‘The Human Factor’

Edward P. Morgan, who for many years was a reporter for CBS and ABC News, currently is chief correspondent for “In the Public Interest radio network. The above was excerpted from a speech at Howard ’s corn mencement exercises on May 14,1988

Urban Distress, Educational Equity, and Local Governance: State Level Policy Implication of Proposition 2 1/2 in Massachusetts

This report examines the impact of Proposition 2-1/2 on different types of communities and the implications of this impact for state aid and state-level policies. The effects of 2-1/2, especially first-year effects in public education, are evaluated from the perspective of four general policy objectives or values: equity, efficiency, accountability, and local autonomy. The primary concern of this report is for various considerations of equity and inequality

EMG Analysis of Neural Activation Patterns of the Gluteal Muscle Complex

Gluteal amnesia is described as a condition in which the neural recruitment patterns of the gluteal muscle complex are insufficient to activate muscle fibers, causing the hamstring and lower back muscles to take up the physical demand. Symptoms due to insufficient gluteal muscle activation include tight hamstrings post-exercise, anterior pelvic tilt, and knee valgus during squat or lunge performance. This could lead to compensation injuries of the lumbar, knee, and ankle joints. Many physical therapy rehabilitation programs of the lower back and lower extremity incorporate gluteal exercises which could potentially treat this condition and prevent compensation injuries. PURPOSE: To identify and test a person experiencing symptoms of gluteal amnesia to determine gluteal muscle activation before and after a therapy program designed to enhance muscle recruitment and function. METHODS: A 74-year-old male experiencing symptoms of unilateral gluteal amnesia was recruited for this case-study. Electromyographic (EMG) analysis of the gluteal muscle complex was recorded while the subject performed movements typically associated with gluteal muscle complex activation. Both the affected and unaffected side were analyzed while the subject performed movements, as well as submaximal and maximal voluntary isometric contractions (MVIC). After baseline testing, a daily, 3-week progressive resistance rehabilitation program consisting of exercises utilizing the gluteal muscle complex was completed. After completion of the rehabilitation program, EMG analysis of the affected and unaffected sides was performed as during the baseline measures. Integrated EMG signals of gluteal activation were compared between pre- and post-tests. Baseline EMG was considered to be 100% of muscle activation. The post-rehabilitation EMG during MVIC was a percentage of the maximal effort output. MVIC of the submaximal tests were obtained by comparing the quadruped hip extension and single leg glute bridge exercises to the standing gluteal squeeze, and the quadruped hip abduction and clam shell exercises to the side lying hip abduction. RESULTS: Increased gluteal complex activation post-rehabilitation was evident in both the affected and unaffected limbs. Specifically, the largest increases of the left and ride side were seen through the quadruped hip extension (18.7%, 52.4%) and quadruped hip abduction (54.1%, 98.8%) exercises, respectively. The left limb presenting with gluteal amnesia symptoms consistently gave lower output values. CONCLUSION: In this case-study, increased EMG activity in the affected muscles, progressive increases in resistance during daily rehabilitation and anecdotal improvements in movement patterns were observed. Based on the results of this case-study, treatment for conditions such as gluteal amnesia and other disorders of ineffective motor unit recruitment should include targeted rehabilitation exercises designed to isolate the affected musculature

Discovery of pulsations in the X-ray transient 4U 1901+03

We describe observations of the 2003 outburst of the hard-spectrum X-ray transient 4U 1901+03 with the Rossi X-ray Timing Explorer. The outburst was first detected in 2003 February by the All-Sky Monitor, and reached a peak 2.5-25 keV flux of 8x10^-9 ergs/cm^2/s (around 240 mCrab). The only other known outburst occurred 32.2 yr earlier, likely the longest presently known recurrence time for any X-ray transient. Proportional Counter Array (PCA) observations over the 5-month duration of the 2003 outburst revealed a 2.763 s pulsar in a 22.58 d orbit. The detection of pulsations down to a flux of 3x10^-11 ergs/cm^2/s (2.5-25 keV), along with the inferred long-term accretion rate of 8.1x10^-11 M_sun/yr (assuming a distance of 10 kpc) suggests that the surface magnetic field strength is below ~5x10^11 G. The corresponding cyclotron energy is thus below 4 keV, consistent with the non-detection of resonance features at high energies. Although we could not unambiguously identify the optical counterpart, the lack of a bright IR candidate within the 1' RXTE error circle rules out a supergiant mass donor. The neutron star in 4U 1901+03 probably accretes from the wind of a main-sequence O-B star, like most other high-mass binary X-ray pulsars. The almost circular orbit e=0.036 confirms the system's membership in a growing class of wide, low-eccentricity systems in which the neutron stars may have received much smaller kicks as a result of their natal supernova explosions.Comment: 7 pages, 6 figures, accepted by ApJ. Very minor addition in response to referee's comment; updated author affiliatio

Metal bioaccumulation and cellular fractionation in an epigeic earthworm (Lumbricus rubellus): the interactive influences of population exposure histories, site-specific geochemistry and mitochondrial genotype

