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Nuclear matrix protein 2 antibody-positive adult dermatomyositis: a case report and review of the literature
Dermatomyositis is a clinically heterogenous inflammatory myopathy with unique cutaneous features. Myositis-specific antibodies can aid in diagnosis and anticipation of patient prognosis. Herein, we report a 22-year-old man who presented with multifocal erythematous plaques with violaceous papules on his bilateral elbows, neck, and face. He was diagnosed with biopsy-proven dermatomyositis and determined to be seropositive for nuclear matrix protein 2 antibody (NXP-2). He was treated with systemic corticosteroids, then intravenous methylprednisolone and azathioprine, and ultimately achieved greatest treatment response with intravenous immune globulin therapy
Identification of gene pathways implicated in Alzheimer's disease using longitudinal imaging phenotypes with sparse regression
We present a new method for the detection of gene pathways associated with a
multivariate quantitative trait, and use it to identify causal pathways
associated with an imaging endophenotype characteristic of longitudinal
structural change in the brains of patients with Alzheimer's disease (AD). Our
method, known as pathways sparse reduced-rank regression (PsRRR), uses group
lasso penalised regression to jointly model the effects of genome-wide single
nucleotide polymorphisms (SNPs), grouped into functional pathways using prior
knowledge of gene-gene interactions. Pathways are ranked in order of importance
using a resampling strategy that exploits finite sample variability. Our
application study uses whole genome scans and MR images from 464 subjects in
the Alzheimer's Disease Neuroimaging Initiative (ADNI) database. 66,182 SNPs
are mapped to 185 gene pathways from the KEGG pathways database. Voxel-wise
imaging signatures characteristic of AD are obtained by analysing 3D patterns
of structural change at 6, 12 and 24 months relative to baseline. High-ranking,
AD endophenotype-associated pathways in our study include those describing
chemokine, Jak-stat and insulin signalling pathways, and tight junction
interactions. All of these have been previously implicated in AD biology. In a
secondary analysis, we investigate SNPs and genes that may be driving pathway
selection, and identify a number of previously validated AD genes including
CR1, APOE and TOMM40
Quiz Games as a model for Information Hiding
We present a general computation model inspired in the notion of information
hiding in software engineering. This model has the form of a game which we call
quiz game. It allows in a uniform way to prove exponential lower bounds for
several complexity problems of elimination theory.Comment: 46 pages, to appear in Journal of Complexit
The LMT Galaxies' 3 mm Spectroscopic Survey: First Results
The molecular phase of the interstellar medium (ISM) in galaxies offers
fundamental insight for understanding star-formation processes and how stellar
feedback affects the nuclear activity of certain galaxies. We present here
Large Millimeter Telescope spectra obtained with the Redshift Search Receiver,
a spectrograph that cover simultaneously the 3 mm band from 74 to 111 GHz with
a spectral resolution of around 100 km/s. The observed galaxies that have been
detected previously in HCN, have different degrees of nuclear activity, one
normal galaxy (NGC 6946), the starburst prototype (M 82) and two ultraluminous
infrared galaxies (ULIRGs, IRAS 17208-0014 and Mrk 231). We plotted our data in
the HCO+/HCN vs. HCN/13CO diagnostic diagram finding that NGC 6946 and M 82 are
located close to other normal galaxies; and that both IRAS 17208-0014 and Mrk
231 are close to the position of the well known ULIRG Arp 220 reported by Snell
et al. (2011). We found that in Mrk 231 -- a galaxy with a well known active
galactic nucleus -- the HCO+/HCN ratio is similar to the ratio observed in
other normal galaxies.Comment: Proceedings to appear in "Massive Young Star Clusters Near and Far:
From the Milky Way to Reionization", 2013 Guillermo Haro Conference. Eds. Y.
D. Mayya, D. Rosa-Gonzalez, & E. Terlevich, INAOE and AMC. 5 pages, 1 figur
Loss of doctor-to-doctor communication:lessons from the reconfiguration of mental health services in England
Evolving rules for document classification
We describe a novel method for using Genetic Programming to create compact classification rules based on combinations of N-Grams (character strings). Genetic programs acquire fitness by producing rules that are effective classifiers in terms of precision and recall when evaluated against a set of training documents. We describe a set of functions and terminals and provide results from a classification task using the Reuters 21578 dataset. We also suggest that because the induced rules are meaningful to a human analyst they may have a number of other uses beyond classification and provide a basis for text mining applications
Mediterranean House Geckos Exploit Novel Resources in a Recipient Lizard Assemblage
A speciesā ecological niche represents the environmental conditions needed for an individual to replace itself and is comprised of multiple resource axes (Pianka 2000 Evol. Ecol.).
One mechanism of establishment of non-native species is via exploitation of novel resources in recipient ecosystems through their unique functional traits (Schalk et al. 2018 Biol. Invas.).
Mediterranean House Geckos (Hemidactylus turcicus) are an exotic species introduced in urban areas across Texas, yet little is known about their resource use relative to native lizards.
We hypothesized that H. turcicus would exhibit low overlap in resource use in their habitat, dietary, and isotopic niches compared to native lizard species (Green Anole [Anolis carolinensis], Little Brown Skink [Scincella lateralis], Five-lined Skink [Plestiodon fasciatus])
Enhanced GABAergic actions resulting from the coapplication of the steroid 3Ī±-hydroxy-5Ī±-pregnane-11,20-dione (alfaxalone) with propofol or diazepam
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