166 research outputs found
Significant Developments in the Immigration Laws of the United States 1982-1983
This synopsis outlines significant developments in immigration law from July 1982 through July 1983
Surface Potential Modulation in Boronate-Functionalized Magnetic Nanoparticles Reveals Binding Interactions: Toward Magnetophoretic Capture/Quantitation of Sugars from Extracellular Matrix
Phenylboronic acids (BAs) are important synthetic receptors that bind reversibly to cis-diols enabling their use in molecular sensing. When conjugated to magnetic iron oxide nanoparticles, BAs have potential for application in separations and enrichment. Realizing this will require a new understanding of their inherent binding modes and measurement of their binding capacity and their stability in/extractability from complex environments. In this work, 3-aminophenylboronic acid was functionalized to superparamagnetic iron oxide nanoparticles (MNPs, core diameter 8.9 nm) to provide stable aqueous suspensions of functionalized particles (BA-MNPs). The progress of sugar binding and its impact on BA-MNP colloidal stability were monitored through the pH-dependence of hydrodynamic size and zeta potential during incubation with a range of saccharides. This provided the first direct observation of boronate ionization pKa in grafted BA, which in the absence of sugar shifted to a slightly more basic pH than free BA. On exposure to sugar solutions under MNP-limiting conditions, pKa moved progressively to lower pH as maximum capacity was gradually attained. The pKa shift is shown to be greater for sugars with greater BA binding affinity, and on-particle sugar exchange effects were inferred. Colloidal dispersion of BA-MNPs after binding was shown for all sugars at all pHs studied, which enabled facile magnetic extraction of glucose from agarose and cultured extracellular matrix expanded in serum-free media. Bound glucose, quantified following magnetophoretic capture, was found to be proportional to the solution glucose content under glucose-limiting conditions expected for the application. The implications for the development of MNP-immobilized ligands for selective magnetic biomarker capture and quantitation from the extracellular environment are discussed.The authors would like to acknowledge the financial support from Science Foundation Ireland under Grant Agreements 13/CDA/2155 and 16/IA/4584, the work was also co-funded under the European Regional Development Fund (13/RC/2073_2). P.B.P. acknowledges the Government of Spain - Ministry of Education, Culture and Sports for the FPU grant (FPU14/04589)
Electrostatically modulated magnetophoretic transport of functionalised iron-oxide nanoparticles through hydrated networks
Factors that determine magnetophoretic transport of magnetic nanoparticles (MNPs) through hydrated polymer networks under the influence of an external magnetic field gradient were studied. Functionalised iron oxide cores (8.9 nm core diameter) were tracked in real-time as they moved through agarose gels under the influence of an inhomogeneous magnetic field. Terminal magnetophoretic velocities were observed in all cases, these were quantified and found to be highly reproducible and sensitive to the con- ditions. Increasing agarose content reduced magnetophoretic velocity, we attribute this to increasingly tortuous paths through the porous hydrated polymer network and propose a new factor to quantify the tortuosity. The impact of MNP surface functionalisation, charge, network fixed charge content, and ionic strength of the aqueous phase on velocity were studied to separate these effects. For MNPs functionalised with polyethylene glycol (PEG) increasing chain length reduced velocity but the tortuosity extracted, which is a function of the network, was unchanged; validating the approach. For charged citrate- and arginine-functionalised MNPs, magnetophoretic velocities were found to increase for particles with posi- tive and decrease for particles with negative zeta potential. In both cases these effects could be moder- ated by reducing the number of agarose anionic residues and/or increasing the ionic strength of the aqueous phase; conditions under which tortuosity again becomes the critical factor. A model for MNP transport identifying the contributions from the tortuous pore network and from electrostatic effects associated with the pore constrictions is proposed
Realistic loophole-free Bell test with atom-photon entanglement
The establishment of nonlocal correlations, obtained through the violation of
a Bell inequality, is not only important from a fundamental point of view, but
constitutes the basis for device-independent quantum information technologies.
