Kasahara, Javier. “Una relectura leibniziana al mecanicismo.”

Kasahara, Javier. “Una relectura leibniziana al mecanicismo.” Eidos 22(2015): 35-48

Descripción del análisis microbiológico realizado mediante maldi-tof en muestras de la fundación santa fe de Bogotá.

Introducción: La rápida detección e identificación bacteriana es fundamental para el manejo de los pacientes críticos que presentan una patología infecciosa, esto requiere de métodos rápidos para el inicio de un correcto tratamiento. En Colombia se usan pruebas microbiología convencional. No hay estudios de espectrofotometría de masas en análisis de muestras de pacientes críticos en Colombia. Objetivo general: Describir la experiencia del análisis microbiológico mediante la tecnología MALDI-TOF MS en muestras tomadas en la Fundación Santa Fe de Bogotá. Materiales y Métodos: Entre junio y julio de 2013, se analizaron 147 aislamientos bacterianos de muestras clínicas, las cuales fueron procesadas previamente por medio del sistema VITEK II. Los aislamientos correspondieron a 88 hemocultivos (60%), 28 urocultivos (19%), y otros cultivos 31 (21%). Resultados: Se obtuvieron 147 aislamientos con identificación adecuada a nivel de género y/o especie así: en el 88.4% (130 muestras) a nivel de género y especie, con una concordancia del 100% comparado con el sistema VITEK II. El porcentaje de identificación fue de 66% en el grupo de bacilos gram negativos no fermentadores, 96% en enterobacterias, 100% en gérmenes fastidiosos, 92% en cocos gram positivos, 100% bacilos gram negativos móviles y 100% en levaduras. No se encontró ninguna concordancia en bacilos gram positivos y gérmenes del genero Aggregatibacter. Conclusiones: El MALDI-TOF es una prueba rápida para la identificación microbiológica de género y especie que concuerda con los resultados obtenidos de manera convencional. Faltan estudios para hacer del MALDI-TOF MS la prueba oro en identificación de gérmenes.Introduction: Rapid detection and bacterial identification is essential for the management of critically ill patients who have an infectious disease, this requires quick and accurate for the start of proper treatment methods. In Colombia conventional microbiology tests are used. No studies mass spectrometry analysis of samples in critically ill patients in Colombia. Objective: Describe the experience of microbiological analysis by MALDI-TOF MS in samples taken at the Santa Fe de Bogota Foundation technology. Materials and Methods: Between June and July 2013, 147 bacterial isolates from clinical samples, which were previously processed by the VITEK IIsystem were analyzed. 88 isolates were blood cultures (60%), 28 urine cultures (19%), and other crops 31 (21%). Results: Of the 147 isolates obtained proper identification to genus and / or species as follows: 88. 4% in (130 samples) to genus and species, with a correlation of 100% compared to the VITEK II system. The identification percentage was 66% in gram negative bacilli group nonfermenting, 96% in Enterobacteriaceae, 100% in fastidious bacteria, 92% in gram-positive cocci, gram-negative bacilli 100% and 100% mobile yeast. There was no correlation in gram-positive bacilli and germs of the genus Aggregatibacter. Conclusions: The MALDI-TOF MS is a quick and easy for microbiological identification of genus and species which correlates with results obtained conventionally test. There are no studies to make the MALDI-TOF MS gold proof identification of germs.Jorge Armando Carrizosa Gonzale

Diseño de un sistema energético fotovoltaico para la Estación de Biodiversidad Tiputini de la Universidad San Francisco de Quito

The Biodiversity Station Tiputini has an energetic deficit, given that a diesel motor produces electricity for 6 hours a day. With the intention to improve its situation, and reduce the environmental impact, the present thesis project proposes the design of a standalone photovoltaic system that allows continuous electricity usage...La estación de biodiversidad Tiputini de la Universidad San Francisco de Quito presenta un déficit energético, debido a que solamente se existe luz eléctrica durante 6 horas al día, generadas por un motor a diésel. Con el afán de mejorar esta situación y reducir el impacto ambiental, el presente trabajo de tesis propone el diseño de un sistema solar fotovoltaico autónomo para la estación que permita tener una generación continua de energía eléctrica..

