Constraining R-axion models through dijet searches at the LHC

The search at hadron colliders for new massive resonances of a few 100 GeVs that couple effectively to colored states is an extremely challenging issue, due principally to the presence of large QCD multijet backgrounds at this energy, rendering the searches at the LHC particularly difficult. Recently, it was realized that these large backgrounds could be overcome by demanding one high-pT jet from initial-state radiation (ISR) and by means of novel jet-reconstruction techniques through which the resulting hadronized products of the massive resonances are reconstructed as a fat-jet, a unique large-radius jet. The ATLAS and CMS Collaborations have recently reported searches for the experimental signature of a single fat-jet in association with an ISR jet. Models of dynamical supersymmetry breaking with an spontaneously broken R-symmetry give rise to the appearance of a pseudo-Nambu?Goldstone boson called the R-axion, which naturally tends to be light. In the parameter space regions where the anomalous R-axion coupling to gluons is boosted, these models can be tested against these new LHC dijet searches. Taking into account the CMS search, we apply the qμ statistical method to the signal events against the background-only expectation and obtain the 95% C.L. exclusion limits on the most relevant model parameters for a particular messenger sector, namely, the R-axion mass ma, the decay constant fa, and the number of color messengers N, being these limits suitable to be applied to more general models with axion-like particles.Fil: Arganda Carreras, Ernesto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Física La Plata. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Física La Plata; Argentina. Universidad Autónoma de Madrid; EspañaFil: Medina, Anibal Damian. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Física La Plata. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Física La Plata; ArgentinaFil: Mileo, Nicolás Ismael. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Física La Plata. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Física La Plata; ArgentinaFil: Morales, Roberto Anibal. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Física La Plata. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Física La Plata; ArgentinaFil: Szynkman, Alejandro Andrés. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Física La Plata. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Física La Plata; Argentin

Novel Higgsino dark matter signal interpretation at the LHC

In the LHC searches for gluinos it is usually assumed that they decay predominantly into the lightest neutralino plus jets. In this work we perform a proof-of-concept collider analysis of a novel supersymmetric signal in which gluinos decay mostly into jets and the bino-like neutralino (χ 30), which in turn decays into the lightest Higgsino-like neutralino (χ 10), considered the dark matter candidate, together with the SM-like Higgs boson (h). This new physics signal then consists of an LHC final state made up by four light jets, four b-jets, and a large amount of missing transverse energy. We identify tt¯, V+jets (V=W, Z), and tt¯+X (X=W, Z, γ∗, h) productions as the most problematic backgrounds, and develop a search strategy for the high luminosity phase of the LHC, reaching signal significances at the evidence level for a luminosity of 1000 fb-1. The prospects for a luminosity of 3000 fb-1 are even more promising, with discovery-level significances.Fil: Arganda Carreras, Ernesto. Departamento de Fisica Teorica ; Facultad de Ciencias ; Universidad Autonoma de Madrid; . Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Física La Plata. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Física La Plata; ArgentinaFil: Delgado de la Rosa, Juan Antonio. University of Notre Dame; Estados UnidosFil: Morales, Roberto Anibal. Departamento de Fisica Teorica ; Facultad de Ciencias ; Universidad Autonoma de Madrid; . Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Física La Plata. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Física La Plata; ArgentinaFil: Quirós, Mariano. Institut de Física d’Altes Energies; Españ

Search strategies for pair production of heavy Higgs bosons decaying invisibly at the LHC

