yang
- Parker Joel S.
- Perou Charles M.
- Peterson James
- Pihl Todd
- Protopopov Alexei
- Radenbaugh Amie
- Ramirez Nilsa C.
- Rathmell W. Kimryn
- Reid Jeffrey G.
- Reuter Victor
- Ricketts Christopher J.
- Roach Jeffrey
- Roberts Steven A.
- Robertson A. Gordon
- Saksena Gordon
- Santoso Netty
- Schein Jacqueline E.
- Schmidt Laura S.
- Schumacher Steven E.
- Seidman Jonathan
- Seiler Michael
- Seth Sahil
- Shaw Kenna R.Mills
- Shen Hui
- Sheth Margi
- Shuch Brian
- Signoretti Sabina
- Simons Janae V.
- Sipahimalani Payal
- Smith Angela B.
- Sofia Heidi J.
- Soloway Mathew G.
- Song Xingzhi
- Sougnez Carrie
- Spellman Paul T.
- Stojanov Petar
- Stuart Josh M.
- Tabak Barbara
- Tam Angela
- Tamboli Pheroze
- Tan Donghui
- Tarnuzzer Roy W.
- Thiessen Nina
- Thompson R. Houston
- Thorne Leigh
- Tickoo Satish K.
- Triche Timothy
- Van Den Berg David J.
- Velaga Sudhakar
- Veluvolu Umadevi
- Vocke Cathy
- Voet Doug
- Walker Kimberly
- Wallen Eric M.
- Walton Jessica
- Wan Yunhu
- Wang Min
- Wang Qiaoyan
- Wang Wenyi
- Wang Zhining
- Waring Scot
- Weinstein John N.
- Weisenberger Daniel J.
- Wheeler David A.
- Wilkerson Matthew D.
- Wise Lisa
- Wong Tina
- Wood Christopher G.
- Worrell Robert
- Wu Junyuan
- Wu Ye
- Xi Liu
- Xu Andrew W.
- Yang Liming
- Yang Lixing
- Zack Travis I.
- Zenklusen Jean Claude
- Zhang Hailei
- Zhang Jianhua
- Zhang Jiashan
- Zhul Jingchun
- Zmuda Erik
- Zou Lihua
- Publication venue
- Publication date
- 01/01/2014
- Field of study
We describe the landscape of somatic genomic alterations of 66 chromophobe renal cell carcinomas (ChRCCs) based on multidimensional and comprehensive characterization, including mitochondrial DNA (mtDNA) and whole genome sequencing. The result is consistent that ChRCC originates from the distal nephron compared to other kidney cancers with more proximal origins. Combined mtDNA and gene expression analysis implicates changes in mitochondrial function as a component of the disease biology, while suggesting alternative roles for mtDNA mutations in cancers relying on oxidative phosphorylation. Genomic rearrangements lead to recurrent structural breakpoints within TERT promoter region, which correlates with highly elevated TERT expression and manifestation of kataegis, representing a mechanism of TERT up-regulation in cancer distinct from previously-observed amplifications and point mutations
Multiplatform Analysis of 12 Cancer Types Reveals Molecular Classification within and across Tissues of Origin
- Author
- Abbott Rachel
- Abbott Scott
- Akbani Rehan
- Aksoy B. Arman
- Aldape Kenneth
- Ally Adrian
- Amin Samirkumar
- Anastassiou Dimitris
- Auman J. Todd
- Baggerly Keith A.
- Balasundaram Miruna
- Balu Saianand
- Baylin Stephen B.
- Benz Christopher C.
- Benz Stephen C.
- Berman Benjamin P.
- Bernard Brady
- Bhatt Ami S.
- Birol Inanc
- Black Aaron D.
- Bodenheimer Tom
- Bootwalla Moiz S.
- Bowen Jay
- Bressler Ryan
- Bristow Christopher A.
- Brooks Angela N.
- Broom Bradley
- Buda Elizabeth
- Burton Robert
- Butterfield Yaron S.N.
- Byers Lauren A.
- Carlin Daniel
- Carter Scott L.
