Characterization of the degree of food processing in the European Prospective Investigation into Cancer and Nutrition: Application of the Nova classification and validation using selected biomarkers of food processing

Background: Epidemiological studies have demonstrated an association between the degree of food processing in our diet and the risk of various chronic diseases. Much of this evidence is based on the international Nova classification system, which classifies food into four groups based on the type of processing: (1) Unprocessed and minimally processed foods, (2) Processed culinary ingredients, (3) Processed foods, and (4) “Ultra-processed” foods (UPF). The ability of the Nova classification to accurately characterise the degree of food processing across consumption patterns in various European populations has not been investigated so far. Therefore, we applied the Nova coding to data from the European Prospective Investigation into Cancer and Nutrition (EPIC) in order to characterize the degree of food processing in our diet across European populations with diverse cultural and socio-economic backgrounds and to validate this Nova classification through comparison with objective biomarker measurements. Methods: After grouping foods in the EPIC dataset according to the Nova classification, a total of 476,768 participants in the EPIC cohort (71.5% women; mean age 51 [standard deviation (SD) 9.93]; median age 52 [percentile (p)25– p75: 58–66] years) were included in the cross-sectional analysis that characterised consumption patterns based on the Nova classification. The consumption of food products classified as different Nova categories were compared to relevant circulating biomarkers denoting food processing, measured in various subsamples (N between 417 and 9,460) within the EPIC cohort via (partial) correlation analyses (unadjusted and adjusted by sex, age, BMI and country). These biomarkers included an industrial transfatty acid (ITFA) isomer (elaidic acid; exogenous fatty acid generated during oil hydrogenation and heating) and urinary 4-methyl syringol sulfate (an indicator for the consumption of smoked food and a component of liquid smoke used in UPF). Results: Contributions of UPF intake to the overall diet in % grams/day varied across countries from 7% (France) to 23% (Norway) and their contributions to overall % energy intake from 16% (Spain and Italy) to >45% (in the UK and Norway). Differences were also found between sociodemographic groups; participants in the highest fourth of UPF consumption tended to be younger, taller, less educated, current smokers, more physically active, have a higher reported intake of energy and lower reported intake of alcohol. The UPF pattern as defined based on the Nova classification (group 4;% kcal/day) was positively associated with blood levels of industrial elaidic acid (r = 0.54) and 4-methyl syringol sulfate (r = 0.43). Associations for the other 3 Nova groups with these food processing biomarkers were either inverse or non-significant (e.g., for unprocessed and minimally processed foods these correlations were –0.07 and –0.37 for elaidic acid and 4-methyl syringol sulfate, respectively). Conclusion: These results, based on a large pan-European cohort, demonstrate sociodemographic and geographical differences in the consumption of UPF. Furthermore, these results suggest that the Nova classification can accurately capture consumption of UPF, reflected by stronger correlations with circulating levels of industrial elaidic acid and a syringol metabolite compared to diets high in minimally processed foods.International Agency for Research on Cancer (IARC)Imperial College LondonNIHR Imperial Biomedical Research Centre (BRC)Danish Cancer Society (Denmark)Ligue Contre le Cancer, Institut Gustave Roussy, Mutuelle Générale de l’Education Nationale, Institut National de la Santé et de la Recherche Médicale (INSERM) (France)German Cancer Aid, German Cancer Research Center (DKFZ), German Institute of Human Nutrition Potsdam-Rehbruecke (DIfE), Federal Ministry of Education and Research (BMBF) (Germany)Associazione Italiana per la Ricerca sul Cancro- AIRC-Italy, Compagnia di SanPaolo and National Research Council (Italy)Dutch Ministry of Public Health, Welfare and Sports (VWS), Netherlands Cancer Registry (NKR), LK Research Funds, Dutch Prevention Funds, Dutch ZON (Zorg Onderzoek Nederland), World Cancer Research Fund (WCRF), Statistics Netherlands (Netherlands)Health Research Fund (FIS) - Instituto de Salud Carlos III (ISCIII), Regional Governments of Andalucía, Asturias, Basque Country, Murcia and Navarra, and the Catalan Institute of Oncology - ICO (Spain)Swedish Cancer Society, Swedish Research Council and County Councils of Skåne and Västerbotten (Sweden)Cancer Research UK (14136 to EPIC-Norfolk; C8221/A29017 to EPIC-Oxford), Medical Research Council (1000143 to EPIC-Norfolk; MR/M012190/1 to EPIC-Oxford) (United Kingdom

