STUDY OF THE PREVALENCE OF Capillaria hepatica IN HUMANS AND RODENTS IN AN URBAN AREA OF THE CITY OF PORTO VELHO, RONDÔNIA, BRAZIL

Introduction: Hepatic capillariosis, caused by Capillaria hepatica (Calodium hepaticum) (Bancroft, 1893), Travassos, 1915 (Nematoda, Trichinelloidea, Capillariidae), is a common zoonosis in rodents but is rare in humans. Seventy-two cases in humans have been reported worldwide since the first case was described by MACARTHUR in 192417,27. This study aimed to determine the prevalence of Capillaria hepatica in humans and rodents in an urban area of Porto Velho, the capital of Rondônia, in Brazil. Methods: After conducting a census of the area, 490 residents were randomly selected, and, after signing a term of consent, provided blood samples that were screened for anti-Capillaria hepatica antibodies. Simultaneously, rats were captured to assess the prevalence of this parasite in rodents by histopathological examination in liver sections. Results: A prevalence of 1.8% was found among residents who had specific antibodies at a dilution of 1:150, indicating exposure to parasite eggs; 0.8% of the subjects also had positive titers at a dilution of 1:400, indicating true infection. The prevalence in rats was 2%. Conclusions: The prevalence of infection with this parasite among humans and rats was low. While the prevalence encountered among humans was within the limits reported in the literature, the prevalence among rodents was much lower.Introdução: Capilaríase hepática é causada pela Capillaria hepatica (syn. Calodium hepaticum) (Bancroft, 1893), Travassos, 1915 (Nematoda, Trichinelloidea, Capillariidae), sendo uma zoonose comum entre roedores, porém rara em humanos. Setenta e dois casos humanos foram relatados na literatura mundial desde o primeiro caso descrito por MACARTHUR em 192417,27. O objetivo desse estudo é determinar a prevalência da Capillaria hepatica em humanos e roedores de área urbana da cidade de Porto Velho, capital de Rondônia, Brasil. Método: Após realizar um censo da área, 490 moradores foram aleatoriamente selecionados e assinaram termo de consentimento, foram colhidas amostras de sangue para testar anticorpos anti-Capillaria hepatica. Simultaneamente, ratos foram capturados para determinação da prevalência deste parasita através do exame histopatológico em cortes de fígado. Resultados: Foi encontrada entre humanos prevalência de 1,8% de positividade para anticorpos específicos em diluição de 1:150, indicando exposição aos ovos do parasito; 0,8% desses também deram testes positivos quando seus soros sofreram diluição de 1:400, indicando infecção verdadeira. Nos ratos, a prevalência foi de 2%. Conclusão: A prevalência encontrada para o parasito entre homens e roedores foi baixa. Enquanto a prevalência encontrada entre humanos esteve dentro dos limites encontrados na literatura, a prevalência entre roedores foi bem menor

Study of the prevalence of Capillaria hepatica in humans and rodents in an urban area of the city of Porto Velho, Rondônia, Brazil.

Submitted by Ana Maria Fiscina Sampaio ([email protected]) on 2015-03-17T13:53:36Z No. of bitstreams: 1 Rocha EJG Study of the....pdf: 138873 bytes, checksum: 3aec7ed9947017e8611f434127d5f363 (MD5)Approved for entry into archive by Ana Maria Fiscina Sampaio ([email protected]) on 2015-03-17T13:53:47Z (GMT) No. of bitstreams: 1 Rocha EJG Study of the....pdf: 138873 bytes, checksum: 3aec7ed9947017e8611f434127d5f363 (MD5)Approved for entry into archive by Ana Maria Fiscina Sampaio ([email protected]) on 2015-03-17T14:10:11Z (GMT) No. of bitstreams: 1 Rocha EJG Study of the....pdf: 138873 bytes, checksum: 3aec7ed9947017e8611f434127d5f363 (MD5)Made available in DSpace on 2015-03-17T14:10:11Z (GMT). No. of bitstreams: 1 Rocha EJG Study of the....pdf: 138873 bytes, checksum: 3aec7ed9947017e8611f434127d5f363 (MD5) Previous issue date: 2015Faculdade São Lucas. Porto Velho, RO, BrasilFaculdade São Lucas. Porto Velho, RO, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Patologia Experimental. Salvador, BA, BrasilLaboratório Central de Saúde Pública de Rondônia. LACEN/RO. Porto Velho, RO, BrasilUnB Universidade de Brasília. Hospital Universitário. Laboratório de Patologia Veterinária. Brasília, DF, BrasilUniversidade Federal de Mato Grosso. Faculdade de Agronomia e Medicina Veterinária. Departamento de Clínica Médica Veterinária. Cuiabá, MG, BrasilFaculdade São Lucas. Porto Velho, RO, BrasilFaculdade São Lucas. Porto Velho, RO, BrasilFaculdade São Lucas. Porto Velho, RO, BrasilUniversity of Sao Paulo. Porto Velho, RO, BrasilIntroduction: Hepatic capillariosis, caused by Capillaria hepatica (Calodium hepaticum) (Bancroft, 1893), Travassos, 1915 (Nematoda, Trichinelloidea, Capillariidae), is a common zoonosis in rodents but is rare in humans. Seventy-two cases in humans have been reported worldwide since the first case was described by MACARTHUR in 192417,27. This study aimed to determine the prevalence of Capillaria hepatica in humans and rodents in an urban area of Porto Velho, the capital of Rondônia, in Brazil. Methods: After conducting a census of the area, 490 residents were randomly selected, and, after signing a term of consent, provided blood samples that were screened for anti-Capillaria hepatica antibodies. Simultaneously, rats were captured to assess the prevalence of this parasite in rodents by histopathological examination in liver sections. Results: A prevalence of 1.8% was found among residents who had specific antibodies at a dilution of 1:150, indicating exposure to parasite eggs; 0.8% of the subjects also had positive titers at a dilution of 1:400, indicating true infection. The prevalence in rats was 2%. Conclusions: The prevalence of infection with this parasite among humans and rats was low. While the prevalence encountered among humans was within the limits reported in the literature, the prevalence among rodents was much lower. KEYWORDS: Capillariasis; Capillaria hepatica; Rondônia