Operational modules for space station construction

Identification of an effective space construction concept is a current objective of NASA studies. One concept, described in this memorandum, consists of repetitive use of operational modules, which minimizes on-orbit stay time for the shuttle. A space station constructed of operational modules may benefit from fabrication and system checkout in ground-based facilities, and since the modules are the primary structure of the space station, a minimum of additional structure, and trips and on-orbit stay time of the shuttle are required

Study of an attitude control system for the astronaut maneuvering unit final report, dec. 1963 - jul. 1964

Attitude control system for astronaut maneuvering unit

Temperature dependence of the interlayer magnetoresistance of quasi-one-dimensional Fermi liquids at the magic angles

The interlayer magnetoresistance of a quasi-one-dimensional Fermi liquid is considered for the case of a magnetic field that is rotated within the plane perpendicular to the most-conducting direction. Within semi-classical transport theory dips in the magnetoresistance occur at integer amgic angles only when the electronic dispersion parallel to the chains is nonlinear. If the field direction is fixed at one of the magic angles and the temperature is varied the resulting variation of the scattering rate can lead to a non-monotonic variation of the interlayer magnetoresistance with temperature. Although the model considered here gives a good description of some of the properties of the Bechgaard salts, (TMTSF)2PF6 for pressures less than 8kbar and (TMTSF)2ClO4 it gives a poor description of their properties when the field is parallel to the layers and of the intralayer transport.Comment: 10pages, RevTeX + epsf, 3 figure

Laminar radial flow between parallel discs and its application to viscometry

This thesis forms a report of the work carried out by the author in the development of a radial flow viscometer. This was done to supplement existing measurements made by more conventional methods and to make use of certain advantages that the method has over other forms of flow viscometers. The viscometer, which consists principally of two flat discs separated by a known distance, the fluid being forced to flow radially inward and leaving through a hole in the centre of one of the discs, has the disadvantage that there is a pressure loss due to inertia effects that cannot be expressed exactly. The author has been mainly concerned with investigating the various solutions available to determine which one agrees best with experiment. Within experimental error it was found that a solution obtained by expressing the pressure and velocities of the Wavier Stokes equations by power series was satisfactory. The author has obtained an alternative solution which, although not exact, appears to agree well with the above solution. A series of measurements of the viscosity of water in the range

Datafication and the practice of intelligence production

Datafication of social life affects what society regards as knowledge. Jasanoff’s regimes of sight framework provides three ideal-type models of authorised knowing in environmental data practice. This paper applies Jasanoff's framework for analysing intelligence practice through an exploratory empirical study of crime and intelligence practitioners in a selection of police services in Australia, New Zealand, Canada and the United States. The paper argues that the ‘view from somewhere’ (VFS) captures the essence of existing police intelligence practices in the four countries but the ‘view from nowhere’ (VFN) is emerging as a possible future for police intelligence – an approach promoted by technology companies and supported mainly by police leaders and managers. The paper investigates the challenges and limits of a shift by police from VFS to VFN in the production of intelligence; the challenges are primarily political, which threaten the dominance of police contextual knowledge over ‘scientific’ knowledge. These political challenges also have symbolic and material implications. The paper concludes that, because of these challenges, a complete shift from VFS to VFN is not likely to happen. At best the two models might co-exist with the latter subordinate to the imperatives of the former, resulting in further tension between sworn officers and civilians, organisational inertia, as well as technologies that may be under-utilised or abandoned

Surveyor batteries Final engineering report

Design and performance of Surveyor spacecraft silver-zinc main batter

Drug resistance mediating Plasmodium falciparum polymorphisms and clinical presentations of parasitaemic children in Uganda.

