Entre profesor, artista y sanador

In the current situation of exhaustion and ongoing changes in the social and economic models and in knowledge paradigms, there has been a confluence of learnings of different orders: scientific, ancestral and metaphysical. As a result, one could say that human groups of various kinds are seeking in one way or another the awakening of consciousness, the quantum leap or spiritual evolution. This could be explained in part by the knowledge that ethno-pharmacology gives us, but, in turn, we can rely on studies based on neuroscience to explain the shamanic phenomenon. These extraordinary conditions could be the trigger the art world had been expecting for decades not to follow the spiral of mutation and flexibilization of roles, which artists have adopted to rethink our role in the world. In this convulsive age the conditions are being laid for really drastic and profound changes that will transform the roles and meaning of creations.En la actual coyuntura de agotamiento y cambios en proceso en los modelos sociales, económicos y de paradigmas del conocimiento, se ha dado una confluencia de saberes de diferente orden: científico, ancestral y metafísico. Como resultado de ello, se podría afirmar que grupos humanos de diversa índole están buscando de una u otra manera el despertar de laconciencia, el salto cuántico o bien la evolución espiritual. Esto se podría explicar en parte por los conocimientos que nos da la etnofarmacognosia de un lado, pero a su vez, nos podemos apoyar en estudios basados en la neurociencia para explicar el fenómeno chamánico. Estas condiciones extraordinarias, podrían ser el detonante que por varias décadas el mundo del arte había estado esperando para no seguir en la espiral de mutación y flexibilización de roles a que nos habíamos visto abocados los artistas para replantear nuestro papel en el mundo; en esta época convulsionada se están cimentando condiciones para cambios realmente drásticos y de fondo que transformarán los roles y el sentido de las creaciones. 

Differences reported in the lifespan and aging of male Wistar rats maintained on diets containing fat with different fatty acid profiles (virgin olive, sunflower or fish oils) are not reflected by histopathological lesions found at death in central nervous and endocrine systems

The present study was designed to examine if dietary fat sources that have shown differences in lifespan and if some aging-related aspects can modulate the range of histopathologic changes in central nervous and endocrine systems that occur during the lifespan of Wistar rats. Moreover, it was attempted to gain insight into the relationship between longevity and the development of the different pathological changes, as well as possible interaction with diet. In order to achieve this, male Wistar rats were randomly assigned to three experimental groups fed semisynthetic and isoenergetic diets from weaning until death with different dietary fat sources, namely virgin olive, sunflower, or fish oil. An individual follow-up until death of each animal was performed. Incidence, severity, and burden of specific or group (i.e., neoplastic or non-neoplastic proliferative and nonproliferative) of lesions was calculated along with individual’s disease and individual organ lesion burden. Most of the histopathological lesions found have been described in previous studies. Neoplasms, and in particular pituitary adenomas followed by brain tumors, were the most prevalent lesions found in the rats and the main cause of death involving both systems. Incidence of brain lesions was associated with age-at-death. Assayed dietary fats did not present differential effects on pathological changes occurring in endocrine and central nervous systems throughout rat lifespan.Spanish Government AGL2008-01057Government of Andalusia AGR83

A Diet Rich in Saturated Fat and Cholesterol Aggravates the Effect of Bacterial Lipopolysaccharide on Alveolar Bone Loss in a Rabbit Model of Periodontal Disease

María D. Navarro-Hortal is a FPU fellow from the Spanish Ministry of Educación y Formación Profesional. The research group was partially supported by the Visiting Scholar Program from the University of Granada. The authors acknowledge Nutraceutical Translations for English language editing of this manuscript.Increasing evidence connects periodontitis with a variety of systemic diseases, including metabolic syndrome, atherosclerosis, and non-alcoholic fatty liver disease (NAFLD). The proposal of this study was to evaluate the role of diets rich in saturated fat and cholesterol in some aspects of periodontal diseases in a lipopolysaccharide (LPS)-induced model of periodontal disease in rabbits and to assess the influence of a periodontal intervention on hyperlipidemia, atherosclerosis, and NAFLD progression to non-alcoholic steatohepatitis. Male rabbits were maintained on a commercial standard diet or a diet rich in saturated fat (3% lard w/w) and cholesterol (1.3% w/w) (HFD) for 40 days. Half of the rabbits on each diet were treated 2 days per week with intragingival injections of LPS from Porphyromonas gingivalis. Morphometric analyses revealed that LPS induced higher alveolar bone loss (ABL) around the first premolar in animals receiving standard diets, which was exacerbated by the HFD diet. A higher score of acinar inflammation in the liver and higher blood levels of triglycerides and phospholipids were found in HFD-fed rabbits receiving LPS. These results suggest that certain dietary habits can exacerbate some aspects of periodontitis and that bad periodontal health can contribute to dyslipidemia and promote NAFLD progression, but only under certain conditions.Ministry of Education, Culture and Sport (Spain)Spanish GovernmentTraslados Temporales FPU (University of Kings College of London