Metallogenesis of the Farallón Negro Rama Norte vein, Farallón Negro, Catamarca province

La veta Farallón Negro Rama Norte forma parte del yacimiento Farallón Negro ubicado en Hualfín, Departamento Belén, Catamarca. Este yacimiento se encuentra dentro del Complejo Volcánico Farallón Negro de edad terciaria, que constituye la roca de caja de un sistema de vetas rico en oro. La veta Farallón Negro Rama Norte tiene rumbo general N40°O e inclinación de 65° NE, tiene una corrida de 600 m, y se extiende desde la superficie hasta unos 400 m en profundidad. La roca de caja es una monzonita, que presenta distintos tipos de alteración hidrotermal: argílica intermedia, silicificación, fílica y propilítica. La veta está compuesta por una ganga de cuarzo, carbonatos y óxidos de manganeso con textura bandeada, coloforme y masiva. Los análisis geoquímicos indican que las muestras de veta ricas en oro son generalmente pobres en Ag y metales base. El oro muestra una correlación positiva con el Sb y una correlación negativa con el Mn. Los altos contenidos en elementos traza (As, Cu, Mo, Pb, V y Zn) de los óxidos de manganeso indican un origen hidrotermal. Los valores de isótopos de carbono y oxígeno de los carbonatos de la ganga sugieren que en el sistema hidrotermal participaron fluidos magmáticos y meteóricos.The Rama Norte vein in Farallón Negro deposit is located in Hualfín, Belén Department, Catamarca. This deposit belongs to the Tertiary Farallón Negro Volcanic Complex, the wall rock of the gold rich vein system. The Farallón Negro Rama Norte vein strikes N40°W, dips 65° NE, has 600 m length extends from the surface to a depth of about 400 meters. The wall rock is a monzonite with different types of hydrothermal alteration: intermediate argillic, silicic, phyllic and propylitic. The vein is composed of quartz, carbonates and Mn-oxides with banded, colloform and massive textures. The geochemical analyses indicate that gold-bearing vein samples are generally Ag- and base-metal poor. Gold also displays a positive correlation with Sb, but a negative correlation with Mn. High trace element contents (As, Cu, Mo, Pb, V and Zn) of polymineralic Mn-oxides suggest a hydrothermal origin. The values of carbon and oxygen isotopes in carbonates indicate magmatic and meteoric fluids participation in the hydrothermal system.Fil: Martínez, Facundo. Fundación Miguel Lillo; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Tucumán; ArgentinaFil: Fogliata, Ana Silvia. Universidad Nacional de Tucumán. Facultad de Ciencias Naturales e Instituto Miguel Lillo; Argentina. Fundación Miguel Lillo; ArgentinaFil: Montenegro, Nicolás. Yacimientos Mineros de Agua de Dionisio; ArgentinaFil: Hagemann, Steffen. University Of Western Australia; Australi

The deposition of the spin crossover Fe(II)-pyrazolylborate complex on Au(111) surface at molecular level

The interaction at molecular level of the spin-crossover FeII((3,5-(CH3)2Pz)3BH)2 complex with the Au(111) surface is analyzed by means of rPBE periodic calculations. Our results show that the adsorption on the metallic surface enhances the transition energy, increasing the relative stability of the low spin (LS) state. The interaction indeed is spin-dependent, stronger for the low spin than the high spin (HS) state. The different strength of the Fe ligand field at low and high temperature manifests on the nature, spatial extension and relative energy of the states close to the Fermi level, with a larger metal-ligand hybridization in the LS state. This feature is of relevance for the differential adsorption of the LS and HS molecules, the spin-dependent conductance, and for the differences found in the corresponding STM images, correctly reproduced from the density of states provided by the rPBE calculations. It is expected that this spin dependence will be a general feature of the SCO molecule-substrate interaction, since it is rooted in the different ligand field of Fe site at low and high temperatures, a common hallmark of the Fe(II) SCO complexes. Finally, the states involved in the LIESST phenomenon has been identify through NEVPT2 calculations on a model reaction path. A tentative pathway for the photoinduced LS--> HS transition is proposed, that does not involve the intermediate triplet states, and nicely reproduces both the blue laser wavelength required for the activation, and the wavelength of the reverse HS -> LS transition.Ministerio de Ciencia e InnovaciónFEDER fundsV Plan Propio de Investigacion Universidad de SevillaANID, Postdoctorado en el extranjero Becas Chile, folio 7420002

