Модельний аспект оцінки ефективності організації управління та мотивації персоналу

This paper proposes methodological aspects of evaluation of organization efficiency of personnel management and motivation on the bases of application of economic and mathematical tools by implementing a three-component algorithmic model. The structural divisions heads’ work effectiveness evaluation is carried out on the basis of econometric systems of structural equations that allow you to rank personality, communicative, innovative, social and corporate managers characteristics that have the greatest impact on the overall performance indicators of the bank staff among which are considered amount of attracted funds; assessment of employee's compliance with the standard; activity efficiency (number of contracts); contribution to development. The obtained modeling results confirm the hypothesis that structural unit managers need to work on the development of their communicative, innovative, personal and social characteristics. Models for analyzing the personnel motivation factors on the bases of the methodology of multivariate statistical factor analysis with initial list of 13 main indicators of staff motivation are proposed; as a result, we set up the aggregated factors that reflect the properties of several motivational components such as financial, social incentives and medical insurance for employees. The model for estimating influence of motivation factors on results of bank's activity on the bases of nonlinear econometric functions is constructed. The regression equation of the motivation factors influence on the bank total profit is obtained. The proposed model toolkit for evaluation of efficiency of management and staff motivation will allow the bank's management to improve motivation and incentives mechanisms in order to raise efficiency of stuff productivity in direction of increasing bank profitability and competitiveness.У статті запропоновано методологічні аспекти оцінки ефективності організації управління персоналом та мотивації на основі застосування економіко-математичного інструментарію шляхом реалізації трьохкомпонентної алгоритмічної моделі. Здійснено оцінку ефективності праці керівників структурних підрозділів на основі економетричних систем структурних рівнянь, що дозволяють ранжувати особистісні, комунікативні, інноваційні, соціальні та корпоративні характеристики, які в найбільшій мірі впливають на загальні показники ефективності роботи персоналу банку, серед яких розглядаються обсяг залучених коштів; оцінка працівника щодо відповідності стандарту; ефективність діяльності (кількість контрактів); вклад у розвиток. Отримані результати підтверджують гіпотезу, що керівникам структурних підрозділів треба працювати над розвитком своїх комунікативних, інноваційних, особистих та соціальних характеристик. Запропоновані моделі аналізу факторів мотивації персоналу за методологією багатовимірного статистичного факторного аналізу на основі вихідного переліку з 13 основних показників мотивації персоналу, у результаті чого сформовані агреговані фактори, що відбивають властивості декількох мотиваційних компонентів, а саме: матеріального стимулювання робітників, соціального стимулювання та охорони здоров’я персоналу. Побудовано модель оцінки впливу факторів мотивації на результати діяльності банку на основі нелінійних економетричних функцій. Отримано регресійне рівняння впливу факторів мотивації на загальний прибуток банку.Запропонований модельний інструментарій оцінювання ефективності управління та мотивації персоналу дозволить керівництву банку вдосконалити механізми стимулювання та заохочення працівників з метою підвищення ефективності їх праці в напрямі підвищення прибутковості та конкурентоспроможності банку

Nanosilver in Biomedicine: Advantages and Restrictions

Nanosilver (in a range 1–100 nm) binds with thyol-, amino- and carboxy-groups of aminoacid residues of proteins and nucleic acids, thus providing inactivation of pathogenic multidrug-resistant microorganisms. Besides antibacterial, antiviral, antifungal and anti-cancer properties Ag-based nanomaterials possess anti-inflammatory, anti-angiogenesis and antiplatelet features. Drug efficacy depends on their stability, toxicity and host immune response. Citrate coated Ag nanoparticles (NPs) remain stable colloid solutions in deionized water but not in the presence of ions due to replacement of Ag+ by electrolyte ions, potential formation of insoluble AgCl, subsequent catalyzed oxidative corrosion of Ag and further dissolution of surface layer of Ag2O. Protein shells protect core of AgNPs from oxidation, dissolution, aggregation and provide specific interactions with ligands. These nanoconjugates can be used for immunoassays and diagnostics but the sensitivity threshold does not exceed 10 pg Cytotoxicity of AgNPs conjugated with proteins is associated with the rate of intracellular Ag+ release, a ‘Trojan horse’ effect, and exceeds one of Ag+ because of endocytosis uptake of NPs but not ions. Relatively toxic nanosilver causes immunosuppression of the majority of cytokines with a few exceptions (IL-1β, G-CSF, MCP-1) whereas AgNO3 additionally activate TNFα and IL8 gene expression

