Eléments de physique ultrasonore. Echographie

Moretti Jean-Luc. Éléments de physique ultrasonore. Échographie. In: Bulletin de l'Académie Vétérinaire de France tome 135 n°2, 1982. pp. 159-176

H^+ -> W^+ l_i^- l_j^+$ decay in the two Higgs doublet model

We study the lepton flavor violating H^+ -> W^+ l_i^- l_j^+ and the lepton flavor conserving $H^+ -> W^+ l_i^- l_i^+ (l_i=\tau, l_j=\mu) decays in the general 2HDM, so called model III. We estimate the decay width \Gamma for LFV (LFC) at the order of the magnitude of (10^{-11}-10^{-5}) GeV ((10^{-9}-10^{-4}) GeV), for 200 GeV\leq m_{H^\pm}\leq 400 GeV, and the intermediate values of the coupling \bar{\xi}^{E}_{N,\tau \mu}\sim 5 GeV (\bar{\xi}^{E}_{N,\tau \tau}\sim 30 GeV). We observe that the experimental result of the process under consideration can give comprehensive information about the physics beyond the standard model and the existing free parameters.Comment: 8 pages, 7 Figure

Perspectives for the detection and measurement of Supersymmetry in the focus point region of mSUGRA models with the ATLAS detector at LHC

This paper discusses the ATLAS potential to study Supersymmetry for the "Focus-Point" region of the parameter space of mSUGRA models. The potential to discovery a deviation from Standard Model expectations with the first few ${fb}^{-1}$ of LHC data was studied using the parametrized simulation of the ATLAS detector. Several signatures were considered, involving hard jets, large missing energy, and either $b$-tagged jets, opposite-sign isolated electron or muon pairs, or top quarks reconstructed exploiting their fully hadronic decays. With only 1 ${fb}^{-1}$ of data each of these signatures may allow to observe an excess of events over Standard Model expectation with a statistical significance exceeding 5 standard deviations. An analytical expression was derived for the shape of the distribution of the dilepton invariant mass arising from the three-body leptonic decay of the neutralinos under the hypothesis of heavy scalars, which is appropriate for the focus-point scenario. The resulting function was used to fit the distribution of the dilepton invariant mass obtained with simulated LHC data, and to extract the value of two kinematic endpoints measuring the $\tilde \chi^0_2 - \tilde \chi^0_1$ and the $\tilde \chi^0_3 - \tilde \chi^0_1$ mass differences. This information was used to constrain the MSSM parameter space compatible with the data

Charged and Pseudoscalar Higgs production at a Muon Collider

We consider single charged Higgs ($H^{\pm}$) and pseudoscalar Higgs ($A^0$) production in association with a gauge boson at $\mu^+\mu^-$ colliders. We find that the tree-level t-channel and s-channel contributions to $\mu^+\mu^-\to H^{\pm}W^{\mp}, A^0Z$ are enhanced for large values of $\tan\beta$, allowing sizeable cross-sections whose analogies at $e^+e^-$ colliders would be very small. These processes provide attractive new ways of producing such particles at $\mu^+\mu^-$ colliders and are superior to the conventional methods in regions of parameter space.Comment: 11 pages Latex, 5 figures, formulae added in sections 2.2 and 2.3, extra discussion in section 2.3, references adde

Habenular expression of rare missense variants of the β4 nicotinic receptor subunit alters nicotine consumption

The CHRNA5-CHRNA3-CHRNB4 gene cluster, encoding the {alpha}5, {alpha}3, and {beta}4 nicotinic acetylcholine receptor (nAChR) subunits, has been linked to nicotine dependence. The habenulo-interpeduncular (Hb-IPN) tract is particularly enriched in {alpha}3{beta}4 nAChRs. We recently showed that modulation of these receptors in the medial habenula (MHb) in mice altered nicotine consumption. Given that {beta}4 is rate-limiting for receptor activity and that single nucleotide polymorphisms (SNPs) in CHRNB4 have been linked to altered risk of nicotine dependence in humans, we were interested in determining the contribution of allelic variants of {beta}4 to nicotine receptor activity in the MHb. We screened for missense SNPs that had allele frequencies >0.0005 and introduced the corresponding substitutions in Chrnb4. Fourteen variants were analyzed by co-expression with {alpha}3. We found that {beta}4A90I and {beta}4T374I variants, previously shown to associate with reduced risk of smoking, and an additional variant {beta}4D447Y, significantly increased nicotine-evoked current amplitudes, while {beta}4R348C, the mutation most frequently encountered in sporadic amyotrophic lateral sclerosis (sALS), showed reduced nicotine currents. We employed lentiviruses to express {beta}4 or {beta}4 variants in the MHb. Immunoprecipitation studies confirmed that {beta}4 lentiviral-mediated expression leads to specific upregulation of {alpha}3{beta}4 but not {beta}2 nAChRs in the Mhb. Mice injected with the {beta}4-containing virus showed pronounced aversion to nicotine as previously observed in transgenic Tabac mice overexpressing Chrnb4 at endogenous sites including the MHb. Habenular expression of the {beta}4 gain-of-function allele T374I also resulted in strong aversion, while transduction with the {beta}4 loss-of function allele R348C failed to induce nicotine aversion. Altogether, these data confirm the critical role of habenular {beta}4 in nicotine consumption, and identify specific SNPs in CHRNB4 that modify nicotine-elicited currents and alter nicotine consumption in mice

Combination, Modulation and Interplay of Modern Radiotherapy with the Tumor Microenvironment and Targeted Therapies in Pancreatic Cancer: Which Candidates to Boost Radiotherapy?