The search for heavy Higgs bosons at the LHC represents an intense experimental program, carried out by the ATLAS and CMS collaborations, which includes the hunt for invisible Higgs decays and dark matter candidates. No significant deviations from the SM backgrounds have been observed in any of these searches, imposing significant constraints on the parameter space of different new physics models with an extended Higgs sector. Here we discuss an alternative search strategy for heavy Higgs bosons decaying invisibly at the LHC, focusing on the pair production of a heavy scalar H together with a pseudoscalar A, through the production mode qq¯→Z⁎→HA. We identify as the most promising signal the final state made up of 4b+ET miss, coming from the heavy scalar decay mode H→hh→bb¯bb¯ with h being the discovered SM-like Higgs boson with mh=125GeV, together with the invisible channel of the pseudoscalar. We work within the context of simplified MSSM scenarios that contain quite heavy sfermions of most types with O(10)TeV masses, while the stops are heavy enough to reproduce the 125 GeV mass for the lightest SM-like Higgs boson. By contrast, the gauginos/higgsinos and the heavy MSSM Higgs bosons have masses near the EW scale. Our search strategies, for a LHC center-of-mass energy of s=14TeV, allow us to obtain statistical significances of the signal over the SM backgrounds with values up to ∼1.6σ and ∼3σ for total integrated luminosities of 300fb−1 and 1000fb−1, respectively.Fil: Arganda, E.. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Física La Plata. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Física La Plata; ArgentinaFil: Diaz-Cruz, J.L.. Benemérita Universidad Autónoma de Puebla; MéxicoFil: Mileo, N.. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Física La Plata. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Física La Plata; ArgentinaFil: Morales, R.A.. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Física La Plata. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Física La Plata; ArgentinaFil: Szynkman, A.. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Física La Plata. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Física La Plata; Argentin

Canagliflozin and renal outcomes in type 2 diabetes and nephropathy

BACKGROUND Type 2 diabetes mellitus is the leading cause of kidney failure worldwide, but few effective long-term treatments are available. In cardiovascular trials of inhibitors of sodium–glucose cotransporter 2 (SGLT2), exploratory results have suggested that such drugs may improve renal outcomes in patients with type 2 diabetes. METHODS In this double-blind, randomized trial, we assigned patients with type 2 diabetes and albuminuric chronic kidney disease to receive canagliflozin, an oral SGLT2 inhibitor, at a dose of 100 mg daily or placebo. All the patients had an estimated glomerular filtration rate (GFR) of 30 to <90 ml per minute per 1.73 m2 of body-surface area and albuminuria (ratio of albumin [mg] to creatinine [g], >300 to 5000) and were treated with renin–angiotensin system blockade. The primary outcome was a composite of end-stage kidney disease (dialysis, transplantation, or a sustained estimated GFR of <15 ml per minute per 1.73 m2), a doubling of the serum creatinine level, or death from renal or cardiovascular causes. Prespecified secondary outcomes were tested hierarchically. RESULTS The trial was stopped early after a planned interim analysis on the recommendation of the data and safety monitoring committee. At that time, 4401 patients had undergone randomization, with a median follow-up of 2.62 years. The relative risk of the primary outcome was 30% lower in the canagliflozin group than in the placebo group, with event rates of 43.2 and 61.2 per 1000 patient-years, respectively (hazard ratio, 0.70; 95% confidence interval [CI], 0.59 to 0.82; P=0.00001). The relative risk of the renal-specific composite of end-stage kidney disease, a doubling of the creatinine level, or death from renal causes was lower by 34% (hazard ratio, 0.66; 95% CI, 0.53 to 0.81; P<0.001), and the relative risk of end-stage kidney disease was lower by 32% (hazard ratio, 0.68; 95% CI, 0.54 to 0.86; P=0.002). The canagliflozin group also had a lower risk of cardiovascular death, myocardial infarction, or stroke (hazard ratio, 0.80; 95% CI, 0.67 to 0.95; P=0.01) and hospitalization for heart failure (hazard ratio, 0.61; 95% CI, 0.47 to 0.80; P<0.001). There were no significant differences in rates of amputation or fracture. CONCLUSIONS In patients with type 2 diabetes and kidney disease, the risk of kidney failure and cardiovascular events was lower in the canagliflozin group than in the placebo group at a median follow-up of 2.62 years

Estudio del sector de Higgs: violación de sabor leptónico y estrategias de búsqueda en el LHC

