12 research outputs found

    Harms and benefits associated with psychoactive drugs: Findings of an international survey of active drug users

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    There have been several recent efforts in the UK and the Netherlands to describe the harms of psychoactive substances based on ratings of either experts or drug users. This study aimed to assess the perceived benefits as well as harms of widely used recreational drugs, both licit and illicit, in an international sample of drug users. The survey was hosted at https://www.internationaldrugsurvey.org/ and was available in three languages. Residents reported their experience of 15 commonly used drugs or drug classes; regular users then rated their harms and benefits. In all, 5791 individuals from over 40 countries completed the survey, although the majority were from English speaking countries. Rankings of drugs differed across 10 categories of perceived benefits. Skunk and herbal cannabis were ranked consistently beneficial, whilst alcohol and tobacco fell below many classified drugs. There was no correlation at all between users’ harm ranking of drugs and their classification in schedules of the USA or ABC system in the UK. Prescription analgesics, alcohol and tobacco were ranked within the top 10 most harmful drugs. These findings suggest that neither the UK nor US classification systems act to inform users of the harms of psychoactive substances. It is hoped the results might inform health professionals and educators of what are considered to be both the harms and benefits of psychoactive substances to young people

    Multiscale digital Arabidopsis predicts individual organ and whole-organism growth

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    Understanding how dynamic molecular networks affect wholeorganism physiology, analogous to mapping genotype to phenotype, remains a key challenge in biology. Quantitative models that represent processes at multiple scales and link understanding from several research domains can help to tackle this problem. Such integrated models are more common in crop science and ecophysiology than in the research communities that elucidate molecular networks. Several laboratories have modeled particular aspects of growth in Arabidopsis thaliana, but it was unclear whether these existing models could productively be combined. We test this approach by constructing a multiscale model of Arabidopsis rosette growth. Four existing models were integrated with minimal parameter modification (leaf water content and one flowering parameter used measured data). The resulting framework model links genetic regulation and biochemical dynamics to events at the organ and whole-plant levels, helping to understand the combined effects of endogenous and environmental regulators on Arabidopsis growth. The framework model was validated and tested with metabolic, physiological, and biomass data from two laboratories, for five photoperiods, three accessions, and a transgenic line, highlighting the plasticity of plant growth strategies. The model was extended to include stochastic development. Model simulations gave insight into the developmental control of leaf production and provided a quantitative explanation for the pleiotropic developmental phenotype caused by overexpression of miR156, which was an open question. Modular, multiscale models, assembling knowledge from systems biology to ecophysiology, will help to understand and to engineer plant behavior from the genome to the field. (Résumé d'auteur

    Data supporting 'Pressure drag for shallow cumulus clouds: from thermals to cloud ensemble'

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    This dataset is used to understand the pressure drag of shallow cumulus clouds, the relationship between the pressure drag of individual clouds and the cloud ensemble. We performed large eddy simulations of shallow cumulus clouds based on the Barbados Oceanographic and Meteorological Experiment (BOMEX) using the Met Office-NERC (National Environment Research Council) Cloud model (MONC). The grid spacing is 25 m in all directions and the domain size is (15X15X3) km^3. As the whole simulation has a huge dataset, we present a subset of the results that can be used to reproduce the figures in 'Pressure drag for shallow cumulus clouds: from thermals to cloud ensemble' (submitted to Geophysical Research Letters; 2020). Access to the all simulation data can be provided on request. The full dataset will be deposited in the CEDA Archive in due course. The dataset contains four sub-directories with generated data and another sub-directory with scripts for plotting the figures in the article. The generated data include: [1]. The conditionally averaged budget terms in vertical velocity equation for different parts of cloud ensemble; [2]. The conditionally averaged budget terms in vertical velocity equation for all tracked clouds; [3]. The conditionally averaged budget terms in vertical velocity equation for tracked clouds with different lifetime; [4]. The conditionally averaged budget terms in vertical velocity equation for each individually tracked cloud over its lifetime; [5]. The vertical cross section data of cloud structure; [6]. The positions of tracked clouds; [7]. The composited structure of clouds at 600m, 1000m and 1800m
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