Herramienta de planificación y dimensionamiento para redes WiMAX

A software tool for planning and dimensioning Wireless Networks based on standard 802.16 is presented in this paper. Due to the deployment of communication systems based on this standard, it is necessary a tool which allows an easy implementation and dimensioning of this type of networks. With this tool the user will be able to evaluate point to point and point to multipoint networks, obtaining results such as losses in the link, power received, signal noise rate, coverage or bit rates the network is able to handle. For that purpose, the tool will employ technical specifications of transmitters and receivers, design parameters of the network and different propagation models

Safeguarding Health at the Workplace: A Study of Work Engagement, Authenticity and Subjective Wellbeing among Religious Workers

: Research in work and organizational psychology has paid little attention to religious workers, something certainly surprising as faith-based organizations play a key role in the welfare state of many countries. This research shows that religious workers in a Catholic order present a high degree of subjective wellbeing, both in terms of flourishing and satisfaction with life in general, and a positive balance of positive and negative feelings. More specifically, this study examines the relationship between authenticity and wellbeing amongst religious workers. Survey responses from 142 religious workers in Spain were analyzed using partial least squares path modelling. The results reveal that subjective wellbeing at work is positively related to authenticity. In addition, this relationship is mediated by their level of work engagement

A nutritional biomarker score of the Mediterranean diet and incident type 2 diabetes: Integrated analysis of data from the MedLey randomised controlled trial and the EPIC-InterAct case-cohort study