- Casasent Tod D.
- Chang Kyle
- Chanock Stephen
- Chen Zhong
- Cherniack Andrew D.
- Chin Lynda
- Cho Dong Yeon
- Cho Juok
- Chu Andy
- Chuah Eric
- Chun Hye Jung E.
- Cibulskis Kristian
- Ciriello Giovanni
- Cleland James
- Cline Melisssa
- Collisson Eric A.
- Craft Brian
- Creighton Chad J.
- Danilova Ludmila
- Davidsen Tanja
- Davis Caleb
- Dees Nathan D.
- Delehaunty Kim
- Demchok John A.
- Dhalla Noreen
- DiCara Daniel
- Ding Li
- Dinh Huyen
- Dobson Jason R.
- Dodda Deepti
- Doddapaneni Harsha Vardhan
- Donehower Lawrence
- Dooling David J.
- Dresdner Gideon
- Drummond Jennifer
- Eakin Andrea
- Edgerton Mary
- Eldred Jim M.
- Eley Greg
- Ellrott Kyle
- Fan Cheng
- Fei Suzanne
- Felau Ina
- Frazer Scott
- Freeman Samuel S.
- Frick Jessica
- Fronick Catrina C.
- Fulton Lucinda L.
- Fulton Robert
- Gabriel Stacey B.
- Gao Jianjiong
- Gastier-Foster Julie M.
- Gehlenborg Nils
- George Myra
- Getz Gad
- Gibbs Richard
- Goldman Mary
- Gonzalez-Perez Abel
- Gross Benjamin
- Guin Ranabir
- Gunaratne Preethi
- Hadjipanayis Angela
- Hamilton Mark P.
- Hamilton Stanley R.
- Han Leng
- Han Yi
- Harper Hollie A.
- Haseley Psalm
- Haussler David
- Hayes D. Neil
- Heiman David I.
- Helman Elena
- Helsel Carmen
- Herbrich Shelley M.
- Herman James G.
- Hinoue Toshinori
- Hirst Carrie
- Hirst Martin
- Hoadley Katherine A.
- Holt Robert A.
- Hoyle Alan P.
- Iype Lisa
- Jacobsen Anders
- Jeffreys Stuart R.
- Jensen Mark A.
- Jones Corbin D.
- Jones Steven J.M.
- Ju Zhenlin
- Jung Joonil
- Kahles Andre
- Kahn Ari
- Kalicki-Veizer Joelle
- Kalra Divya
- Kanchi Krishna Latha
- Kandoth Cyriac
- Kane David W.
- Kim Hoon
- Kim Jaegil
- Knijnenburg Theo
- Koboldt Daniel C.
- Kovar Christie
- Kramer Roger
- Kreisberg Richard
- Kucherlapati Raju
- Ladanyi Marc
- Laird Peter W.
- Lander Eric S.
- Larson David E.
- Lawrence Michael S.
- Lee Darlene
- Lee Eunjung
- Lee Semin
- Lee William
- Lehmann Kjong Van
- Leinonen Kalle
- Leiserson Max D.M.
- Leraas Kristen M.
- Lerner Seth
- Levine Douglas A.
- Lewis Lora
- Ley Timothy J.
- Li Haiyan I.
- Li Jun
- Li Wei
- Liang Han
- Lichtenberg Tara M.
- Lin Jake
- Lin Ling
- Lin Pei
- Liu Wenbin
- Liu Yingchun
- Liu Yuexin
- Lopez-Bigas Nuria
- Lorenzi Philip L.
- Lu Charles
- Lu Yiling
- Luquette Lovelace J.
- Ma Singer
- Magrini Vincent J.
- Mahadeshwar Harshad S.
- Mardis Elaine R.
- Margolin Adam A.
- Marra Marco A.
- Mayo Michael
- McAllister Cynthia
- McGuire Sean E.
- McLellan Michael D.
- McMichael Joshua F.
- Melott James
- Meng Shaowu
- Meyerson Matthew
- Mieczkowski Piotr A.
- Miller Christopher A.
- Miller Martin L.
