Accessing Rare Heterocycles from Alkynyl Ethers and Nitrogenous Electrophiles & The Development of Small Molecule Inhibitors Against Naegleria \u3ci\u3efowleri\u3c/i\u3e infection

https://tigerprints.clemson.edu/csrp/1002/thumbnail.jp

Economic Feasibility of Ethanol Production from Sweet Sorghum Juice in Texas

The economic feasibility of producing ethanol from sweet sorghum juice is projected using Monte Carlo simulation models to estimate the price ethanol plants will likely have to pay for sweet sorghum and the uncertain returns for ethanol plants. Ethanol plants in high yielding regions will likely generate returns on assets of 11%-12% and in low yield areas the returns on assets will be less than 10%.Sweet Sorghum, Ethanol, Monte Carlo Simulation, Agribusiness, Agricultural Finance, Crop Production/Industries, Farm Management, Risk and Uncertainty, D20 G10 D81 C15,

A longitudinal evaluation of a project-based learning initiative in an engineering undergraduate programme

Project-based learning (PBL) is a well-known student-centred methodology for engineering design education. The methodology claims to offer a number of educational benefits. This paper evaluates the student perceptions of the initial and second offering of a first-year design unit at Griffith University in Australia. It builds on an earlier evaluation conducted after the initial offering of the unit. It considers the implementation of the recommended changes. Evaluations of the two offerings reveal that students (in both the initial and second offering) generally enjoyed the experience, but that the second offering was found to be a significantly more enjoyable learning experience. Students in the second offering also reported a significantly better understanding of what they needed to do for the design projects and where to find the requisite information. The oral presentation aspect of the initial and second offerings received the lowest satisfaction rating. The inclusion (and delivery) of the computer-aided drawing component of the unit is seen as a positive aspect by some students, but many others comment on it negatively. The best aspects of the PBL unit and those aspects needing further improvement were similar to the findings of other investigations documented in the literature

Is the Cepheus E Outflow driven by a Class 0 Protostar?

New early release observations of the Cepheus E outflow and its embedded source, obtained with the Spitzer Space Telescope, are presented. We show the driving source is detected in all 4 IRAC bands, which suggests that traditional Class 0 classification, although essentially correct, needs to accommodate the new high sensitivity infrared arrays and their ability to detected deeply embedded sources. The IRAC, MIPS 24 and 70 microns new photometric points are consistent with a spectral energy distribution dominated by a cold, dense envelope surrounding the protostar. The Cep E outflow, unlike its more famous cousin the HH 46/47 outflow, displays a very similar morphology in the near and mid-infrared wavelengths, and is detected at 24 microns. The interface between the dense molecular gas (where Cep E lies) and less dense interstellar medium, is well traced by the emission at 8 and 24 microns, and is one of the most exotic features of the new IRAC and MIPS images. IRS observations of the North lobe of the flow confirm that most of the emission is due to the excitation of pure H2 rotational transitions arising from a relatively cold (Tex~700 K) and dense (N{H}~9.6E20 cm-2 molecular gas.Comment: 14 pages (pre-print format), including 6 figures. Published in ApJ Special Spitzer Issue (2004

COMPTEL gamma ray and neutron measurements of solar flares

COMPTEL on the Compton Gamma Ray Observatory has measured the flux of x‐rays and neutrons from several solar flares. These data have also been used to image the Sun in both forms of radiation. Unusually intense flares occurred during June 1991 yielding data sets that offer some new insight into of how energetic protons and electrons are accelerated and behave in the solar environment. We summarize here some of the essential features in the solar flare data as obtained by COMPTEL during June 1991

Neutron and gamma‐ray measurements of the solar flare of 1991 June 9

The COMPTEL Imaging Compton Telescope on‐board the Compton Gamma Ray Observatory measured significant neutron and γ‐ray fluxes from the solar flare of 9 June 1991. The γ‐ray flux had an integrated intensity (≳1 MeV) of ∼30 cm−2, extending in time from 0136 UT to 0143 UT, while the time of energetic neutron emission extended approximately 10 minutes longer, indicating either extended proton acceleration to high energies or trapping and precipitation of energetic protons. The production of neutrons without accompanying γ‐rays in the proper proportion indicates a significant hardening of the precipitating proton spectrum through either the trapping or extended acceleration process