ФИГУРЫ ТАНАТОСА И ЭРОСА В ПОЭТИКЕ А. С. ПУШКИНА

The article deals with ontological issues of creativity and mortal implied sense of Pushkin's fairy tale. The study object is the figures of Thanatos and Eros in ‘The Tale of the Golden Cockerel’ fairy tale. The images of King Dadon and the Queen of Shamakhan are revealed in symbiotic relationship with folklore aesthetics. Reference to folklore is caused not only by genre of the work but also by metaphysical nature of oral tradition since the Russian people have a special attitude to the theme of death. This is evidenced by the Russian fairy tale with search of “the other kingdom” in which a hero must suffer a temporary death in order to get a wonderful object, save a prophetic bride and obtain the sacred knowledge.El artículo trata sobre cuestiones ontológicas de la creatividad y el sentido implícito mortal del cuento de hadas de Pushkin. El objeto de estudio son las figuras de Thanatos y Eros en el cuento de hadas "El cuento del gallo de oro". Las imágenes del rey Dadon y la reina de Shamakhan se revelan en una relación simbiótica con la estética del folklore. La referencia al folclore es causada no solo por el género de la obra sino también por la naturaleza metafísica de la tradición oral, ya que el pueblo ruso tiene una actitud especial hacia el tema de la muerte. Esto se evidencia en el cuento de hadas ruso con la búsqueda del "otro reino" en el que un héroe debe sufrir una muerte temporal para obtener un objeto maravilloso, salvar a una novia profética y obtener el conocimiento sagrado.В статье рассматриваются онтологические вопросы творчества, мортальный подтекст пушкинской сказки. Предметом исследования выступают фигуры Танатоса и Эроса в «Сказке о золотом петушке». Образы царя Дадона и Шамаханской Царицы раскрываются в неразрывной связи с фольклорной эстетикой. Обращение к фольклору обусловлено не только жанром произведения, но и самой метафизической природой устного народного творчества, так как русский народ особым образом относится к теме смерти. Об этом свидетельствует и русская волшебная сказка с поисками «иного царства», в которой герой обязательно должен пережить временную смерть, чтобы добыть чудесный предмет, выручить вещую невесту, приобщиться к сакральным знаниям

Study a tolerance of university students (anexample - Penza State Technological University)

The article examines the problem of tolerance, presents the results of a diagnostic study of tolerance in students of Penza State Technological University, students in technical and humanitarian specialties.  During the study, we used the rapid questionnaire “Tolerance Index”, which allows us to assess the overall level of tolerance, and the questionnaire “Types of Ethnic Identity”, aimed at identifying ethnic identity and its transformation. The results of the study indicate the effectiveness of the educational work of the university on the development a tolerance in students

Abstract P-39: Fluorescent Silver Nanoclusters with Immunoglobulins and Albumins

Background: Multiplex biomedical assays including molecular genetic tests and immunoanalysis require multiple fluorophores with a wide excitation range and different emission spectra. In comparison with organic fluorophores and quantum dots, the metal nanoclusters (NC) consisting of a few to hundred atoms have the following advantages: small size, large Stokes shift, prolonged fluorescence lifetime and biocompatibility. Our research was aimed at construction of fluorescent AgNC with the main blood proteins and transmission electron microscopy (TEM). Methods: AgNC were synthesized from AgNO3 in the presence of albumins and immunoglobulins (Ig) of different classes and origin at pH 9-11 with NaBH4 recovery. The resulting AgNC with proteins were loaded to "Formvar/Carbon 200 Mesh Copper" copper grids (Ted Pella, USA) and examined using TEM system JEM 2100 Plus (JEOL, Japan) without contrast. Fluorescence excitation/emission spectra were measured in quartz cuvette using the FluoroMax + spectrofluorometer (Horiba Scientific, Japan). Results: Recovery of Ag+ ions did not occur in the presence of IgG and albumins without NaBH4 at different temperatures, pH, and incubation time. Broad excitation spectra of AgNC were in a range 340-540 nm. Their emission spectra correlated with the original AgNO3 concentration and did not depend on protein and pH. NC stabilized with IgG or albumin with blue fluorescence and emission maximum at 420 nm contained NC from 0.6 nm and higher. Green AgNC with proteins had bright fluorescence at 430-470 nm and red NC showed emission maximum at 650 nm. TEM revealed discrete AgNC and their numerous aggregates in each sample of fluorescent NC in spite of different fluorescent emission spectra. According to the MTT test, AgNC with human IgG and BSA with protein concentrations up to 3 mg/ml were not toxic for human larynx carcinoma HEp-2 cells despite cytotoxicity of silver nanoparticles covered with IgG or albumin envelopes as well as Cd and AuNC with BSA. Conclusion: AgNC with antibodies and albumin with a broad size range and aggregation possess tunable fluorescence emission spectra with broad excitation at 340-540 nm. Different emission spectra permit AgNC to be used in multiplex assays. AgNC were not toxic for human tissue culture and may be applied for bioimaging