BackgroundPlasmodium falciparum genetic polymorphisms that mediate altered drug sensitivity may impact upon virulence. In a cross-sectional study, Ugandan children with infections mutant at pfcrt K76T, pfmdr1 N86Y, or pfmdr1 D1246Y had about one-fourth the odds of symptomatic malaria compared to those with infections with wild type (WT) sequences. However, results may have been confounded by greater likelihood in those with symptomatic disease of higher density mixed infections and/or recent prior treatment that selected for WT alleles.MethodsPolymorphisms in samples from paired episodes of asymptomatic and symptomatic parasitaemia in 114 subjects aged 4-11 years were followed longitudinally in Tororo District, Uganda. Paired episodes occurred within 3-12 months of each other and had no treatment for malaria in the prior 60 days. The prevalence of WT, mixed, and mutant alleles was determined using multiplex ligase detection reaction-fluorescent microsphere assays.ResultsConsidering paired episodes in the same subject, the odds of symptomatic malaria were lower for infections with mutant compared to WT or mixed sequence at N86Y (OR 0.26, 95% CI 0.09-0.79, p = 0.018), but not K76T or D1246Y. However, symptomatic episodes (which had higher densities) were more likely than asymptomatic to be mixed (for N86Y OR 2.0, 95% CI 1.04-4.0, p = 0.036). Excluding mixed infections, the odds of symptomatic malaria were lower for infections with mutant compared to WT sequence at N86Y (OR 0.33, 95% CI 0.11-0.98, p = 0.046), but not the other alleles. However, if mixed genotypes were grouped with mutants in this analysis or assuming that mixed infections consisted of 50% WT and 50% mutant genotypes, the odds of symptomatic infection did not differ between infections that were mutant or WT at the studied alleles.ConclusionsAlthough infections with only the mutant pfmdr1 86Y genotype were associated with symptomatic infection, this association could primarily be explained by greater parasite densities and therefore greater prevalence of mixed infections in symptomatic children. These results indicate limited association between the tested polymorphisms and risk of symptomatic disease and highlight the value of longitudinal studies for assessing associations between parasite factors and clinical outcomes

Hydrocarbon ions in the lower ionosphere of Saturn

[1] Radio occultation measurements of the Saturn ionosphere have shown that persistent but variable electron density layers appear well below the major peaks. We model here the region of hydrocarbon ions that is below the main peak and is produced by absorption of solar photons in the wavelength range 842 to 1116 Å, which penetrate to altitudes below the methane homopause in the wings of the H2 absorption lines, and in the gaps between groups of lines. In this wavelength range, H2 absorbs photons in discrete transitions to rovibrational levels of electronically excited states, which then decay to a range of rovibrational levels of the electronic ground state, or to the continuum of the ground state. The cross sections for these discrete absorptions vary by several orders of magnitude from the peaks to the wings of the absorption lines. We find that the adoption of high resolution photoabsorption cross sections for the H2 bands leads to different photoionization profiles for both the hydrocarbons and H atoms, and to peak inline imagephotoproduction profiles that are more than an order of magnitude larger than those computed with low resolution cross sections. For the present model, we find that ionization by energetic electrons that accompany the absorption of soft X-rays appears in the same altitude range. We predict that a broad region of hydrocarbon ions appears well below the main peak, in the altitude range 600 to 1000 km above the 1 bar level (2–0.04 μbar) with a maximum electron density of ∼3×103cm−3 at low solar activity

Acute hemorrhagic demyelination in a murine model of multiple sclerosis

Acute hemorrhagic leukoencephalomyelitis (AHLE) is a rare neurological condition characterized by the development of acute hemorrhagic demyelination and high mortality. The pathomechanism of AHLE, as well as potential therapeutic approaches, have remained elusive due to the lack of suitable animal models. We report the first murine model of AHLE using a variation of the Theiler's Murine Encephalitis Virus (TMEV) MS model. During acute TMEV infection, C57BL/6 mice do not normally undergo demyelination. However, when 7 day TMEV infected C57BL/6 mice are intravenously administered the immunodominant CD8 T cell peptide, VP2121–130, animals develop characteristics of human AHLE based on pathologic, MRI and clinical features including microhemorrhages, increased blood-brain barrier permeability, and demyelination. The animals also develop severe disability as assessed using the rotarod assay. This study demonstrates the development of hemorrhagic demyelination in TMEV infected C57BL/6 mice within 24 hours of inducing this condition through intravenous administration of CD8 T cell restricted peptide. This study is also the first demonstration of rapid demyelination in a TMEV resistant non-demyelinating strain without transgenic alterations or pharmacologically induced immunosuppression