Reproductive traits and lactation performance of Kenana cows at Umbenein Livestock Research Station, Sinnar State, Sudan

Sudanese Kenana breed is one of the largest east African Zebu cattle. Its performance is close to the best dairy breeds in Africa. This study aimed to estimate selected reproduction and lactation traits and effects of sire, lactation number and year of calving on those traits in Kenana cows at Umbenein Livestock Research Station, Sinnar State, Sudan. The official records of the station during the years 2000 -2017 were used. Overall mean of age at first calving, calving interval, open, dry and lactation periods (day) and lactation, daily and standard yields (kg) were 1673, 468, 184, 151, 315, 2260, 7 and 2042, respectively. The daughters of the sire of Umbenein Research Station showed earlier age at first calving and shorter calving interval, open and dry periods, while those of the sire of Umbenein village were higher in lactation, daily and standard yields. Lactation number had significant effects (P≤0.05) on lactation yield, calving interval and open period and were least in the fourth lactation. Daily and standard yields were higher in the third lactation, with a clear drop in the fourth one. Year of calving had significant effects (P≤0.05) on calving interval, open period, daily and standard yields. All traits studied, except lactation period, were higher in 2009-2011 years of calving and decreased in 2012-2014 and 2015-2017 calvings

Wilson’s Disease and Autoimmune Hepatitis Coexistence: A Cause of Diagnostic Delay

This case report describes a 27-year-old housewife who presented with a progressive and insidious onset of abdominal distension, loss of appetite, and fatigue which started 3 months before her presentation. The physical assessment showed moderate ascites and small liver size, and no other peripheral evidence of chronic liver disease was observed. A diagnosis of liver cirrhosis and was confirmed by investigations and imaging, where ascites responded well to therapy with diuretics. Investigations for the cause of cirrhosis was established through the diagnosis of autoimmune hepatitis, and she was started on steroids and azathioprine with partial improvement in liver biochemistry. She presented 8 months later with neuropsychiatric symptoms in the form of slurred speech and difficulty walking. Accordingly, Wilson’s disease was suspected to be the cause and further investigations confirmed this. A chelating agent, D penicillamine, was added to her immunosuppressive treatment. Nine months later she showed slow improvement in her neurological symptoms and was referred for assessment for liver transplantation. Wilson’s disease, although rare, should be suspected in patients with decompensated liver disease. The dominance of clinical and epidemiological features of autoimmune hepatitis as a common causative pathology for chronic liver disease in young and middle-aged ladies may hide the presence of other serious different pathologies such as Wilson’s disease

Pharmacodynamics Drug Interactions of Metformin with Aspirin and Nifedipine

Metformin is now being recognized as the standard therapy in T2D patients who are overweight. Metformin has many drug-disease interactions that can increase the risk of metformin-associated lactic acidosis. Therefore this study was conducted to evaluate any possible pharmacodynamic interactions between metformin and drugs used to treat chronic diseases e.g. Hypertension. The rats were fasted overnight before inducing diabetes with streptozotocin. The rats were given an intraperitoneal injection of streptozotocin (50 mg kg−1) freshly prepared in 0.1M sodium citrate buffer. The diabetic state was confirmed 72 h after streptozotocin injection. Diabetic rats were grouped into seven groups each group of five rats and distributed among the normal control group diabetic control group and the treatment groups. The treatment continued for 10 days. Blood samples were taken before treatment and after 10 days and analyzed for serum glucose, cholesterol, HDL, LDL, and triglycerides. In the diabetic control group which was given STZ alone the blood glucose level decreased significantly (p < 0.05) after 10 days but still above the hyperglycemic level (200mg/dl). The same was observed in the group treated with metformin. The group treated with nifedipine and aspirin showed significant reduction (p < 0.01) in the glucose level below the hyperglycemic level (200mg/dl). While the groups treated with (Metformin + Nifedipine) and (Metformin +Aspirin) showed highly significant reduction (P<0.001) in blood glucose level. These results conclude that the combination of (metformin +Nifedipine) and the combination of (Metformin + Aspirin) have highly significant hypoglycemic effect. It also showed that Nifedipine has promising role in reducing blood glucose level, lipid profile especially LDL-cholesterol, and body weight

Reproductive and lactation performance of Kenana and Butana crossbred cows, Gezira State, Sudan

