The Impact of Technology on Individuals with Down Syndrome and Their Families

The purpose of this study was to determine the role technology plays in the everyday lives of individuals with Down syndrome and their families. Data was collected via an online questionnaire for parents of adolescents with Down syndrome and took place in two phases: the pilot phase and the large-scale data collection phase. The pilot phase consisted of constructing, giving, and modifying the questionnaire. The large-scale data collection phase included disseminating the questionnaire through social media and resulted in 107 responses. These revealed that technology is widely used by individuals with Down syndrome. As a main outcome, technology provided these individuals with opportunities to act independently and allowed their family units to make necessary adaptations to achieve higher levels of functioning

The Uses of Ambiguity : Representing the "People" and the Stability of States Unions

Peer reviewedPublisher PD

Adaptive networks as second order governance systems

We connect the idea of 'levers for change' with 'governance capacity' and propose 'adaptive networks' as an ideal type embedded in, and leveraging change in, governance systems. Discourses connect practices of citizens and companies with that governance system. Aware of interdependencies, individuals may act in the interest of the whole system and self-organize into adaptive networks, and influence discourses to a common end. Their effectiveness depends on second-orderedness: adaptive networks in niches outside the governance system may influence it through levers. The motivation and competence to build creative tension helps adaptive networks emerge and coevolve with power networks, improving governance capacity

Influence of participant and reviewer characteristics in application scores for a hematology research training program

The American Society of Hematology Clinical Research Training Institute (CRTI) is a clinical research training program with a competitive application process. The objectives were to compare application scores based on applicant and reviewer sex and underrepresented minority (URM) status. We included applications to CRTI from 2003 to 2019. The application scores were transformed into a scale from 0 to 100 (100 was the strongest). The factors considered were applicant and reviewer sex and URM status. We evaluated whether there was an interaction between the characteristics and time related to application scores. In total, 713 applicants and 2106 reviews were included. There was no significant difference in scores according to applicant sex. URM applicants had significantly worse scores than non-URM applicants (mean [standard error] 67.9 [1.56] vs 71.4 [0.63]; P = .0355). There were significant interactions between reviewer sex and time (P = .0030) and reviewer URM status and time (P = .0424); thus, results were stratified by time. For the 2 earlier time periods, male reviewers gave significantly worse scores than did female reviewers; this difference did not persist for the most recent time period. The URM reviewers did not give significantly different scores across time periods. URM applicants received significantly lower scores than non-URM applicants. The impact of reviewer sex and URM status changed over time. Although male reviewers gave lower scores in the early periods, this effect did not persist in the late period. Efforts are required to mitigate the impact of applicant URM status on application scores

A simple, reproducible method for monitoring the treatment of tumours using dynamic contrast-enhanced MR imaging

Dynamic contrast-enhanced MR imaging (DCE-MRI) may act as a biomarker for successful cancer therapy. Simple, reproducible techniques may widen this application. This paper demonstrates a single slice imaging technique. The image acquisition is performed in less than 500 ms making it relatively insensitive to respiratory motion. Data from phantom studies and a reproducibility study in solid human tumours are presented. The reproducibility study showed a coefficient of variation (CoV) of 19.1% for Ktrans and 15.8% for the initial area under the contrast enhancement curve (IAUC). This was improved to 16 and 13.9% if tumours of diameter less than 3 cm were excluded. The individual repeatability (the range within which individual measurements are expected to fall) was 30.6% for Ktrans and 26.5% for IAUC for tumours greater than 3 cm diameter. This approach to DCE–MRI image acquisition can be performed with standard clinical scanners, and data analysis is straightforward. For treatment trials with 10 patients in a cohort, the CoV implies that the method would be sensitive to a treatment effect of greater than 18%. The individual repeatability is well inside the 40% change shown to be important in clinical studies using this DCE–MRI technique

Multi-proxy record of Holocene paleoenvironmental conditions from Yellowstone Lake, Wyoming, USA

A composite 11.82 m-long (9876e-67 cal yr BP) sediment record from Yellowstone Lake, Wyoming was analyzed using a robust set of biological and geochemical proxies to investigate the paleoenvironmental evolution of the lake and its catchment in response to long-term climate forcing. Oxygen isotopes from diatom frustules were analyzed to reconstruct Holocene climate changes, and pollen, charcoal, diatom assemblages, and biogenic silica provided information on terrestrial and limnological responses. The long-term trends recorded in the terrestrial and limnic ecosystems over the last 9800 years reflect the influence of changes in the amplification of the seasonal cycle of insolation on regional climate. The early Holocene (9880e6700 cal yr BP) summer insolation maximum and strengthening of the northeastern Pacific subtropical high-pressure system created warm dry conditions and decreasing summer insolation in the middle (6700e3000 cal yr BP) and late (3000e-67 cal yr BP) Holocene resulted in progressively cooler, wetter conditions. Submillenial climate variation is also apparent, with a wetter/cooler interval between 7000 and 6800 cal yr BP and warmer and/or drier conditions from 4500 to 3000 cal yr BP and at ca. 1100 cal yr BP. These data show that the Yellowstone Lake basin had a climate history typical of a summer-dry region, which helps to better define the spatial variability of Holocene climate in the Greater Yellowstone Ecosystem