MPLEMENTACIÓN DE LA PANTALLA RELACIONADAS CON EL MARGEN DE SOLVENCIA, PATRIMONIO TÉCNICO Y OTROS REQUERIMIENTOS DE PATRIMONIO DE LOS ESTABLECIMIENTOS DE CRÉDITO; GENERACIÓN DEL FORMATO 239

El proyecto correspondiente a la parte práctica del examen complexivo, el cual consiste en dar cumplimiento con los cambios normativos dispuestos por el decreto 1477 de 2018 y la circular externa 020 de septiembre del 2019 de la Superintendencia Financiera de Colombia. En la cual hace referencia a la abolición de los formatos 301 (Declaración del control de ley de márgenes de solvencia) y 110 (Cuentas no PUC para el cálculo de patrimonio técnico)

Novel Insights into the Combination of Metal- and Biocatalysis: Cascade One-Pot Synthesis of Enantiomerically Pure Biaryl Alcohols in Deep Eutectic Solvents

Paris J, Rios-Lombardia N, Moris F, Gröger H, Gonzalez-Sabin J. Novel Insights into the Combination of Metal- and Biocatalysis: Cascade One-Pot Synthesis of Enantiomerically Pure Biaryl Alcohols in Deep Eutectic Solvents. CHEMCATCHEM. 2018;10(19):4417-4423.One of the pioneering examples of chemoenzymatic cascades in water such as the palladium-catalysed Suzuki-cross coupling followed by an enzymatic reduction has been revisited by the employment of a medium containing Deep Eutectic Solvents (DESs) for the catalytic performance. Thus, the unique properties of these neoteric solvents enabled to reach high substrate concentration for the overall process. Moreover, both isolated enzymes and whole cells exhibited excellent activities which allowed to obtain a set of chiral biaryl alcohols in good yields and very high enantiomeric excess (> 99%)

Meteorological Conditions Associated with Lightning Ignited Fires and Long-Continuing-Current Lightning in Arizona, New Mexico and Florida

Lightning is the main precursor of wildfires in Arizona, New Mexico, and Florida during the fire season. Forecasting the occurrence of Lightning-Ignited Wildfires (LIW) is an essential tool to reduce their impacts on the environment and society. Long-Continuing-Current (LCC) lightning is proposed to be the main precursor of LIW. The long-lasting continuing current phase of LCC lightning is that which is more likely to ignite vegetation. We investigated the meteorological conditions and vegetation type associated with LIW and LCC lightning flashes in Arizona, New Mexico, and Florida. We analyzed LIW between 2009 and 2013 and LCC lightning between 1998 and 2014 and combined lightning and meteorological data from a reanalysis data set. According to our results, LIW tend to occur during dry thunderstorms with a high surface temperature and a high temperature gradient between the 700 hPa and the 450 hPa vertical levels for high-based clouds. In turn, we obtained a high lightning-ignition efficiency in coniferous forests, such as the ponderosa pine in Arizona and New Mexico and the slash pine in Florida. We found that the meteorological conditions that favor fire ignition and spread are more significant in Florida than in Arizona and New Mexico, while the meteorological conditions that favor the occurrence of LIW in Arizona and New Mexico are closely related with the meteorological conditions that favor high lightning activity. In turn, our results indicate high atmospheric instability during the occurrence of LIW. Our findings suggest that LCC (>18 ms) lightning tends to occur in thunderstorms with high relative humidity and ice content in the clouds, and with low temperature in the entire troposphere. Additionally, a weak updraft in the lower troposphere and a strong one in the upper troposphere favor the occurrence of LCC (>18 ms) lightning. We found that the meteorological conditions that favor the occurrence of LCC (>18 ms) lightning are not necessarily the preferential meteorological conditions for LIW

