CGIAR’s role in digital extension services

CGIAR’s digital extension services bridge the gap between the development and the adoption of new climate change adaptation strategies. These services include new ways to disperse information on rainfed systems of agriculture, nutrition, pest control, new crop varieties, crop management practices, and more

Mpox, herpes, and enteroviruses: Differential diagnosis

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Bioelectrocatalysis at mesoporous antimony doped tin oxide electrodes—Electrochemical characterization and direct enzyme communication

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Biotin ergopeptide probes for dopamine receptors

The incorporation of chemical modifications into the structure of bioactive compounds is often difficult because the biological properties of the new molecules must be retained with respect to the native ligand. Ergopeptides, with their high affinities at D and D dopamine receptors, are particularly complex examples. Here, we report the systematic derivatization of two ergopeptides with different peptide-based spacers and their evaluation by radioligand binding assays. Selected spacer-containing ergopeptides with minimal biological alteration and a proper anchoring point were further derivatized with a biotin reporter. Detailed characterization studies identified 13 as a biotin ergopeptide maintaining high affinity and agonist behavior at dopamine receptors, being a useful tool for the study of heteromers involving D R, D R, or D R