906 research outputs found
Mandatory multidisciplinary approach for the evaluation of the lymph node status in rectal cancer
Colorectal cancer is the third most frequently reported malignancy and also the third leading cancer-related cause of death worldwide. Lymph node evaluation, both preoperatively and postoperatively, represents an important aspect of the diagnosis and therapeutic strategy in colorectal cancer, such that an accurate preoperative staging is required for a correct therapeutic strategy. Treatment of rectal cancer with positive lymph nodes, a very important predictive prognostic parameter, is currently based on neoadjuvant chemoradiotherapy followed by total/ surgical mesorectal excision and adjuvant regimen.
Preoperative evaluation of the lymph node status in rectal cancer is based on endoscopic ultrasound and magnetic resonance imaging, but their accuracy, specificity, and sensitivity still require improvement. Postoperative evaluation also presents points of debate, especially related to the role of sentinel lymph node mapping and their final implication, represented by detection of micrometastases and isolated tumor cells. The pathologic interpretation of tumor deposits represents other points in discussion. From a surgical perspective, extended lateral lymph node dissection vs. abstinence and (neo)adjuvant therapeutic approach represent another unresolved issue.
This review presents the major controversies existing today in the treatment and pathologic interpretation of the lymph nodes in rectal cancer, the role/ indication and value of the lateral pelvic lymph node dissection, and the postoperative interpretation of the value of the micrometastatic disease and tumor deposits
Climate Monitoring and Water Resources Management for the Main Crops in the Transylvanian Plain, Romania
Observation of Photovoltaic Effect and Single-photon Detection in Nanowire Silicon Pn-junction
We study nanowire silicon pin and pn-junctions at room and low temperature. Photovoltaic effects are observed for both devices at room temperature. At low temperature, nanowire pn-junction devices show their ability to detect single photon. This ability was not been observed for pin devices. Phosphorus-boron dopant cluster in the depletion region is considered to have the main role for single-photon detection capability. Fundamental mechanism of dopant-based single-photon detection in nanowire pn-junction is described in details
Mandatory multidisciplinary approach for the evaluation of the lymph node status in rectal cancer
Colorectal cancer is the third most frequently reported malignancy and also the third leading cancer-related cause of death worldwide. Lymph node evaluation, both preoperatively and postoperatively, represents an important aspect of the diagnosis and therapeutic strategy in colorectal cancer, such that an accurate preoperative staging is required for a correct therapeutic strategy. Treatment of rectal cancer with positive lymph nodes, a very important predictive prognostic parameter, is currently based on neoadjuvant chemoradiotherapy followed by total/ surgical mesorectal excision and adjuvant regimen.
