Analog VLSI neural network integrated circuits

Two analog very large scale integration (VLSI) vector matrix multiplier integrated circuit chips were designed, fabricated, and partially tested. They can perform both vector-matrix and matrix-matrix multiplication operations at high speeds. The 32 by 32 vector-matrix multiplier chip and the 128 by 64 vector-matrix multiplier chip were designed to perform 300 million and 3 billion multiplications per second, respectively. An additional circuit that has been developed is a continuous-time adaptive learning circuit. The performance achieved thus far for this circuit is an adaptivity of 28 dB at 300 KHz and 11 dB at 15 MHz. This circuit has demonstrated greater than two orders of magnitude higher frequency of operation than any previous adaptive learning circuit

Reentrant Melting of Soliton Lattice Phase in Bilayer Quantum Hall System

At large parallel magnetic field $B_\parallel$, the ground state of bilayer quantum Hall system forms uniform soliton lattice phase. The soliton lattice will melt due to the proliferation of unbound dislocations at certain finite temperature leading to the Kosterlitz-Thouless (KT) melting. We calculate the KT phase boundary by numerically solving the newly developed set of Bethe ansatz equations, which fully take into account the thermal fluctuations of soliton walls. We predict that within certain ranges of $B_\parallel$, the soliton lattice will melt at $T_{\rm KT}$. Interestingly enough, as temperature decreases, it melts at certain temperature lower than $T_{\rm KT}$ exhibiting the reentrant behaviour of the soliton liquid phase.Comment: 11 pages, 2 figure

Social enterprise and disruption innovation: evaluating the role of Rumie's free educational software in seven developing economies

This paper reviews the provision of free educational hardware and software provided by one social enterprise to under resourced children in seven countries. The social and economic challenges faced by this social enterprise are highlighted; the implications for social enterprise of adopting disruptive innovation and of blended learning techniques in an educational context; and the importance of evaluating projects in terms of research methods. Three research questions were posed: what is the educational benefit of using Rumie? [Value dimension]; what criteria can be used to evaluate the use of Rumie in the field? [The capability dimension]; what feedback is there from students, teachers, etc. [The collaboration dimension]. Quantitative usage data and qualitative feedback were collected. Findings show that the tablets help improve pupils math and reading abilities and the educal entertainment does not appear to be at the expense of learning about more traditional subjects. Feedback from teachers and pupils appears to be extremely positive. More specific lessons learned about research methods in evaluating social entrepreneurship projects in developing economies are identified; and implications for adapting the theory of disruptive innovation

NOD2/RICK-dependent β-defensin 2 regulation is protective for nontypeable Haemophilus influenzae-induced middle ear infection.

Middle ear infection, otitis media (OM), is clinically important due to the high incidence in children and its impact on the development of language and motor coordination. Previously, we have demonstrated that the human middle ear epithelial cells up-regulate β-defensin 2, a model innate immune molecule, in response to nontypeable Haemophilus influenzae (NTHi), the most common OM pathogen, via TLR2 signaling. NTHi does internalize into the epithelial cells, but its intracellular trafficking and host responses to the internalized NTHi are poorly understood. Here we aimed to determine a role of cytoplasmic pathogen recognition receptors in NTHi-induced β-defensin 2 regulation and NTHi clearance from the middle ear. Notably, we observed that the internalized NTHi is able to exist freely in the cytoplasm of the human epithelial cells after rupturing the surrounding membrane. The human middle ear epithelial cells inhibited NTHi-induced β-defensin 2 production by NOD2 silencing but augmented it by NOD2 over-expression. NTHi-induced β-defensin 2 up-regulation was attenuated by cytochalasin D, an inhibitor of actin polymerization and was enhanced by α-hemolysin, a pore-forming toxin. NOD2 silencing was found to block α-hemolysin-mediated enhancement of NTHi-induced β-defensin 2 up-regulation. NOD2 deficiency appeared to reduce inflammatory reactions in response to intratympanic inoculation of NTHi and inhibit NTHi clearance from the middle ear. Taken together, our findings suggest that a cytoplasmic release of internalized NTHi is involved in the pathogenesis of NTHi infections, and NOD2-mediated β-defensin 2 regulation contributes to the protection against NTHi-induced otitis media

Interlayer tunneling in double-layer quantum Hall pseudo-ferromagnets

We show that the interlayer tunneling I--V in double-layer quantum Hall states displays a rich behavior which depends on the relative magnitude of sample size, voltage length scale, current screening, disorder and thermal lengths. For weak tunneling, we predict a negative differential conductance of a power-law shape crossing over to a sharp zero-bias peak. An in-plane magnetic field splits this zero-bias peak, leading instead to a ``derivative'' feature at $V_B(B_{||})=2\pi\hbar v B_{||}d/e\phi_0$, which gives a direct measure of the dispersion of the Goldstone mode corresponding to the spontaneous symmetry breaking of the double-layer Hall state.Comment: 4 pgs. RevTex, submitted to Phys. Rev. Let

Electrogenic transport and K(+) ion channel expression by the human endolymphatic sac epithelium.

The endolymphatic sac (ES) is a cystic organ that is a part of the inner ear and is connected to the cochlea and vestibule. The ES is thought to be involved in inner ear ion homeostasis and fluid volume regulation for the maintenance of hearing and balance function. Many ion channels, transporters, and exchangers have been identified in the ES luminal epithelium, mainly in animal studies, but there has been no functional study investigating ion transport using human ES tissue. We designed the first functional experiments on electrogenic transport in human ES and investigated the contribution of K(+) channels in the electrogenic transport, which has been rarely identified, even in animal studies, using electrophysiological/pharmacological and molecular biological methods. As a result, we identified functional and molecular evidence for the essential participation of K(+) channels in the electrogenic transport of human ES epithelium. The identified K(+) channels involved in the electrogenic transport were KCNN2, KCNJ14, KCNK2, and KCNK6, and the K(+) transports via those channels are thought to play an important role in the maintenance of the unique ionic milieu of the inner ear fluid