EUS-Guided Pancreatic Cyst Ablation: a Clinical and Technical Review

Purpose of Review Pancreatic cystic lesions represent a growing public health dilemma, particularly as our population ages and cross-sectional imaging becomes more sensitive. Mucinous cysts carry a clinically significant risk of developing pancreatic cancer, which carries an extremely poor prognosis. Determining which cysts will develop cancer may be challenging, and surgical resection of the pancreas carries significant morbidity. The goal of this paper is to review the rationale for cyst ablation and discuss prior and current research on cyst ablation techniques and efficacy. Indications, contraindications, and factors related to optimal patient selection are outlined. Recent Findings Endoscopic ultrasound-guided chemoablation of pancreatic cysts has been performed in neoplastic cysts, with varying levels of efficacy. Safety concerns arose due to the risk of pancreatitis in alcohol-based treatments; however, the most recent data using a non-alcohol chemoablation cocktail suggests that ablation is effective without the need for alcohol, resulting in a significantly more favorable adverse event profile. Summary Endoscopic ultrasound-guided chemoablation of neoplastic pancreatic cysts is a promising, minimally invasive approach for treatment of cysts, with recent significant advances in safety and efficacy, suggesting that it should play a role in the treatment algorithm

Ultrafast magnetophotoconductivity of semi-insulating gallium arsenide

The speed of opto-electronic switches is increased or decreased by the application of a magnetic field. This is achieved by inducing a carrier drift toward or away from the semiconductor surface, resulting in the enhancement or suppression of surface recombination. We establish that surface recombination plays a major role in determining the speed of the opto-electronic switch

K-8 Pre-service Teachers’ Algebraic Thinking: Exploring the Habit of Mind Building Rules to Represent Functions

In this study, through the lens of the algebraic habit of mind Building Rules to Represent Functions, we examined 18 pre-service middle school teachers\u27 ability to use algebraic thinking to solve problems. The data revealed that pre-service teachers\u27 ability to use different features of the habit of mind Building Rules to Represent Functions varied across the features. Significant correlations existed between 8 pairs of the features. The ability to justify a rule was the weakest of the seven features and it was correlated with the ability to chunk information. Implications for mathematics teacher education are discussed

Exploring the Relationship between K-8 Prospective Teachers’ Algebraic Thinking Proficiency and the Questions They Pose during Diagnostic Algebraic Thinking Interviews

In this study, we explored the relationship between prospective teachers’ algebraic thinking and the questions they posed during one-on-one diagnostic interviews that focused on investigating the algebraic thinking of middle school students. To do so, we evaluated prospective teachers’ algebraic thinking proficiency across 125 algebra-based tasks and we analyzed the characteristics of questions they posed during the interviews. We found that prospective teachers with lower algebraic thinking proficiency did not ask any probing questions. Instead, they either posed questions that simply accepted and affirmed student responses or posed questions that guided the students toward an answer without probing student thinking. In contrast, prospective teachers with higher algebraic thinking proficiency were able to pose probing questions to investigate student thinking or help students clarify their thinking. However, less than half of their questions were of this probing type. These results suggest that prospective teachers’ algebraic thinking proficiency is related to the types of questions they ask to explore the algebraic thinking of students. Implications for mathematics teacher education are discussed

Interpretation of runaway electron synchrotron and bremsstrahlung images

The crescent spot shape observed in DIII-D runaway electron synchrotron radiation images is shown to result from the high degree of anisotropy in the emitted radiation, the finite spectral range of the camera and the distribution of runaways. The finite spectral camera range is found to be particularly important, as the radiation from the high-field side can be stronger by a factor $10^6$ than the radiation from the low-field side in DIII-D. By combining a kinetic model of the runaway dynamics with a synthetic synchrotron diagnostic we see that physical processes not described by the kinetic model (such as radial transport) are likely to be limiting the energy of the runaways. We show that a population of runaways with lower dominant energies and larger pitch-angles than those predicted by the kinetic model provide a better match to the synchrotron measurements. Using a new synthetic bremsstrahlung diagnostic we also simulate the view of the Gamma Ray Imager (GRI) diagnostic used at DIII-D to resolve the spatial distribution of runaway-generated bremsstrahlung.Comment: 21 pages, 11 figure

Transformation from proper time on earth to coordinate time in solar system barycentric space-time frame of reference

An expression was derived for the time transformation t - tau, where t is coordinate time in the solar system barycentric space-time frame of reference and tau is proper time obtained from a fixed atomic clock on earth. This transformation is suitable for use in the computation of high-precision earth-based range and Doppler observables of a spacecraft or celestial body located anywhere in the solar system; it can also be used in obtaining computed values of very long baseline interferometry data types. The formulation for computing range and Doppler observables, which is an explicit function of the transformation t - tau, is described briefly

Thermal recoil force, telemetry, and the Pioneer anomaly

Precision navigation of spacecraft requires accurate knowledge of small forces, including the recoil force due to anisotropies of thermal radiation emitted by spacecraft systems. We develop a formalism to derive the thermal recoil force from the basic principles of radiative heat exchange and energy-momentum conservation. The thermal power emitted by the spacecraft can be computed from engineering data obtained from flight telemetry, which yields a practical approach to incorporate the thermal recoil force into precision spacecraft navigation. Alternatively, orbit determination can be used to estimate the contribution of the thermal recoil force. We apply this approach to the Pioneer anomaly using a simulated Pioneer 10 Doppler data set.Comment: 10 pages, 3 figures. Published versio

Splenic Injury and ERCP: A Possible Risk for Patients with Advanced Chronic Pancreatitis

Splenic injury is a rare but potentially life-threatening complication of endoscopy, with very few cases of endoscopic retrograde cholangiopancreatography (ERCP)-induced injury reported in the literature. Here we report a patient with chronic alcoholic pancreatitis who was diagnosed with a sub-capsular splenic laceration nearly 6 days after an ERCP. Clinicians should be alerted to the potential post-procedure complications associated with ERCP, particularly as this procedure is being utilized more frequently for the management of patients with complex hepatobiliary and pancreatic conditions

Independent analysis of the orbits of Pioneer 10 and 11

Independently developed orbit determination software is used to analyze the orbits of Pioneer 10 and 11 using Doppler data. The analysis takes into account the gravitational fields of the Sun and planets using the latest JPL ephemerides, accurate station locations, signal propagation delays (e.g., the Shapiro delay, atmospheric effects), the spacecrafts' spin, and maneuvers. New to this analysis is the ability to utilize telemetry data for spin, maneuvers, and other on-board systematic effects. Using data that was analyzed in prior JPL studies, the anomalous acceleration of the two spacecraft is confirmed. We are also able to put limits on any secondary acceleration (i.e., jerk) terms. The tools that were developed will be used in the upcoming analysis of recently recovered Pioneer 10 and 11 Doppler data files.Comment: 22 pages, 5 figures; accepted for publication in IJMP