Design of the high intensity exotic beams SPIRAL 2 project

International audienceThe SPIRAL 2 facility will be able to deliver stable heavy ion beams and deuteron beams at very high intensity, allowing to produce and accelerate light and heavy rare ion beams. The driver will accelerate a 5 mA deuteron beam up to 20 MeV/u and also q/A=1/3 heavy ions up to 14.5 MeV/u. The injector consist of the ion sources, a 4-vane RFQ and the low and medium beam transfer lines. It is followed by an independently phased superconducting linac with compact cryostats separated with warm focusing sections. The overall design and results of simulations with combined errors, the results of tests of prototypes for the most critical components are presented

Wind Impact Assessment of a Sour Gas Release in an Offshore Platform

Complex installations that involve dangerous substances, such as oil and gas or nuclear plants, must mandatorily undergo a quantitative risk assessment (QRA) according to current regulations. This requires, among others, the simulation of hundreds of accidental scenarios, which are typically carried out using empirical tools due to their fast response. Nonetheless, since they are not able to guarantee sufficient accuracy, especially when complex geometries are involved, computational fluid dynamics (CFD) tools are increasingly used. In this work, a high-pressure accidental release of a sour gas (CH4-H2S) in an offshore platform under several wind conditions is considered. A methodology used to perform a wind sensitivity analysis via CFD, while avoiding high computational costs, is presented. The wind intensity impact on some risk-related figures of merit, such as the high lethality or irreversible injuries areas, is discussed in relation to the flammability and toxicity limits of the released mixture. The results show that even a very low amount of H2S in the released mixture can strongly affect the threat zones. A progressive decrease in the toxic and flammable volumes in the platform is observed as the wind velocity increases; nonetheless, a saturation effect appears in high wind speed scenarios

Experimental and numerical study of vacuum resin infusion of stiffened carbon fiber reinforced panels

Liquid resin infusion processes are becoming attractive for aeronautic applications as an alternative to conventional autoclave-based processes. They still present several challenges, which can be faced only with an accurate simulation able to optimize the process parameters and to replace traditional time-consuming trial-and-error procedures. This paper presents an experimentally validated model to simulate the resin infusion process of an aeronautical component by accounting for the anisotropic permeability of the reinforcement and the chemophysical and rheological changes in the crosslinking resin. The input parameters of the model have been experimentally determined. The experimental work has been devoted to the study of the curing kinetics and chemorheological behavior of the thermosetting epoxy matrix and to the determination of both the in-plane and out-of-plane permeability of two carbon fiber preforms using an ultrasonic-based method, recently developed by the authors. The numerical simulation of the resin infusion process involved the modeling of the resin flow through the reinforcement, the heat exchange in the part and within the mold, and the crosslinking reaction of the resin. The time necessary to fill the component has been measured by an optical fiber-based equipment and compared with the simulation results

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International audienceThe GANIL facility consists of three successive cyclotrons. The tuning of these cyclotrons and of the transfer beam lines isachieved in about 24 hours. Reducing this setting time would enable to increase the time allocated to physics experiments.New tools are realized for automatic beam tuning. These tools are expected to make the tuning easier, shorter and morereproducible

A meteo-hydrological prediction system based on a multi-model approach for precipitation forecasting

International audienceThe precipitation forecasted by a numerical weather prediction model, even at high resolution, suffers from errors which can be considerable at the scales of interest for hydrological purposes. In the present study, a fraction of the uncertainty related to meteorological prediction is taken into account by implementing a multi-model forecasting approach, aimed at providing multiple precipitation scenarios driving the same hydrological model. Therefore, the estimation of that uncertainty associated with the quantitative precipitation forecast (QPF), conveyed by the multi-model ensemble, can be exploited by the hydrological model, propagating the error into the hydrological forecast. The proposed meteo-hydrological forecasting system is implemented and tested in a real-time configuration for several episodes of intense precipitation affecting the Reno river basin, a medium-sized basin located in northern Italy (Apennines). These episodes are associated with flood events of different intensity and are representative of different meteorological configurations responsible for severe weather affecting northern Apennines. The simulation results show that the coupled system is promising in the prediction of discharge peaks (both in terms of amount and timing) for warning purposes. The ensemble hydrological forecasts provide a range of possible flood scenarios that proved to be useful for the support of civil protection authorities in their decision

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International audienceThe GANIL facility consists of three successive cyclotrons. The tuning of these cyclotrons and of the transfer beam lines isachieved in about 24 hours. Reducing this setting time would enable to increase the time allocated to physics experiments.New tools are realized for automatic beam tuning. These tools are expected to make the tuning easier, shorter and morereproducible

Superconducting booster cyclotron studies at GANIL

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Les Modeling of a Diurnal Cycle

LES modeling of a diurnal cycl

Evidence for the differential expression of a variant EGF receptor protein in human prostate cancer

Earlier studies have demonstrated an unexplained depletion of the epidermal growth factor receptor (EGFR) protein expression in prostatic cancer. We now attribute this phenomenon to the presence of a variant EGFR (EGFRvIII) that is highly expressed in malignant prostatic neoplasms. In a retrospective study, normal, benign hyperplastic and malignant prostatic tissues were examined at the mRNA and protein levels for the presence of this mutant receptor. The results demonstrated that whilst EGFRvIII was not present in normal prostatic glands, the level of expression of this variant protein increased progressively with the gradual transformation of the tissues to the malignant phenotype. The selective association of high EGFRvIII levels with the cancer phenotype underlines the role that this mutant receptor may maintain in the initiation and progression of malignant prostatic growth, and opens the way for new approaches in the management of this disease including gene therapy. © 2000 Cancer Research Campaig