- Miller Michael
- Mills Gordon B.
- Moore Richard A.
- Morgan Margaret
- Morton Donna
- Mose Lisle E.
- Mungall Andrew J.
- Muzny Donna
- Ng Sam
- Nguyen Lam
- Niu Beifang
- Noble Michael S.
- Noushmehr Houtan
- O'Laughlin Michelle
- Ojesina Akinyemi I.
- Omberg Larsson
- Ozenberger Brad
- Pantazi Angeliki
- Parfenov Michael
- Park Peter J.
- Parker Joel S.
- Paull Evan
- Pedamallu Chandra Sekhar
- Perou Charles M.
- Pihl Todd
- Pohl Craig
- Pot David
- Protopopov Alexei
- Przytycka Teresa
- Radenbaugh Amie
- Ramirez Nilsa C.
- Ramirez Ricardo
- Raphael Benjamin J.
- Reid Jeffrey
- Ren Xiaojia
- Reva Boris
- Reynolds Sheila M.
- Rhie Suhn K.
- Roach Jeffrey
- Robertson A. Gordon
- Rovira Hector
- Ryan Michael
- Rätsch Gunnar
- Saksena Gordon
- Salama Sofie
- Sander Chris
- Santoso Netty
- Schein Jacqueline E.
- Schmidt Heather
- Schultz Nikolaus
- Schumacher Steven E.
- Seidman Jonathan
- Senbabaoglu Yasin
- Seth Sahil
- Sharpe Samantha
- Shen Hui
- Shen Ronglai
- Sheth Margi
- Shi Yan
- Shmulevich Ilya
- Silva Grace O.
- Simons Janae V.
- Sinha Rileen
- Sipahimalani Payal
- Smith Scott M.
- Sofia Heidi J.
- Sokolov Artem
- Soloway Mathew G.
- Song Xingzhi
- Sougnez Carrie
- Spellman Paul
- Staudt Louis
- Stewart Chip
- Stojanov Petar
- Stuart Joshua M.
- Su Xiaoping
- Sumer S. Onur
- Sun Yichao
- Swatloski Teresa
- Tabak Barbara
- Tam Angela
- Tamborero David
- Tan Donghui
- Tang Jiabin
- Tarnuzzer Roy
- Taylor Barry S.
- Thiessen Nina
- Thorsson Vesteinn
- Triche Timothy
- Uzunangelov Vladislav
- Van Den Berg David J.
- Van Waes Carter
- Van't Veer Laura J.
- Vandin Fabio
- Varhol Richard J.
- Vaske Charles J.
- Veluvolu Umadevi
- Verhaak Roeland
- Voet Doug
- Walker Jason
- Wallis John W.
- Waltman Peter
- Wan Yunhu
- Wang Min
- Wang Wenyi
- Wang Zhining
- Waring Scot
- Weinhold Nils
- Weinstein John N.
- Weisenberger Daniel J.
- Wendl Michael C.
- Wheeler David
- Wilkerson Matthew D.
- Wilson Richard K.
- Wise Lisa
- Wolf Denise M.
- Wong Andrew
- Wu Chang Jiun
- Wu Chia Chin
- Wu Hsin Ta
- Wu Junyuan
- Wylie Todd
- Xi Liu
- Xi Ruibin
- Xia Zheng
- Xu Andrew W.
- Yang Da
- Yang Liming
- Yang Lixing
- Yang Tai Hsien Ou
- Yang Yang
- Yao Jun
- Yao Rong
- Yau Christina
- Ye Kai
- Yoshihara Kosuke
- Yuan Yuan
- Yung Alfred K.
