Global-scale human pressure evolution imprints on sustainability of river systems

Human pressures on river systems pose a major threat to the sustainable development of human societies in the twenty-first century. Previous studies showed that a large part of global river systems was already exposed to relevant anthropogenic pressures at the beginning of this century. A relevant question that has never been explained in the literature so far is whether these pressures are increasing in time, therefore representing a potential future challenge to the sustainability of river systems. This paper proposes an index we call \u201cDifferential Human Pressure on Rivers\u201d (DHPR) to quantify the annual evolution of human pressure on river systems. DHPR identifies a per-year percentage increment (or decrement) of normalized human pressures on river systems (i.e., ratio of annual values to long-term average). This index, based on annual nightlights and stationary discharge data, is estimated for 2195 major river basins over a period of 22 years, from 1992 to 2013. The results show that normalized annual human pressure on river systems increased globally, as indicated by an average DHPR value of 1.9\u2009% per year, whereby the greatest increase occurred in the northern tropical and equatorial areas. The evaluation of DHPR over this 22-year period allows the identification of hot-spot areas, therefore offering guidance on where the development and implementation of mitigation strategies and plans are most needed (i.e., where human pressure is strongly increasing)

Cannabinoid system combined to classic targets for a new MTDL strategy: design and synthesis of natural inspired molecules for Alzheimer's disease

In this thesis is described the design and synthesis of potential agents for the treatment of the multifactorial Alzheimer’s disease (AD). Our multi-target approach was to consider cannabinoid system involved in AD, together with classic targets. In the first project, designed modifications were performed on lead molecule in order to increase potency and obtain balanced activities on fatty acid amide hydrolase and cholinesterases. A small library of compounds was synthesized and biological results showed increased inhibitory activity (nanomolar range) related to selected target. The second project was focused on the benzofuran framework, a privileged structure being a common moiety found in many biologically active natural products and therapeutics. Hybrid molecules were designed and synthesized, focusing on the inhibition of cholinesterases, Aβ aggregation, FAAH and on the interaction with CB receptors. Preliminary results showed that several compounds are potent CB ligands, in particular the high affinity for CB2 receptors, could open new opportunities to modulate neuroinflammation. The third and the fourth project were carried out at the IMS, Aberdeen, under the supervision of Prof. Matteo Zanda. The role of the cannabinoid system in the brain is still largely unexplored and the relationship between the CB1 receptors functional modification, density and distribution and the onset of a pathological state is not well understood. For this reasons, Rimonabant analogues suitable as radioligands were synthesized. The latter, through PET, could provide reliable measurements of density and distribution of CB1 receptors in the brain. In the fifth project, in collaboration with CHyM of York, the goal was to develop arginine analogues that are target specific due to their exclusively location into NOS enzymes and could work as MRI contrasting agents. Synthesized analogues could be suitable substrate for the transfer of polarization by p-H2 molecules through SABRE technique transforming MRI a more sensitive and faster technique

Panta Rhei: an evolving scientific decade with a focus on water systems

Abstract. The paper presents an overview of the activity of Panta Rhei, the research decade launched in 2013 by the International Association of Hydrological Sciences. After one year of activity Panta Rhei has already stimulated several initiatives and a worldwide involvement of researchers in hydrology and sister disciplines. Providing an overview of the status of Panta Rhei is essential to further promote the participation of scientists and the completion of its structure, which is currently being shaped by receiving Research Theme and Working Group proposals from the community

Human signatures derived from nighttime lights along the Eastern Alpine river network in Austria and Italy

Abstract. Understanding how human settlements and economic activities are distributed with reference to the geographical location of streams and rivers is of fundamental relevance for several issues, such as flood risk management, drought management related to increased water demands by human population, fluvial ecosystem services, water pollution and water exploitation. Besides the spatial distribution, the evolution in time of the human presence constitutes an additional key question. This work aims at understanding and analysing the spatial and temporal evolution of human settlements and associated economic activity, derived from nighttime lights, in the Eastern Alpine region. Nightlights, available at a fine spatial resolution and for a 22-year period, constitute an excellent data base, which allows one to explore in details human signatures. In this experiment, nightlights are associated to five distinct distance-from-river classes. Our results clearly point out an overall enhancement of human presence across the considered distance classes during the last 22 years, though presenting some differences among the study regions. In particular, the river network delineation, by considering different groups of river pixels based on the Strahler order, is found to play a central role in the identification of nightlight spatio-temporal trends

Study of a mobile app interface supporting behaviour change in electric vehicles use

This paper is based on a study aimed at examining how historical data on energy consumptions in electric vehicles could be (re)designed by taking into account Kahneman’s theories (in particular “Fast and Slow thinking”, Kahneman, 2011 and “Prospect Theory”, Kahneman & Tversky, 1979): they should be applied to support driver’s behaviour changing, in particular eco-driving, by focusing on loss rather than gain. This paper describes i) the design of an HMI concept as part of a mobile app, providing information on energy consumption in two versions (loss/gain of recovered km). It is based on a literature analysis on energy use behaviour and eco-driving and an analysis of information systems for home energy use and instrument clusters already in use in electric vehicles (Fully Electric - FEV and Hybrid - HEV, ii) a heuristic evaluation of the HMI concept; ii) outcomes from a co-design session

