177 research outputs found

    Regulation of pituitary growth hormone synthesis by NAD+ dependent deacetylase Sirt1

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    Agents that learn how to generate arguments from other agents

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    Learning how to argue is a key ability for a negotiator agent. In this paper, we propose an approach that allows agents to learn how to build arguments by observing how other agents argue in a negotiation context. Particularly, our approach enables the agent to infer the rulesfor argument generation that other agents apply to build their arguments. To carry out this goal, the agent stores the arguments uttered by other agents and the facts of the negotiation context where each argument is uttered. Then, an algorithm for fuzzy generalized association rules is applied to discover the desired rules. This kind of algorithm allows us (a) to obtain general rules that can be applied to dierent negotiation contexts; and (b) to deal with the uncertainty about the knowledge of what facts of the context are taken into account by the agents. The experimental results showed that it is possible to infer argument generation rules from a reduced number of observed arguments.Fil: Amandi, Analia Adriana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Tandil. Instituto Superior de Ingenieria del Software; ArgentinaFil: Monteserin, Ariel José. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Tandil. Instituto Superior de Ingenieria del Software; Argentin

    A Reinforcement Learning Approach to Improve the Argument Selection Effectiveness in Argumentation-based Negotiation

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    Argument selection is considered the essence of the strategy in argumentation-based negotiation. An agent, which is arguing during a negotiation, must decide what arguments are the best to persuade the opponent. In fact, in each negotiation step, the agent must select an argument from a set of candidate arguments by applying some selection policy. Following this policy, the agent observes some factors of the negotiation context, for instance: trust in the opponent and expected utility of the negotiated agreement, among others. Usually, argument selection policies are dened statically. However, as the negotiation context varies from a negotiation to another, dening a static selection policy it is not useful. Therefore, the agent should modify its selection policy in order to adapt it to the dierent negotiation contexts as the agent´s experience increases. In this paper, we present a reinforcement learning approach that allows the agent to improve the argument selection eciency by updating the argument selection policy. To carry out this goal, the argument selection mechanism is represented as a reinforcement learning model. We tested this approach in a multiagent system, in a stationary as well as in a dynamic environment, and obtained promising results in both.Fil: Amandi, Analia Adriana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Tandil. Instituto Superior de Ingenieria del Software; ArgentinaFil: Monteserin, Ariel José. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Tandil. Instituto Superior de Ingenieria del Software; Argentin

    Four decades of transmission of a multidrug-resistant Mycobacterium tuberculosis outbreak strain

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    The rise of drug-resistant strains is a major challenge to containing the tuberculosis (TB) pandemic. Yet, little is known about the extent of resistance in early years of chemotherapy and when transmission of resistant strains on a larger scale became a major public health issue. Here we reconstruct the timeline of the acquisition of antimicrobial resistance during a major ongoing outbreak of multidrug-resistant TB in Argentina. We estimate that the progenitor of the outbreak strain acquired resistance to isoniazid, streptomycin and rifampicin by around 1973, indicating continuous circulation of a multidrug-resistant TB strain for four decades. By around 1979 the strain had acquired additional resistance to three more drugs. Our results indicate that Mycobacterium tuberculosis (Mtb) with extensive resistance profiles circulated 15 years before the outbreak was detected, and about one decade before the earliest documented transmission of Mtb strains with such extensive resistance profiles globally.Fil: Eldholm, Vegard. Norwegian Institute of Public Health; NoruegaFil: Monteserin, Johana. Dirección Nacional de Institutos de Investigación. Administración Nacional de Laboratorios e Institutos de Salud. Instituto Nacional de Enfermedades Infecciosas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Rieux, Adrien. Colegio Universitario de Londres; Reino UnidoFil: Lopez, Beatriz. Dirección Nacional de Institutos de Investigación. Administración Nacional de Laboratorios e Institutos de Salud. Instituto Nacional de Enfermedades Infecciosas; ArgentinaFil: Sobkowiak, Benjamin. Colegio Universitario de Londres; Reino UnidoFil: Ritacco, Gloria Viviana. Dirección Nacional de Institutos de Investigación. Administración Nacional de Laboratorios e Institutos de Salud. Instituto Nacional de Enfermedades Infecciosas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Balloux, Francois. Colegio Universitario de Londres; Reino Unid

    Spectral/hp element methods: recent developments, applications, and perspectives

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    The spectral/hp element method combines the geometric flexibility of the classical h-type finite element technique with the desirable numerical properties of spectral methods, employing high-degree piecewise polynomial basis functions on coarse finite element-type meshes. The spatial approximation is based upon orthogonal polynomials, such as Legendre or Chebychev polynomials, modified to accommodate C0-continuous expansions. Computationally and theoretically, by increasing the polynomial order p, high-precision solutions and fast convergence can be obtained and, in particular, under certain regularity assumptions an exponential reduction in approximation error between numerical and exact solutions can be achieved. This method has now been applied in many simulation studies of both fundamental and practical engineering flows. This paper briefly describes the formulation of the spectral/hp element method and provides an overview of its application to computational fluid dynamics. In particular, it focuses on the use the spectral/hp element method in transitional flows and ocean engineering. Finally, some of the major challenges to be overcome in order to use the spectral/hp element method in more complex science and engineering applications are discussed

    Regulation of pituitary growth hormone synthesis by NAD+ dependent deacetylase Sirt1

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    Gramaticalidad, corrección y adecuación en el aula de lengua. Observaciones desde la gramática generativa / Grammaticality, correctness and adequacy in the Language classroom. Observations from the Generative framework

