Is Lenalidomide, in Combination with Dexamethasone, a Safe and Effective Treatment for Relapsed Multiple Myeloma?

OBJECTIVE: The objective of this systematic review is to determine whether or not lenalidomide, in combination with dexamethasone, is a safe and effective treatment for relapsed multiple myeloma

Diseño de una guia web-interactiva en base a los contenidos de la asignatura dirigida a docentes y estudiantes

PDFEl propósito de esta tesis de investigación es considerar el diseño de una guía web interactiva para la asignatura de emprendimiento y gestión para la Unidad Educativa “Zeñon Vélez Viteri” para que los docentes hagan la enseñanza-aprendizaje dinámica e interesante utilizando la tecnología así los estudiantes se incentiven con gran interés en las clases impartidas por el docente. En los antecedentes de estudio de esta investigación no guarda semejanza con otros trabajos planteados. El contenido del marco teórico está centrado al uso de los sistemas tecnológica con la guía web interactiva, los cuales posibilitan el acceso con gran interés el estudiante como a profesores desde cualquier lugar y en cualquier momento, mediante una conexión en la Unidad Educativa. La filosofía planteada incluye una aproximación constructiva basada en el constructivismo social de la educación, enfatizando que los educandos puedan contribuir a la experiencia educativa mediante el uso de las herramientas tecnológicas. Se lo considera como un proyecto factible: entre sus fases abarca una investigación descriptiva y explicativa, además incluye una investigación documental y de campo. Como instrumento de investigación se utilizó la observación, a través de entrevistas, encuestas, aplicadas mediante muestreo aleatorio, especialmente en los segmentos docentes y estudiantes de la población en estudio correspondiente a 26 docentes y 723 estudiantes. De los cuales se tomó como muestra a 6 educandos y 90 estudiantes. El aporte de esta tesis de investigación es lograr el mejoramiento de la enseñanza aprendizaje en la asignatura de emprendimiento y gestión a los estudiantes con el objetivo de preparar y enviar a la sociedad educandos capaces de enfrentarse a cualquier circunstancia en la vida diaria. La propuesta planteada, es el diseño de una guía web interactiva, que apoya al docente en su labor educativa para que aprenda de una manera significativa, y a la vez pedagógica, práctica y dinámica, porque es un sistema virtual interactivo.The purpose of this research thesis is to consider the design of an interactive web guide for the subject of entrepreneurship and management for Educational Unit "Zenon Velez Viteri" for teachers to make teaching and learning dynamic and interesting using technology so students They must be encouraged with great interest in the classes taught by the teacher. In the background of this research study no resemblance to other works raised. The content of the theoretical framework is focused on the use of technological systems with interactive web guide, which provide access with great interest the student and teachers from anywhere and at any time, through a connection in the Educational Unit. The stated philosophy includes a constructive approach based on social constructivism of education, emphasizing that learners can contribute to the educational experience through the use of technological tools. It is considered as a feasible project between phases includes a descriptive and explanatory research also includes a documentary and field research. As a research tool used observation, through interviews, surveys, implemented by random sampling, especially teachers and students study population segments corresponding to 26 teachers and 723 students. Of which was sampled to 6 students and 90 students. The contribution of this thesis research is to improve teaching and learning in the subject of entrepreneurship and management students in order to prepare and send the learners society able to face any circumstance in daily life. The proposal put forward, is the design of an interactive web guide, which supports teachers in their educational work to learn in a meaningful way, and to educational, practical and dynamic time, because it is an interactive virtual system.

Rutas de la investigación educativa y pedagógica: en la Facultad de Educación de la Uniminuto

Sin resumen

Rutas de la investigación educativa y pedagógica: en la Facultad de Educación de la Uniminuto

Sin resumen

Rutas de la investigación educativa y pedagógica: en la Facultad de Educación de la Uniminuto

Sin resumen

The involvement of PKD in Fcγ receptor activation of the NADPH oxidase in human neutrophils

NADPH oxidase is a membrane bound enzyme, crucial in the destruction of pathogens by neutrophils. We have studied the signalling cascade leading to the activation of the NADPH oxidase upon activation of the Fc receptor, with a particular focus on the involvement of protein kinases in this process. Activation of the NADPH oxidase following Fcγ receptor stimulation was studied in human neutrophils using inhibitors of tyrosine kinases, phosphatidyl inositol 3-kinase and protein kinase C (PKC), which are all involved in this signalling cascade. Results with different PKC inhibitors showed unexpected results. While Go 6976 inhibited activation completely, Ro 31-8220 caused only a 60% inhibition. Thus a Go 6976-sensitive Ro 31-8220-insensitive component was suspected. Evidence from the literature suggest that Go 6976 but not Ro 31-8220 inhibits an isotype of the PKC family, PKCµ/Protein kinase D (PKD), in vitro, indicating that PKD could be involved in NADPH oxidase activation. PKD antisense oligonucleotides inhibited NADPH oxidase activation, supporting an involvement of PKD. Kinase assays showed that PKD is activated upon Fc receptor ligation. Immunofluorescence techniques showed that PKD is present in the plasma membrane and appears in the phagosomal membrane upon phagocytosis, further linking its functions to NADPH oxidase activation. The NADPH oxidase contains the membrane bound proteins, gp22phox and gp91phox and the cytosolic components, p47phox, p40phox and p67phox, which translocate to the phagosomal membrane upon activation. Translocation of these cytosolic components is driven by phosphorylation. We have shown that PKD phosphorylates p40phox and p47phox but not p67phox. Mass spectrometry studies and 2 dimensional gel electrophoresis technology indicated that PKD may not only play a role in the activation of the NADPH oxidase, as described, but may also phosphorylate other proteins, including some involved in cytoskeletal function, signalling and metabolism. The further characterisation and the roles of these need investigation. Thus PKD is present in neutrophils and is activated upon Fc receptor stimulation. It also plays a role in the signalling cascade that leads to NADPH oxidase

Divinity of woman, her superiority over man,

"Biographical sketch of the author, by Wm. J. Schaefle": p. 8-14."Third edition revised."Mode of access: Internet