Topography- and nightlight-based national flood risk assessment in Canada

Abstract. In Canada, flood analysis and water resource management, in general, are tasks conducted at the provincial level; therefore, unified national-scale approaches to water-related problems are uncommon. In this study, a national-scale flood risk assessment approach is proposed and developed. The study focuses on using global and national datasets available with various resolutions to create flood risk maps. First, a flood hazard map of Canada is developed using topography-based parameters derived from digital elevation models, namely, elevation above nearest drainage (EAND) and distance from nearest drainage (DFND). This flood hazard mapping method is tested on a smaller area around the city of Calgary, Alberta, against a flood inundation map produced by the city using hydraulic modelling. Second, a flood exposure map of Canada is developed using a land-use map and the satellite-based nightlight luminosity data as two exposure parameters. Third, an economic flood risk map is produced, and subsequently overlaid with population density information to produce a socioeconomic flood risk map for Canada. All three maps of hazard, exposure, and risk are classified into five classes, ranging from very low to severe. A simple way to include flood protection measures in hazard estimation is also demonstrated using the example of the city of Winnipeg, Manitoba. This could be done for the entire country if information on flood protection across Canada were available. The evaluation of the flood hazard map shows that the topography-based method adopted in this study is both practical and reliable for large-scale analysis. Sensitivity analysis regarding the resolution of the digital elevation model is needed to identify the resolution that is fine enough for reliable hazard mapping, but coarse enough for computational tractability. The nightlight data are found to be useful for exposure and risk mapping in Canada; however, uncertainty analysis should be conducted to investigate the effect of the overglow phenomenon on flood risk mapping

ANALISI DELLA PRESSIONE ANTROPICA SUL RETICOLO IDROGRAFICO ITALIANO TRAMITE DATI SATELLITARI DI LUMINOSITÀ NOTTURNA AD ALTA DEFINIZIONE

- I dati satellitari di luce notturna consentono la stima del livello di antropizzazione del territorio. - Al fine della valutazione del rischio idraulico in Italia, si analizzano dati di luminosità notturna in prossimità planimetrica ed altimetrica della rete idrografica . - L’analisi dei trend temporali di luminosità notturna in prossimità dei corsi idrici permette l’individuazione di possibili aree a rischio idraulico. con quanto riportato in letteratur

Robot-Assisted Radical Hysterectomy for Cervical Cancer: Review of Surgical and Oncological Outcomes

Robot-assisted procedures are being increasingly incorporated in gynaecologic oncology. Several studies have confirmed the feasibility and safety of robotic radical hysterectomy for selected patients with early-stage cervical cancer. It has been demonstrated that robotic radical hysterectomy offers an advantage over other surgical approaches with regard to operative time, blood loss, and hospital stay. Also initial evidences concerning oncological outcomes seem to confirm the equivalence to traditional open technique. Despite the fact that costs of robotic system are still high, they could be partially offset by several health-related and social benefits: less pain, faster dismissal, and return to full activity than other surgical approaches. The development of robotic technology may facilitate the spread of minimally invasive surgery in gynaecological oncology, overcoming some drawbacks of laparoscopic technique for challenging intervention such as radical hysterectomy. Further studies are needed to evaluate overall and disease-free survival of this technique and associated morbidity after adjuvant therapies

Globally Universal Fractal Pattern of Human Settlements in River Networks

River networks play a key role in the spatial organization of human settlements. Both river networks and human settlements have been found to exhibit regular self-similar patterns, but little is known about the generalized spatial patterns of human settlements embedded within river networks. Here based on night light data, we find a universal fractal structure at the global scale, with both robust Hortonian scaling relationships with the extent of human settlements and statistically significant power law scaling of the power spectra of human area functions. Globally, we find consistent patterns of power law preferential downstream clustering of human settlements across all six populated continents, typically up to 40% of the maximum flow length. This downstream clustering suggests an optimum distribution of humans in large river basins for trade, transport, and natural resource utilization but with attendant implications for human impacts on rivers. Recognition of such spatial patterns helps generalize assessments of human impacts on rivers, with direct implications for management of water quality and biological diversity in river networks

dose administration maneuvers and patient care in tobramycin dry powder inhalation therapy

Abstract The purpose of this work was to study a new dry powder inhaler (DPI) of tobramycin capable to simplify the dose administration maneuvers to maximize the cystic fibrosis (CF) patient care in antibiotic inhalation therapy. For the purpose, tobramycin/sodium stearate powder (TobraPS) having a high drug content, was produced by spray drying, characterized and the aerodynamic behavior was investigated in vitro using different RS01 DPI inhalers. The aerosols produced with 28, 56 or 112 mg of tobramycin in TobraPS powder using capsules size #3, #2 or #0 showed that there was quasi linear relationship between the amount loaded in the device and the FPD. An in vivo study in healthy human volunteers showed that 3–6 inhalation acts were requested by the volunteers to inhale 120 mg of TobraPS powder loaded in a size #0 capsule aerosolized with a prototype RS01 device, according to their capability to inhale. The amount of powder emitted at 4 kPa pressure drop at constant air flow well correlated with the in vivo emission at dynamic flow, when the same volume of air passed through the device. The novel approach for the administration of 112 mg of tobramycin in one capsule could improve the convenience and adherence of the CF patient to the antibiotic therapy