Preoperative evaluation of the lymph node status in rectal cancer is based on endoscopic ultrasound and magnetic resonance imaging, but their accuracy, specificity, and sensitivity still require improvement. Postoperative evaluation also presents points of debate, especially related to the role of sentinel lymph node mapping and their final implication, represented by detection of micrometastases and isolated tumor cells. The pathologic interpretation of tumor deposits represents other points in discussion. From a surgical perspective, extended lateral lymph node dissection vs. abstinence and (neo)adjuvant therapeutic approach represent another unresolved issue.
This review presents the major controversies existing today in the treatment and pathologic interpretation of the lymph nodes in rectal cancer, the role/ indication and value of the lateral pelvic lymph node dissection, and the postoperative interpretation of the value of the micrometastatic disease and tumor deposits
Π‘Π°Ρ Π°ΡΠ½ΡΠΉ Π΄ΠΈΠ°Π±Π΅Ρ 1 ΡΠΈΠΏΠ° Ρ Π΄Π΅ΡΠ΅ΠΉ: ΠΊΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠΈΠ΅ ΠΈ ΠΌΠ΅ΡΠ°Π±ΠΎΠ»ΠΈΡΠ΅ΡΠΊΠΈΠ΅ ΠΎΡΠΎΠ±Π΅Π½Π½ΠΎΡΡΠΈ Π² Π½Π°ΡΠ°Π»Π΅ Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΡ
Department of Pediatric Endocrinology, Emil Cotaga Childrenβs Republican Hospital, Congresul III al Medicilor de Familie din Republica Moldova, 17β18 mai, 2012, ChiΕinΔu, Republica Moldova, ConferinΕ£a NaΕ£ionalΔ βMaladii bronhoobstructive la copiiβ, consacratΔ profesorului universitar, doctor habilitat Victor GheΕ£eul, 27 aprilie, ChiΕinΔu, Republica MoldovaThe aim of the study was to determine the clinical and biochemical characteristics of type 1 diabetes mellitus (DM) at presentation in children. The
registered data set comprised blood glucose, pH, serum bicarbonate levels, glycosylated hemoglobin and clinical symptoms at disease manifestation. 53
children with type 1 DM were included in this study. Polydipsia (90.1%), polyuria (81.4%), and weight loss (84.1%) were the most frequent symptoms
anticipating disease detection. Enuresis was recorded in 32.8%. A total of 73.6% patients had DKA (pH < 7.3) at disease onset. Children under 10 years
showed more pronounced ketoacidosis that developed in a shorter period of time. Blood glucose testing in children with enuresis, weight loss and family
history of diabetes is essential for timely diagnosis.ΠΠ°Π½Π½ΠΎΠ΅ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠ΅ Π±ΡΠ»ΠΎ Π²ΡΠΏΠΎΠ»Π½Π΅Π½ΠΎ Ρ ΡΠ΅Π»ΡΡ ΠΎΠΏΡΠ΅Π΄Π΅Π»Π΅Π½ΠΈΡ ΠΊΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΈ Π±ΠΈΠΎΡ
ΠΈΠΌΠΈΡΠ΅ΡΠΊΠΈΡ
Ρ
Π°ΡΠ°ΠΊΡΠ΅ΡΠΈΡΡΠΈΠΊ Π²ΠΏΠ΅ΡΠ²ΡΠ΅ Π²ΡΡΠ²Π»Π΅Π½Π½ΠΎΠ³ΠΎ ΡΠ°Ρ
Π°ΡΠ½ΠΎΠ³ΠΎ
Π΄ΠΈΠ°Π±Π΅ΡΠ° 1 ΡΠΈΠΏΠ° Ρ Π΄Π΅ΡΠ΅ΠΉ. ΠΡΠ»ΠΈ ΡΠ΅Π³ΠΈΡΡΡΠΈΡΠΎΠ²Π°Π½Ρ ΠΈ ΠΏΡΠΎΠ°Π½Π°Π»ΠΈΠ·ΠΈΡΠΎΠ²Π°Π½Ρ ΡΠ»Π΅Π΄ΡΡΡΠΈΠ΅ ΠΏΠΎΠΊΠ°Π·Π°ΡΠ΅Π»ΠΈ: ΡΡΠΎΠ²Π΅Π½Ρ Π³Π»ΡΠΊΠΎΠ·Ρ, ΡΠ ΠΈ Π±ΠΈΠΊΠ°ΡΠ±ΠΎΠ½Π°Ρ ΠΊΡΠΎΠ²ΠΈ,
Π³Π»ΠΈΠΊΠΈΡΠΎΠ²Π°Π½Π½ΡΠΉ Π³Π΅ΠΌΠΎΠ³Π»ΠΎΠ±ΠΈΠ½, ΠΊΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠΈΠ΅ ΡΠΈΠΌΠΏΡΠΎΠΌΡ Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΡ. ΠΡΠ»ΠΈ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½Ρ 53 Π΄Π΅ΡΠ΅ΠΉ. ΠΠΎΠ»ΠΈΠ΄ΠΈΠΏΡΠΈΡ (90,1%), ΠΏΠΎΠ»ΠΈΡΡΠΈΡ (81,4%) ΠΈ ΠΏΠΎΡΠ΅ΡΡ
Π²Π΅ΡΠ° (84,1%) Π±ΡΠ»ΠΈ Π²ΡΡΠ²Π»Π΅Π½Ρ ΠΊΠ°ΠΊ ΡΠ°ΠΌΡΠ΅ ΡΠ°ΡΠΏΡΠΎΡΡΡΠ°Π½Π΅Π½Π½ΡΠ΅ ΡΠΈΠΌΠΏΡΠΎΠΌΡ Π΄ΠΎ ΠΏΠΎΠ΄ΡΠ²Π΅ΡΠΆΠ΄Π΅Π½ΠΈΡ Π΄ΠΈΠ°Π³Π½ΠΎΠ·Π°. ΠΠ½ΡΡΠ΅Π· Π±ΡΠ» Π·Π°ΡΠ΅Π³ΠΈΡΡΡΠΈΡΠΎΠ²Π°Π½ Ρ 32,8% Π΄Π΅ΡΠ΅ΠΉ.