Subcellular fractionation techniques were used to describe temporal changes (at intervals from T0 to T70 days) in the Pb, Zn and P partitioning profiles of Lumbricus rubellus populations from one calcareous (MDH) and one acidic (MCS) geographically isolated Pb/Zn-mine sites and one reference site (CPF). MDH and MCS individuals were laboratory maintained on their native field soils; CPF worms were exposed to both MDH and MCS soils. Site-specific differences in metal partitioning were found: notably, the putatively metal-adapted populations, MDH and MCS, preferentially partitioned higher proportions of their accumulated tissue metal burdens into insoluble CaPO4-rich organelles compared with naive counterparts, CPF. Thus, it is plausible that efficient metal immobilization is a phenotypic trait characterising metal tolerant ecotypes. Mitochondrial cytochrome oxidase II (COII) genotyping revealed that the populations indigenous to mine and reference soils belong to distinct genetic lineages, differentiated by 13%, with 7 haplotypes within the reference site lineage but fewer (3 and 4, respectively) in the lineage common to the two mine sites. Collectively, these observations raise the possibility that site-related genotype differences could influence the toxico-availability of metals and, thus, represent a potential confounding variable in field-based eco-toxicological assessments

International Retrovirology Association brings together scientists and clinicians to bridge discoveries about human T-lymphotropic viruses from the laboratory to clinical trials

Human T-lymphotropic virus type 1 (HTLV-1) and HTLV-2 were among the first human retroviruses discovered in the early 1980's. The International Retrovirology Association is an organized effort that fostered the efforts of scientists and clinicians to form interdisciplinary groups to study this group of retroviruses and their related diseases. The Association promotes excellent science, patient education, and fosters the training of young scientists to promote "bench-to-bedside" research. The International Conference on Human Retrovirology: HTLV and Related Viruses sponsored by the Association supports clinicians and researchers in the exchange of research findings and stimulation of new research directions. This years conference will be held from June 22 to 25, in Montego Bay, Jamaica . Since its inception in 1988, these conferences have provided a highly interactive forum for the global community of HTLV scientists. This is of particular importance as HTLV research enters its third decade and a new generation of scientists takes over this important work. Many of the scientists attending the meeting will be from developing countries where HTLV is endemic, consistent with the history of international collaborations that have characterized HTLV research. The International Conference on Human Retrovirology provides a unique opportunity for researchers of all disciplines interested in HTLV infections to meet their peers and to address the questions facing clinicians and scientists who study retroviruses, like HTLV

RXTE Discovery of Coherent Millisecond Pulsations during an X-ray Burst from KS 1731-260

A highly coherent 523.92+-0.05 Hz periodic X-ray signal has been observed during a type I X-ray burst from the low-mass X-ray binary system KS 1731-260 with the PCA on RXTE. The spectral evolution of the burst indicates photospheric-radius expansion and contraction. The 524 Hz signal occurred at the end of the contraction phase, lasted for ~2 s, was highly coherent (Q >~ 900), and had a pulse fraction (ratio of sinusoidal amplitude to mean count rate) of 6.2+-0.6%. KS 1731-260 is one of only three systems that have exhibited high-coherence millisecond oscillations during X-ray bursts and the first reported where the pulsations are associated with photospheric contraction. These coherent signals may be interpreted as a direct indication of the neutron star spin.Comment: 15 pages plus 4 Postscript figures; AASTeX format; submitted to Astrophysical Journal Letter

HST/NICMOS Observations of Fast Infrared Flickering in the Microquasar GRS 1915+105

We report infrared observations of the microquasar GRS 1915+105 using the NICMOS instrument of the Hubble Space Telescope during 9 visits in April-June 2003. During epochs of high X-ray/radio activity near the beginning and end of this period, we find that the $1.87$\um infrared flux is generally low ($\sim 2$ mJy) and relatively steady. However, during the X-ray/radio ``plateau'' state between these epochs, we find that the infrared flux is significantly higher ($\sim 4-6$ mJy), and strongly variable. In particular, we find events with amplitudes $\sim 20-30$% occurring on timescales of $\sim 10-20$s (e-folding timescales of $\sim 30$s). These flickering timescales are several times faster than any previously-observed infrared variability in GRS 1915+105 and the IR variations exceed corresponding X-ray variations at the same ($\sim 8s$) timescale. These results suggest an entirely new type of infrared variability from this object. Based on the properties of this flickering, we conclude that it arises in the plateau-state jet outflow itself, at a distance $<2.5$ AU from the accretion disk. We discuss the implications of this work and the potential of further flickering observations for understanding jet formation around black holes.Comment: 19 pages, incl. 4 figures; accepted for publication in Ap

Molecular genetic differentiation in earthworms inhabiting a heterogeneous Pb-polluted landscape

A Pb-mine site situated on acidic soil, but comprising of Ca-enriched islands around derelict buildings was used to study the spatial pattern of genetic diversity in Lumbricus rubellus. Two distinct genetic lineages ('A' and 'B'), differentiated at both the mitochondrial (mtDNA COII) and nuclear level (AFLPs) were revealed with a mean inter-lineage mtDNA sequence divergence of approximately 13%, indicative of a cryptic species complex. AFLP analysis indicates that lineage A individuals within one central 'ecological island' site are uniquely clustered, with little genetic overlap with lineage A individuals at the two peripheral sites. FTIR microspectroscopy of Pb-sequestering chloragocytes revealed different phosphate profiles in residents of adjacent acidic and calcareous islands. Bioinformatics found over-representation of Ca pathway genes in ESTPb libraries. Subsequent sequencing of a Ca-transport gene, SERCA, revealed mutations in the protein's cytosolic domain. We recommend the mandatory genotyping of all individuals prior to field-based ecotoxicological assays, particularly those using discriminating genomic technologies