A participatory regional partnership approach to promote nutrition and physical activity through environmental and policy change in rural Missouri

BACKGROUND: Rural residents are less likely than urban and suburban residents to meet recommendations for nutrition and physical activity. Interventions at the environmental and policy level create environments that support healthy eating and physical activity. COMMUNITY CONTEXT: Healthier Missouri Communities (Healthier MO) is a community-based research project conducted by the Prevention Research Center in St. Louis with community partners from 12 counties in rural southeast Missouri. We created a regional partnership to leverage resources and enhance environmental and policy interventions to improve nutrition and physical activity in rural southeast Missouri. METHODS: Partners were engaged in a participatory action planning process that included prioritizing, implementing, and evaluating promising evidence-based interventions to promote nutrition and physical activity. Group interviews were conducted with Healthier MO community partners post intervention to evaluate resource sharing and sustainability efforts of the regional partnership. OUTCOME: Community partners identified the benefits and challenges of resource sharing within the regional partnership as well as the opportunities and threats to long-term partnership sustainability. The partners noted that the regional participatory process was difficult, but the benefits outweighed the challenges. INTERPRETATION: Regional rural partnerships may be an effective way to leverage relationships to increase the capacity of rural communities to implement environmental and policy interventions to promote nutrition and physical activity

Effectiveness of the Mindfulness in Schools Programme: non-randomised controlled feasibility study

Open Access Article. Copyright ©2013 The Royal College of PsychiatristsMindfulness-based approaches for adults are effective at enhancing mental health, but few controlled trials have evaluated their effectiveness among young people

Child Anxiety and Depression Symptom Trajectories and Predictors over 15 Months of the Coronavirus Pandemic

Repeated measures are required to monitor and map trajectories of mental health symptoms that are sensitive to the changing distal and proximal stressors throughout the coronavirus (COVID-19) pandemic. Understanding symptoms in young children is particularly important given the short- and long-term implications of early-onset internalizing symptoms. This study utilized an intensive longitudinal approach to assess the course and environmental correlates of anxiety and depression symptoms in 133 children, ages 4–11 (Mage = 7.35, SD = 1.03), in the United States during the COVID-19 pandemic. Caregivers completed 48 repeated assessments from April 7, 2020, to June 15, 2021, on child and caregiver mental health symptoms, family functioning, and COVID-19-related environmental changes. Results from a series of multilevel growth models demonstrate that child depression symptoms were highest following initial stay-at-home orders (April 2020) and linearly decreased over time, while child anxiety symptoms were variable over the 15-month period. Caregiver depression symptoms and family conflict significantly predicted levels of child depression symptoms. In contrast, caregiver depression symptoms, caregiver anxiety symptoms, and time spent home quarantining significantly predicted levels of child anxiety symptoms. Results suggest that depression and anxiety symptoms in young children may have unique trajectories over the course of the coronavirus pandemic and highlight symptom-specific risk factors for each symptom

Advancing system and policy changes for social and racial justice: comparing a Rural and Urban Community-Based Participatory Research Partnership in the U.S.

Abstract Background The paper examines the role of community-based participatory research (CBPR) within the context of social justice literature and practice. Methods Two CBPR case studies addressing health inequities related to Type 2 Diabetes and Cardiovascular disease were selected from a national cross-site study assessing effective academic-community research partnerships. One CBPR partnership works with African Americans in rural Pemiscot County, Missouri and the other CBPR partnership works with African American and Latinos in urban South Bronx, New York City. Data collection included semi-structured key informant interviews and focus groups. Analysis focused on partnerships’ context/history and their use of multiple justice-oriented strategies to achieve systemic and policy changes in order to address social determinants of health in their communities. Results Community context and history shaped each partnership’s strategies to address social determinants. Four social justice approaches (identity/recognition, procedural, distributive, and structural justice) used by both partnerships were identified. These social justice approaches were employed to address underlying causes of inequitable distribution of resources and power structures, while remaining within a scientific research framework. Conclusion CBPR can bridge the role of science with civic engagement and political participation, empowering community members to become political agents who integrate evidence into their social justice organizing strategies.http://deepblue.lib.umich.edu/bitstream/2027.42/136166/1/12939_2016_Article_509.pd

Dual Relief of T-lymphocyte Proliferation and Effector Function Underlies Response to PD-1 Blockade in Epithelial Malignancies

Although understanding of T-cell exhaustion is widely based on mouse models, its analysis in patients with cancer could provide clues indicating tumor sensitivity to immune checkpoint blockade (ICB). Data suggest a role for costimulatory pathways, particularly CD28, in exhausted T-cell responsiveness to PD-1/PD-L1 blockade. Here, we used single-cell transcriptomic, phenotypic, and functional approaches to dissect the relation between CD8+ T-cell exhaustion, CD28 costimulation, and tumor specificity in head and neck, cervical, and ovarian cancers. We found that memory tumor–specific CD8+ T cells, but not bystander cells, sequentially express immune checkpoints once they infiltrate tumors, leading, in situ, to a functionally exhausted population. Exhausted T cells were nonetheless endowed with effector and tumor residency potential but exhibited loss of the costimulatory receptor CD28 in comparison with their circulating memory counterparts. Accordingly, PD-1 inhibition improved proliferation of circulating tumor–specific CD8+ T cells and reversed functional exhaustion of specific T cells at tumor sites. In agreement with their tumor specificity, high infiltration of tumors by exhausted cells was predictive of response to therapy and survival in ICB-treated patients with head and neck cancer. Our results showed that PD-1 blockade–mediated proliferation/reinvigoration of circulating memory T cells and local reversion of exhaustion occur concurrently to control tumors

Mindfulness and rumination: Mediators of change in depressive symptoms? A preliminary investigation of a universal mindfulness intervention for adolescents

Mindfulness-based interventions reduce depressive symptoms and rumination, and enhance mindfulness in adults; this non-randomised controlled feasibility study aimed to determine whether these conclusions apply to young people, and whether mindfulness and rumination mediate the effect on depressive symptoms. Participants aged 12-16 received a nine-week universal mindfulness intervention in schools delivered by trained teachers (intervention group, N = 256) or their regular school curriculum (control group, N = 266). Intervention schools were matched to control schools on key variables (publicly-funded versus private, mainstream versus special needs). Young people who received the intervention reported fewer depressive symptoms post-intervention relative to controls, which was maintained at three-month follow-up. Mindfulness and rumination were unchanged immediately after the intervention, however by follow-up, intervention participants were significantly more mindful and less likely to ruminate than controls. The extent to which young people practiced mindfulness was negatively correlated with depressive symptoms at post-intervention and follow-up, positively correlated with mindfulness at post-intervention and follow-up, and positively correlated with rumination at follow-up. This universal mindfulness intervention shows promise for reducing depressive symptoms, reducing rumination and increasing mindfulness in young people, however further research is warranted, particularly regarding the mechanisms of change

Production, disposal and environmental impact of common plastics

reservedLa tesi illustrerà il ciclo di vita delle plastiche comunemente utilizzate, in particolare la produzione e lo smaltimento, per poi concludere con l'eventuale riciclo