528 research outputs found
Species Abundance Patterns in Complex Evolutionary Dynamics
An analytic theory of species abundance patterns (SAPs) in biological
networks is presented. The theory is based on multispecies replicator dynamics
equivalent to the Lotka-Volterra equation, with diverse interspecies
interactions. Various SAPs observed in nature are derived from a single
parameter. The abundance distribution is formed like a widely observed
left-skewed lognormal distribution. As the model has a general form, the result
can be applied to similar patterns in other complex biological networks, e.g.
gene expression.Comment: 4 pages, 3 figures. Physical Review Letters, in pres
Photoelectron Angular Distributions for Two-photon Ionization of Helium by Ultrashort Extreme Ultraviolet Free Electron Laser Pulses
Phase-shift differences and amplitude ratios of the outgoing and
continuum wave packets generated by two-photon ionization of helium atoms are
determined from the photoelectron angular distributions obtained using velocity
map imaging. Helium atoms are ionized with ultrashort extreme-ultraviolet
free-electron laser pulses with a photon energy of 20.3, 21.3, 23.0, and 24.3
eV, produced by the SPring-8 Compact SASE Source test accelerator. The measured
values of the phase-shift differences are distinct from scattering phase-shift
differences when the photon energy is tuned to an excited level or Rydberg
manifold. The difference stems from the competition between resonant and
non-resonant paths in two-photon ionization by ultrashort pulses. Since the
competition can be controlled in principle by the pulse shape, the present
results illustrate a new way to tailor the continuum wave packet.Comment: 5 pages, 1 table, 3 figure
The Conservation Status of Marine Biodiversity of the Pacific Islands of Oceania
The Pacific Islands of Oceania are small islands and atolls occurring over a vast expanse of ocean that are characterized by immense biodiversity and endemism. This project represents a major expansion of the coverage of the Pacific Islands’ marine biodiversity on the IUCN Red List of Threatened Species. The threats to Pacific Island marine biodiversity are many. Results from IUCN Red List initiatives such as this can guide decision-making and conservation prioritization of Pacific Island governments, non-governmental organizations (NGOs) and the private sector. By shaping regional and national policies with these data in mind, priority sites for maintaining marine biodiversity can be identified and conserved
Thiazolidinediones enhance vascular endothelial growth factor expression and induce cell growth inhibition in non-small-cell lung cancer cells
<p>Abstract</p> <p>Background</p> <p>It is known that thiazolidinediones are involved in regulating the expression of various genes, including the vascular endothelial growth factor (VEGF) gene via peroxisome proliferator-activated receptor γ (PPARγ); VEGF is a prognostic biomarker for non-small-cell lung cancer (NSCLC).</p> <p>Methods</p> <p>In this study, we investigated the effects of troglitazone and ciglitazone on the mRNA expression of VEGF and its receptors in human NSCLC cell lines, RERF-LC-AI, SK-MES-1, PC-14, and A549. These mRNA expressions were evaluated by quantitative real-time reverse transcription-polymerase chain reaction (RT-PCR) analysis. We also studied the effect of Je-11, a VEGF inhibitor, on the growth of these cells.</p> <p>Results</p> <p>In NSCLC cells, thiazolidinediones increased the mRNA expression of VEGF and neuropilin-1, but not that of other receptors such as fms-like tyrosine kinase and kinase insert domain receptor-1. Furthermore, the PPARγ antagonist GW9662 completely reversed this thiazolidinedione-induced increase in VEGF expression. Furthermore, the addition of VEGF inhibitors into the culture medium resulted in the reversal of thiazolidinedione-induced growth inhibition.</p> <p>Conclusions</p> <p>Our results indicated that thiazolidinediones enhance VEGF and neuropilin-1 expression and induce the inhibition of cell growth. We propose the existence of a pathway for arresting cell growth that involves the interaction of thiazolidinedione-induced VEGF and neuropilin-1 in NSCLC.</p
OGLE-2005-BLG-071Lb, the Most Massive M-Dwarf Planetary Companion?
We combine all available information to constrain the nature of
OGLE-2005-BLG-071Lb, the second planet discovered by microlensing and the first
in a high-magnification event. These include photometric and astrometric
measurements from Hubble Space Telescope, as well as constraints from higher
order effects extracted from the ground-based light curve, such as microlens
parallax, planetary orbital motion and finite-source effects. Our primary
analysis leads to the conclusion that the host of Jovian planet
OGLE-2005-BLG-071Lb is an M dwarf in the foreground disk with mass M= 0.46 +/-
0.04 Msun, distance D_l = 3.3 +/- 0.4 kpc, and thick-disk kinematics v_LSR ~
103 km/s. From the best-fit model, the planet has mass M_p = 3.8 +/- 0.4 M_Jup,
lies at a projected separation r_perp = 3.6 +/- 0.2 AU from its host and so has
an equilibrium temperature of T ~ 55 K, i.e., similar to Neptune. A degenerate
model less favored by \Delta\chi^2 = 2.1 (or 2.2, depending on the sign of the
impact parameter) gives similar planetary mass M_p = 3.4 +/- 0.4 M_Jup with a
smaller projected separation, r_\perp = 2.1 +/- 0.1 AU, and higher equilibrium
temperature T ~ 71 K. These results from the primary analysis suggest that
OGLE-2005-BLG-071Lb is likely to be the most massive planet yet discovered that
is hosted by an M dwarf. However, the formation of such high-mass planetary
companions in the outer regions of M-dwarf planetary systems is predicted to be
unlikely within the core-accretion scenario. There are a number of caveats to
this primary analysis, which assumes (based on real but limited evidence) that
the unlensed light coincident with the source is actually due to the lens, that
is, the planetary host. However, these caveats could mostly be resolved by a
single astrometric measurement a few years after the event.Comment: 51 pages, 12 figures, 3 tables, Published in Ap
OGLE-2005-BLG-153: Microlensing Discovery and Characterization of A Very Low Mass Binary
The mass function and statistics of binaries provide important diagnostics of
the star formation process. Despite this importance, the mass function at low
masses remains poorly known due to observational difficulties caused by the
faintness of the objects. Here we report the microlensing discovery and
characterization of a binary lens composed of very low-mass stars just above
the hydrogen-burning limit. From the combined measurements of the Einstein
radius and microlens parallax, we measure the masses of the binary components
of and . This discovery
demonstrates that microlensing will provide a method to measure the mass
function of all Galactic populations of very low mass binaries that is
independent of the biases caused by the luminosity of the population.Comment: 6 pages, 3 figures, 1 tabl
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