Masonry cross vaults: an overview of the historical developments

The cross vault represents one of the most diffused and fascinating structural typologies of the European architectural heritage. Its history began almost two thousand years ago and reached a widespread use during the Middle Ages with the outstanding gothic cathedrals. Without any proper scientific support but only using trial-and-error methods, considering each building as a scaled specimen of a new one to be built, the ancient workmanship achieved a proper competence represented by the so-called rules of thumb. However, despite this long-lasting history, it is only from the eighteenth centuries that scholars have tried to tackle the problem of analytically describing its structural behaviour. In this regard, the first part of the present study is devoted to the evolution of cross vaults from the geometrical and constructive standpoint, whereas the second one describes the historical advancements of its structural behaviour, until the development of modern limit analysis

Texas Business Review, March 1975

The Business Situation in Texas; Growth of the Texas Economy, 1959-1974; Texas Construction; The Energy Economy: U.S. Oil Imports and Exports, 1860-1974Bureau of Business Researc

Optimization of force-limiting seismic devices connecting structural subsystems

This paper is focused on the optimum design of an original force-limiting floor anchorage system for the seismic protection of reinforced concrete (RC) dual wall-frame buildings. This protection strategy is based on the interposition of elasto-plastic links between two structural subsystems, namely the lateral force resisting system (LFRS) and the gravity load resisting system (GLRS). The most efficient configuration accounting for the optimal position and mechanical characteristics of the nonlinear devices is obtained numerically by means of a modified constrained differential evolution algorithm. A 12-storey prototype RC dual wall-frame building is considered to demonstrate the effectiveness of the seismic protection strategy

Retrospective Evaluation of Clinical Experience With Intravenous Ascorbic Acid in Patients With Cancer.

BACKGROUND: Intravenous ascorbic acid (IV AA) has been used extensively in cancer patients throughout the United States. Currently, there are limited data on the safety and clinical effects of IV AA. The purpose of this study was to expand the current literature using a retrospective analysis of adverse events and symptomatic changes of IV AA in a large sample of cancer patients. METHODS: We conducted a retrospective chart review of all patients receiving IV AA for cancer at the Thomas Jefferson University Hospital over a 7-year period. We assessed all reports of adverse events, laboratory findings, and hospital or emergency department admissions. We also reviewed quality-of-life data, including fatigue, nausea, pain, appetite, and mood. RESULTS: There were 86 patients who received a total of 3034 doses of IV AA ranging from 50 to 150g. In all, 32 patients received only ascorbic acid as part of their cancer management (1197 doses), whereas 54 patients received ascorbic acid in conjunction with chemotherapy (1837 doses). The most common adverse events related to ascorbic acid were temporary nausea and discomfort at the injection site. All events reported in the ascorbic acid alone group were associated with less than 3% of the total number of infusions. Patients, overall, reported improvements in fatigue, pain, and mood while receiving ascorbic acid. CONCLUSIONS: The results of this retrospective analysis support the growing evidence that IV AA is generally safe and well tolerated in patients with cancer, and may be useful in symptom management and improving quality of life

The regions of the sequence most exposed to the solvent within the amyloidogenic state of a protein initiate the aggregation process.

Formation of misfolded aggregates is an essential part of what proteins can do. The process of protein aggregation is central to many human diseases and any aggregating event needs to be prevented within a cell and in protein design. In order to aggregate, a protein needs to unfold its native state, at least partially. The conformational state that is prone to aggregate is difficult to study, due to its aggregating potential and heterogeneous nature. Here, we use a systematic approach of limited proteolysis, in combination with electrospray ionisation mass spectrometry, to investigate the regions that are most flexible and solvent-exposed within the native, ligand-bound and amyloidogenic states of muscle acylphosphatase (AcP), a protein previously shown to form amyloid fibrils in the presence of trifluoroethanol. Seven proteases with different degrees of specificity have been used for this purpose. Following exposure to the aggregating conditions, a number of sites along the sequence of AcP become susceptible to proteolytic digestion. The pattern of proteolytic cleavages obtained under these conditions is considerably different from that of the native and ligand-bound conformations and includes a portion within the N-terminal tail of the protein (residues 6-7), the region of the sequence 18-23 and the position 94 near the C terminus. There is a significant overlap between the regions of the sequence found to be solvent-exposed from the present study and those previously identified to be critical in the rate-determining steps of aggregation from protein engineering approaches. This indicates that a considerable degree of solvent exposure is a feature of the portions of a protein that initiate the process of aggregation

Levi umbilical surfaces in complex space

We define a complex connection on a real hypersurface of \C^{n+1} which is naturally inherited from the ambient space. Using a system of Codazzi-type equations, we classify connected real hypersurfaces in \C^{n+1}, $n\ge 2$, which are Levi umbilical and have non zero constant Levi curvature. It turns out that such surfaces are contained either in a sphere or in the boundary of a complex tube domain with spherical section.Comment: 18 page

On the genesis of different regimes in canopy flows: a numerical investigation

We have performed fully resolved simulations of turbulent flows over various submerged rigid canopies covering the wall of an open channel. All the numerical predictions have been obtained considering the same nominal bulk Reynolds number (i.e. Reb=UbH