The MedLey trial was funded by a National Health and Medical Research Council Grant (#APP1050949 to KJM). The InterAct project was funded by the EU FP6 programme (grant number LSHM_CT_2006_037197 to NJW). Biomarker measurements for carotenoids were funded jointly by the InterAct project, the EPIC-CVD project, and the MRC Cambridge Initiative (RG71466 and SJAH/004 to NJW, NGF, JD, AB). EPIC-CVD has been supported by the UK Medical Research Council (MR/L003120/1 to ASB and JD), the British Heart Foundation (RG/13/13/30194 and RG/18/13/33946 to ASB and JD), the European Commission Framework Programme 7 (HEALTH -F2-2012-279233 to ASB and JD), the European Research Council (268834 to ASB and JD), and the National Institute for Health Research (NIHR; Cambridge Biomedical Research Centre at the Cambridge University Hospitals NHS Foundation Trust, BRC-1215-20014 to ASB and JD). This work was also supported by Health Data Research UK (to ASB and JD), which is funded by the UK Medical Research Council, Engineering and Physical Sciences Research Council, Economic and Social Research Council, Department of Health and Social Care (England), Chief Scientist Office of the Scottish Government Health and Social Care Directorates, Health and Social Care Research and Development Division (Welsh Government), Public Health Agency (Northern Ireland), and Wellcome. The coordination of EPIC is financially supported by the International Agency for Research on Cancer (IARC) and also by the Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London which has additional infrastructure support provided by the NIHR Imperial Biomedical Research Centre (BRC). The national cohorts are supported by: Danish Cancer Society (Denmark); Ligue Contre le Cancer, Institut Gustave Roussy, Mutuelle Ge'ne'rale de l'Education Nationale, Institut National de la Sante' et de la Recherche Me'dicale (INSERM) (France); German Cancer Aid, German Cancer Research Center (DKFZ), German Institute of Human Nutrition Potsdam-Rehbruecke (DIfE), Federal Ministry of Education and Research (BMBF) (Germany); Associazione Iblea Ricerca Epidemiologica (A.I.R.E. - ONLUS) Ragusa, Associazione Italiana per la Ricerca sul Cancro-AIRC-Italy, Compagnia di San Paolo, National Research Council and Sicilian Regional Government (Italy); Dutch Ministry of Public Health, Welfare and Sports (VWS), Netherlands~Cancer Registry (NKR), LK Research Funds, Dutch Prevention Funds, Dutch ZON (Zorg Onderzoek Nederland), World Cancer Research Fund (WCRF), Statistics Netherlands (The Netherlands); Health Research Fund (FIS) -Instituto de Salud Carlos III (ISCIII), Regional Governments of Andaluci'a, Asturias, Basque Country, Murcia and Navarra, and the Catalan Institute of Oncology -ICO (Spain); Swedish Cancer Society, Swedish Research Council and County Councils of Skane and Vasterbotten (Sweden); Cancer Research UK (14136 to NJW; C8221/A29017), Medical Research Council (1000143 to NJW; MR/M012190/1) (United Kingdom). JGS was supported by the MRC PhD studentship. NJW, NGF, and FI acknowledge funding from the Medical Research Council Epidemiology Unit (MC_UU_00006/1, MC_UU_00006/3); and NJW, NGF and AK from the NIHR Cambridge Biomedical Research Centre (IS-BRC-1215-20014; NIHR203312). NGF and JD are NIHR Senior Investigators. JD holds a British Heart Foundation Professorship. MBS acknowledges funding from the Federal Ministry of Education and Research and the State of Brandenburg (DZD grant 82DZD03D03). JSZ has received funding from Westlake University (No YSYY0209) and European Union's Horizon 2020 research and innovation programme under the Marie Sklodowska-Curie grant agreement No 701708. PWF has received funding from Novo Nordisk, Swedish Diabetes Association, Swedish Heart-Lung Foundation, European Research Council. ER has received funding from Imperial College Biomedical Research Centre. The funders of the studies had no role in the study design, data collection, data analysis, data interpretation, or report preparation. Trial Australian.Background Self-reported adherence to the Mediterranean diet has been modestly inversely associated with incidence of type 2 diabetes (T2D) in cohort studies. There is uncertainty about the validity and magnitude of this association due to subjective reporting of diet. The association has not been evaluated using an objectively measured biomarker of the Mediterranean diet. Methods and findings We derived a biomarker score based on 5 circulating carotenoids and 24 fatty acids that discriminated between the Mediterranean or habitual diet arms of a parallel design, 6-month partial-feeding randomised controlled trial (RCT) conducted between 2013 and 2014, the MedLey trial (128 participants out of 166 randomised). We applied this biomarker score in an observational study, the European Prospective Investigation into Cancer and Nutrition (EPIC)-InterAct case-cohort study, to assess the association of the score with T2D incidence over an average of 9.7 years of follow-up since the baseline (1991 to 1998). We included 22,202 participants, of whom 9,453 were T2D cases, with relevant biomarkers from an original case-cohort of 27,779 participants sampled from a cohort of 340,234 people. As a secondary measure of the Mediterranean diet, we used a score estimated from dietary-self report. Within the trial, the biomarker score discriminated well between the 2 arms; the cross-validated C-statistic was 0.88 (95% confidence interval (CI) 0.82 to 0.94). The score was inversely associated with incident T2D in EPIC-InterAct: the hazard ratio (HR) per standard deviation of the score was 0.71 (95% CI: 0.65 to 0.77) following adjustment for sociodemographic, lifestyle and medical factors, and adiposity. In comparison, the HR per standard deviation of the self-reported Mediterranean diet was 0.90 (95% CI: 0.86 to 0.95). Assuming the score was causally associated with T2D, higher adherence to the Mediterranean diet in Western European adults by 10 percentiles of the score was estimated to reduce the incidence of T2D by 11% (95% CI: 7% to 14%). The study limitations included potential measurement error in nutritional biomarkers, unclear specificity of the biomarker score to the Mediterranean diet, and possible residual confounding. Conclusions These findings suggest that objectively assessed adherence to the Mediterranean diet is associated with lower risk of T2D and that even modestly higher adherence may have the potential to reduce the population burden of T2D meaningfully.EU FP6 programme LSHM_CT_2006_037197European Commission Framework Programme 7 HEALTH-F2-2012-279233European Research Council (ERC)World Health OrganizationHealth Research Fund (FIS) - Instituto de Salud Carlos III (ISCIII)Catalan Institute of Oncology - ICO (Spain)Spanish Government 701708Marie Curie Actions 701708European Union's Horizon 2020, Marie Sklodowska-Curie 70170

Dietary Intake of 91 Individual Polyphenols and 5-Year Body Weight Change in the EPIC-PANACEA Cohort