Kenana and Butana cattle are the main indigenous dairy breeds in the Sudan. However, their productive performance is generally low compared to exotic breeds. This necessitates the crossbreeding with high milk producing breeds to meet the increasing demand for milk and dairy products through improving the genetic potential of the indigenous dairy cattle breeds. The objectives of this study were to determine the overall performance of Kenana and Butana 50% crosses with Friesian bulls, to estimate selected reproductive and lactation traits and to study the effects of dam breed, parity, lactation number, season and year of calving on those traits. A total number of 120 records for 30 dairy cows, each for four lactation seasons were used. Data were collected from the master records of Elbashaier dairy farm, about 10 km south of Wadmedani. They covered the years 1990- 2005. The overall means of crossbred dairy cows (days) for age at first calving, calving interval, open period, dry period and lactation period were 970, 400, 122, 65 and 332, respectively. Lactation, daily and standard yields (kg) were 3771, 12 and 3505, respectively. Kenana crossbred cows had higher calving interval, open, dry, lactation periods and lactation yield. Butana crossbred cows had higher age at first calving, daily and standard lactation yields. However, the effect of dam breed was not significant. Dam parity had significant effects (P≤0.05) on all traits except dry period. Age at first calving increased gradually while calving interval and lactation period decreased gradually with parity. Lactation yield was higher in the first and second parities, and daily and standard lactation yields were higher in the fourth parity. Lactation number had significant effects (P≤0.05) on all traits, except open period. Lactation period was higher in the first lactation, while dry period, lactation, daily and standard yields were least in the first lactation and increased with advanced lactation. Season of calving had significant effects (P≤0.05) on calving interval, open period, daily and standard lactation yields. Calving interval, open and lactation periods were longer, while, daily and standard lactation yields were lower during winter. Year of calving had significant effects (P≤0.05) on all traits except dry period. Age at first calving increased gradually with age

Production and Quality Evaluation of Vinegar from Tamarind (Tamarindus indica L.) Fruit Pulp

ABSTRACT       Vinegar is a liquid consisting mainly of acetic acid (CH3COOH) and water. The acetic acid is produced by the fermentation of ethanol by acetic acid bacteria. This study aimed to produce vinegar from tamarind fruit pulp and evaluation of its quality. Samples of tamarind fruit were collected from different sites in Sudan: Gedaref (GT), Damazin (DT) and Obeid (OT). The vinegar yields from 1 kg tamarind pulp from (GT), (DT) and (KT) were 300, 200, 260 ml, respectively. The physical characteristics of tamarind fruit pulp and its seeds were determined. The average fruit length, width and weight were 14.28± 0.31mm, 11.06± 1.1mm and 12.33± 0.7g, respectively The production of vinegar was carried out at three stages. The concentration of acetic acid of the produced vinegar from (GT), (DT) and (OT) were equivalent to (16.2%), (19%) and (17.7%), and pH values of these samples were found to be (2.2), (1.9) and (2.0), respectively. The study recommends the efficient industrial use of tamarind fruit in many products such as vinegar.&nbsp

The Effect of Mashing Methods on the Production of Nonalcoholic Sorghum Malt Beverage

Although sorghum (Sorghum bicolor) has been used traditionally to produce foods, malt and alcoholic beverages in Sudan, its structure and nutritional function have not been enough studied. Sorghum can be malted and processed into malted foods and beverages. The objective of this study was to study the effect of mashing methods on malt quality and wort composition to produce non-alcoholic sorghum malt beverage.  Malting was carried out at 30°C for 5 days under non-aerated condition. Mashing methods included decantation at 80°C (wort A) and at 100°C (wort B). Wort composition in terms of α –amino nitrogen, total soluble nitrogen, reducing sugars, pH, colour, original gravity and viscosity were determined. The results of wort A were 114 mg/l, 43%, 39.42 mg/ml, 6.59, 9 EBC, 1.026 and 0.846 cP, respectively. Whereas the results of wort B were 125 mg/l, 53%, 41.67 mg/ml, 6.68, 11 EBC, 1.025 and 0.864 cP, respectively. Decantation mashing at 100°C produced much better results in terms of malt and wort properties than that at 80°C where boiling the mash at 100°C adequately gelatinized residual sorghum malt starch, since sorghum starch has a gelatinization temperature of 80°C

