Reducing Legislative Gridlock: The Case for Rank Choice Voting

American polarization has become extremely heightened in the recent political climate. As a result, partisan conflicts between Republicans and Democrats have caused a decrease in ideological moderation and a willingness to compromise, particularly within the legislative process. This has contributed to an increase in gridlock, which is the inability to pass legislation in an effective manner that actively contributes to the good of the American public. As bipartisan legislation efforts have decreased, America is in need of a reform that will contribute to reducing legislative gridlock caused by intensified partisan polarization. In this project, I analyze rank choice voting as a potential reform for reducing gridlock. After reading previous literature on the root causes of gridlock and the application of rank choice voting, I synthesize these theories with relevant case studies. I specifically focus on case studies within the United States that have instituted rank choice voting in the recent decades. I examine how the implementation of rank choice voting has contributed to reducing political extremism in campaigns, resulting in more moderate candidates being elected. With more centrist representatives in office, I analyze how this relates to a decrease in legislative gridlock, as polarization is reduced. The ultimate goal of this thesis is to establish a case for the benefits of rank choice voting by showing tangible evidence that rank choice voting has been successful in reducing legislative gridlock

Complete Genome Sequence of a Divergent Human Rhinovirus C Isolate from an Infant with Severe Community-Acquired Pneumonia in Colorado, USA.

Here, we report the genome sequence of a divergent human rhinovirus C isolate identified from an infant with a severe community-acquired respiratory infection. RNA sequencing performed on an Illumina platform identified reads aligning to human rhinovirus species, which were de novo assembled to produce a coding-complete genome sequence

Pulmonary hypertension in infants with bronchopulmonary dysplasia

An increase in the number of preterm infants and a decrease in the gestational age at birth have resulted in an increase in the number of patients with significant bronchopulmonary dysplasia (BPD) and secondary pulmonary hypertension (PH). PH contributes significantly to the high morbidity and mortality in the BPD patients. Therefore, regular monitoring for PH by using echocardiography and B-type natriuretic peptide (BNP) or N-terminal-proBNP must be conducted in the BPD patients with greater than moderate degree to prevent PH and to ensure early treatment if PH is present. In the BPD patients with significant PH, multi-modality treatment, including treatment for correcting an underlying disease, oxygen supply, use of diverse selective pulmonary vasodilators (inhaled nitric oxide, inhaled prostacyclins, sildenafil, and endothelin-receptor antagonist) and other methods, is mandatory

Social Networks and Mobile Applications Use in Young Patients With Kidney Disease

Objective: To evaluate the use and benefits of social networking sites (SNS) and mobile applications (MA) in young patients with kidney disease (KD).Background: Pediatric KD is prevalent. The Internet is increasingly being used to communicate rapid healthcare information to children about acute and chronic diseases with greater medical care satisfaction. There is a lack of data on social media (SM) utility in pediatric KD.Materials and Methods: A descriptive, observational, and cross-sectional study was conducted on a national level. Data were collected from 4 different centers through a reviewed questionnaire.Results: 83.9% of the 428 participants were Lebanese. The average age was 11.4 years (±7.1). 69.9% had chronic KD out of which 17.4% had undergone a kidney transplant while 9% were on dialysis. 69.6% of the participants affirmed the need of SM for the health of the sick child while only 9.8% are participating in a scientific forum and 4.7% used SM to find a potential organ donor. Some study variables were statistically associated with the participants' age, nationality, and stage of KD.Conclusions: SM is important for the support and management of pediatric KD. We believe that SNS and MA will play a leading role in the lives of our patients in the upcoming future and will push the physician to be an active participant in the evolution of communication networks. To identify the efficacy of SM in enhancing communication between patients and health professionals, further stratified studies are needed

Molecular Identification of Bacteria in Tracheal Aspirate Fluid from Mechanically Ventilated Preterm Infants

BACKGROUND: Despite strong evidence linking infections to the pathogenesis of bronchopulmonary dysplasia (BPD), limitations of bacterial culture methods have precluded systematic studies of airway organisms relative to disease outcomes. Application of molecular bacterial identification strategies may provide new insight into the role of bacterial acquisition in the airways of preterm infants at risk for BPD. METHODS: Serial (within 72 hours, 7, 14, and 21 days of life) tracheal aspirate samples were collected from 10 preterm infants with gestational age ≤34 weeks at birth, and birth weight of 500-1250 g who required mechanical ventilation for at least 21 days. Samples were analyzed by quantitative real time PCR assays for total bacterial load and by pyrosequencing for bacterial identification. RESULTS: Subjects were diagnosed with mild (1), moderate (3), or severe (5) BPD. One patient died prior to determination of disease severity. 107,487 sequences were analyzed, with mean of 3,359 (range 1,724-4,915) per sample. 2 of 10 samples collected <72 hours of life contained adequate bacterial DNA for successful sequence analysis, one of which was from a subject exposed to chorioamnionitis. All other samples exhibited bacterial loads >70copies/reaction. 72 organisms were observed in total. Seven organisms represented the dominant organism (>50% of total sequences) in 31/32 samples with positive sequences. A dominant organism represented>90% of total sequences in 13 samples. Staphylococcus, Ureaplasmaparvum, and Ureaplasmaurealyticum were the most frequently identified dominant organisms, but Pseudomonas, Enterococcus, and Escherichia were also identified. CONCLUSIONS: Early bacterial colonization with diverse species occursafter the first 3 days of life in the airways of intubated preterm infants, and can be characterized by bacterial load and marked species diversity. Molecular identification of bacteria in the lower airways of preterm infants has the potential to yield further insight into the pathogenesis of BPD