An update on the exploratory use of curcumin in neuropsychiatric disorders

This article belongs to the Special Issue Dietary Antioxidants against Neurodegenerative Diseases.Curcumin is a polyphenol extracted from the rhizome of the turmeric plant. Beyond its common use as a culinary spice in Eastern Asia, curcumin has been proposed as a therapeutic compound due to its antioxidant, anti-inflammatory and neuroprotective properties. Thus, its efficacy has been evaluated in various inflammatory-based psychiatric disorders, such as schizophrenia, depression, or autism. Our aim is to review those preclinical and clinical studies carried out in psychiatric disorders whose therapeutic approach has involved the use of curcumin and, therefore, to discern the possible positive effect of curcumin in these disorders. Preclinical studies and completed clinical trials of curcumin for psychiatric disorders published from January 2005 to October 2021 were identified through searching relevant databases until 31st October 2021. Sixty-five preclinical studies and 15 clinical trials and open-label studies were selected. Results showed a bias toward studies in depression and, to a lesser extent, schizophrenia. In all disorders, the results were positive in reducing psychiatric deficits. Despite the considerable number of beneficial outcomes reported, the small number of trials and the heterogeneity of protocols make it difficult to draw solid conclusions about the real potency of curcumin in psychiatric disorders.M.L.S.-M. was supported by the Ministerio de Ciencia, Innovación y Universidades, Instituto de Salud Carlos III (project number PI17/01766, and grant number BA21/00030), co-financed by the European Regional Development Fund (ERDF), "A way to make Europe", CIBER de Salud Mental (project number CB07/09/0031), Delegación del Gobierno para el Plan Nacional sobre Drogas (project number 2017/085); and Fundación Alicia Koplowitz (FAK16/01). D.R.-M. was supported by Consejería de Educación e investigación, Comunidad de Madrid, co-funded by the European Social Fund "Investing in your future" (grant, PEJD-2018-PRE/BMD-7899). N.L.-R. was supported by the Instituto de investigación Sanitaria Gregorio Marañón, "Programa Intramural de Impulso a la I+D+I 2019". The CNIC is supported by the Instituto de Salud Carlos III (ISCIII), the Ministerio de Ciencia e Innovación (MCIN) and the Pro CNIC Foundation, and is a Severo Ochoa Center of Excellence (SEV-2015-0505)

Spin-crossover complexes in nanoscale devices: main ingredients of the molecule–substrate interactions

Spin-crossover complexes embedded in nanodevices experience effects that are absent in the bulk that can modulate, quench and even suppress the spin-transition. In this work we explore, by means of state-of-the-art quantum chemistry calculations, different aspects of the integration of SCO molecules on active nanodevices, such as the geometry and energetics of the interaction with the substrate, extension of the charge transfer between the substrate and SCO molecule, impact of the applied external electric field on the spin-transition, and sensitivity of the transport properties on the local conditions of the substrate. We focus on the recently reported encapsulation of Fe(II) spin-crossover complexes in single-walled carbon nanotubes, with new measurements that support the theoretical findings. Even so our results could be useful to many other systems where SCO phenomena take place at the nanoscale, the spin-state switching is probed by an external electric field or current, or the substrate is responsible for the quenching of the SCO mechanism.Ministerio de Ciencia e Innovación de España, Agencia Estatal de Investigación de España y Fondos FEDER. (MCI/ AEI/FEDER,UE) PGC2018-101689-B-I00, RTI2018-096075-A-C22 y RYC2019-028429-

Diseño, construcción y control de un prototipo de brazo robótico antropomórfico para la soldadura por punto de direfentes figuras, mediante el uso de cinemática inversa y visión artificial

El proyecto técnico consiste en el diseño, construcción y control de un prototipo de brazo robótico antropomórfico de tres grados de libertad para la soldadura de punto de piezas metálicas, mediante la obtención de las coordenadas de los puntos de interés utilizando visión artificial. El proyecto utiliza amplios conocimientos de mecánica, electrónica y programación para automatizar de manera eficaz las funciones que realiza el prototipo. En este trabajo se detalla paso a paso el diseño y la construcción de cada una de sus partes. También se realiza el estudio del modelo cinemático inverso del brazo robótico para el cálculo de los ángulos de giro de cada servomotor para que el efector final se coloque en una coordenada o punto establecido. Además, se especifica el hardware y software empleados para el control general del prototipo en el que se incluye la programación en Matlab y la conexión de todos los componentes electrónicos utilizados para establecer el orden lógico de funcionamiento. Finalmente, se realizan pruebas de funcionamiento y también se calcula el porcentaje de error con el que trabaja tanto la visión artificial como el modelo cinemático inverso.The technical project consists of the design, construction and control of an anthropomorphic robotic arm prototype with three degrees of freedom for spot welding of metal parts, by obtaining the coordinates of the points of interest using artificial vision. The project uses extensive knowledge of mechanics, electronics and programming to effectively automate the functions performed by the prototype. This work details the design and construction of each of its parts step by step. The study of the inverse kinematic model of the robotic arm is also carried out to calculate the angles of rotation of each servomotor so that the final effector is placed in an established coordinate or point. In addition, the hardware and software used for the general control of the prototype in which Matlab programming is included and the connection of all the electronic components used to establish the logical order of specified operation. Finally, performance tests are performed and the percentage of mistake with which both the artificial vision and the inverse kinematic model works