V. N. Vinogradov Faculty Therapy Clinic of Sechenov University: the flagship of the therapeutic service of the Russian Federation. A review

The history of the Faculty Therapy Clinic of Sechenov University is presented. The stages of the formation of its therapeutic school are discussed. Diagnostic and therapeutic methods first developed and implemented in the clinic are described in detail

Monitoring of respiratory viral infections in Moscow during 2011–2022

Introduction. Respiratory viruses (RV) circulate throughout the world and in all seasons of the year. Long-term monitoring of the distribution of respiratory pathogens is necessary to analyze the relevance of diagnostic systems to current viral isolates, to assess the risks of infection and the need for vaccine development and use, as well as to investigate the interdependence of RV reproduction in mixed infections. Objective — to study the causative agents of acute respiratory viral infections (ARVI) in Moscow during 2011–2022 by reverse transcription with subsequent polymerase chain reaction with fluorescent hydrolysis probes detection in real-time (RT2-PCR). Materials and Methods. Nasopharyngeal swabs from 3908 patients with acute respiratory infections were examined by the RT2-PCR. Results. Monitoring of RV spread in Moscow showed cyclical changes in frequencies with three dominant species: influenza A virus (up to 31.3%), respiratory syncytial virus (up to 24.8%) and human rhinoviruses (up to 21.3%) in 2011–2020. The increase in the portion of unidentified clinical specimens from 1.2 to 28.5% in 2022 indicated incomplete accordance of diagnostic systems to modern RV isolates or the emergence of new species or strains of pathogens. Unidirectional changes in dynamics were registered for 5 out of 9 studied RVs with correlation coefficients of 0.43–0.79. High frequencies of mixed acute respiratory viral infections (up to 33.4%) along with unidentified samples do not allow us to accurately assess the risks of infection with various RV in Moscow, but prove the necessity of preventing infectious diseases with the most common RV. Conclusion. Analysis of the dynamics of RV frequencies in Moscow showed the preservation of the dominant species: influenza A virus, respiratory syncytial virus and human rhinoviruses. During the period of vaccination against COVID-19, the proportion of seasonal coronaviruses increased

Tickborne Pathogen Detection, Western Siberia, Russia

Ixodes and Dermacentor ticks harbor Borrelia, Anaplasma/Ehrlichia, Bartonella, and Babesia species

Corrigendum to 'Immunoprotection against toxic biomarkers is retained during Parkinson's disease progression?' [Journal of Neuroimmunology, 233 (2011) 221-227]

The authors regret that one of the author names for this article was presented incorrectly in the printed version. ‘Olga R. Bocharova’ should have been ‘Olga A. Bocharova’. The correct presentation of the author names can be seen above and in the online version of this paper. The authors would like to apologise for any inconvenience caused

Dysregulation of Long Intergenic Non-Coding RNA Expression in the Schizophrenia Brain

BACKGROUND: Transcriptomic studies of the brains of schizophrenia (SZ) patients have produced abundant but largely inconsistent findings about the disorders pathophysiology. These inconsistencies might stem not only from the heterogeneous nature of the disorder, but also from the unbalanced focus on particular cortical regions and protein-coding genes. Compared to protein-coding transcripts, long intergenic non-coding RNA (lincRNA) display substantially greater brain region and disease response specificity, positioning them as prospective indicators of SZ-associated alterations. Further, a growing understanding of the systemic character of the disorder calls for a more systematic screening involving multiple diverse brain regions. AIM: We aimed to identify and interpret alterations of the lincRNA expression profiles in SZ by examining the transcriptomes of 35 brain regions. METHODS: We measured the transcriptome of 35 brain regions dissected from eight adult brain specimens, four SZ patients, and four healthy controls, using high-throughput RNA sequencing. Analysis of these data yielded 861 annotated human lincRNAs passing the detection threshold. RESULTS: Of the 861 detected lincRNA, 135 showed significant region-dependent expression alterations in SZ (two-way ANOVA, BH-adjusted p 0.05) and 37 additionally showed significant differential expression between HC and SZ individuals in at least one region (post hoc Tukey test, p 0.05). For these 37 differentially expressed lincRNAs (DELs), 88% of the differences occurred in a cluster of brain regions containing axon-rich brain regions and cerebellum. Functional annotation of the DEL targets further revealed stark enrichment in neurons and synaptic transmission terms and pathways. CONCLUSION: Our study highlights the utility of a systematic brain transcriptome analysis relying on the expression profiles measured across multiple brain regions and singles out white matter regions as a prospective target for further SZ research