Role of Anopheles stephensi Mosquitoes in Malaria Outbreak, Djibouti, 2019

International audienceAnopheles stephensi mosquitoes share urban breeding sites with Aedes aegypti and Culex quinquefasciatus mosquitoes in the Republic of Djibouti. We present evidence that A. stephensi mosquitoes might be responsible for an increase in malaria incidence in this country. We also document resistance of Plasmodium falciparum to dihydroartemisinin/piperaquin

<it>Plasmodium vivax</it> and <it>Plasmodium falciparum</it> infections in the Republic of Djibouti: evaluation of their prevalence and potential determinants

<p>Abstract</p> <p>Background</p> <p>Formerly known as a hypoendemic malaria country, the Republic of Djibouti declared the goal of pre-eliminating malaria in 2006. The aim of the present study was to evaluate the prevalence of <it>Plasmodium falciparum</it>, <it>Plasmodium vivax</it> and mixed infections in the Djiboutian population by using serological tools and to identify potential determinants of the disease and hotspots of malaria transmission within the country.</p> <p>Methods</p> <p>The prevalence of <it>P</it>. <it>falciparum</it> and <it>P</it>. <it>vivax</it> within the districts of the capital city and the rest of the Republic of Djibouti were assessed using 13 and 2 serological markers, respectively. The relationship between the immune humeral response to <it>P</it>. <it>falciparum</it> and <it>P</it>. <it>vivax</it> and variables such as age, gender, wealth status, urbanism, educational level, distance to rivers/lakes, living area, having fever in the last month, and staying in a malaria-endemic country more than one year was estimated and analysed by questionnaires administered to 1910 Djiboutians. Multivariate ordinal logistic regression models of the immune humeral response were obtained for <it>P</it>. <it>falciparum</it> and <it>P</it>. <it>vivax</it>.</p> <p>Results</p> <p>The <it>P</it>. <it>falciparum</it> and <it>P</it>. <it>vivax</it> seroprevalence rates were 31.5%, CI95% [29.4-33.7] and 17.5%, CI95% [15.8-19.3], respectively. Protective effects against <it>P</it>. <it>falciparum</it> and <it>P</it>. <it>vivax</it> were female gender, educational level, and never having visited a malaria-endemic area for more than one year. For <it>P</it>. <it>falciparum</it> only, a protective effect was observed for not having a fever in the last month, living more than 1.5 km away from lakes and rivers, and younger ages.</p> <p>Conclusions</p> <p>This is the first study that assessed the seroprevalence of <it>P</it>. <it>vivax</it> in the Republic of Djibouti. It is necessary to improve knowledge of this pathogen in order to create an effective elimination programme. As supported by recent observations on the subject, the Republic of Djibouti has probably demonstrated a real decrease in the transmission of <it>P</it>. <it>falciparum</it> in the past seven years, which should encourage authorities to improve efforts toward elimination.</p