4,297 research outputs found
Non-Gaussian features of primordial magnetic fields in power-law inflation
We show that a conformal-invariance violating coupling of the inflaton to
electromagnetism produces a cross correlation between curvature fluctuations
and a spectrum of primordial magnetic fields. According to this model, in the
case of power-law inflation, a primordial magnetic field is generated with a
nearly flat power spectrum and rms amplitude ranging from nG to pG. We study
the cross correlation, a three-point function of the curvature perturbation and
two powers of the magnetic field, in real and momentum space. The
cross-correlation coefficient, a dimensionless ratio of the three-point
function with the curvature perturbation and magnetic field power spectra, can
be several orders of magnitude larger than expected as based on the amplitude
of scalar metric perturbations from inflation. In momentum space, the
cross-correlation peaks for flattened triangle configurations, and is three
orders of magnitude larger than the squeezed triangle configuration. These
results suggest likely methods for distinguishing the observational signatures
of the model.Comment: 15 pages, 2 figure
Classical analogy for the deflection of flux avalanches by a metallic layer
Sudden avalanches of magnetic flux bursting into a superconducting sample
undergo deflections of their trajectories when encountering a conductive layer
deposited on top of the superconductor. Remarkably, in some cases flux is
totally excluded from the area covered by the conductive layer. We present a
simple classical model that accounts for this behaviour and considers a
magnetic monopole approaching a semi-infinite conductive plane. This model
suggests that magnetic braking is an important mechanism responsible for
avalanche deflection.Comment: 14 pages, 5 figure
Treating Thalassemia Patients with Luspatercept: An Expert Opinion Based on Current Evidence
Luspatercept has recently been approved for the treatment of beta-thalassemia and its use in clinical practice has been increasing. As it is the first erythroid maturation drug available for this diagnosis, the expertise about its use is still limited. To address this point, and to promote awareness and guide the clinical use of luspatercept in beta-thalassemia, this paper was developed as a consensus by experts from the Italian Society of Thalassemia and Hemoglobinopathies (SITE). After a brief presentation of the core features of luspatercept, a comprehensive set of questions is addressed, covering relevant aspects for the practical management of this new therapeutic option
The impact of allergic rhinitis in clinical practice: an italian survey
Allergic rhinitis (AR) is a very common disorder. The current Survey was conducted on a sample of about 5,000 adult subjects in 5 Italian cities. A questionnaire, containing 15 questions, was administered on the road. AR affects about 20% of the general population. The most common diagnostic test was the skin prick test, but only 12% of patients performed an allergy test to confirm the diagnosis. About 50% of patients did not take any medicine. Even about 40% of treatments were suggested by friends or pharmacists. In conclusion, the current Survey demonstrated that AR is a common disorder in Italy, the diagnostic work-up is still incorrect, and the therapeutic approach does not adhere to the guidelines. Therefore, there is a need to implement adequate information on this topic in Italy
Effects of twenty years of ungulate browsing on forest regeneration at Paneveggio Reserve, Italy
Forest ecosystems are threatened by different natural disturbances. Among them, the irruption of large herbivores represents one of the most alarming issues. Several local-scale studies have been carried out to clarify the mechanisms governing ungulate\u2013forest interactions, to understand the effect of wild ungulates overabundance, and to apply conservation plans. However, information at large scales, over long periods of observation and from unmanipulated conditions is still scarce. This study aims to improve our knowledge in this field by using repeated inventories to investigate: the types of damage produced by ungulate populations on young trees, the drivers that stimulate browsing activity and its consequences on the specific composition of seedlings and saplings. To reach these goals, we used data collected during a twenty-year monitoring program (1994\u20132014) in the forests of Paneveggio-Pale di San Martino Nature Park (Italy). We applied descriptive statistics to summarize the data, GLMs to identify the drivers of browsing activity and Non-Metric Multidimensional Scaling (nMDS) ordinations to investigate the changes in specific composition of young trees across 20 years. We detected increasing browsing activity from 1994 to 2008 and a decline in 2014. Ungulates browsed preferentially in mature stands, and fed mostly on seedlings and saplings under 150 cm of height. The analysis of the environmental drivers of browsing pressure on the smallest size classes of plants suggests that foraging behavior is influenced by snowpack conditions, ungulate density and seasonality. Moreover, results underline the fact that ungulates feed mostly on palatable species, especially European rowan, but can also use unpalatable plants as emergency food under high competition levels. nMDS results suggest that rowan seed dispersion might be promoted by deer movements, however, saplings of this species were not able to exceed 30 cm of height because of heavy browsing. This bottleneck effect led to the dominance of unpalatable species, mostly Norway spruce, reducing diversity during forest regeneration. If prolonged, this effect could lead to a reduction of tree species richness, with cascading effects on many parts of the ecosystem, and threatening the resilience of the forest to future disturbances
Blastic plasmacytoid dendritic cell neoplasm: Genomics mark epigenetic dysregulation as a primary therapeutic target
Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare and aggressive hematologic malignancy for which there is still no effective B therapy. In order to identify genetic alterations useful for a new treatment design, we used whole-exome sequencing to analyze 14 BPDCN patients and the patient-derived CAL-1 cell line. The functional enrichment analysis of mutational data reported the epigenetic regulatory program to be the most significantly undermined (P<0.0001). In particular, twenty-five epigenetic modifiers were found mutated (e.g. ASXL1, TET2, SUZ12, ARID1A, PHF2, CHD8); ASXL1 was the most frequently affected (28.6% of cases). To evaluate the impact of the identified epigenetic mutations at the gene-expression and Histone H3 lysine 27 trimethylation/acetylation levels, we performed additional RNA and pathology tissue-chromatin immunoprecipitation sequencing experiments. The patients displayed enrichment in gene signatures regulated by methylation and modifiable by decitabine administration, shared common H3K27-acetylated regions, and had a set of cell-cycle genes aberrantly up-regulated and marked by promoter acetylation. Collectively, the integration of sequencing data showed the potential of a therapy based on epigenetic agents. Through the adoption of a preclinical BPDCN mouse model, established by CAL-1 cell line xenografting, we demonstrated the efficacy of the combination of the epigenetic drugs 5’-azacytidine and decitabine in controlling disease progression in vivo
NMR Profiling of Exhaled Breath Condensate Defines Different Metabolic Phenotypes of Non-Cystic Fibrosis Bronchiectasis
Infestação de plantas espontâneas em cultivo de café solteiro ou consorciado com banana em sistema agroecológico.
bitstream/item/69051/1/062-germani-infestacao.pdfPublicado também no Cadernos de Agroecologia, v. 7, n.2, 2012
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