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    El marco teórico de la Gramática Generativa argumenta que el ser humano posee una facultad del lenguaje con especificaciones lingüísticas heredada genéticamente. Desde este enfoque, el niño no asiste a la escuela para aprender su lengua materna ya que esta ya fue adquirida y no presenta aspectos deficientes o rudimentarios que deban ser perfeccionados. En este sentido, se plantea la necesidad de correrse de una pedagogía tradicional que solo focalice la práctica escolar en actividades como la memorización de reglas o análisis de oraciones. Este trabajo presenta posibles implicancias pedagógicas que la concepción innatista supone para la enseñanza de gramática en la clase de lengua. A la luz de estas implicancias teóricas, se busca reflexionar acerca de las nociones de gramaticalidad, corrección y adecuación y la manera en que estas pueden materializarse en una práctica pedagógica que permita explorar los mecanismos productivos de la lengua a través de tareas de análisis, comparación y generalización. Concretamente, esta discusión se presentará con actividades realizadas en el marco de dos talleres para docentes en Río Negro que muestran estos ejes centrales con temas como el uso del artículo definido con nombres propios y diferentes fenómenos de concordancia en la variedad de español presente en la Línea Sur de esta provincia.ABSTRACTThe Generative framework argues that human beings are genetically endowed to acquire language. This capacity comes from a language faculty with linguistic specifications that shape the language acquisition process. According to this approach, the child does not attend school to learn his mother tongue since he has already acquired it and this language is as perfect and complex as any other human language in the world. In this sense, it is suggested that we move away from a traditional view on grammar teaching that only focuses school practices on activities such as rule memorisation or sentence analysis. This paper analyses the pedagogical implications that the Innatist programme has on the teaching of grammar in the language classroom. First, we reflect on the notions of grammaticality, correctness and adequacy and how these can materialise into activities that allow for the exploration of language through activities that involve the analysis, comparison and generalisation of linguistic phenomena. To achieve this aim, the activities proposed in two workshops for teachers, in Río Negro will be analysed. These show a possible way in which these central axes can be dealt with in grammar topics such as the use of the definite article with proper names and different agreement phenomena in the Spanish variety characteristic of people at Linea Sur in our province

    Cosmic Covariance and the Low Quadrupole Anisotropy of the Wilkinson Microwave Anisotropy Probe (WMAP) Data

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    The quadrupole power of cosmic microwave background (CMB) temperature anisotropies seen in the WMAP data is puzzlingly low. In this paper we demonstrate that Minimum Variance Optimization (MVO), a technique used by many authors (including the WMAP science team) to separate the CMB from contaminating foregrounds, has the effect of forcing the extracted CMB map to have zero statistical correlation with the foreground emission. Over an ensemble of universes the true CMB and foreground are indeed expected to be uncorrelated, but any particular sky pattern (such as the one we happen to observe) will generate non-zero measured correlations simply by chance. We call this effect "cosmic covariance" and it is a possible source of bias in the CMB maps cleaned using the MVO technique. We show that the presence of cosmic covariance is expected to artificially suppress the variance of the Internal Linear Combination (ILC) map obtained via MVO. It also propagates into the multipole expansion of the ILC map, generating a quadrupole deficit with more than 90% confidence. Since we do not know the CMB and the foregrounds a priori, there is therefore an unknown contribution to the uncertainty in the measured quadrupole power, over and above the usual cosmic variance contribution. Using the MVO on a series of Monte Carlo simulations that assume Gaussian CMB fluctuations, we estimate that the real quadrupole power of the CMB lies in the range [305.16,400.40] microKelvin^2 (at the 1-sigma level).Comment: 3 figures, submitted to Ap

    Group recommender systems: A multi-agent solution

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    Providing recommendations to groups of users has become a promising research area, since many items tend to be consumed by groups of people. Various techniques have been developed aiming at making recommendations to a group as a whole. Most works use aggregation techniques to combine preferences, recommendations or profiles. However, satisfying all group members in an even way still remains as a challenge. To deal with this problem, we propose an extension of a multi-agent approach based on negotiation techniques for group recommendation. In the approach, we use the multilateral Monotonic Concession Protocol (MCP) to combine individual recommendations into a group recommendation. In this work, we extend the MCP protocol to allow users to personalize the behavior of the agents. This extension was evaluated in two different domains (movies and points of interest) with satisfactory results. We compared our approach against different baselines, namely: a preference aggregation algorithm, a recommendation aggregation algorithm, and a simple one-step negotiation. The results show evidence that, when using our negotiation approach, users in the groups are more uniformly satisfied than with traditional aggregation approaches.Fil: Villavicencio, Christian Paulo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Instituto Superior de Ingeniería del Software. Universidad Nacional del Centro de la Provincia de Buenos Aires. Instituto Superior de Ingeniería del Software; ArgentinaFil: Schiaffino, Silvia Noemi. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Instituto Superior de Ingeniería del Software. Universidad Nacional del Centro de la Provincia de Buenos Aires. Instituto Superior de Ingeniería del Software; ArgentinaFil: Diaz Pace, Jorge Andres. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Instituto Superior de Ingeniería del Software. Universidad Nacional del Centro de la Provincia de Buenos Aires. Instituto Superior de Ingeniería del Software; ArgentinaFil: Monteserin, Ariel José. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Instituto Superior de Ingeniería del Software. Universidad Nacional del Centro de la Provincia de Buenos Aires. Instituto Superior de Ingeniería del Software; Argentin
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