Polyphenols are bioactive compounds from plants with antioxidant properties that may have a protective role against body weight gain, with adipose tissue and systemic oxidative stress as potential targets. We aimed to investigate the dietary intake of individual polyphenols and their association with 5-year body weight change in a sub-cohort of the European Prospective Investigation into Cancer and Nutrition (EPIC). This study included 349,165 adult participants from nine European countries. Polyphenol intake was estimated through country-specific validated dietary questionnaires and the Phenol-Explorer database. Body weight was obtained at recruitment and after a mean follow-up time of 5 years. Associations were estimated using multilevel mixed linear regression models. From 91 polyphenols included, the majority (n = 67) were inversely associated with 5-year body weight change after FDR-correction (q < 0.05). The greatest inverse associations were observed for quercetin 3-O-rhamnoside (change in weight for doubling in intake: -0.071 (95% CI: -0.085; -0.056) kg/5 years). Only 13 polyphenols showed positive associations with body weight gain, mainly from the subclass hydroxycinnamic acids (HCAs) with coffee as the main dietary source, such as 4-caffeoylquinic acid (0.029 (95% CI: 0.021; 0.038) kg/5 years). Individual polyphenols with fruit, tea, cocoa and whole grain cereals as the main dietary sources may contribute to body weight maintenance in adults. Individual HCAs may have different roles in body weight change depending on their dietary source.Instituto De Salud Carlos III (European Regional Development Fund, ERDF, a way to build Europe) European Commission PI18/00191World Health Organization 2005328Department of Epidemiology and Biostatistics, School of Public Health, Imperial College LondonDanish Cancer SocietyLigue Contre le Cancer (France) Institut Gustave Roussy (France) Mutuelle Generale de l'Education Nationale (France)Institut National de la Sante et de la Recherche Medicale (Inserm)Deutsche Krebshilfe German Cancer Research Center (DKFZ) (Germany) German Institute of Human Nutrition Potsdam-Rehbruecke (DIfE) (Germany)Federal Ministry of Education & Research (BMBF)Fondazione AIRC per la ricerca sul cancro Compagnia di San Paolo Consiglio Nazionale delle Ricerche (CNR)Netherlands Government Netherlands Government World Cancer Research Fund International (WCRF)Netherlands GovernmentHealth Research Fund (FIS)-Instituto de Salud Carlos III (ISCIII) (Spain)Junta de Andalucia Principality of Asturias Regional Government of Basque Country (Spain) Regional Government of Murcia (Spain) Regional Government of Navarra (Spain) Catalan Institute of Oncology-ICO (Spain)Swedish Cancer Society Swedish Research Council County Council of Skane (Sweden) County Council of Vaesterbotten (Sweden)Cancer Research UK UK Research & Innovation (UKRI) Medical Research Council UK (MRC) 14136 C8221/A29017 1000143 MR/M012190/1NIHR Cambridge Biomedical Research Centre diet, nutrition and lifestyle theme MC_UU_0006/3Consejo Nacional de Ciencia y Tecnologia (CONACyT) IS-BRC-1215-20014Instituto de Salud Carlos III (European Social Fund (ESF) investing in your future) 693636 FI19/00185 CD20/00071 CPII20/0000

The Subjective Well-Being Challenge in the Accounting Profession: The Role of Job Resources

The main activity of the accountant is the preparation and audit of the financial information of a company. The subjective well-being of the accountant is important to ensure a balanced professional judgment and to offer a positive image of the profession in the face of the incorporation and retention of talent. However, accountants are subjected to intense pressures that affect their well-being in the performance of their tasks. In this paper, the job demands–resources theoretical framework is adopted to analyze the relationships between job demands, job resources, and the subjective well-being of a large sample of 739 accounting experts at the European level. Applying a structural equations model, the results confirm, on the one hand, the direct effects provided in the theoretical framework and, on the other, a new mediating role of job demands–subjective well-being relationship resources

Consideraciones para la implantación de la videoconferencia en el aula

Asociadas al crecimiento de INTERNET y haciendo uso de ésta, aparecen Nuevas Tecnologías encaminadas a la comunicación entre personas de distintos puntos del planeta. La videoconferencia aporta una serie de beneficios evidentes sobre los demás medios de cAssociated to Internet growing and its usage, new technologies aiming to make communication easier among people from different parts of the planet are appearing. The videoconference provides several evident benefits over the rest of the media. Adding the possibility to see our interlocutors when we are chatting with them in the distance makes communication even more complete, creating a sense of presence among all the participants. Distanced Education ought to take advantage of the benefits that this new tool provides. This paper shows and analyzes some aspects to consider in order to make its establishment real in the classroom

Efecto del tamaño de la ventana de promediado y la histéresis variable en algoritmos de handover horizontal en redes convergentes

