Oral lesions in HIV infected individuals from Ribeirão Preto, Brazil

Objectives: The aim of this study was to diagnosis oral lesions related to HIV infection in individuals followed in the General Hospital of the School of Medicine of Ribeirão Preto, University of São Paulo, Brazil. The presence of oral lesions was correlated with gender, age, smoking habit, levels of CD4 lymphocytes, HIV load, time of HIV seropositivity, AIDS condition, use of removable dental prosthesis, and use of HAART. Materials and Methods: 340 HIV infected individuals were selected for this study, all participants of the study were examined by only one practiced dentist which performed anamnesis, peribuccal and oral examination. Results: Oral lesions were observed in 113 of 340 (33.2%) HIV infected individuals. These oral lesions included: oral candidiasis (17.7%) of pseudomembranous (10.8%) and of erythematous types (6.9%), angular cheilitis (13.9%), hairy leukoplakia (11.8%), and oral ulcers (2.1%). Oral candidiasis lesions were more frequently observed in women (p.033). Smoking addict participants presented a high frequency of tongue hairy leukoplakia (p.038) and a reduced frequency of oral ulcers (p.018). Hairy leukoplakia and pseudomembranous candidiasis were inversely correlated to CD4+L levels and directly correlated with HIV load, behaving as immune depression markers. Hairy leukoplakia and pseudomembranous candidiasis also showed an inverse correlation with HAART use (p<.0001). Patients using mobile dental prosthesis presented a high frequency of erythematous candidiasis (p.003). Conclusion: The inverse correlation with CD4+L level and the direct correlation with HIV load suggest that oral lesions could be used as alternative clinical markers for poor immune condition in HIV infected individuals

La esclavitud y sus lugares de memoria - Río de Janeiro y sus "maravillas"

Colonial y esclavitud Río de Janeiro es un contraste con la idea de una ciudad maravillosa. A pesar del esfuerzo actual para insertar el elemento "maravilla" en la región portuaria, fue a través de él que llegaron miles de africanos destinados a la esclavitud. El texto reflexiona sobre Cais do Valongo y el cementerio de los nuevos negros, tratándolos como lugares de memoria del tráfico y los descendientes de africanos esclavizados. También se abordarán los diferentes usos públicos y políticos que se hacen de estos sitios, ya que ha recibido una atención diferente de los ámbitos público y privado, y también internacionalmente, como la UNESCO. La memoria de la zona ha funcionado constantemente desde que el Imperio tuvo dos momentos en la República: Pereira Passos y la importante remodelación de la ciudad a principios del siglo XX y recientemente en vista de las obras de revitalización de Oporto. Palabras clave: Valongo, africanos, memoria.The colonial Rio de Janeiro and slave is a contrast to the wonderful city of idea . Despite the current effort to put the question " wonder" in the port area , it was for her that thousands of Africans for enslavement arrived. The text reflects on the Valongo 's Wharf and the cemetery of new blacks, treating them as site traffic memory and the descendants of enslaved Africans . Different public and political uses made of these sites will also be treated once it has received different attention by the public and private spheres , as well as international , such as UNESCO . The area had its memory worked constantly from the Empire and the Republic has two stages: Pereira Passos and the major refurbishment of the city in the early twentieth century and recently before the Port redeveloped . Keywords: Valongo, African, memory.O Rio de Janeiro colonial e escravista é um contraste à ideia de cidade maravilhosa. Apesar do esforço atual de inserir o quesito “maravilha” na região portuária, foi por ela que milhares de africanos destinados a escravização chegaram. O texto reflete sobre o Cais do Valongo e o cemitério dos pretos novos, tratando-os como locais de memória do tráfico e dos descendentes de africanos escravizados. Os diferentes usos públicos e políticos feitos desses locais também serão tratados uma vez que tem recebido diferentes atenções por parte das esferas pública e privada, e também internacional, como a UNESCO. A área teve sua memória constantemente trabalhada desde o Império tendo na República dois momentos: Pereira Passos e a grande remodelação da cidade no início do século XX e recentemente diante das obras de revitalização do Porto. Palavras-chaves: Valongo, africanos, memória

Inquérito sorológico para hantavírus em doadores de sangue no Estado de Santa Catarina, Brasil

Emergent diseases such as Hantavirus Cardio-pulmonary Syndrome (HCPS) are able to create a significant impact on human populations due to their seriousness and high fatality rate. Santa Catarina, located in the South of Brazil, is the leading state for HCPS with 267 reported cases from 1999 to 2011. We present here a serological survey on hantavirus in blood donors from different cities of the state of Santa Catarina, with an IgG-ELISA using a recombinant nucleocapsid protein from Araraquara hantavirus as an antigen. In total, 314 donors from blood banks participated in the study, geographically covering the whole state. Among these, 14 individuals (4.4%) had antibodies to hantavirus: four of 50 (8% positivity) from Blumenau, four of 52 (7.6%) from Joinville, three of 50 (6%) from Florianópolis, two of 50 (4%) from Chapecó and one of 35 (2.8%) from Joaçaba. It is possible that hantaviruses are circulating across almost the whole state, with important epidemiological implications. Considering that the seropositive blood donors are healthy individuals, it is possible that hantaviruses may be causing unrecognized infections, which are either asymptomatic or clinically nonspecific, in addition to HCPS. It is also possible that more than one hantavirus type could be circulating in this region, causing mostly benign infections.Doenças emergentes como a Síndrome Cárdio-Pulmonar por Hantavírus (SCPH) são capazes de promover um grande impacto nas populações humanas devido a sua severidade e alta letalidade. Santa Catarina, localizada ao Sul do Brasil, é o estado com o maior número de relatos de SCPH, com 267 casos desde 1999 a 2011. Apresentamos aqui um inquérito sorológico para hantavírus em doadores de sangue de diferentes cidades do Estado de Santa Catarina, usando um teste IgG-ELISA com proteína recombinante de nucleocapsídeo do hantavírus Araraquara como antígeno. No total, 314 doadores de banco de sangue participaram do estudo, cobrindo geograficamente todo o Estado. Dentre estes, 14 indivíduos (4,4%) apresentaram anticorpos para hantavírus: quatro de 50 (8% de positividade) provenientes de Blumenau, quatro de 52 (7,6%) de Joinville, três de 50 (6%) de Florianópolis, dois de 50 (4%) de Chapecó e um de 35 (2,8%) de Joaçaba. É possível que hantavírus estejam circulando praticamente em todo o Estado, com implicações epidemiológicas importantes. Considerando que os doadores de sangue soropositivos são indivíduos saudáveis, é possível que hantavírus possam estar causando infecções não diagnosticadas, sejam elas assintomáticas ou clinicamente inespecíficas, além da SCPH. É possível ainda que mais de um tipo de hantavírus possa estar circulando na região, causando infecções mais benignas

SAPHO: has the time come for tailored therapy?

SAPHO (synovitis, acne, pustulosis, hyperostosis and osteitis) syndrome is a heterogeneous condition combining osteoarticular and cutaneous manifestations. Conventional treatments are mostly ineffective. We hereby report two patients, the first with an aggressive form of disease and the second with an incomplete response to two different anti-TNF-α agents. Both were successfully treated with tocilizumab and ustekinumab, respectively, over a long period of time. A narrative review of a biological therapy in SAPHO syndrome yielded very little information on the specific use of these agents. We highlight the advantages of personalising therapy and describe emerging promising treatments for this disease.info:eu-repo/semantics/publishedVersio

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