- Zack Travis
- Zeng Dong
- Zenklusen Jean Claude
- Zhang Hailei
- Zhang Jianhua
- Zhang Jiashan
- Zhang Nianxiang
- Zhang Qunyuan
- Zhang Wei
- Zhao Wei
- Zheng Siyuan
- Zhu Jing
- Zmuda Erik
- Zou Lihua
- Publication venue
- Publication date
- 01/01/2014
- Field of study
Recent genomic analyses of pathologically-defined tumor types identify “within-a-tissue” disease subtypes. However, the extent to which genomic signatures are shared across tissues is still unclear. We performed an integrative analysis using five genome-wide platforms and one proteomic platform on 3,527 specimens from 12 cancer types, revealing a unified classification into 11 major subtypes. Five subtypes were nearly identical to their tissue-of-origin counterparts, but several distinct cancer types were found to converge into common subtypes. Lung squamous, head & neck, and a subset of bladder cancers coalesced into one subtype typified by TP53 alterations, TP63 amplifications, and high expression of immune and proliferation pathway genes. Of note, bladder cancers split into three pan-cancer subtypes. The multi-platform classification, while correlated with tissue-of-origin, provides independent information for predicting clinical outcomes. All datasets are available for data-mining from a unified resource to support further biological discoveries and insights into novel therapeutic strategies
Retrospective evaluation of whole exome and genome mutation calls in 746 cancer samples
- Author
- A Gordon Robertson
- Abdullah Kahraman
- Abel Gonzalez-Perez
- Adam A Margolin
- Adam Abeshouse
- Adam Grundhoff
- Adam J Struck
- Adam J Struck
- Adam J Wright
- Adam Lambert
- Adam P Butler
- Adam P Butler
- Adel El-Naggar
- Adnan M Nagrial
- Adrian Ally
- Adrian Baez-Ortega
- Adrian Thorogood
- Adriana Salcedo
- Adrienne M Flanagan
- Ake Borg
- Akihiro Fujimoto
- Akihiro Suzuki
- Akinyemi I Ojesina
- Alain Viari
- Alan J Robertson
- Alan P Hoyle
- Alan Thompson
- Alasdair Stenhouse
- Alastair M Thompson
- Aldo Scarpa
- Alessandro Pastore
- Alex Buchanan
- Alex Buchanan
- Alexander Claviez
- Alexander J Lazar
- Alexander Martinez-Fundichely
- Alfonso Muñoz
- Alfonso Valencia
- Aliaksei Z Holik
- Alice Meng
- Alicia L Bruzos
- Allison Creason
- Allison P Heath
- Alvin Wei Tian Ng
- Alvis Brazma
- Amaro Taylor-Weiner
- Amber L Johns
- Amie Radenbaugh
- Amit G Deshwar
- Ana Dueso-Barroso
- Ana Mijalkovic Mijalkovic-Lazic
- Ana Milovanovic
- Ana Milovanovic
- Andre Kahles
- Andrea Haake
- Andrea Holbrook
- Andrea L Richardson
- Andrea Mafficini
- Andrea Ruzzenente
- Andreas Behren
- Andreas Rosenwald
- Andreia V Pinho
- Andrew Berchuck
- Andrew D Cherniack
- Andrew J Dunford
- Andrew J Mungall
- Andrew J Spillane
- Andrew Menzies
- Andrew Menzies
- Andrew P Barbour
- Andrew Tutt
- Andrew V Biankin
- Andrey Korshunov
- Andrés Lanzós
- Andy Cafferkey
- Andy G Lynch
- Angela Chou
- Angela N Brooks
- Angela Tam
- Angelica Ochoa
- Angelika N Christ
- Angelo P Dei Tos
- Anieta M Sieuwerts
- Anil K Sood
- Anita Langerød
- Anja Füllgrabe
- Anke K Bergmann
- Ann-Marie Patch
- Anna deFazio
- Anna Ehinger
- Anna Fitzgerald
- Anne Hamilton
- Anne Vincent-Salomon
- Anne Y Warren