73,6% ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ² ΠΈΠΌΠ΅Π»ΠΈ Π΄ΠΈΠ°Π±Π΅ΡΠΈΡΠ΅ΡΠΊΠΈΠΉ ΠΊΠ΅ΡΠΎΠ°ΡΠΈΠ΄ΠΎΠ· (ΡΠ < 7,3) Π² ΠΌΠΎΠΌΠ΅Π½Ρ ΡΡΡΠ°Π½ΠΎΠ²Π»Π΅Π½ΠΈΡ Π΄ΠΈΠ°Π³Π½ΠΎΠ·Π°. ΠΠ΅ΡΠΈ Π΄ΠΎ 10 Π»Π΅Ρ ΠΏΠΎΠΊΠ°Π·Π°Π»ΠΈ Π±ΠΎΠ»Π΅Π΅ Π²ΡΡΠ°ΠΆΠ΅Π½Π½ΡΠΉ
ΠΊΠ΅ΡΠΎΠ°ΡΠΈΠ΄ΠΎΠ·, ΠΊΠΎΡΠΎΡΡΠΉ ΡΠ°Π·Π²ΠΈΠ»ΡΡ Π² Π±ΠΎΠ»Π΅Π΅ ΠΊΠΎΡΠΎΡΠΊΠΈΠ΅ ΡΡΠΎΠΊΠΈ. ΠΠ½ΡΡΠ΅Π·, ΠΏΠΎΡΠ΅ΡΡ Π²Π΅ΡΠ° ΠΈ ΡΠ΅ΠΌΠ΅ΠΉΠ½Π°Ρ ΠΏΡΠ΅Π΄ΡΠ°ΡΠΏΠΎΠ»ΠΎΠΆΠ΅Π½Π½ΠΎΡΡΡ ΠΊ ΡΠ°Ρ
Π°ΡΠ½ΠΎΠΌΡ Π΄ΠΈΠ°Π±Π΅ΡΡ ΡΠ²Π»ΡΡΡΡΡ
ΠΏΠΎΠΊΠ°Π·Π°Π½ΠΈΡΠΌΠΈ ΠΊ ΠΎΠΏΡΠ΅Π΄Π΅Π»Π΅Π½ΠΈΡ Π³Π»ΡΠΊΠΎΠ·Ρ Π² ΠΊΡΠΎΠ²ΠΈ Ρ Π΄Π΅ΡΠ΅ΠΉ Π΄Π»Ρ ΡΠ²ΠΎΠ΅Π²ΡΠ΅ΠΌΠ΅Π½Π½ΠΎΠΉ Π΄ΠΈΠ°Π³Π½ΠΎΡΡΠΈΠΊΠΈ Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΡ
Stable bundles on hypercomplex surfaces
A hypercomplex manifold is a manifold equipped with three complex structures
I, J, K satisfying the quaternionic relations. Let M be a 4-dimensional compact
smooth manifold equipped with a hypercomplex structure, and E be a vector
bundle on M. We show that the moduli space of anti-self-dual connections on E
is also hypercomplex, and admits a strong HKT metric. We also study manifolds
with (4,4)-supersymmetry, that is, Riemannian manifolds equipped with a pair of
strong HKT-structures that have opposite torsion. In the language of Hitchin's
and Gualtieri's generalized complex geometry, (4,4)-manifolds are called
``generalized hyperkaehler manifolds''. We show that the moduli space of
anti-self-dual connections on M is a (4,4)-manifold if M is equipped with a
(4,4)-structure.Comment: 17 pages. Version 3.0: reference adde
efam: an expanded, metaproteome-supported HMM profile database of viral protein families
Motivation: Viruses infect, reprogram and kill microbes, leading to profound ecosystem consequences, from elemental cycling in oceans and soils to microbiome-modulated diseases in plants and animals. Although metagenomic datasets are increasingly available, identifying viruses in them is challenging due to poor representation and annotation of viral sequences in databases. Results: Here, we establish efam, an expanded collection of Hidden Markov Model (HMM) profiles that represent viral protein families conservatively identified from the Global Ocean Virome 2.0 dataset. This resulted in 240 311 HMM profiles, each with at least 2 protein sequences, making efam >7-fold larger than the next largest, panecosystem viral HMM profile database. Adjusting the criteria for viral contig confidence from 'conservative' to 'eXtremely Conservative' resulted in 37 841 HMM profiles in our efam-XC database. To assess the value of this resource, we integrated efam-XC into VirSorter viral discovery software to discover viruses from less-studied, ecologically distinct oxygen minimum zone (OMZ) marine habitats. This expanded database led to an increase in viruses recovered from every tested OMZ virome by similar to 24% on average (up to similar to 42%) and especially improved the recovery of often-missed shorter contigs (<5 kb). Additionally, to help elucidate lesser-known viral protein functions, we annotated the profiles using multiple databases from the DRAM pipeline and virion-associated metaproteomic data, which doubled the number of annotations obtainable by standard, single-database annotation approaches. Together, these marine resources (efam and efam-XC) are provided as searchable, compressed HMM databases that will be updated bi-annually to help maximize viral sequence discovery and study from any ecosystem
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