Role of Lipids in the Onset, Progression and Treatment of Periodontal Disease. A Systematic Review of Studies in Humans

The risk of different oral problems (root caries, tooth mobility, and tooth loss) can be increased by the presence of periodontal disease, which has also been associated with a growing list of systemic diseases. The presence of some bacteria is the primary etiology of this disease; a susceptible host is also necessary for disease initiation. In this respect, the progression of periodontal disease and healing of the periodontal tissues can be modulated by nutritional status. To clarify the role of lipids in the establishment, progression, and/or treatment of this pathology, a systematic review was conducted of English-written literature in PubMed until May 2016, which included research on the relationship of these dietary components with the onset and progression of periodontal disease. According to publication type, randomized-controlled trials, cohort, case-control and cross-sectional studies were included. Among all the analyzed components, those that have any effect on oxidative stress and/or inflammation seem to be the most interesting according to current evidence. On one hand, there is quite a lot of information in favor of a positive role of n-3 fatty acids, due to their antioxidant and immunomodulatory effects. On the other hand, saturated fat-rich diets increase oxidative stress as well the as intensity and duration of inflammatory processes, so they must be avoided.Alfonso Varela-López is recipient of a fellowship of FPU program from the Spanish Ministry of Education. Authors acknowledge to the University of Granada and the Autonomous Government of Andalusia for partial support of the research team

Geological setting and genesis of stratabound barite deposits at Múzquiz, Coahuila in northeastern Mexico

Peer ReviewedPreprin

Phylogenomic analysis of natural products biosynthetic gene clusters allows discovery of arseno-organic metabolites in model streptomycetes

We are indebted with Marnix Medema, Paul Straight and Sean Rovito, for useful discussions and critical reading of the manuscript, as well as with Alicia Chagolla and Yolanda Rodriguez of the MS Service of Unidad Irapuato, Cinvestav, and Araceli Fernandez for technical support in high-performance computing. This work was funded by Conacyt Mexico (grants No. 179290 and 177568) and FINNOVA Mexico (grant No. 214716) to FBG. PCM was funded by Conacyt scholarship (No. 28830) and a Cinvestav posdoctoral fellowship. JF and JFK acknowledge funding from the College of Physical Sciences, University of Aberdeen, UK.Peer reviewedPublisher PD

Implementación de Lean Manufacturing para la mejora de la productividad en una empresa logística, Huachipa, 2023

La presente investigación tiene por objetivo principal determinar objetivo general es Determinar de qué manera la aplicación de lean manufacturing mejora la productividad en una empresa industrial, Huachipa 2023 2023. para ello se evaluará a cada momento como avanza el proceso en área de almacén y así seguir de cerca la mejora en los resultados Al observar los primeros indicadores podemos inferir que la empresa está teniendo un problema de desorden de productos porque no están distribuidos correctamente y tienen poco espacio para moverse entre los mismos ingredientes. Por esta razón tienen un bajo índice de resultados de eficiencia del 83% y eficiencia del 87% y se deben realizar mejoras en estos puntos de la empresa para lograr un mayor índice de productividad. Luego de observar las mejoras realizadas en las empresas, estos resultados se obtuvieron en los indicadores de 92% de eficiencia y 96% de eficiencia al utilizar herramientas de producción ajustada (5s y Kaisen), ayudándonos a organizar mejor el almacenamiento y asignar mejor el espacio. Estos resultados en la empresa logística serán beneficiosos porque será más fácil encontrar productos y será posible enviarlos a los clientes de forma más rápida y eficiente