Physicochemical properties and biological effects of quaternary ammonium methacrylates in an experimental adhesive resin for bonding orthodontic brackets

Fixed orthodontic appliances may lead to biofilm accumulation around them that may increase caries risk. This study aimed to evaluate the influence of quaternary ammonium methacrylates (QAMs) on the physicochemical properties, cytotoxicity, and antibacterial activity of adhesive resins for orthodontic purposes. Methodology: A base resin was prepared with a comonomer blend and photoinitiator/co-initiator system. Two different QAMs were added to the base adhesive: dimethylaminododecyl methacrylate at 5 wt.% (DMADDM) or dimethylaminohexadecyl methacrylate (DMAHDM) at 10 wt.%. The base adhesive, without QAMs, (GC) and the commercial Transbond™ XT Primer 3M (GT) were used as control. The resins were tested immediately and after six months of aging in the water regarding the antibacterial activity and shear bond strength (SBS). The antibacterial activity was tested against Streptococcus mutans via metabolic activity assay (MTT test). The groups were also tested for the degree of conversion (DC) and cytotoxicity against keratinocytes. Results:The resins containing QAM showed antibacterial activity compared to the commercial material by immediately reducing the metabolic activity by about 60%. However, the antibacterial activity decreased after aging (p<0.05). None of the groups presented any differences for SBS (p>0.05) and DC (p>0.05). The incorporation of DMADDM and DMAHDM significantly reduced the keratinocyte viability compared to the GT and GC groups (p<0.05). Conclusion: Both adhesives with QAMs showed a significant reduction in bacterial metabolic activity, but this effect decreased after water aging. Lower cell viability was observed for the group with the longer alkyl chain-QAM, without significant differences for the bonding ability and degree of conversion. The addition of QAMs in adhesives may affect the keratinocytes viability, and the aging effects maybe decrease the bacterial activity of QAM-doped materials

Beni comuni. Quarto rapporto sulla cooperazione sociale in Italia

A dieci anni dalla prima edizione, il quarto rapporto sulla cooperazione sociale aggiorna e amplia il quadro conoscitivo su uno dei più innovativi fenomeni imprenditoriali, che ha contribuito ad arricchire il panorama delle istituzioni sociali del paese.- Indice #5- Premessa di Marco Demarie #13- Presentazione di Corrado Passera #15- Prefazione di Vilma Mazzocco e Johnny Dotti #21- Cap.I La cooperazione sociale in Italia: tendenze evolutive e scenari di sviluppo, Flaviano Zandonai #33- Cap.II Un quadro teorico sull’impresa sociale, Carlo Borzaga #55- Cap.III Le traiettorie di sviluppo della cooperazione sociale, Gianfranco Marocchi #75- Cap.IV Imprenditorialità sociale tra innovazione e controllo dei mercati, Nereo Zamaro #107- Cap.V Cooperazione sociale e Mezzogiorno, Marco Musella #139- Cap.VI Le culture organizzative della cooperazione sociale: identità in movimento, Luca Fazzi e Sandro Stanzani #151- Cap.VII La cooperazione sociale nella rete del welfare locale, Sergio Pasquinelli #187- Cap.VIII I benefici individuali dei lavoratori svantaggiati nelle imprese sociali, Carlo Borzaga, Monica Loss e Domenico Zalla #207- Cap.IX Cooperazione sociale e qualità dei servizi, Giuseppe Scaratti #237- Cap.X La cooperazione sociale in una prospettiva di genere, Barbara Moreschi #265- Cap.XI Cooperativa sociale come impresa sociale? Le condizioni di imprenditorialità nel terzo settore, Michele Andreaus #285- Cap.XII Oltre il contracting out: nuove forme di relazione con le amministrazioni pubbliche, Franco Dalla Mura #319- Cap.XIII Finalità e organizzazione delle cooperative sociali: alcune indicazioni dal nuovo diritto societario, Antonio Fici #349- Cap.XIV L’impresa sociale in Italia: una quantificazione del fenomeno, Stefano Cima #377- Cap.XV Le condizioni di sviluppo delle imprese sociali nelle regioni del Centro-Nord, Carlo Borzaga e Mariangela Mongera #405- Cap.XVI Dal volontariato all’impresa sociale, Gabriella Bartolomeo e Flaviano Zandonai #439- Cap.XVII L’impresa sociale in Europa: alcuni spunti di comparazione, Paola Iamiceli #457- Cap.XVIII La nuova legge sull’impresa sociale, Felice Scalvini #485- Bibliografia #49