- Anne-Lise Børresen-Dale
- Annegien Broeks
- Anthony DiBiase
- Anthony J Gill
- Anthony Ng
- Anthony R Green
- Antonia L Pritchard
- Antonio Pea
- Antonios Koures
- Aparna Prasad
- Apurva M Hegde
- Aquila Fatima
- Arcadi Navarro
- Arie B Brinkman
- Arif O Harmanci
- Arindam Maitra
- Armando Lopez-Guillermo
- Arndt Borkhardt
- Arnoud Boot
- Asger Hobolth
- Ashley Williams
- Ashton A Connor
- Atul J Butte
- Aurélien Chateigner
- Austin J Hepperla
- Axel Aretz
- Aya Sasaki-Oku
- Ayellet V Segre
- B F Francis Ouellette
- Bailey Matthew H
- Barbara Hutter
- Barbara Hutter
- Barbara Kremeyer
- Bartha M Knoppers
- Beifang Niu
- Beifang Niu
- Beifang Niu
- Benedikt Brors
- Benita Kiat Tee Tan
- Benjamin J Raphael
- Benjamin P Berman
- Benjamin Raeder
- Bernardo Rodriguez-Martin
- Bernhard Radlwimmer
- Bernice H Wong
- Beth Karlan
- Bin Tean Teh
- Bin Zhu
- Birgit Burkhardt
- Bishoy M Faltas
- Bodil Bjerkehagen
- Bogdan Czerniak
- Boris Winterhoff
- Borislav C Rusev
- Bradly G Wouters
- Brandi N Davis-Dusenbery
- Brian Craft
- Brian D O'Connor
- Brian Patrick O'Neill
- Brice Aminou
- Calvin Wing Yiu Chan
- Cameron M Soulette
- Carl Herrmann
- Carl Morrison
- Carlo Gambacorti-Passerini
- Carlos Caldas
- Carlos D Bustamante
- Carlos López-Otín
- Carlota Rubio-Perez
- Carmen Gomez
- Carolien H M van Deurzen
- Carolyn M Hutter
- Carolyn M Hutter
- Carrie Cibulskis
- Caterina Vicentini
- Catherine A Shang
- Catherine D Moser
- Catherine J Kennedy
- Catrina C Fronick
- Chad J Creighton
- Chandra Sekhar Pedamallu
- Chang Li
- Charles David Imbusch
- Charles M Perou
- Charles Saller
- Charles Short
- Charlie E Massie
- Chawalit Pairojkul
- Chen Hong
- Chen Ye
- Cheng-Zhong Zhang
- Chin-Lee Wu
- Chip Stewart
- Chip Stewart
- Chip Stewart
- Choon Kiat Ong
- Chris Lawerenz
- Chris Mitchell
- Chris Sander
- Christian von Mering
- Christiane Buchholz
- Christina K Yung
- Christina K Yung
- Christina Yau
- Christine A Iacobuzio-Donahue
- Christine Chomienne
- Christine Desmedt
- Christine P'ng
- Christof von Kalle
- Christoph Borst
- Christoph Plass
- Christopher A Miller
- Christopher Benz
- Christopher J Scarlett
- Christopher J Yoon
- Christopher K Wong
- Christopher M Lalansingh
- Christopher M Lalansingh
- Christopher Ogden
- Christopher S Foster
- Christopher Umbricht
- Christopher W Toon
- Christos Sotiriou
- Cindy Bell
- Cinzia Cantù
- Ciyue Shen
- Claes Wadelius
- Clare Verrill
- Clarissa Gerhauser
- Claudia Calabrese
- Claudio Bassi
- Claudio Luchini
- Claudiu Farcas
- Clemency Jolly
- Colin A Purdie
- Colin A Semple
- Colin C Collins
- Colin S Cooper
- Conrad R Leonard
- Constance H Li
- Corbin D Jones
- Craig Shriver
- Cristina López
- Cyriac Kandoth
- Cyril Fisher
- D Neil Hayes
- Dai-Ying Wu
- Daiming Fan
- Daisuke Komura
- Dale W Garsed
- Daniel A Leongamornlert
- Daniel Baumhoer
- Daniel Hübschmann
- Daniel J Turner
- Daniel J Weisenberger
- Daniel M Berney
- Daniel Rosebrock
- Daniel S Brewer
- Daniela S Gerhard
- Danielle Pasternack
- Darell Bigner
- Dariush Etemadmoghadam
- Darlene Lee
- Darrin F Taylor
- Dave Larson
- David A Wheeler
- David A Wheeler
- David C Wedge
- David Craft
- David D L Bowtell
- David E Neal
- David Haan
- David Haussler
