890 research outputs found
A comparison of leather properties of skins from ten different South African sheep breeds
(South African J of Animal Science, 2000, 30, Supplement 1: 129-130
Gambling Treatment Diversion Court: First in Nevada
The first Gambling Treatment Diversion Court was established in Las Vegas, Nevada in fall of 2018 following more than 25 years of effort by passionately concerned non-profit Executives, therapists, lawyers and judges. This panel represents one leader from each of those areas, including Judge Cheryl Moss, the first judge to open the Gambling Treatment Diversion Court (GTDC), Dayvid Figler, the first attorney to successfully represent a gambling client and refer her to the GTDC, Carol O\u27Hare, Executive Director of the non-profit Nevada Council on Problem Gambler with 25+ years leadership and advocacy for problem gamblers, Sydney Smith, M.A., Clinical Director of RISE treatment center in Las Vegas and nationally- and state-certified gambling counselor, and Denise F. Quirk, M.A., Clinical Director of the Reno Problem Gambling Center and nationally- and Nevada-certified problem gambling counselor and instructor at the University of Nevada, Reno. The panel will share the development of gambling diversion treatment, legal challenges and victories, the process of the GTDC, case studies of individuals with Gambling Disorder who have endured and succeeded in the legal process, and discussion relevant to the impact of the gambling diversion process at all levels of evaluation, advocacy, treatment and support for gamblers and communities
Substrate specificity and the effect of calcium on Trypanosomabrucei metacaspase 2
Metacaspases are cysteine peptidases found only in yeast, plants and lower eukaryotes, including the protozoa. To investigate the extended substrate specificity and effects of Ca<sup>2+</sup> on the activation of these enzymes, detailed kinetic, biochemical and structural analyses were carried out on metacaspase 2 from Trypanosoma brucei (TbMCA2). These results reveal that TbMCA2 has an unambiguous preference for basic amino acids at the P<sub>1</sub> position of peptide substrates and that this is most probably a result of hydrogen bonding from the P<sub>1</sub> residue to Asp95 and Asp211 in TbMCA2. In addition, TbMCA2 also has a preference for charged residues at the P<sub>2</sub> and P<sub>3</sub>positions and for small residues at the prime side of a peptide substrate. Studies into the effects of Ca<sup>2+</sup> on the enzyme revealed the presence of two Ca<sup>2+</sup> binding sites and a reversible structural modification of the enzyme upon Ca<sup>2+</sup> binding. In addition, the concentration of Ca<sup>2+</sup> used for activation of TbMCA2 was found to produce a differential effect on the activity of TbMCA2, but only when a series of peptides that differed in P<sub>2</sub> were examined, suggesting that Ca<sup>2+</sup>activation of TbMCA2 has a structural effect on the enzyme in the vicinity of the S2 binding pocket. Collectively, these data give new insights into the substrate specificity and Ca<sup>2+</sup> activation of TbMCA2. This provides important functional details and leads to a better understanding of metacaspases, which are known to play an important role in trypanosomes and make attractive drug targets due to their absence in humans
The relationship between body composition and physical fitness in 14 year old adolescents residing within the Tlokwe local municipality, South Africa: The PAHL study
<p>Abstract</p> <p>Background</p> <p>Little is known about the relationship between body composition and physical fitness in 14 year-old high school adolescents of South Africa. Baseline data from a longitudinal study on physical activity and health (PAHLS) may provide valuable information for future studies, hence to inform public health policy makers. The objectives of this study are to determine the prevalence of underweight, normal weight and overweight among adolescents aged 14 years in the Tlokwe Local Municipality of the North West Province of South Africa, and to assess the association between physical fitness and body composition separately for boys and girls, adjusted for race and locality.</p> <p>Methods</p> <p>Body weight, height and triceps, and subscapular skinfolds of 256 adolescents (100 boys and 156 girls) aged 14 years were measured, and percentage body fat and body mass index (BMI) were calculated. BMI was used to determine underweight, normal weight and overweight based on the standard criterion. Physical fitness was assessed by standing broad jump, bent arm hang and sit-ups according to the EUROFIT fitness standard procedures. Multinomial logistic regression analyses stratified for gender and adjusted for race (black or white), and the locality (urban or township) of the schools were used to analyze the data.</p> <p>Results</p> <p>In the total group 35.9% were underweight and 13.7% overweight. Boys were more underweight (44%) than girls (30.7%). The prevalence of overweight was 8% in boys and 17.3% in girls. BMI was strongly (p = 0.01) related with percentage body fat. Strong and significant positive associations between physical fitness and BMI for the underweight girls with high physical fitness scores (OR, 10.69 [95%CI: 2.81-40.73], and overweight girls with high physical fitness scores (OR, 0.11 [95%CI: 0.03-0.50]) were found. Non-significant weaker positive relationship between physical fitness and BMI for the underweight boys with high physical fitness scores (OR, 1.80 [95%CI: 0.63-5.09]), and the overweight boys with high physical fitness scores (OR, 0.18 [95%CI: 0.02-1.78]) were found.</p> <p>Conclusion</p> <p>Both underweight and overweight among boys and girls in Tlokwe Local Municipality exist, and their effects on physical fitness performances were also noticed. As such, strategic physical activity, interventions or follow-up studies recognizing this relationship particularly in the overweight adolescents are needed. In addition, authorities in health and education departments dealing with adolescents should make use of this evidence base information in policies development.</p