Pancreatic ductal adenocarcinoma cancer (PDAC) is a highly diverse disease with low tumor immunogenicity. PDAC is also one of the deadliest solid tumor and will remain a common cause of cancer death in the future. Treatment options are limited, and tumors frequently develop resistance to current treatment modalities. Since PDAC patients do not respond well to immune checkpoint inhibitors (ICIs), novel methods for overcoming resistance are being explored. Compared to other solid tumors, the PDAC's tumor microenvironment (TME) is unique and complex and prevents systemic agents from effectively penetrating and killing tumor cells. Radiotherapy (RT) has the potential to modulate the TME (e.g., by exposing tumor-specific antigens, recruiting, and infiltrating immune cells) and, therefore, enhance the effectiveness of targeted systemic therapies. Interestingly, combining ICI with RT and/or chemotherapy has yielded promising preclinical results which were not successful when translated into clinical trials. In this context, current standards of care need to be challenged and transformed with modern treatment techniques and novel therapeutic combinations. One way to reconcile these findings is to abandon the concept that the TME is a well-compartmented population with spatial, temporal, physical, and chemical elements acting independently. This review will focus on the most interesting advancements of RT and describe the main components of the TME and their known modulation after RT in PDAC. Furthermore, we will provide a summary of current clinical data for combinations of RT/targeted therapy (tRT) and give an overview of the most promising future directions

An effective lagrangian description of charged Higgs decays H^+ -> Wg, WZ and Wh

Charged Higgs decays are discussed within an effective lagrangian extension of the two-higgs doublet model, assuming new physics appearing in the Higgs sector of this model. Low energy constrains are used to imposse bounds on certain dimension -six operators that describe the modified charged Higgs interactions. These bounds are used then to study the decays H^+ -> Wg, WZ and Wh, which can have branching ratios of order 10^-5, 10^-1 and O(1), respectively; thse modes are thus sensitive probes of the symmetries of the Higgs sector that could be tested at future colliders.Comment: 15 pages, 3 figure

Parathyroid scintigraphy findings in chronic kidney disease patients with recurrent hyperparathyroidism

Background Parathyroidectomy (PTX), either subtotal or total with forearm autografting, is a well-established treatment for refractory renal hyperparathyroidism (RHPT). However, 20–30% of patients develop persistent or recurrent disease. Obtaining accurate localization before reoperation is difficult. Patients and methods The study group comprised 21 consecutive adult patients (18 undergoing haemodialysis and 3 with a renal graft) imaged using 99mTc-sestamibi/123I subtraction scintigraphy. Of the 21 patients, 12 had undergone one previous PTX and the other 9 between two and four parathyroid operations. All patients had symptoms and signs of severe RHPT. The mean serum PTH level was 1,142 pg/ml. 99mTc-Sestamibi and 123I images were recorded simultaneously. Imaging views comprised a planar view of the neck and mediastinum, followed by a magnified pinhole view over the thyroid bed area. If parathyroid ectopy was detected, SPECT or SPECT-CT was performed. The forearm was imaged in case of autograft. Results Parathyroid scintigraphy was negative in one patient and positive in the other 20 (sensitivity 95.2%). One patient had uptake corresponding to two unresected parathyroid glands. Recurrence at the site of the partially resected gland or autograft was seen in 11 patients. However, six of them had a second 99mTc-sestamibi focus corresponding to a supernumerary parathyroid gland. Seven other patients had a supernumerary parathyroid gland as the sole cause of relapse. Three of the supernumerary glands showed major ectopy (intrathyroidal, low mediastinal, undescended within the vagus nerve). One patient had parathyromatosis with multiple parathyroid nodules scattered over the left side of the neck. Reoperation was possible in 13 patients, with no false-positive findings. Conclusion Many patients referred with the hypothesis of hyperplasia of a subtotally resected parathyroid gland or autograft were found to harbour a supernumerary parathyroid gland missed at the initial surgery

On Measuring Split-SUSY Neutralino and Chargino Masses at the LHC

In Split-Supersymmetry models, where the only non-Standard Model states produceable at LHC-energies consist of a gluino plus neutralinos and charginos, it is conventionally accepted that only mass differences among these latter are measureable at the LHC. The present work shows that application of a simple `Kinematic Selection' technique allows full reconstruction of neutralino and chargino masses from one event, in principle. A Monte Carlo simulation demonstrates the feasibilty of using this technique at the LHC.Comment: 17 pages, 4 figures; EPJC versio

Choice of implicit and explicit operators for the upwind differencing method

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/76274/1/AIAA-1988-624-513.pd