Theonis Data

Introduzione ed edizione critica elettronica dei 'Data' di Euclide 'ex traditione Maurolyci' costituiti da un primo libro che presenta una trascelta di proposizioni euclidee e da un secondo libro che si configura come una ricca miscellanea di proposizioni di carattere aritmetico e geometrico attinte da diversi autori, tra cui Maurolico stesso

Neonatal neurologic emergencies requiring access to paediatric emergency units: a retrospective observational study

Herein, authors present a retrospective, multi-center study to determine the number of accesses to Pediatric Emergency Unit (PEU) of patients within 28 days of life, admitted to (1) the Acute and Emergency Pediatric Unit, San Marco University Hospital, Catania, Italy; (2) Garibaldi Hospital for Emergency Care, Catania, Italy; (3) Cannizzaro Hospital for Emergency Care, Catania, Italy. We included neonates admitted for neurologic problems, from January 2015 to December 2020, to the 1-Acute and Emergency Access of the San Marco University Hospital, Catania, Italy [observation center 1 (OC1)]; 2-Garibaldi Hospital for Emergency Care, Catania, Italy (Observation Center 2-OC2); 3-Cannizzaro Hospital for Emergency Care, Catania, Italy (Observation Center 3-OC3). For each patient, we evaluated the severity of urgency, by studying the admission triage-coloured codes, the clinical data at admission and the discharge diagnosis. Neonates who had access to PEU were 812 in the OC1, 3720 in the OC2, and 748 in the OC3 respectively; 69 (8.4%), 138 (3.7%), and 55 (7.4%) was the proportion of neonatal accesses for neurological conditions. We observed that in the study period, the three hospitals had an important decrease of pediatric accesses to their PEU, but the proportion of neonates who had access to the OC1 for neurologic diseases, with respect to the total neonatal accesses, remained stable. We found that the most frequent neurologic disease for which newborns had access to PEU was Cyanosis, (46.1% of all neonatal accesses). Apnea was the second most frequent cause, with a number of 76 accesses (29%). In the literature there are numerous studies on the assessment of diseases that most frequently concern the pediatric patient in an emergency room, but there are very few references on neonatal accesses for urgent neurologic diseases. Therefore, appropriate training is required to avoid unnecessary tests without overlooking potentially serious conditions

PRIMO PROTOCOLLO PER NEUROBLASTOMA AD ALTO RISCHIO siop EUROPE NEUROBLASTOMA. REPORT AD INTERIM DELLA CASISTICA ITALIANA.

Risultati del protocollo SIOP Europa sul neuroblastoma ad alto rischi

Metastatic neuroblastoma in infants: are survival rates excellent only within the stringent framework of clinical trials?

Introduction: SIOPEN INES protocol yielded excellent 5-year survival rates for MYCN-non-amplified metastatic\uc2\ua0neuroblastoma. Patients deemed ineligible due to lack or delay of MYCN status or late registration were treated, but not included in the study. Our goal was to analyse survival at 10\uc2\ua0years among the whole population. Materials and methods: Italian and Spanish metastatic INES patients\ue2\u80\u99 data are reported. SPSS 20.0 was used for statistical analysis. Results: Among 98 infants, 27 had events and 19 died, while 79 were disease free. Five- and 10-year event-free survival (EFS) were 73 and 70\uc2\ua0%, and overall survival (OS) was 81 and 74\uc2\ua0%, respectively. MYCN status was significant for EFS, but not for OS in multivariate analysis. Conclusions: The survival rates of patients who complied with all the inclusion criteria for INES trials are higher compared to those that included also not registered patients. Five-year EFS and OS for INES 99.2 were 87.8 and 95.7\uc2\ua0%, while our stage 4s population obtained 78 and 87\uc2\ua0%. Concerning 99.3, 5-year EFS and OS were 86.7 and 95.6\uc2\ua0%, while for stage 4 we registered 61 and 68\uc2\ua0%. MYCN amplification had a strong impact on prognosis and therefore we consider it unacceptable that many patients were not studied for MYCN and probably inadequately treated. Ten-year survival rates were shown to decrease: EFS from 73 to 70\uc2\ua0% and OS from 81 to 74\uc2\ua0%, indicating a risk of late events, particularly in stage 4s. Population-based registries like European ENCCA WP 11-task 11 will possibly clarify these data

Borrowers and innovators in the history of printing Sacrobosco: The case of the “in-octavo tradition

International audienc