Supersymmetry and Electroweak Breaking in the Interval
Hypermultiplets are considered in the five-dimensional interval where all
fields are continuous and the boundary conditions are dynamically obtained from
the action principle. The orbifold boundary conditions are obtained as
particular cases. We can interpret the Scherk-Schwarz supersymmetry breaking as
a misalignment of boundary conditions while a new source of supersymmetry
breaking corresponding to a mismatch of different boundary parameters is
identified. The latter can be viewed as coming from boundary supersymmetry
breaking masses for hyperscalars and the nature of the corresponding
supersymmetry breaking parameter is analyzed. For some regions of the parameter
space where supersymmetry is broken (either by Scherk-Schwarz boundary
conditions or by boundary hyperscalar masses) electroweak symmetry breaking can
be triggered at the tree level.Comment: 28 pages, 5 figure
Graviton emission from a higher-dimensional black hole
We discuss the graviton absorption probability (greybody factor) and the
cross-section of a higher-dimensional Schwarzschild black hole (BH). We are
motivated by the suggestion that a great many BHs may be produced at the LHC
and bearing this fact in mind, for simplicity, we shall investigate the
intermediate energy regime for a static Schwarzschild BH. That is, for
, where is the mass of the black hole and
is the energy of the emitted gravitons in -dimensions. To find
easily tractable solutions we work in the limit , where is the
angular momentum quantum number of the graviton.Comment: 10 pages, 8 figures, references added, typos corrected. Graviton
degeneracy factor included; main results remain unchange
Pregnancy Reprograms the Epigenome of Mammary Epithelial Cells and Blocks the Development of Premalignant Lesions
Pregnancy causes a series of cellular and molecular changes in mammary epithelial cells (MECs) of female adults. In addition, pregnancy can also modify the predisposition of rodent and human MECs to initiate oncogenesis. Here, we investigate how pregnancy reprograms enhancer chromatin in the mammary epithelium of mice and influences the transcriptional output of the oncogenic transcription factor cMYC. We find that pregnancy induces an expansion of the active cis-regulatory landscape of MECs, which influences the activation of pregnancy-related programs during re-exposure to pregnancy hormones in vivo and in vitro. Using inducible cMYC overexpression, we demonstrate that post-pregnancy MECs are resistant to the downstream molecular programs induced by cMYC, a response that blunts carcinoma initiation, but does not perturb the normal pregnancy-induced epigenomic landscape. cMYC overexpression drives post-pregnancy MECs into a senescence-like state, and perturbations of this state increase malignant phenotypic changes. Taken together, our findings provide further insight into the cell-autonomous signals in post-pregnancy MECs that underpin the regulation of gene expression, cellular activation, and resistance to malignant development
Dynamics of oscillating scalar field in thermal environment
There often appear coherently oscillating scalar fields in particle physics
motivated cosmological scenarios, which may have rich phenomenological
consequences. Scalar fields should somehow interact with background thermal
bath in order to decay into radiation at an appropriate epoch, but introducing
some couplings to the scalar field makes the dynamics complicated. We
investigate in detail the dynamics of a coherently oscillating scalar field,
which has renormalizable couplings to another field interacting with thermal
background. The scalar field dynamics and its resultant abundance are
significantly modified by taking account of following effects : (1) thermal
correction to the effective potential, (2) dissipation effect on the scalar
field in thermal bath, (3) non-perturbative particle production events and (4)
formation of non-topological solitons. There appear many time scales depending
on the scalar mass, amplitude, couplings and the background temperature, which
make the efficiencies of these effects non-trivial.Comment: 45 pages, 6 figures; v2: several typos corrected; v3: minor
corrections and references added; v4: minor corrections to reflect the
published version; v5: minor correction
Tachyon warm inflationary universe model in the weak dissipative regime
Warm inflationary universe model in a tachyon field theory is studied in the
weak dissipative regime. We develop our model for an exponential potential and
the dissipation parameter =constant. We describe scalar and
tensor perturbations for this scenario.Comment: 9 pages, accepted by European Physical Journal
Simulations of galactic dynamos
We review our current understanding of galactic dynamo theory, paying
particular attention to numerical simulations both of the mean-field equations
and the original three-dimensional equations relevant to describing the
magnetic field evolution for a turbulent flow. We emphasize the theoretical
difficulties in explaining non-axisymmetric magnetic fields in galaxies and
discuss the observational basis for such results in terms of rotation measure
analysis. Next, we discuss nonlinear theory, the role of magnetic helicity
conservation and magnetic helicity fluxes. This leads to the possibility that
galactic magnetic fields may be bi-helical, with opposite signs of helicity and
large and small length scales. We discuss their observational signatures and
close by discussing the possibilities of explaining the origin of primordial
magnetic fields.Comment: 28 pages, 15 figure, to appear in Lecture Notes in Physics "Magnetic
fields in diffuse media", Eds. E. de Gouveia Dal Pino and A. Lazaria
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