Target of Opportunity Observations Detectability of Kilonovae with WFST

Kilonovae are approximately thermal transients, produced by mergers of binary neutron stars (BNSs) and NS-black hole binaries. As the optical counterpart of the gravitational wave event GW170817, AT2017gfo is the first kilonova detected with smoking-gun evidence. Its observation offers vital information for constraining the Hubble constant, the source of cosmic $r$-process enrichment, and the equation of state of neutron stars. The 2.5-meter Wide-Field Survey Telescope (WFST) operates at six bands (u, g, r, i, z, w), spanning from 320 to 925 nm. It will be completed in the first half of 2023, and with a field-of-view diameter of 3 degrees, aims to detect kilonovae in the near future. In this article, considering the influence of the host galaxies and sky brightness, we generate simulated images to investigate WFST's ability to detect AT2017gfo-like kilonovae. Due to their spectra, host galaxies can significantly impact kilonova detection at a longer wavelength. When kilonovae are at peak luminosity, we find that WFST performs better in the g and r bands and can detect 90\% (50\%) kilonovae at a luminosity distance of 248 Mpc (338 Mpc) with 30 s exposures. Furthermore, to reflect actual efficiency under target-of-opportunity observations, we calculate the total time of follow-up under various localization areas and distances. We find that if the localization areas of most BNS events detected during the fourth observing (O4) run of LIGO and Virgo are hundreds of deg$^2$, WFST is expected to find $\sim$30\% kilonovae in the first two nights during O4 period.Comment: 18 pages, 11 figure

Epidemiology of Methicillin-resistant and Methicillin-sensitive Staphylococcus aureus infections in Lebanon

Background. Methicillin-resistant Staphylococcus aureus (MRSA) is a prevalent pathogen associated with significant morbidity and mortality. In Lebanon, MRSA rates have recently started to rise. We aimed to determine risk factors for acquiring MRSA and Methicillin-sensitive Staphylococcus aureus (MSSA) infections and identify independent risk factors for in-hospital mortality among patients with S. aureus infection. Methods. We used a case-case-control study design that included patients with infections and compared them to uninfected controls. Two multivariable regression models were constructed to determine variables associated with acquiring MRSA and MSSA infections. We explored independent predictors of mortality in the overall population compared with the MRSA subgroup. Results. 356 patients with S. aureus infections were identified and compared to 208 uninfected controls. A recent history of surgery and underlying diabetes were independent risk factors for acquiring both infections. Having a urinary catheter for more than 6 days and steroid therapy were unique risk factors for MRSA infection (aOR 28.1, 95% CI 3.5-223.6 and 3.7, 95% CI 1.6-8.7, respectively). Risk factors exclusively associated with MRSA infection included ICU admission, acute renal failure, and malignancy. Conclusions. Risk factors associated with MRSA infection are distinct from those associated with MSSA infection. This can be used to risk stratify patients and will aid in choosing empirical antibiotic therapy

O IDEALISMO DE ZYGMUND BAUMAN E O ESTADO DE DIREITO LÍQUIDO

Zygmund Bauman, grande pensador da pós-modernidade, tem significativa relevância na análise do mundo contemporâneo. Filósofo e sociólogo, seus estudos eram baseados nos vínculos entre os indivíduos na sociedade, que tendem a ter relações menos frequentes e menos duradouras; como dito pelo próprio autor, são “relações líquidas”, formulando o conceito na obra Amor Líquido (2004) e a insegurança seria parte estrutural da constituição social da pós-modernidade; realiza a crítica ao Estado, que deve oferecer liberdade e segurança ao indivíduo, mas que o oprime, criando incessantes normas que o cerceiam, conforme descreve no livro Medo Líquido (2008). Bauman tem características do ideal da corrente filosófica voltada ao pessimismo, que pode ser encontrado em sua crítica à pós-modernidade. De fato, quanto à sociedade que se esforça para manter a exaltação das virtudes do capitalismo divisor entre detentores e produtores, ele se insere na contracorrente, procurando expor a face desumana do sistema do capital