The Health Care Consequences of Smoking and its Regulation

The literature on the health economics of smoking presents two principal facts: that smoking increases health care costs, and that restrictions on smoking lead to reductions in smoking prevalence and intensity. Some researchers have hypothesized that these two facts, in combination, allow the inference that restricting smoking will lower health care costs. For a variety of reasons, however, observed associations between smoking and health care use on the one hand, and regulations and smoking on the other, do not imply a casual effect of the restrictions on health care. This paper extends the literature by examining whether cigarette tax increases lead to lower health care costs. Using data from the 1991 and 1993 National Heath Interview Surveys, it first reproduces the principal results in the literature on smoking, taxes, and health care utilization, and then estimates the effects of tobacco taxes on health care. The results indicate that once one controls for endogenous quits, the health care benefits of smoking cessation are greater than previously believed. There is weak evidence that tax increases lead to higher cessation rates. In combination, these results suggest that, in addition providing a source for funding excess health care costs, tax increases may lower health care costs (for given longevity) directly by inducing smokers to quit.

The Gas Properties of the W3 GMC: A HARP study

We present 12CO, 13CO and C18O J=3-2 maps of the W3 GMC made at the James Clerk Maxwell Telescope. We combine these observations with Five Colleges Radio Astronomy Observatory CO J=1-0 data to produce the first map of molecular-gas temperatures across a GMC and the most accurate determination of the mass distribution in W3 yet obtained. We measure excitation temperatures in the part of the cloud dominated by triggered star formation (the High Density Layer, HDL) of 15-30 K, while in the rest of the cloud, which is relatively unaffected by triggering (Low Density Layer, LDL), the excitation temperature is generally less than 12 K. We identify a temperature gradient in the HDL which we associate with an age sequence in the embedded massive star-forming regions. We measure the mass of the cloud to be 4.4+/-0.4 x 10^5 solar masses, in agreement with previous estimates. Existing sub-mm continuum data are used to derive the fraction of gas mass in dense clumps as a function of position in the cloud. This fraction, which we interpret as a Clump Formation Efficiency (CFE), is significantly enhanced across the HDL, probably due to the triggering. Finally, we measure the 3D rms Mach Number as a function of position and find a correlation between the Mach number and the CFE within the HDL only. This correlation is interpreted as due to feedback from the newly-formed stars and a change in its slope between the three main star-forming regions is construed as another evolutionary effect. We conclude that triggering has affected the star-formation process in the W3 GMC primarily by creating additional dense structures that can collapse into stars. Any traces of changes in CFE due to additional turbulence have since been overruled by the feedback effects of the star-forming process itself.Comment: 14 pages, 11 figures, 1 table, accepted for publication in MNRA

Failure analysis of a Stirling engine heat pipe

Failure analysis was conducted on a heat pipe from a Stirling Engine test rig which was designed to operate at 1073 K. Premature failure had occurred due to localized overheating at the leading edge of the evaporator fin. It was found that a crack had allowed air to enter the fin and react with the sodium coolant. The origin of the crack was found to be located at the inner surface of the Inconel 600 fin where severe intergranular corrosion had taken place

"Napsterizing" Pharmaceuticals: Access, Innovation, and Consumer Welfare

We analyze the effects on consumers of an extreme policy experiment -- Napsterizing' pharmaceuticals -- whereby all patent rights on branded prescription drugs are eliminated for both existing and future prescription drugs without compensation to the patent holders. The question of whether this policy maximizes consumer welfare cannot be resolved on an a priori basis due to an obvious tradeoff: While accelerating generic entry will yield substantial gains in consumer surplus associated with greater access to the current stock of pharmaceuticals, future consumers will be harmed by reducing the flow of new pharmaceuticals to the market. Our estimates of the consumer surpluses at stake are based on the stylized facts concerning how generic entry has affected prices, outputs, and market shares. We find that providing greater access to the current stock of prescription drugs yields large benefits to existing consumers. However, realizing those benefits has a substantially greater cost in terms of lost consumer benefits from reductions in the flow of new drugs. Specifically, the model yields the result that for every dollar in consumer benefit realized from providing greater access to the current stock, future consumers would be harmed at a rate of three dollars in present value terms from reduced future innovation. We obtain this result even accounting for the stylized fact that after generic entry branded drugs continue to earn significant price premia over generic products and hence recognizing that Napsterizing does not completely eliminate the incentives to innovate.

Weekly Versus Monthly Testosterone Administration On Fast and Slow Skeletal Muscle Fibers in Older Adult Males

Context: In older adults, loss of mobility due to sarcopenia is exacerbated in men with low serum T. T replacement therapy is known to increase muscle mass and strength, but the effect of weekly (WK) vs monthly (MO) administration on specific fiber types is unknown. Objective: To determine the efficacy of WK vs MO T replacement on the size and functional capacity of individual fast and slow skeletal muscle fiber types. Design, Setting, and Patients: Subjects were randomized into a 5-month, double-blind, placebo-controlled trial. All subjects (ages, 61–71 y) were community-dwelling men who had T levels \u3c 500 ng/dL. Intervention: Subjects were dosed weekly for 5 months, receiving continuous T (WK, n = 5; 100 mg T enanthate, im injection), monthly cycled T (MO, n = 7; alternating months of T and placebo), or placebo (n = 7). Muscle biopsies of the vastus lateralis were obtained before and after treatment. Main Outcome Measures: Main outcomes for individual slow and fast fibers included fiber diameter, peak force (P0), rate of tension development, maximal shortening velocity, peak power, and Ca2+ sensitivity. Results: Both treatments increased fiber diameter and peak power, with WK treatment 5-fold more effective than MO in increasing type I fiber P0. WK effects on fiber diameter and force were 1.5-fold higher in slow fibers compared to fast fibers. In fast type II fibers, diameter and P0 increased similarly between treatments. The increased power was entirely due to increased fiber size and force. Conclusions: In conclusion, T replacement effects were fiber-type dependent, restricted to increases in cell size, P0, and peak power, and dependent on the paradigm selected (WK vs MO)

Supersonic through-flow fan design

The NASA Lewis Research Center has embarked on a program to experimentally prove the concept of a supersonic through-flow fan which is to maintain supersonic velocities throughout the compression system with only weak shock-wave flow losses. The detailed design of a supersonic through-flow fan and estimated off-design performance with the use of advanced computational codes are described. A multistage compressor facility is being modified for the newly designed supersonic through-flow fan and the major aspects of this modification are briefly described