Presentamos en esta tesis diferentes estudios fenomenológicos de ciertas extensiones del Modelo Estándar de la Fı́sica de Partı́culas. En particular, estudiamos el sector de Higgs considerando también la posibilidad de incluir bosones más pesados que el único bosón escalar contenido en el Modelo Estándar. Más especı́ficamente, analizamos interacciones de Higgs con violación de sabor leptónico y también la posibilidad de observar en el LHC decaimientos de bosones de Higgs pesados en canales invisibles. El primer estudio lo realizamos en el contexto del Modelo Estándar Supersimétrico Mı́nimo y está centrado en el análisis de los decaimientos de bosones de Higgs neutros en dos leptones de distinto sabor. Consideramos como fuente de violación de sabor leptónico posibles mezclas en el sector de sleptones de modo que dichos procesos se producen radiativamente a un loop. Trabajamos bajo la “Aproximación de Inserción de Masa”, es decir, no tratamos los grados de libertad internos en los loops en la base fı́sica sino en la base de interacción electrodébil. De esta manera obtuvimos expresiones analı́ticas para las tasas de decaimiento y vértices efectivos facilitando su contrastación experimental y su interpretación en términos del espacio de parámetros del modelo estudiado. Comparamos los resultados analı́ticos alcanzados con las predicciones numéricas existentes en la literatura y presentamos las estimaciones más optimistas para las anchuras parciales de decaimientos en las regiones del espacio de parámetros permitidas por los datos experimentales actuales. En el segundo estudio continuamos la misma lı́nea de análisis de decaimientos de Higgs con violación de sabor leptónico pero lo realizamos en el contexto del modelo de seesaw inverso. En este caso, la violación de sabor leptónico es generada por los acoplamientos tipo Yukawa de los neutrinos derechos pesados que se acoplan al bosón de Higgs estándar. Encontramos los vértices efectivos para introducir estas interacciones de “Nueva Fı́sica” en otro tipo de procesos como el decaimiento de un leptón a tres idénticos de distinto sabor que el inicial. Por último, en el tercer estudio, desarrollamos una estrategia de búsqueda dedicada a la producción de un par de bosones de Higgs pesados H − A del Modelo Estándar Supersimétrico Mı́nimo en el Gran Colisionador de Hadrones para una energı́a del centro de masa de √s = 14 TeV. Realizamos un análisis de los fondos para este proceso y propusimos cortes cinemáticos para maximizar la sensibilidad de la señal en el canal de decaimiento de cuatro quarks b con energı́a transversa perdida. Diseñamos una estrategia en dos regiones de señal y analizamos las posibles luminosidades de evidencia y descubrimiento en cada caso.Fil: Morales, Roberto Anibal. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Departamento de Física; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Física La Plata. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Física La Plata; Argentin

Effective lepton flavor violating Hij vertex from right-handed neutrinos within the mass insertion approximation

In this work we present a new computation of the lepton flavor violating Higgs boson decays that are generated radiatively to one-loop from heavy right-handed neutrinos. We work within the context of the inverse seesaw model with three νR and three extra singlets X, but the results could be generalized to other low scale seesaw models. The novelty of our computation is that it uses a completely different method by means of the mass insertion approximation which works with the electroweak interaction states instead of the usual 9 physical neutrino mass eigenstates of the inverse seesaw model. This method also allows us to write the analytical results explicitly in terms of the most relevant model parameters, that are the neutrino Yukawa coupling matrix Yν and the right-handed mass matrix MR, which is very convenient for a phenomenological analysis. This Yν matrix, being generically nondiagonal in flavor space, is the only one responsible for the induced charged lepton flavor violating processes of our interest. We perform the calculation of the decay amplitude up to order O(Yν2+Yν4). We also study numerically the goodness of the mass insertion approximation results. In the last part we present the computation of the relevant one-loop effective vertex Hij for the lepton flavor violating Higgs decay which is derived from a large MR mass expansion of the form factors. We believe that our simple formula found for this effective vertex can be of interest for other researchers who wish to estimate the H→īj rates in a fast way in terms of their own preferred input values for the relevant model parameters Yν and MR.Fil: Arganda Carreras, Ernesto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Física La Plata. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Física La Plata; ArgentinaFil: Herrero, M. J.. Universidad Autónoma de Madrid; EspañaFil: Marcano, X.. Universidad Autónoma de Madrid; EspañaFil: Morales, Roberto Anibal. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Física La Plata. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Física La Plata; ArgentinaFil: Szynkman, Alejandro Andrés. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Física La Plata. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Física La Plata; Argentin

