Entwicklung von hochbeanspruchten Fahrzeugschraubenfedern aus niedrig- bzw. unlegierten Kohlenstoffstaehlen Schlussbericht. Abschlussdatum: Juli 1982

TIB: RN 2598 (83-120)+a / FIZ - Fachinformationszzentrum Karlsruhe / TIB - Technische InformationsbibliothekSIGLEDEGerman

A Study to Compare Oral Sumatriptan with Oral Aspirin plus Oral Metoclopramide in the Acute Treatment of Migraine

In a double-blind, placebo-controlled study, the efficacy, safety and tolerability of 100 mg oral sumatriptan, given as a dispersible tablet, was compared with that of 900 mg oral aspirin plus 10 mg oral metoclopramide in the acute treatment of migraine. A total of 358 patients treated up to three migraine attacks within 3 months, recording clinical information on a diary card. In attack 1, headache relief after 2 h, defined as a reduction in severity from severe or moderate pain to mild or no pain, was recorded in 56% (74/133) of patients who took sumatriptan and 45 % (62/138) of patients who took aspirin plus metoclopramide (p = 0.078). This analysis of the primary efficacy end point was not statistically significant. However, for attacks 2 and 3 (secondary end points), headache relief was achieved in 58 versus 36% of patients (p = 0.001) and 65 versus 34% of patients (p < 0.001), respectively. Relief from nausea, vomiting, photophobia and phonophobia was similar in both treatment groups. Rescue medication was required by fewer patients treated with sumatriptan than by those who received aspirin plus metoclopramide (attack 1, 34 versus 56%, p < 0.001; attack 2, 32 versus 51 %, p = 0.001, and attack 3, 35 versus 54%, p = 0.001). Sumatriptan also produced a faster improvement and resolution of migraine attacks. Comparing the sumatriptan and aspirin plus metoclopramide treatment groups, complete resolution of the attack occurred within 6 h in 32 versus 19% (attack 1), 35 versus 23% (attack 2) and 32 versus 20% of patients (attack 3). There was, however, a lower incidence of headache recurrence within 48 h in patients who received aspirin plus metoclopramide: attack 1, 42 % on sumatriptan versus 33% on aspirin plus metoclopramide (NS); attack 2, 37 versus 27% (NS), and attack 3, 42 versus 30% (p = 0.038). Adverse events were reported by 42 % of patients on sumatriptan and 29% of patients on aspirin plus metoclopramide (p = 0.009), but these were generally mild or moderate. Treatment was rated as reasonable, good or excellent by 66 % of patients in the sumatriptan group, compared with 45% of those in the aspirin plus metoclopramide group (p < 0.001). Moreover, 70% of sumatriptan-treated patients said they would be prepared to take the treatment again, compared with 46% of patients who received aspirin plus metoclopramide (p < 0.001). Overall, oral sumatriptan produced faster and greater relief of migraine headache and was more highly rated by patients than oral aspirin plus oral metoclopramide

Activité des navires de pêche 2017 : quartier maritime Marseille

Ce document est réalisé dans le cadre du projet « Système d'Informations Halieutiques » (SIH) de l'Ifremer, qui constitue le réseau d'observation des ressources halieutiques et des usages associés. Ce projet s'inscrit dans la mission de service d'intérêt public de l'Ifremer consistant à « connaître, évaluer et mettre en valeur les ressources des océans et permettre leur exploitation durable ». Outre la collecte des données pertinentes permettant l'analyse du secteur des pêches, le SIH a en charge l'élaboration d'indicateurs sur les flottilles de pêche et leur restitution sous forme de synthèses aux différents acteurs de la filière pêche (depuis la recherche jusqu'aux professionnels et gestionnaires) et du grand public

State of the Climate in 2012

International audienceEditors note: For easy download the posted pdf of the State of the Climate for 2012 is a very low-resolution file. A high-resolution copy of the report is available by clicking here. Please be patient as it may take a few minutes for the high-resolution file to download