Enhanced transmission of slit arrays in an extremely thin metallic film

Horizontal resonances of slit arrays are studied. They can lead to an enhanced transmission that cannot be explained using the single-mode approximation. A new type of cavity resonance is found when the slits are narrow for a wavelength very close to the period. It can be excited for very low thicknesses. Optimization shows these structures could constitute interesting monochromatic filters

Radiative lepton flavor violating decays in the Randall Sundrum background with localized leptons

We study the radiative lepton flavor violating l_i -> l_j\gamma decays in the two Higgs doublet model, respecting the Randall Sundrum scenario and estimate the contributions of the KK modes of left (right) handed charged lepton doublets (singlets) on the branching ratios. We observe that the branching ratios are sensitive to the contributions of the charged lepton KK modes.Comment: 23 pages, 10 figures, 2 table

DEEP: a provenance-aware executable document system

The concept of executable documents is attracting growing interest from both academics and publishers since it is a promising technology for the dissemination of scientific results. Provenance is a kind of metadata that provides a rich description of the derivation history of data products starting from their original sources. It has been used in many different e-Science domains and has shown great potential in enabling reproducibility of scientific results. However, while both executable documents and provenance are aimed at enhancing the dissemination of scientific results, little has been done to explore the integration of both techniques. In this paper, we introduce the design and development of DEEP, an executable document environment that generates scientific results dynamically and interactively, and also records the provenance for these results in the document. In this system, provenance is exposed to users via an interface that provides them with an alternative way of navigating the executable document. In addition, we make use of the provenance to offer a document rollback facility to users and help to manage the system's dynamic resources

Force indeterminacy in the jammed state of hard disks

Granular packings of hard discs are investigated by means of contact dynamics which is an appropriate technique to explore the allowed force-realizations in the space of contact forces. Configurations are generated for given values of the friction coefficient, and then an ensemble of equilibrium forces is found for fixed contacts. We study the force fluctuations within this ensemble. In the limit of zero friction the fluctuations vanish in accordance with the isostaticity of the packing. The magnitude of the fluctuations has a non-monotonous friction dependence. The increase for small friction can be attributed to the opening of the angle of the Coulomb cone, while the decrease as friction increases is due to the reduction of connectivity of the contact-network, leading to local, independent clusters of indeterminacy. We discuss the relevance of indeterminacy to packings of deformable particles and to the mechanical response properties.Comment: 4 pages, 3 figures. Minor changes, journal reference adde

Treatment of patients with multiple myeloma progressing on frontline-therapy with lenalidomide

Over the last years, there has been great progress in the treatment of multiple myeloma with many new agents and combinations having been approved and being now routinely incorporated into treatment strategies. As a result, patients are experiencing benefits in terms of survival and better tolerance. However, the multitude of treatment options also presents a challenge to select the best options tailored to the specific patient situation. Lenalidomide is increasingly being used as part of frontline therapy in newly diagnosed multiple myeloma. This agent is typically administered until disease progression. It is currently unclear, how to best manage patients, who relapse while receiving lenalidomide as part of their frontline treatment. We conducted a review to summarize the available evidence in this setting. Our summary shows that there are very few data from current trials testing new combinations based on carfilzomib, pomalidomide, or daratumumab that address this specific patient population. Our review is aimed to summarize the available evidence to assist treatment decision making and to raise awareness of this lack of data to encourage further analyses and the incorporation of sequencing questions in future trial designs