Canagliflozin and renal outcomes in type 2 diabetes and nephropathy

BACKGROUND Type 2 diabetes mellitus is the leading cause of kidney failure worldwide, but few effective long-term treatments are available. In cardiovascular trials of inhibitors of sodium–glucose cotransporter 2 (SGLT2), exploratory results have suggested that such drugs may improve renal outcomes in patients with type 2 diabetes. METHODS In this double-blind, randomized trial, we assigned patients with type 2 diabetes and albuminuric chronic kidney disease to receive canagliflozin, an oral SGLT2 inhibitor, at a dose of 100 mg daily or placebo. All the patients had an estimated glomerular filtration rate (GFR) of 30 to <90 ml per minute per 1.73 m2 of body-surface area and albuminuria (ratio of albumin [mg] to creatinine [g], >300 to 5000) and were treated with renin–angiotensin system blockade. The primary outcome was a composite of end-stage kidney disease (dialysis, transplantation, or a sustained estimated GFR of <15 ml per minute per 1.73 m2), a doubling of the serum creatinine level, or death from renal or cardiovascular causes. Prespecified secondary outcomes were tested hierarchically. RESULTS The trial was stopped early after a planned interim analysis on the recommendation of the data and safety monitoring committee. At that time, 4401 patients had undergone randomization, with a median follow-up of 2.62 years. The relative risk of the primary outcome was 30% lower in the canagliflozin group than in the placebo group, with event rates of 43.2 and 61.2 per 1000 patient-years, respectively (hazard ratio, 0.70; 95% confidence interval [CI], 0.59 to 0.82; P=0.00001). The relative risk of the renal-specific composite of end-stage kidney disease, a doubling of the creatinine level, or death from renal causes was lower by 34% (hazard ratio, 0.66; 95% CI, 0.53 to 0.81; P<0.001), and the relative risk of end-stage kidney disease was lower by 32% (hazard ratio, 0.68; 95% CI, 0.54 to 0.86; P=0.002). The canagliflozin group also had a lower risk of cardiovascular death, myocardial infarction, or stroke (hazard ratio, 0.80; 95% CI, 0.67 to 0.95; P=0.01) and hospitalization for heart failure (hazard ratio, 0.61; 95% CI, 0.47 to 0.80; P<0.001). There were no significant differences in rates of amputation or fracture. CONCLUSIONS In patients with type 2 diabetes and kidney disease, the risk of kidney failure and cardiovascular events was lower in the canagliflozin group than in the placebo group at a median follow-up of 2.62 years

Os condicionantes econômicos e políticos no relacionamento Brasil-Venezuela de 1990-1998

No presente trabalho busca-se explicar as transformações ocorridas nas relações entre Brasil e Venezuela ao longo de um período que se inicia em 1990 e se estende até 1998. Temse como objetivo identificar os condicionantes políticos e econômicos e os agentes principais desse processo que se caracterizou pela aceleração e densificação das relações bilaterais, principalmente após o encontro presidencial de La Guzmania, no dia 4 de março de 1994. Para melhor compreender esse processo, são estudados, num primeiro capítulo, os antecedentes das relações entre Brasil e Venezuela; em seguida, no segundo capítulo, são analisadas as transformações ocorridas no sistema internacional entre as décadas de 1980 e 1990, depois são analisados os processos de formação de blocos e de cooperação na América Latina nesse novo contexto internacional e o impacto das transformações do cenário internacional nas políticas externas do Brasil e da Venezuela. Finalmente, no último capítulo, através da análise dos dados empíricos coletados durante a pesquisa de campo e do estudo da bibliografia disponível, busca-se verificar os fatos políticos e econômicos, ocorridos entre 1990 a 1998, que marcaram as relações entre os dois países e explicar a intensificação do processo de aproximação entre Brasil e Venezuela nesse período.This paper aims to analyze the relationship between Brazil and Venezuela, from 1990 to 1998. The intention is to confirm, and then explain, the process, during those nine years, that brought the two countries into a deeper cooperation. For a better understanding, the past history of the relationship between Brazil and Venezuela is studied in the first chapter; in the next chapter, the transformations of the international system within 1980 and 1990, the Free Trade Areas trend in Latin America, and the impact of those changes in the international system over the Brazilian and Venezuelan foreign policies is analyzed. Finally, in the last chapter, relationship between Brazil and Venezuela is studied in details through the analysis of the researched data. It intends to identify the political and economical motivations behind the pattern’s change in the relationship between the two countries

Work Integration: Social Enterprises in Italy

This working paper is a project of the EMES European Research Network which is devoted to third sector research. This particular paper focuses on the Italian labour market of the 1990s and the ways in which business enterprise can encourage the integration of socially disadvantaged workers. It describes the ways that the third sector (and also the government and the for-profit sector) has dealt with disadvantaged workers by creating social enterprise. The paper includes a large proportion of statistics and a bibliography

Review of indicators for comparing environmental effects across energy sources

Robust, quantitative comparisons of environmental effects across energy sources can support development of energy planning strategies that meet growing demand while managing and minimizing undesirable effects on environmental resources. Multicriteria analyses of energy systems often use a suite of indicators to make such comparisons, but those indicators and their units of measure vary among studies. We reviewed 179 papers that described or applied energy indicators to compare environmental effects of different primary energy sources to answer four questions: (1) what environmental indicators have been used in multicriteria energy-source comparisons? (2) across studies, how consistently are these indicators used to quantify effects? (3) to what degree are different effects accounted for across energy sources and locations? and (4) how comprehensive are indicators in terms of assessing known environmental effects? For reviewed studies, we quantified the number of unique indicators and the diversity of indicators used to measure different effects. We also recorded the specific measurement units applied to quantify each indicator, the energy sources evaluated, and the continent where each study was conducted. While we found that many environmental effects of energy development have been analyzed across multiple sources, indicators were frequently measured, interpreted, and applied in ways that are not directly comparable, and some known environmental effects were infrequently assessed. We also found an emphasis on applying indicators to renewable energy sources; assessing current and potential energy sources, both renewable and nonrenewable, would greatly clarify the full suite of tradeoffs among sources and can inform energy development strategies that minimize adverse environmental effects. Overall, our review indicated that making comprehensive comparisons of the effects of energy development across sources may require efforts to standardize how effects are measured, synthesize effects literature into an open-source database, expand the range of environmental effects analyzed, and establish consistent frameworks for comparison