a longitudinal study among men and women with non-small cell lung cancer

Background We investigated the determinants of trajectories of physical symptoms related to lung cancer (a quality of life [QOL] aspect) and self- efficacy among patients with non-small cell lung cancer (NSCLC). It was hypothesized that gender and family cancer history in first-degree relatives would have synergistic effects on QOL-lung cancer specific symptoms and self- efficacy. Women with family cancer history were expected to be at risk of poorer adjustment. Methods Quantitative, longitudinal design was applied. Participants provided their responses at 3–4 days after surgery, 1-month follow-up, and 4-month follow-up. We recruited 102 in-patients (men: 51%) with NSCLC who underwent surgery aimed at removing a lung tumor. Self-report data were collected with QLQ-LC13 and a scale for self-efficacy for managing illness. Results Mixed-models analysis indicated that trajectories of physical quality of life (symptoms of lung cancer) as well as self-efficacy were unfavorable among women with family cancer history. Conclusions Among NSCLC patients, gender and family cancer history may be considered basic screening criteria for identifying groups of patients at risk for poorer physical QOL (higher level of physical symptoms related to lung cancer) and lower incline of self-efficacy after cancer surgery

Origin and History of Mitochondrial DNA Lineages in Domestic Horses

Domestic horses represent a genetic paradox: although they have the greatest number of maternal lineages (mtDNA) of all domestic species, their paternal lineages are extremely homogeneous on the Y-chromosome. In order to address their huge mtDNA variation and the origin and history of maternal lineages in domestic horses, we analyzed 1961 partial d-loop sequences from 207 ancient remains and 1754 modern horses. The sample set ranged from Alaska and North East Siberia to the Iberian Peninsula and from the Late Pleistocene to modern times. We found a panmictic Late Pleistocene horse population ranging from Alaska to the Pyrenees. Later, during the Early Holocene and the Copper Age, more or less separated sub-populations are indicated for the Eurasian steppe region and Iberia. Our data suggest multiple domestications and introgressions of females especially during the Iron Age. Although all Eurasian regions contributed to the genetic pedigree of modern breeds, most haplotypes had their roots in Eastern Europe and Siberia. We found 87 ancient haplotypes (Pleistocene to Mediaeval Times); 56 of these haplotypes were also observed in domestic horses, although thus far only 39 haplotypes have been confirmed to survive in modern breeds. Thus, at least seventeen haplotypes of early domestic horses have become extinct during the last 5,500 years. It is concluded that the large diversity of mtDNA lineages is not a product of animal breeding but, in fact, represents ancestral variability

Against all odds: ethical dilemmas in modern peri- and neonatal medicine

Recent advances in neonatal and perinatal medicine (NPM) enable greater chances of survival for premature infants. Due to the advent of neonatal intensive care units (NICU), infants born today at 24-25 weeks of gestation have an increased chance of survival. Over the past few years, the limits of viability have been further challenged, aiming to push the boundary of survivability down to 22-23 weeks of gestation. These advances come with controversies and concerns regarding long-term neurodevelopmental and learning disabilities. The decision to stop intensive support in futile circumstances requires the involvement of family members and a multidisciplinary team of healthcare providers who may not share the same views, therefore necessitating a collaborative, interdisciplinary care framework to promote communication and transparency in healthcare decision-making. This balanced approach requires consideration of clinical evidence while respecting the personal, cultural, and religious views of the family. Additionally, the growing influence of social media has a profound impact on healthcare information, public perception, and care expectations. The cost of supporting premature infants and caring for prematurity-related morbidities with unique developmental needs can carry a substantial financial burden. In high-income countries, these costs undergo constant contemplation due to financial pressures entangled with questions about quality of life, pain, and suffering. In contrast, restricted resources in low-income countries mean that care is largely limited to treating full-term infants and providing only essential care to support a healthy pregnancy. The incidence of preterm birth in low-income countries can be reduced through better maternal education, family planning, extended breastfeeding, more optimal birth spacing, preventive health measures, and hygiene strategies. </p

Women with family cancer history are at risk for poorer physical quality of life and lower self-efficacy: a longitudinal study among men and women with non-small cell lung cancer

Background: We investigated the determinants of trajectories of physical symptoms related to lung cancer (a quality of life [QOL] aspect) and self-efficacy among patients with non-small cell lung cancer (NSCLC). It was hypothesized that gender and family cancer history in first-degree relatives would have synergistic effects on QOL-lung cancer specific symptoms and self-efficacy. Women with family cancer history were expected to be at risk of poorer adjustment. Methods: Quantitative, longitudinal design was applied. Participants provided their responses at 3–4 days after surgery, 1-month follow-up, and 4-month follow-up. We recruited 102 in-patients (men: 51%) with NSCLC who underwent surgery aimed at removing a lung tumor. Self-report data were collected with QLQ-LC13 and a scale for self-efficacy for managing illness. Results: Mixed-models analysis indicated that trajectories of physical quality of life (symptoms of lung cancer) as well as self-efficacy were unfavorable among women with family cancer history. Conclusions: Among NSCLC patients, gender and family cancer history may be considered basic screening criteria for identifying groups of patients at risk for poorer physical QOL (higher level of physical symptoms related to lung cancer) and lower incline of self-efficacy after cancer surgery

Twenty-five thousand years of fluctuating selection on leopard complex spotting and congenital night blindness in horses.

International audienceLeopard complex spotting is inherited by the incompletely dominant locus, LP, which also causes congenital stationary night blindness in homozygous horses. We investigated an associated single nucleotide polymorphism in the TRPM1 gene in 96 archaeological bones from 31 localities from Late Pleistocene (approx. 17 000 YBP) to medieval times. The first genetic evidence of LP spotting in Europe dates back to the Pleistocene. We tested for temporal changes in the LP associated allele frequency and estimated coefficients of selection by means of approximate Bayesian computation analyses. Our results show that at least some of the observed frequency changes are congruent with shifts in artificial selection pressure for the leopard complex spotting phenotype. In early domestic horses from Kirklareli-Kanligecit (Turkey) dating to 2700-2200 BC, a remarkably high number of leopard spotted horses (six of 10 individuals) was detected including one adult homozygote. However, LP seems to have largely disappeared during the late Bronze Age, suggesting selection against this phenotype in early domestic horses. During the Iron Age, LP reappeared, probably by reintroduction into the domestic gene pool from wild animals. This picture of alternating selective regimes might explain how genetic diversity was maintained in domestic animals despite selection for specific traits at different times