Ventricular function after coronary artery bypass grafting: Evaluation by magnetic resonance imaging and myocardial strain analysis

AbstractObjectiveMagnetic resonance imaging with radiofrequency tissue tagging permits quantitative assessment of regional systolic myocardial strain. We sought to investigate the utility of this imaging modality to quantitatively determine preoperative impairment and postoperative improvement in ventricular function in patients with ischemic heart disease.MethodsMagnetic resonance imaging with radiofrequency tissue tagging was performed on 6 patients (average age 60.2 ± 13.7 years) with coronary artery disease and 32 control subjects with no known heart disease. Patients with coronary artery disease underwent imaging before and 3 months after coronary artery bypass grafting. The ventricle was divided into 6 segments within a midventricular plane. Regional 2-dimensional left ventricular circumferential strain was calculated from tagged magnetic resonance images throughout systole. Circumferential strain results were compared in patients before and after and 3 months after coronary artery bypass grafting and also in control subjects.ResultsBefore the operation circumferential strain identified 100% (10/10) of all regional wall motion abnormalities seen by preoperative ventriculography. Postoperatively, improvements were demonstrated in 56% (20/36) of the regions, and these improvements agreed with viability testing by single-photon emission computed tomography when available. Additionally, preoperative global circumferential strain for the ischemic group was significantly depressed relative to that in control subjects (0.11 ± 0.05 vs 0.20 ± 0.03, P < .001). Global circumferential strain correlated with ejection fraction by ventriculography (r = 0.84, P < .01) and improved after coronary artery bypass grafting (0.14 ± 0.05 vs 0.11 ± 0.05, P < .01).ConclusionsMagnetic resonance imaging with radiofrequency tissue tagging permitted circumferential strain calculation. This technology quantitatively demonstrated improvements in left ventricular wall motion after coronary artery bypass grafting for both individual regions and the entire ventricle. This noninvasive method may prove useful in preoperative evaluation and postoperative serial assessment of left ventricular wall motion

Thermodynamics of Hot Neutron Stars and Universal Relations

Over the last few years, the detection of gravitational waves from binary neutron star systems has rekindled our hopes for a deeper understanding of the unknown nature of ultradense matter. In particular, gravitational wave constraints on the tidal deformability of a neutron star can be translated into constraints on several neutron star properties using a set of universal relations. Apart from binary neutron star mergers, supernova explosions are also important candidates for the detection of multimessenger signals. Such observations may allow us to impose significant constraints on the binding energy of neutron stars. The purpose of the present study is twofold. Firstly, we investigate the agreement of finite temperature equations of state with established universal relations. Secondly, we examine the possible existence of a universal relation between the binding energy and the dimensionless tidal deformability, which are the bulk properties connected to the most promising sources for multimessenger signals. We find that hot equations of state are not always compatible with accepted universal relations. Therefore, the use of such expressions for probing general relativity or imposing constraints on the structure of neutron stars would be inconclusive (when thermal effects are present). Additionally, we show that the binding energy and the dimensionless tidal deformability exhibit a universal trend at least for moderate neutron star masses. The latter allows us to set bounds on the binding energy of a 1.4 M⊙ neutron star using data from the GW170817 event. Finally, we provide a relation between the compactness, the binding energy and the dimensionless tidal deformability of a neutron star that is accurate for cold and hot isentropic equations of state