2015 Brainhack Proceedings

Table of contents I1 Introduction to the 2015 Brainhack Proceedings R. Cameron Craddock, Pierre Bellec, Daniel S. Margules, B. Nolan Nichols, Jörg P. Pfannmöller A1 Distributed collaboration: the case for the enhancement of Brainspell’s interface AmanPreet Badhwar, David Kennedy, Jean-Baptiste Poline, Roberto Toro A2 Advancing open science through NiData Ben Cipollini, Ariel Rokem A3 Integrating the Brain Imaging Data Structure (BIDS) standard into C-PAC Daniel Clark, Krzysztof J. Gorgolewski, R. Cameron Craddock A4 Optimized implementations of voxel-wise degree centrality and local functional connectivity density mapping in AFNI R. Cameron Craddock, Daniel J. Clark A5 LORIS: DICOM anonymizer Samir Das, Cécile Madjar, Ayan Sengupta, Zia Mohades A6 Automatic extraction of academic collaborations in neuroimaging Sebastien Dery A7 NiftyView: a zero-footprint web application for viewing DICOM and NIfTI files Weiran Deng A8 Human Connectome Project Minimal Preprocessing Pipelines to Nipype Eric Earl, Damion V. Demeter, Kate Mills, Glad Mihai, Luka Ruzic, Nick Ketz, Andrew Reineberg, Marianne C. Reddan, Anne-Lise Goddings, Javier Gonzalez-Castillo, Krzysztof J. Gorgolewski A9 Generating music with resting-state fMRI data Caroline Froehlich, Gil Dekel, Daniel S. Margulies, R. Cameron Craddock A10 Highly comparable time-series analysis in Nitime Ben D. Fulcher A11 Nipype interfaces in CBRAIN Tristan Glatard, Samir Das, Reza Adalat, Natacha Beck, Rémi Bernard, Najmeh Khalili-Mahani, Pierre Rioux, Marc-Étienne Rousseau, Alan C. Evans A12 DueCredit: automated collection of citations for software, methods, and data Yaroslav O. Halchenko, Matteo Visconti di Oleggio Castello A13 Open source low-cost device to register dog’s heart rate and tail movement Raúl Hernández-Pérez, Edgar A. Morales, Laura V. Cuaya A14 Calculating the Laterality Index Using FSL for Stroke Neuroimaging Data Kaori L. Ito, Sook-Lei Liew A15 Wrapping FreeSurfer 6 for use in high-performance computing environments Hans J. Johnson A16 Facilitating big data meta-analyses for clinical neuroimaging through ENIGMA wrapper scripts Erik Kan, Julia Anglin, Michael Borich, Neda Jahanshad, Paul Thompson, Sook-Lei Liew A17 A cortical surface-based geodesic distance package for Python Daniel S Margulies, Marcel Falkiewicz, Julia M Huntenburg A18 Sharing data in the cloud David O’Connor, Daniel J. Clark, Michael P. Milham, R. Cameron Craddock A19 Detecting task-based fMRI compliance using plan abandonment techniques Ramon Fraga Pereira, Anibal Sólon Heinsfeld, Alexandre Rosa Franco, Augusto Buchweitz, Felipe Meneguzzi A20 Self-organization and brain function Jörg P. Pfannmöller, Rickson Mesquita, Luis C.T. Herrera, Daniela Dentico A21 The Neuroimaging Data Model (NIDM) API Vanessa Sochat, B Nolan Nichols A22 NeuroView: a customizable browser-base utility Anibal Sólon Heinsfeld, Alexandre Rosa Franco, Augusto Buchweitz, Felipe Meneguzzi A23 DIPY: Brain tissue classification Julio E. Villalon-Reina, Eleftherios Garyfallidi

Kidney and Cardiovascular Effects of Canagliflozin According to Age and Sex: A Post Hoc Analysis of the CREDENCE Randomized Clinical Trial

