Effectiveness of Protease Inhibitor Monotherapy versus Combination Antiretroviral Maintenance Therapy: A Meta-Analysis

The unparalleled success of combination antiretroviral therapy (cART) is based on the combination of three drugs from two classes. There is insufficient evidence whether simplification to ritonavir boosted protease inhibitor (PI/r) monotherapy in virologically suppressed HIV-infected patients is effective and safe to reduce cART side effects and costs

Point Biserial Correlation (PBC) for 1 to 20 clusters.

PBC was very similar for 3, 4 and 5 partitions. Therefore, we chose to build 4 clusters of patients (vertical dashed line). (PNG)</p

Distributions of the procedure–specific risks of HCV infection in case of contaminated equipment.

Distributions of the procedure–specific risks of HCV infection in case of contaminated equipment.</p

Panel of ward characteristics for each ward in the surgery hospital.

(A) HCV prevalence in each ward with their associated 95% confidence intervals. (B) Average number of procedures per patient. Procedure types are represented from the high-risk ones to the low-risk ones (from left to right). (C) Boxplots of average ward-specific risk of HCV infection, coloured according to the number of patients visiting these wards. Mean values are represented by purple diamond dots. Three wards are not represented because no patients underwent invasive procedures within them.</p