Row Widths for Full Season Soybeans in Kentucky

Soybean yields in Kentucky have increased steadily in the past 20 years as a result of improved varieties and production practices. To achieve even higher yields new varieties and better production practices need to be developed and tested. One possibility for increasing soybean yields is to plant in narrow rows using varieties which respond to this practice. Although previous research in Kentucky has not shown a yield advantage for full season soybeans planted in narrow rows, researchers in other states have recently shown increases in yield with narrowing row widths. A number of new varieties have also been developed specifically for narrow row plantings. These varieties are shorter, lodge less, and have a high yield potential. This study was designed to answer the question: Will narrow row widths provide higher yields for these soybean varieties when grown under full season conditions in Kentucky

Place matters: but does local leadership?

The arrival of New Labour into Government witnessed the prominent re-emergence of place onto the policy agenda. This heralded a range of area-based-initiatives designed to both tackle neighbourhood forms of deprivation and to re-establish a sense of identity and connection between individuals and their local community. In terms of place-making, effective and inclusive participation, representation and leadership were all identified as prerequisites for the creation of sustainable communities . But how important is local leadership and strategic vision within local public service organisations in achieving the desired place-making outcomes? This paper examines the extent to which local leadership and strategic vision represents a significant factor in promoting higher levels of satisfaction, belonging, cohesion and participation across single tier councils in England. The ensuing empirical evidence raises significant questions not only about the importance of local leadership in place-making, but also the environmental and organizational factors that shape local places

Kinetic Characterization of Salmonella FliK-FlhB Interactions Demonstrates Complexity of the Type III Secretion Substrate-Specificity Switch

The bacterial flagellum is a complex macromolecular machine consisting of more than 20000 proteins, most of which must be exported from the cell via a dedicated Type III secretion apparatus. At a defined point in flagellar morphogenesis, hook completion is sensed and the apparatus switches substrate specificity type from rod and hook proteins to filament ones. How the switch works is a subject of intense interest. FIiK and F1hBs play central roles. In the present study, two optical biosensing methods were used to characterize FIiK-F1hB interactions using wild-type and two variant FlhBs from mutants with severe flagellar structural defects. Binding was found to be complex with fast and slow association and dissociation components. Surprisingly, wild-type and variant FlhBs had similar kinetic profiles and apparent affinities, which ranged between I and 10.5 μM, suggesting that the specificity switch is more complex than presently understood. Other binding experiments provided evidence for a conformational change after binding. Liquid chromatography-mass spectrometry (LC-MS) and NMR experiments were performed to identify a cyclic intermediate product whose existence supports the mechanism of autocatalytic cleavage at FlhB residue N269. The present results show that while autocatalytic cleavage is necessary for proper substrate specificity switching, it does not result in an altered interaction with FIiK. strongly suggesting the involvement of other proteins in the mechanism

Initial results from COMPTEL—an overview

COMPTEL is presently completing the first full sky survey in MeV gamma‐ray astronomy (0.7 to 30 MeV). An overview of initial results from the survey is given: among these are the observations of the Crab and Vela pulsars with unprecedented accuracy, the observation of the black hole candidates Cyg X‐1 and Nova Persei 1992, an analysis of the diffuse Galactic continuum emission from the Galactic center region, the broad scale distribution of the 1.8 MeV line from radioactive 2 6Al, upper limits on gamma‐ray line emission from SN 1991T, observations of the three quasars 3C273, 3C279 and PKS 0528+134 and the radio galaxy Cen A, measurements of energy spectra, time histories and locations of a number of cosmic gamma‐ray bursts, and gamma‐ray and neutron emission from solar flares