- David Haussler
- David Hedley
- David Huntsman
- David I Heiman
- David J Adams
- David J Van Den Berg
- David K Chang
- David K Miller
- David Khoo
- David Mutch
- David N Louis
- David Nicol
- David Ocana
- David R Jones
- David R Jones
- David Scott
- David T Bowen
- David T W Jones
- David Tamborero
- David Torrents
- David Torrents
- David Townend
- David Vicente
- Davide Antonello
- Declan Cahill
- Denis Larsimont
- Denis Yuen
- Denise Brooks
- Deniz Demircioğlu
- Dennis C Sgroi
- Dennis Karsch
- Dennis T Maglinte
- Dennis Wigle
- Derek W Wright
- Dianne E Chadwick
- Dido Lenze
- Dieter Kube
- Dieter Weichenhan
- Dilip D Giri
- Dimitri Livitz
- Dimitri Livitz
- Dimple Chakravarty
- Ding
- Dirk Schadendorf
- Dmitry A Gordenin
- Dominik Glodzik
- Don Chalmers
- Dong Guanlan
- Dongbing Liu
- Donghoon Lee
- Donghui Tan
- Donna M Muzny
- Dorthe Grabau
- Douglas A Levine
- Douglas F Easton
- Douglas Voet
- Duncan Beardsmore
- Dursi Lewis Jonathan
- Edward W Rowe
- Eigo Shimizu
- Ekta Khurana
- Elaine R Mardis
- Electron Kebebew
- Elena Piñeiro-Yáñez
- Elena Provenzano
- Elias Campo
- Elisabet Barrera
- Elisabetta Sereni
- Elizabeth A Musgrove
- Elizabeth L Appelbaum
- Elizabeth L Christie
- Elli Papaemmanuil
- Ellrott Kyle
- Emilie Lalonde
- Eoghan Harrington
- Eric Chuah
- Eric Green
- Eric Lander
- Eric Minwei Liu
- Eric Z Ma
- Eric Z Ma
- Erik Garrison
- Erik Larsson
- Erik Mayer
- Erik N Bergstrom
- Erin Curley
- Ermin Hodzic
- Erwin G Van Meir
- Esa Pitkänen
- Esther Rheinbay
- Esther Rheinbay
- Eun Pyo Hong
- Eunjung Alice Lee
- Eva G Alvarez
- Eva Hellstrom-Lindberg
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- Yu Fan
- Yu-Jia Shiah
- Yuan Ji
- Yuan Yuan
- Yuichi Shiraishi
- Yulia Newton
- Yulia Rubanova
- Yumeng Wang
- Yupeng Cun
- Yussanne Ma
- Zachary Heins
- Zechen Chong
- Zechen Chong
- Zemin Zhang
- Zhaohong Chen
- Zhenggang Wu
- Zhenggang Wu
- Zhining Wang
- Zhongming Zhao
- Ziao Lin
- Zsofia Kote-Jarai
- Ólafur Andri Stefánsson
- Øystein Garred
- Publication venue
- Nature Communications
- Publication date
- 01/01/2020
- Field of study
Funder: NCI U24CA211006Abstract: The Cancer Genome Atlas (TCGA) and International Cancer Genome Consortium (ICGC) curated consensus somatic mutation calls using whole exome sequencing (WES) and whole genome sequencing (WGS), respectively. Here, as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium, which aggregated whole genome sequencing data from 2,658 cancers across 38 tumour types, we compare WES and WGS side-by-side from 746 TCGA samples, finding that ~80% of mutations overlap in covered exonic regions. We estimate that low variant allele fraction (VAF < 15%) and clonal heterogeneity contribute up to 68% of private WGS mutations and 71% of private WES mutations. We observe that ~30% of private WGS mutations trace to mutations identified by a single variant caller in WES consensus efforts. WGS captures both ~50% more variation in exonic regions and un-observed mutations in loci with variable GC-content. Together, our analysis highlights technological divergences between two reproducible somatic variant detection efforts
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