On the role of continuing currents in lightning-induced fire ignition

Lightning flashes are an important source of wildfires worldwide, contributing to the emission of trace gases to the atmosphere. Based on experiments and field observation, continuing cur rents in lightning have since a long time been proposed to play a significant role in the ignition of wildfires. However, simultaneous detections of optical and radio signals from fire-igniting lightning confirming the role of continuing currents in igniting wildfires are rare. In this work, we first analyze the optical signal of the lightning-ignited wildfires reported by the Geostationary Lightning Mapper over the Contiguous United States (CONUS) during the summer of 2018, and we then analyze the optical and the Extremely Low Frequency signal of a confirmed fire-igniting lightning flash in the Swiss Alps. Despite data uncertainties, we found that the probability of ignition of a lightning flash with Continuing Current (CC) lasting more than 10 ms is higher than that of cloud-to-ground lightning in CONUS. Finally, we confirm the existence of a long continuing current (lasting about 400 ms) associated with a long-lasting optical signal (lasting between 2 and 4 s) of a video-recorded fire-igniting lightning flash

The multikinase inhibitor EC‐70124 synergistically increased the antitumor activity of doxorubicin in sarcomas

Cytotoxic drugs like doxorubicin remain as the most utilized agents in sarcoma treatment. However, advanced sarcomas are often resistant, thus stressing the need for new therapies aimed to overcome this resistance. Multikinase inhibitors provide an efficient way to target several pro-tumorigenic pathways using a single agent and may constitute a valuable strategy in the treatment of sarcomas, which frequently show an aberrant activation of pro-tumoral kinases. Therefore, we studied the antitumor activity of EC-70124, an indolocarbazole analog that have demonstrated a robust ability to inhibit a wide range of pro-survival kinases. Evaluation of the phospho-kinase profile in cell-of-origin sarcoma models and/or sarcoma primary cell lines evidenced that PI3K/AKT/mTOR, JAK/STAT or SRC were among the most highly activated pathways. In striking contrast with the structurally related drug midostaurin, EC-70124 efficiently prevented the phosphorylation of these targets and robustly inhibited proliferation through a mechanism associated to the induction of DNA damage, cell cycle arrest and apoptosis. In addition, EC-70124 was able to partially reduce tumor growth in vivo. Importantly, this compound inhibited the expression and activity of ABC efflux pumps involved in drug resistance. In line with this ability, we found that the combined treatment of EC-70124 with doxorubicin resulted in a synergistic cytotoxic effect in vitro and an increased antitumor activity of this cytotoxic drug in vivo. Altogether, these results uncover the capability of the novel multikinase inhibitor EC-70124 to counteract drug resistance in sarcoma and highlight its therapeutic potential when combined with current treatmentsPeer ReviewedPostprint (author's final draft

“Stripe” Transcription Factors Provide Accessibility to Co-Binding Partners in Mammalian Genomes

Regulatory elements activate promoters by recruiting transcription factors (TFs) to specific motifs. Notably, TF-DNA interactions often depend on cooperativity with colocalized partners, suggesting an underlying cis-regulatory syntax. To explore TF cooperativity in mammals, we analyze ∼500 mouse and human primary cells by combining an atlas of TF motifs, footprints, ChIP-seq, transcriptomes, and accessibility. We uncover two TF groups that colocalize with most expressed factors, forming stripes in hierarchical clustering maps. The first group includes lineage-determining factors that occupy DNA elements broadly, consistent with their key role in tissue-specific transcription. The second one, dubbed universal stripe factors (USFs), comprises ∼30 SP, KLF, EGR, and ZBTB family members that recognize overlapping GC-rich sequences in all tissues analyzed. Knockouts and single-molecule tracking reveal that USFs impart accessibility to colocalized partners and increase their residence time. Mammalian cells have thus evolved a TF superfamily with overlapping DNA binding that facilitate chromatin accessibility

Learning from 27F: A Comparative Assessment Of Urban Reconstruction Processes After The 2010 Eathquake In Chile

The earthquake followed by a tsunami that hit Chile in February 2010 not only left a wave of destruction and a number of deaths of over 500 people, too started a number of relief and recovery initiatives led by different institutions, from the government to universities, private companies to NGOs. However, the roles of these actors, their interactions and the effects of these on post-disaster reconstruction have not been to date actually evaluated. There is still not enough information to judge whether all those well-intentioned efforts were or were not the best way to mobilize resources for help and recovery. The purpose of this report is precisely to collect and analyze projects, programs and policies related to the reconstruction and redevelopment in the cities of Curicó, Talca, Constitución, Pelluhue and Dichato in order to develop an independent and comprehensive assessment of the reactions for disaster relief and reconstruction in 2010