Integrated care and the working record

By default, many discussions and specifications of electronic health records or integrated care records often conceptualize the record as a passive information repository. This article presents data from a case study of work in a medical unit in a major metropolitan hospital. It shows how the clinicians tailored, re-presented and augmented clinical information to support their own roles in the delivery of care for individual patients. This is referred to as the working record: a set of complexly interrelated clinician-centred documents that are locally evolved, maintained and used to support delivery of care in conjunction with the more patient-centred chart that will be stored in the medical records department on the patient’s discharge. Implications are drawn for how an integrated care record could support the local tailorability and flexibility that underpin this working record and hence underpin practice

Spectral pattern similarity analysis: Tutorial and application in developmental cognitive neuroscience

The human brain encodes information in neural activation patterns. While standard approaches to analyzing neural data focus on brain (de-)activation (e.g., regarding the location, timing, or magnitude of neural responses), multivariate neural pattern similarity analyses target the informational content represented by neural activity. In adults, a number of representational properties have been identified that are linked to cognitive performance, in particular the stability, distinctiveness, and specificity of neural patterns. However, although growing cognitive abilities across childhood suggest advancements in representational quality, developmental studies still rarely utilize information-based pattern similarity approaches, especially in electroencephalography (EEG) research. Here, we provide a comprehensive methodological introduction and step-by-step tutorial for pattern similarity analysis of spectral (frequency-resolved) EEG data including a publicly available pipeline and sample dataset with data from children and adults. We discuss computation of single-subject pattern similarities and their statistical comparison at the within-person to the between-group level as well as the illustration and interpretation of the results. This tutorial targets both novice and more experienced EEG researchers and aims to facilitate the usage of spectral pattern similarity analyses, making these methodologies more readily accessible for (developmental) cognitive neuroscientists

Chromatic nearest neighbor searching: A query sensitive approach☆☆A preliminary version of this paper appeared in the Proceedings of the 7th Canadian Conference on Computational Geometry, 1995, pp. 261–266.

AbstractThe nearest neighbor problem is that of preprocessing a set P of n data points in Rd so that, given any query point q, the closest point in P to q can be determined efficiently. In the chromatic nearest neighbor problem, each point of P is assigned a color, and the problem is to determine the color of the nearest point to the query point. More generally, given k⩾1, the problem is to determine the color occurring most frequently among the k nearest neighbors. The chromatic version of the nearest neighbor problem is used in many applications in pattern recognition and learning. In this paper we present a simple algorithm for solving the chromatic k nearest neighbor problem. We provide a query sensitive analysis, which shows that if the color classes form spatially well separated clusters (as often happens in practice), then queries can be answered quite efficiently. We also allow the user to specify an error bound ε⩾0, and consider the same problem in the context of approximate nearest neighbor searching. We present empirical evidence that for well clustered data sets, this approach leads to significant improvements in efficiency

Method and Compositions for Biofouling Deterrence

A method of deterring biofouling of a surface comprising attaching an adduct having formula (I) or noradrenalin to the surface. Formula (I) being defined as compounds that have the formula A-L-R wherein A is i) a C6 or C10 substituted aryl ring, or ii) a C1-C9 substituted or unsubstituted heteroaryl ring: L is a linking group, and R is a primary amino moiety comprising unit

Induction of Selective Inner Hair Cell Damage by Carboplatin

Carboplatin (diammine [1,1 cyclobutane dicarboxylato (2)-0,0\u27] platinum) is an anti-cancer agent which can be toxic to the inner ear. We have explored the nature of this ototoxicity in the chinchilla. In this species, initial degenerative changes appear to be restricted to the inner hair cell (IHC) regions of the organ of Corti. This finding is intriguing and unusual since all other known ototoxic drugs, such as aminoglycosides, are predominantly associated with outer hair cell damage. In the present study, the mechanism of ototoxicity was investigated by comparing two different routes of carboplatin administration. Carboplatin was administered either intravenously (i.v.) or intraperitoneally (i.p.). The mode of administration influenced electrophysiological and morphological changes. Hearing thresholds were elevated in the i.v. group significantly more than in the i.p. group at all tested frequencies. The degree of hair cell damage was evaluated by scanning electron microscopy at four frequency regions in each cochlea. IHC damage in the i.v. group was significantly more severe than in the i.p. group. Carboplatin effects on a different species, the guinea pig, were also determined to clarify interspecies differences. In the guinea pig, outer hair cell damage occurred sporadically and inner hair cells remained intact. In contrast, chinchilla inner hair cells are susceptible to the ototoxic effects of carboplatin. The degree of hair cell damage appears to be dependent on the peak level of carboplatin rather than on the total dose. This animal model provides a new tool for the investigation of inner and outer hair cell function

U.S. Commission on Immigration Reform

The U.S. Commission on Immigration Reform was created by Congress to assess U.S. immigration policy and make recommendations regarding its implementation and effects. Mandated in the Immigration Act of 1990 to submit an interim report in 1994 and a final report in 1997, the Commission has undertaken public hearings, fact-finding missions, and expert consultations to identify the major immigration-related issues facing the United States today.LBJ School of Public Affair

NLTE modeling of Stokes vector center-to-limb variations in the CN violet system

The solar surface magnetic field is connected with and even controls most of the solar activity phenomena. Zeeman effect diagnostics allow for measuring only a small fraction of the fractal-like structured magnetic field. The remaining hidden magnetic fields can only be accessed with the Hanle effect. Molecular lines are very convenient for applying the Hanle effect diagnostics thanks to the broad range of magnetic sensitivities in a narrow spectral region. With the UV version of the Zurich Imaging Polarimeter ZIMPOL II installed at the 45 cm telescope of the Istituto Ricerche Solari Locarno (IRSOL), we simultaneously observed intensity and linear polarization center-to-limb variations in two spectral regions containing the (0,0) and (1,1) bandheads of the CN B 2 {\Sigma} - X 2 {\Sigma} system. Here we present an analysis of these observations. We have implemented coherent scattering in molecular lines into a NLTE radiative transfer code. A two-step approach was used. First, we separately solved the statistical equilibrium equations and compute opacities and intensity while neglecting polariza- tion. Then we used these quantities as input for calculating scattering polarization and the Hanle effect. We have found that it is impossible to fit the intensity and polarization simultaneously at different limb angles in the frame- work of standard 1D modeling. The atmosphere models that provide correct intensity center-to-limb variations fail to fit linear polar- ization center-to-limb variations due to lacking radiation field anisotropy. We had to increase the anisotropy by means of a specially introduced free parameter. This allows us to successfully interpret our observations. We discuss possible reasons for underestimating the anisotropy in the 1D modeling.Comment: 15 pages, 10 figures, accepted for publication in Astronomy&Astrophysic