Although several nonlocality tests have been performed so far, all of them
suffered from either the locality or the detection loopholes. Recent studies
have suggested that the use of atom-photon entanglement can lead to Bell
inequality violations with moderate transmission and detection efficiencies. In
this paper we propose an experimental setup realizing a simple atom-photon
entangled state that, under realistic experimental parameters available to
date, achieves a significant violation of the Clauser-Horn-Shimony-Holt
inequality. Most importantly, the violation remains when considering typical
detection efficiencies and losses due to required propagation distances.Comment: 21 pages, 5 figures, 3 table, to appear in Nature Com
Colour Deconfinement and Quarkonium Binding
At high temperatures, strongly interacting matter becomes a plasma of
deconfined quarks and gluons. In statistical QCD, deconfinement and the
properties of the resulting quark-gluon plasma can be investigated by studying
the in-medium behaviour of heavy quark bound states. In high energy nuclear
interactions, quarkonia probe different aspects of the medium formed in the
collision. We survey the results of recent charmonium production studies in SPS
and RHIC experiments.Comment: 50 pages, 53 figures; revised section 6.
Transport Properties of the Quark-Gluon Plasma -- A Lattice QCD Perspective
Transport properties of a thermal medium determine how its conserved charge
densities (for instance the electric charge, energy or momentum) evolve as a
function of time and eventually relax back to their equilibrium values. Here
the transport properties of the quark-gluon plasma are reviewed from a
theoretical perspective. The latter play a key role in the description of
heavy-ion collisions, and are an important ingredient in constraining particle
production processes in the early universe. We place particular emphasis on
lattice QCD calculations of conserved current correlators. These Euclidean
correlators are related by an integral transform to spectral functions, whose
small-frequency form determines the transport properties via Kubo formulae. The
universal hydrodynamic predictions for the small-frequency pole structure of
spectral functions are summarized. The viability of a quasiparticle description
implies the presence of additional characteristic features in the spectral
functions. These features are in stark contrast with the functional form that
is found in strongly coupled plasmas via the gauge/gravity duality. A central
goal is therefore to determine which of these dynamical regimes the quark-gluon
plasma is qualitatively closer to as a function of temperature. We review the
analysis of lattice correlators in relation to transport properties, and
tentatively estimate what computational effort is required to make decisive
progress in this field.Comment: 54 pages, 37 figures, review written for EPJA and APPN; one parag.
added end of section 3.4, and one at the end of section 3.2.2; some Refs.
added, and some other minor change
The Intentional Use of Service Recovery Strategies to Influence Consumer Emotion, Cognition and Behaviour
Service recovery strategies have been identified as a critical factor in the success of. service organizations. This study develops a conceptual frame work to investigate how specific service recovery strategies influence the emotional, cognitive and negative behavioural responses of . consumers., as well as how emotion and cognition influence negative behavior. Understanding the impact of specific service recovery strategies will allow service providers' to more deliberately and intentionally engage in strategies that result in positive organizational outcomes. This study was conducted using a 2 x 2 between-subjects quasi-experimental design. The results suggest that service recovery has a significant impact on emotion, cognition and negative behavior. Similarly, satisfaction, negative emotion and positive emotion all influence negative behavior but distributive justice has no effect
Review: The increasing importance of carbon nanotubes and nanostructured conducting polymers in biosensors
The growing need for analytical devices requiring smaller sample volumes, decreased power consumption and improved performance have been driving forces behind the rapid growth in nanomaterials research. Due to their dimensions, nanostructured materials display unique properties not traditionally observed in bulk materials. Characteristics such as increased surface area along with enhanced electrical/optical properties make them suitable for numerous applications such as nanoelectronics, photovoltaics and chemical/biological sensing. In this review we examine the potential that exists to use nanostructured materials for biosensor devices. By incorporating nanomaterials, it is possible to achieve enhanced sensitivity, improved response time and smaller size. Here we report some of the success that has been achieved in this area. Many nanoparticle and nanofibre geometries are particularly relevant, but in this paper we specifically focus on organic nanostructures, reviewing conducting polymer nanostructures and carbon nanotubes
Prognostic impact of the expression of putative cancer stem cell markers CD133, CD166, CD44s, EpCAM, and ALDH1 in colorectal cancer
The aim of this study was to elucidate the prognostic impact of putative cancer stem cell markers CD133, CD166, CD44s, EpCAM, and aldehyde dehydrogenase-1 (ALDH1) in colorectal cancer
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