9 research outputs found
Human rabies associated with domestic cat exposures in South Africa, 1983–2018
Rabies is a fatal encephalitic disease caused by lyssaviruses belonging to the family Rhabdoviridae.
At the time of this report, a total of 16 species of lyssaviruses, which included the prototype rabies
virus (RABV), and 2 related but unclassified bat lyssaviruses, Taiwan and Kothalati, had been
recognised by the International Committee on Taxonomy of Viruses (ICTV 2019). Globally RABV,
also referred to as ‘classic rabies’, circulates in natural transmission cycles involving domestic
dogs and various wildlife species. In the Americas, RABV is found in certain insectivorous and
haematophagous bat species (Banyard et al. 2013). The public health burden of rabies is, however,
very closely related to the occurrence of the disease in domestic dogs; thus, human cases of rabies
are mostly reported from areas where dog rabies is uncontrolled (Hampson et al. 2015). An annual
estimation of 59 000 human deaths occur worldwide with 95% of rabies cases occurring in Africa
and Asia (Hampson et al. 2015). In South Africa, RABV circulates both in domestic animals and
wildlife cycles, involving the canid and mongoose variants of the virus (Nel, Thomson & Von
Teichman 1993). The urban cycle involves domestic dogs reported from various locations in the
country, but particularly from the KwaZulu-Natal, Eastern Cape, Limpopo and Mpumalanga
provinces (Cohen et al. 2007; Zulu, Sabeta & Nel 2009). Sylvatic cycles of the canid variant RABV
in bat-eared foxes and black-backed jackal (Zulu et al. 2009) and the mongoose variant RABV in
certain species of mongoose occur in South Africa (Van Zyl, Markotter & Nel 2010). Apart from
the reservoir species, canid and mongoose RABV infections are reported in an array of domestic
and wildlife species in the country, with these animals primarily serving as dead-end hosts (Sabeta
et al. 2018). Laboratory-confirmed human rabies cases in South Africa are predominantly dogmediated,
and seven cases of rabies linked to other domestic species and wildlife have been
reported (Weyer et al. 2011).http://www.jsava.co.zaam2020Medical VirologyVeterinary Tropical Disease
A case of human survival of rabies, South Africa
Human survival from rabies is exceptionally rare. We report a case of human survival (with severe neurological sequelae) in a child
from South Africa. The patient was exposed to rabid dogs on two separate occasions and subjected to incomplete post-exposure
prophylaxis for rabies.http://www.tandfonline.com/loi/ojid20am2017Microbiology and Plant Patholog
Adult male circumcision as an intervention against HIV: An operational study of uptake in a South African community (ANRS 12126)
<p>Abstract</p> <p>Background</p> <p>To evaluate the knowledge, attitudes and beliefs about adult male circumcision (AMC), assess the association of AMC with HIV incidence and prevalence, and estimate AMC uptake in a Southern African community.</p> <p>Methods</p> <p>A cross-sectional biomedical survey (ANRS-12126) conducted in 2007-2008 among a random sample of 1198 men aged 15 to 49 from Orange Farm (South Africa). Face-to-face interviews were conducted by structured questionnaire. Recent HIV infections were evaluated using the BED incidence assay. Circumcision status was self-reported and clinically assessed. Adjusted HIV incidence rate ratios (aIRR) and prevalence ratios (aPR) were calculated using Poisson regression.</p> <p>Results</p> <p>The response rate was 73.9%. Most respondents agreed that circumcised men could become HIV infected and needed to use condoms, although 19.3% (95%CI: 17.1% to 21.6%) asserted that AMC protected fully against HIV. Among self-reported circumcised men, 44.9% (95%CI: 39.6% to 50.3%) had intact foreskins. Men without foreskins had lower HIV incidence and prevalence than men with foreskins (aIRR = 0.35; 95%CI: 0.14 to 0.88; aPR = 0.45, 95%CI: 0.26 to 0.79). No significant difference was found between self-reported circumcised men with foreskins and other uncircumcised men. Intention to undergo AMC was associated with ethnic group and partner and family support of AMC. Uptake of AMC was 58.8% (95%CI: 55.4% to 62.0%).</p> <p>Conclusions</p> <p>AMC uptake in this community is high but communication and counseling should emphasize what clinical AMC is and its effect on HIV acquisition. These findings suggest that AMC roll-out is promising but requires careful implementation strategies to be successful against the African HIV epidemic.</p
A case of human survival of rabies, South Africa
Human survival from rabies is exceptionally rare. We report a case of human survival (with severe neurological sequelae) in a child
from South Africa. The patient was exposed to rabid dogs on two separate occasions and subjected to incomplete post-exposure
prophylaxis for rabies.http://www.tandfonline.com/loi/ojid20am2017Microbiology and Plant Patholog