En las redes convergentes inalámbricas, el traspaso horizontal entre distintos puntos de acceso de la red WLAN es una gran fuente de degradación de la calidad de la VoIP y otros servicios conversacionales en tiempo real. Esto es debido a que este tipo de redes no fueron concebidas originalmente para soportar este tipo de servicios, y los traspasos siguen un protocolo ¿cortar antes de realizar¿, produciéndose interrupciones en la comunicación motivadas por el tiempo que necesitan los terminales en volver a asociarse a la red. En este artículo se estudia el efecto que tienen el tamaño de la ventana de promediado de la señal, la histéresis variable y el retardo del handover por parecido entre potencia de puntos de acceso de destino sobre el número de traspasos y las caídas de la potencia de señal por debajo del valor de sensibilidad del terminal, causantes principales de las interrupciones en la comunicación, y, con ello, de la degradación de la calidad de las comunicaciones

Despliegues de femtoceldas LTE en interiores comparación con otras tecnologías inalámbricas

Long Term Evolution (LTE) has appeared with the aim of improving the performance of 3G networks, increasing spectral efficiency and peak rates both at downlink and uplink, reducing latency and increasing flexibility of frequency allocation. Therefore, LTE is expected to have a key role in the development of wireless networks and services in the next years, and, of course, in specific dedicated in-building solutions. Due to that fact, an analysis of LTE performance in indoor scenarios in terms of capacity and grade of service is essential, as well as its comparison with other indoor solutions, pointing out the technical challenges derived, and describing and proposing performance assessment rules to be used in LTE deployments

Medición de la inclusión digital a través de los servicios de gobierno electrónico en la población rural de Colombia. Caso: municipio de Valledupar

En el presente documento se expone el sistema de medición de la e-inclusión a través de los servicios del e-government en la población rural. Con el fin de lograr esta meta, se propuso desarrollar tres objetivos. En primera instancia se realizó la comparación de los referentes que evalúan el Gobierno electrónico, enfocados en la medición de la inclusión digital, como segundo, se diseñaron las dimensiones, variables, indicadores y posibles desagregaciones que constituyen el sistema de indicadores. Por último, aplicar el sistema de indicadores en una población objetivo y así obtener retroalimentación. Como resultados del desarrollo de los objetivos se obtuvo: a) la consolidación de los conceptos de la e-inclusión y el e-government como así mismo la identificación de referentes y factores asociados a la temática. b) El conjunto de variables e indicadores según los factores de la e-inclusión y el e-government, que sirvieron de base para la construcción del sistema de evaluación con sus desagregaciones. c) El sistema de evaluación compuesto por tres factores: acceso a infraestructura, habilidades digitales y participación ciudadana. Sistema de evaluación que fue validado por docentes y estudiantes de derecho e ingeniería industrial de la Universidad de Santander. d) Que luego de la aplicación en los habitantes de cuatro corregimientos de municipio de Valledupar, el análisis de los resultados arrojo resultados importantes. Este trabajo permitió identificar aspectos determinantes en el análisis de la e-inclusión y el e-government, como así mismo la aplicabilidad en muchos escenarios del territorio nacional que presenten condición de vulnerabilidad, esto por el conjunto de indicadores amplios propuestos. Por último, se puede indicar que el sistema de evaluación puede ser utilizado como base de estudio y análisis de los gobiernos locales que construyen sus planes desarrollo. El presente trabajo ha de ser aporte significativo para lograr avanzar en el estudio de la e-inclusión y el e-government en el territorio colombiano.This paper presents the system for measuring e-inclusion through e-government services in the rural population. In order to achieve this goal, it was proposed to develop three objectives. In the first instance, a comparison was made of the benchmarks that evaluate e-Government, focused on the measurement of digital inclusion, and secondly, the dimensions, variables, indicators and possible disaggregations that constitute the indicators system were designed. Finally, to apply the system of indicators in a target population and to obtain feedback. As a result of the development of the objectives, A) the consolidation of the concepts of e-inclusion and e-government as well as the identification of referents and factors associated with the theme were obtained. B) The set of variables and indicators according to the factors of e-inclusion and e-government, which served as the basis for the construction of the evaluation system with its disaggregations. C) The evaluation system is composed of three factors: access to infrastructure, digital skills and citizen participation. Evaluation system that was validated by teachers and students of law and industrial engineering at the University of Santander. D) That after the application in the inhabitants of four municipalities of Valledupar, the analysis of the results yielded important results. This work allowed to identify determinant aspects in the analysis of e-inclusion and e-government, as well as the applicability in many scenarios of the national territory that present a condition of vulnerability, this by the set of broad indicators proposed. Finally, it can be pointed out that the evaluation system can be used as the basis of study and analysis of the local governments that build their development plans. The present work has to be a significant contribution in order to achieve progress in the study of e-inclusion and e-government in the Colombian territory.Maestrí