Comparison of Residual based Cointegration Tests: Evidence from Monte Carlo

In this article ten cointegration tests based on residuals of cointegrating equation are compared on basis of stringency criterion: a robust technique for comparison of tests using Monte Carlo simulations. Two tests i.e. Phillips and Ouliaris’ Pu and Choi Durbin-Hausman statistic are the leading performers and are recommended for any sample size. The remaining eight tests are recommended for only large sample sizes of 200 or greater. The use of all these ten tests is not recommended when presence of both intercept and linear time trend is assumed in cointegrating equation unless the sample size is very large i.e. greater than 200

SLOW INDUSTRIAL OUTPUT GROWTHEVIDENCE-BASED ON KOHAT ROAD INDUSTRIAL ESTATE PESHAWAR-PAKISTAN

The past decade has seen slowdowns in measured labor productivity growth across a broad swath of developed economies. The industrial sector grew 5.02 per cent in the outgoing fiscal year as opposed to the growth rate of 5.8pc recorded a year ago, in Pakistan. The main objective of this research is to examinethe small industrial performance in Peshawar-Pakistan. KPK is the smallest province in terms of area, among the four provinces, and the third-largest in terms of population. This study is about the total units Kohat road 124 industrial estates and 71 are closed which has spawned many social evils such a phenomenal increase in smuggling, trade and macro-unemployed youths indulge in illegal commercial ventures. The results show that the contribution of small-scale industrial sector toward the socio-economic development of the province is not significant. Furthermore, the main reasons are inconvenient location (away from the seaport), non-availability of skilled labor, inconsistent government policies, the dearth of local capital, lack of infrastructure and comparatively poor law and order situation, due to Afghan War, and operation in tribal areas. Nonetheless, certain policy recommendations were suggested based on the finding

Comparison of Residual based Cointegration Tests: Evidence from Monte Carlo

In this article ten cointegration tests based on residuals of cointegrating equation are compared on basis of stringency criterion: a robust technique for comparison of tests using Monte Carlo simulations. Two tests i.e. Phillips and Ouliaris’ Pu and Choi Durbin-Hausman statistic are the leading performers and are recommended for any sample size. The remaining eight tests are recommended for only large sample sizes of 200 or greater. The use of all these ten tests is not recommended when presence of both intercept and linear time trend is assumed in cointegrating equation unless the sample size is very large i.e. greater than 200

Genome-wide identification and characterization of bZIP transcription factors and their expression profile under abiotic stresses in Chinese pear (Pyrus bretschneideri)

Background: In plants, basic leucine zipper transcription factors (TFs) play important roles in multiple biological processes such as anthesis, fruit growth & development and stress responses. However, systematic investigation and characterization of bZIP-TFs remain unclear in Chinese white pear. Chinese white pear is a fruit crop that has important nutritional and medicinal values. Results: In this study, 62 bZIP genes were comprehensively identified from Chinese Pear, and 54 genes were distributed among 17 chromosomes. Frequent whole-genome duplication (WGD) and dispersed duplication (DSD) were the major driving forces underlying the bZIP gene family in Chinese white pear. bZIP-TFs are classified into 13 subfamilies according to the phylogenetic tree. Subsequently, purifying selection plays an important role in the evolution process of PbbZIPs. Synteny analysis of bZIP genes revealed that 196 orthologous gene pairs were identified between Pyrus bretschneideri, Fragaria vesca, Prunus mume, and Prunus persica. Moreover, cis-elements that respond to various stresses and hormones were found on the promoter regions of PbbZIP, which were induced by stimuli. Gene structure (intron/exon) and different compositions of motifs revealed that functional divergence among subfamilies. Expression pattern of PbbZIP genes differential expressed under hormonal treatment abscisic acid, salicylic acid, and methyl jasmonate in pear fruits by real-time qRT-PCR. Conclusions: Collectively, a systematic analysis of gene structure, motif composition, subcellular localization, synteny analysis, and calculation of synonymous (Ks) and non-synonymous (Ka) was performed in Chinese white pear. Sixty-two bZIP-TFs in Chinese pear were identified, and their expression profiles were comprehensively analyzed under ABA, SA, and MeJa hormones, which respond to multiple abiotic stresses and fruit growth and development. PbbZIP gene occurred through Whole-genome duplication and dispersed duplication events. These results provide a basic framework for further elucidating the biological function characterizations under multiple developmental stages and abiotic stress responses.This work was performed at the school of Life Sciences, Anhui agricultural university, Hefei, China and was supported by National Natural Science Foundation of China (No. 31640068) and Natural Science Youth Foundation of Anhui Agricultural University (No. 2019zd01). These funding bodies had no role in the design of the study, collection, analysis, and interpretation of data or in writing the manuscript

Detection of BCR-ABL kinase domain mutations in CD34+ cells from newly diagnosed chronic phase CML patients and their association with imatinib resistance