Rationale & Objective: It is unclear whether the effect of canagliflozin on adverse kidney and cardiovascular events in those with diabetic kid-ney disease varies by age and sex. We assessed the effects of canagliflozin among age group categories and between sexes in the Canagli-flozin and Renal Endpoints in Diabetes with Established Nephropathy Clinical Evaluation (CREDENCE) study.Study Design: Secondary analysis of a random-ized controlled trial. Setting & Participants: Participants in the CREDENCE trial. Intervention: Participants were randomly assigned to receive canagliflozin 100 mg/d or placebo.Outcomes: Primary composite outcome of kid-ney failure, doubling of serum creatinine con-centration, or death due to kidney or cardiovascular disease. Prespecified secondary and safety outcomes were also analyzed. Out-comes were evaluated by age at baseline (<60, 60-69, and >_70 years) and sex in the intention-to-treat population using Cox regression models.Results: The mean age of the cohort was 63.0 & PLUSMN; 9.2 years, and 34% were female. Older age and female sex were independently associ-ated with a lower risk of the composite of adverse kidney outcomes. There was no evidence that the effect of canagliflozin on the primary outcome (acomposite of kidney failure, a doubling of serum creatinine concentration, or death from kidney or cardiovascular causes) differed between age groups (HRs, 0.67 [95% CI, 0.52-0.87], 0.63 [0.4 8-0.82], and 0.89 [0.61-1.29] for ages <60, 60-69, and >_70 years, respectively; P = 0.3 for interaction) or sexes (HRs, 0.71 [95% CI, 0.5 4-0.95] and 0.69 [0.56-0.8 4] in women and men, respectively; P = 0.8 for interaction). No differences in safety outcomes by age group or sex were observed.Limitations: This was a post hoc analysis with multiple comparisons.Conclusions: Canagliflozin consistently reduced the relative risk of kidney events in people with diabetic kidney disease in both sexes and across age subgroups. As a result of greater background risk, the absolute reduction in adverse kidney outcomes was greater in younger participants.Funding: This post hoc analysis of the CREDENCE trial was not funded. The CREDENCE study was sponsored by Janssen Research and Development and was conducted collaboratively by the sponsor, an academic-led steering committee, and an academic research organization, George Clinical.Trial Registration: The original CREDENCE trial was registered at ClinicalTrials.gov with study number NCT02065791

Effect of SGLT2 Inhibitors on Stroke and Atrial Fibrillation in Diabetic Kidney Disease: Results From the CREDENCE Trial and Meta-Analysis

BACKGROUND AND PURPOSE: Chronic kidney disease with reduced estimated glomerular filtration rate or elevated albuminuria increases risk for ischemic and hemorrhagic stroke. This study assessed the effects of sodium glucose cotransporter 2 inhibitors (SGLT2i) on stroke and atrial fibrillation/flutter (AF/AFL) from CREDENCE (Canagliflozin and Renal Events in Diabetes With Established Nephropathy Clinical Evaluation) and a meta-analysis of large cardiovascular outcome trials (CVOTs) of SGLT2i in type 2 diabetes mellitus.METHODS: CREDENCE randomized 4401 participants with type 2 diabetes mellitus and chronic kidney disease to canagliflozin or placebo. Post hoc, we estimated effects on fatal or nonfatal stroke, stroke subtypes, and intermediate markers of stroke risk including AF/AFL. Stroke and AF/AFL data from 3 other completed large CVOTs and CREDENCE were pooled using random-effects meta-analysis.RESULTS: In CREDENCE, 142 participants experienced a stroke during follow-up (10.9/1000 patient-years with canagliflozin, 14.2/1000 patient-years with placebo; hazard ratio [HR], 0.77 [95% CI, 0.55-1.08]). Effects by stroke subtypes were: ischemic (HR, 0.88 [95% CI, 0.61-1.28]; n=111), hemorrhagic (HR, 0.50 [95% CI, 0.19-1.32]; n=18), and undetermined (HR, 0.54 [95% CI, 0.20-1.46]; n=17). There was no clear effect on AF/AFL (HR, 0.76 [95% CI, 0.53-1.10]; n=115). The overall effects in the 4 CVOTs combined were: total stroke (HRpooled, 0.96 [95% CI, 0.82-1.12]), ischemic stroke (HRpooled, 1.01 [95% CI, 0.89-1.14]), hemorrhagic stroke (HRpooled, 0.50 [95% CI, 0.30-0.83]), undetermined stroke (HRpooled, 0.86 [95% CI, 0.49-1.51]), and AF/AFL (HRpooled, 0.81 [95% CI, 0.71-0.93]). There was evidence that SGLT2i effects on total stroke varied by baseline estimated glomerular filtration rate (P=0.01), with protection in the lowest estimated glomerular filtration rate (<45 mL/min/1.73 m2]) subgroup (HRpooled, 0.50 [95% CI, 0.31-0.79]).CONCLUSIONS: Although we found no clear effect of SGLT2i on total stroke in CREDENCE or across trials combined, there was some evidence of benefit in preventing hemorrhagic stroke and AF/AFL, as well as total stroke for those with lowest estimated glomerular filtration rate. Future research should focus on confirming these data and exploring potential mechanisms. Registration: URL: https://www.clinicaltrials.gov; Unique identifier: NCT02065791