Hepatoprotective Effect of Captopril on Liver Toxicity Induced by High and Low Dose of Paracetamol in Rats:Histological Study

Many patients may administered medications like captopril (ACE inhibitor) for treatment of chronic diseases and may also take Paracetamol as an Over The Counter (OTC) drug which may interact with captopril. Therefore, the aim of this study is to evaluate of the hepatoprotective effect of captopril on liver toxicity induced by low and high dose of paracetamol in rats. This study was conducted in two phases: first study for low dose of paracetamol (300 mg/kg); animals were divided into 4 groups of 6 rats each (n = 6); all groups were treated orally either 0.9 % Normal Saline (NS), captopril 20 mg/kg, paracetamol 300 mg/kg or captopril 20 mg/kg plus paracetamol 300 mg/kg for 10 consecutive days. Second study for single high dose of paracetamol (3000 mg/kg); animals were divided into 4 groups of 6 rats each (n = 6); all groups were pretreated orally either 0.9 % Normal Saline (NS) or captopril 20 mg/kg for 7 consecutive days followed by single oral administration of Paracetamol 3000 mg/kg or normal saline. The administration of Paracetamol or normal saline was performed 24 hours after the last administration of captopril. After 48 hours of hepatic injury induction, the animals were then sacrificed and the liver was removed for histopathological studies. Low dose (300 mg/kg) for 10 days and high single dose (3000 mg/kg) of paracetamol produced hepatotoxic effects. While captopril 20 mg/kg showed marked protection against changes induced by low and high dose of paracetamol on the liver

Successful Conservative Management of Scrotal Edema Resulting from Uncomplicated Peritoneal Fluid Leak

Introduction: Peritoneal fluid leaks are frequent in continuous ambulatory peritoneal dialysis (CAPD) patients and may manifest as subcutaneous or genital edema or as apparent ultrafiltration (UF) failure. Genital swelling in CAPD patients is often due to dialysate leak through a small clinically-undetectable inguinal hernia, and may require herniorrhaphy. If imaging studies exclude an associated hernia or patent processus vaginalis, a conservative approach may be adopted. Case report: An 80 year-old bed-ridden male developed gross bilateral scrotal swelling (without cough impulse) and apparent UF failure shortly after initiation of CAPD. Computed tomography peritoneography (CTP) showed bilateral scrotal fluid collections without a hernia or patent processus vaginalis. An attempt to maintain the patient on CAPD by reducing the dialysate volume, scrotal elevation and adopting a supine position was not successful; CAPD was substituted with temporary hemodialysis (HD) for four weeks. Scrotal swelling reversed after one week of CAPD cessation and did not recur when supine PD with intermittent dry periods was reinstituted a few weeks later. Satisfactory UF could also be easily attained. This was compatible with caudal fluid migration through peritoneal defects being the underlying cause. The patient had been successfully maintained on CAPD for the last 18 months. Conclusion: Fluid dissection through soft tissues can result in gross genital edema and apparent ultrafiltration failure in CAPD patients. Supine PD, scrotal elevation with intermittent dry periods may be a practical alternative management in the absence of automated dialysis facilities. The severity of dialysate leak does not preclude a satisfactory response to this conservative management. Keywords: peritoneal dialysis, dialysate leak, genital edema, ultrafiltration failur

Paromomycin for the Treatment of Visceral Leishmaniasis in Sudan: A Randomized, Open-Label, Dose-Finding Study

Visceral leishmaniasis (VL) is a parasitic disease transmitted through the bite of sandflies. The WHO estimates 500,000 new cases of VL each year, with more than 90% of cases occurring in Southeast Asia, East Africa, and South America. If left untreated, VL can be fatal. We had previously conducted a large multi-center study in Sudan, East Africa, to assess the efficacy of paromomycin (PM) alone or in combination with sodium stibogluconate. Clinical studies in India have shown that 15 mg/kg/day PM for 21 days was an effective cure. However, the same treatment regimen was not efficacious in two study sites in Sudan. Here, our aim was to assess two high-dose regimens of PM in Sudan: 15 mg/kg/day for 28 days and 20 mg/kg/day for 21 days. The results suggest that, at these total doses, PM is more efficacious than when given daily at 15 mg/kg for 21 days, and that high doses are required to treat VL in Sudan. Efficacy of 20 mg/kg/day PM for 21 days is currently being evaluated in a prospective, comparative phase III trial in East Africa