BCR-ABL kinase domain (KD) mutations, the most common cause of imatinib resistance, are infrequently detected in newly diagnosed chronic-phase chronic myeloid leukemia (CP-CML) patients. Recent studies indicate pre-existing mutations (PEMs) can be detected in a higher percentage of CML patients using CD34+ stem/progenitor cells, and these mutations may correlate with imatinib resistance. We investigated KD mutations in CD34+ stem cells from 100 CP-CML patients by multiplex ASO-PCR and sequencing ASO-PCR products at the time of diagnosis. PEMs were detected in 32/100 patients and included F311L, M351T, and T315I. After a median follow-up of 30 months (range 8-48), all patients with PEMs exhibited imatinib resistance. Of 68 patients without PEMs, 24 developed imatinib resistance. Mutations were detected in 21 of these patients by ASO-PCR and KD sequencing. All 32 patients with PEMs had the same mutations. In imatinib-resistant patients without PEMs, we detected F311L, M351T, Y253F, and T315I mutations. All imatinib-resistant patients without T315I and Y253F mutations responded to imatinib dose escalation. In conclusion, BCR-ABL PEMs can be detected in a substantial number of CP-CML patients when investigated using CD34+ stem/progenitor cells. These mutations are associated with imatinib resistance, and mutation testing using CD34+ cells may facilitate improved, patient-tailored treatment

Lie analysis and nonlinear propagating waves of the (3 + 1)-dimensional generalized Boiti–Leon–Manna–Pempinelli equation

The (3+1)-dimensional generalized Boiti-Leon-Manna-Pempinelli equation, which describes the evolution of Riemann wave propagation in an in-compressible fluid along three mutually perpendicular axes, is investigated in this research article. The study encompasses the analysis of Lie symmetries, corresponding symmetry reductions, and conservation laws associated with the equation. The Lie symmetry method is employed to determine the infinitesimal generators of the considered equation. Furthermore, commutator table is generated, and symmetry groups corresponding to each infinitesimal generator are derived. By utilizing the similarity reduction technique, the original nonlinear partial differential equation is transformed into nonlinear ordinary differential equations. Then, generalized exp(−ϕ(ζ)) expansion technique is utilized to solve the reduced equations and estimate specific traveling wave solutions for the equation. Moreover, graphical representations are employed to illustrate the traveling wave solutions, employing suitable parameter values. Additionally, the multiplier approach is utilized to calculate conserved vectors for the equation under consideration

Robust Sliding Mode Control of a Unipolar Power Inverter

The key issue in the practical implementation of the sliding mode (SM) control–based power inverter is the variable switching frequency. This variable switching frequency not only induces electromagnetic interference (EMI) noise, but also reduces the efficiency of the inverter, as the size of the inductor and capacitor does not alter in tandem with this variable frequency. In this context, fixed switching frequency–based SM control techniques are proposed; however, some of them are too complex, while others compromise the inherent properties of SM control. In this research, a fixed frequency SM controller is proposed, which is based on the novel low-pass filter extraction of the discontinuous control signal. This allows the technique to be implemented with fewer hardware components, thus reducing the complications of implementation, while maintaining the robustness and parametric invariance of SM control. A simulation-based comparison with an existing pulse width modulated (PWM) SM controller is presented as the benchmark. In comparison with the sigmoid function SM controller, an improvement of 50% in the settling time along with zero steady-state errors and a further 37% and 42% improvement in the undershoot and overshoot, respectively, is reported in the simulation. A hardware setup is established to validate the proposed technique, which substantiates the simulation results and its disturbance rejection properties

Gene expression, growth performance and body composition of Labeo rohita fingerlings fed on polyphenols supplement

The aim of this research was to investigate the impacts of polyphenols-supplemented diet on growth, body composition and gene expressions of insulin-like growth factor (IGF) and growth hormone (GH) in Labeo rohita fingerlings fed canola meal-based diets. Two plant extracts; Salvadora persica and Salvadora oleoides were used to assess the efficacy of L. rohita. Twelve test diets, including control (no supplementation) and supplemented with S. persica, S. oleoides and their mixture at the levels of 200, 400 and 800 mg/kg, were formulated. The gene expression of IGFs and GH was observed to be regulated significantly (p< 0.05) in the liver tissue of fingerlings when fed with supplemented diet. The highest expression of GH was observed at 200 mg/kg mixture diet. The results of growth performance showed that maximum weight gain% (215%) and SGR (1.63) was recorded at 200 mg/kg mixture diet. The results of carcass analysis showed that they were significantly (p< 0.05) influenced by supplemented diet when compared with control diet. As growth performance is under genetic control, the synthesis and release of IGF are stimulated by binding of GH to receptors present in the liver. Conclusively, the results showed that rohu fingerlings shown the best results of growth performance, body composition and gene expression of IGF and GH, when fed on mixture of S. persica and S. oleoides at 200 mg/kg