Anesthetics and Long Term Cancer Outcomes : May Epigenetics Be the Key for Pancreatic Cancer?

Peer reviewedPublisher PD

Metoclopramide and propofol to prevent nausea and vomiting during cesarean section under spinal anesthesia : A randomized, placebo-controlled, double-blind trial

Funding This research received no external funding. Acknowledgment Elisa Fabbri, Ivan Dell’Atti, Fabio Palombo, Massimo di Marzio, Rosalia Di Martino, Daniela Albanese, Nadia D’Urso, Vera Hendrix for their contribution to the present work. Publisher Copyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland.Peer reviewedPublisher PD

Recurrence kinetics after laparoscopic versus open surgery in colon cancer. A meta-analysis

Funding Information: No paper reported any conflicts of interest. Seven reported no external funding. The COST trial received a number of grants from the National Cancer Institute [15] and the COLOR trial received funding from Ethicon Endo‐surgery and the Swedish Cancer Foundation [19]. Neither corporation influenced initiation, design or any other aspect of the study. Funding Information: 4 Independent Researcher, supported by the European Society of Anaesthesiology and Intensive Care Mentorship Programme, B‐1000 Brussels, Belgium; [email protected] reviewedPublisher PD

How Anesthetic, Analgesic and Other Non-Surgical Techniques During Cancer Surgery Might Affect Postoperative Oncologic Outcomes:A Summary of Current State of Evidence

The question of whether anesthetic, analgesic or other perioperative intervention during cancer resection surgery might influence long-term oncologic outcomes has generated much attention over the past 13 years. A wealth of experimental and observational clinical data have been published, but the results of prospective, randomized clinical trials are awaited. The European Union supports a pan-European network of researchers, clinicians and industry partners engaged in this question (COST Action 15204: Euro-Periscope). In this narrative review, members of the Euro-Periscope network briefly summarize the current state of evidence pertaining to the potential effects of the most commonly deployed anesthetic and analgesic techniques and other non-surgical interventions during cancer resection surgery on tumor recurrence or metastasis

Gene polymorphisms of superoxide dismutases and catalase in diabetes mellitus

<p>Abstract</p> <p>Background</p> <p>Reactive oxygen species generated by hyperglycaemia modify structure and function of lipids, proteins and other molecules taking part in chronic vascular changes in diabetes mellitus (DM). Low activity of scavenger enzymes has been observed in patients with DM. Protective role of scavenger enzymes may be deteriorated by oxidative stress. This study was undertaken to investigate the association between gene polymorphisms of selected antioxidant enzymes and vascular complications of DM.</p> <p>Results</p> <p>Significant differences in allele and genotype distribution among T1DM, T2DM and control persons were found in SOD1 and SOD2 genes but not in CAT gene (p < 0,01). Serum SOD activity was significantly decreased in T1DM and T2DM subjects compared to the control subjects (p < 0,05). SOD1 and SOD2 polymorphisms may affect SOD activity. Serum SOD activity was higher in CC than in TT genotype of SOD2 gene (p < 0,05) and higher in AA than in CC genotype of SOD1 gene (p < 0,05). Better diabetes control was found in patients with CC than with TT genotype of SOD2 gene. Significantly different allele and genotype frequencies of SOD2 gene polymorphism were found among diabetic patients with macroangiopathy and those without it. No difference was associated with microangiopathy in all studied genes.</p> <p>Conclusion</p> <p>The results of our study demonstrate that oxidative stress in DM can be accelerated not only due to increased production of ROS caused by hyperglycaemia but also by reduced ability of antioxidant defense system caused at least partly by SNPs of some scavenger enzymes.</p

Principles and Implementation for Adult and Pediatric Surgery

Gentium Basic and Gentium Book Basic font software by J. Victor Gaultney. The Gentium project, and the Gentium Basic and Gentium Book Basic fonts, are maintained by SIL International. Gentium font software is licensed under the SIL Open Font License, Version 1.1. This license is available at http://scripts.sil.org/OFL.Anesthesiology is an ever-changing field. The publishers and author of this guide have made every effort to provide information that is accurate and complete as of the date of publication. However, in view of the rapid changes occurring in regional anesthesia, as well as the possibility of human error, this Guide may contain technical inaccuracies, typographical or other errors. It is the responsibility of the physician who relies on experience and knowledge about the patient to determine the most adequate treatment. The information contained herein is provided “as is” and without warranty of any kind. The contributors to this book, including Flying Publisher & Kamps disclaim responsibility for any errors or omissions or for results obtained from the use of information contained herein

Metoclopramide and Propofol to Prevent Nausea and Vomiting during Cesarean Section under Spinal Anesthesia: A Randomized, Placebo-Controlled, Double-Blind Trial

Background: Intra-operative nausea, vomiting and retching (NVR) are frequently associated with subarachnoid anesthesia (SA) in women undergoing cesarean section (CS). In this study performed in women undergoing CS under SA with a risk factor control strategy, we compared saline (placebo), propofol, metoclopramide and both drugs to prevent NVR. Methods: We recorded NVR events in 110 women undergoing CS who were randomized after umbilical cord clamping to receive saline (S; n = 27), metoclopramide 10 mg (M; n = 28), propofol 1 mg/kg/h (P; n = 27) or both drugs (PM; n = 28). Results: The proportion of women with intra-operative nausea was: S: 17/27 (63%); P: 15/27 (56%); M: 13/28 (46%); PM: 6/28 (21%) (p = 0.012, Cram&eacute;r&rsquo;s V = 0.31 (large effect). The proportion of women with intra-operative vomiting/retching was: S: 9/27 (33%); M: 7/27 (25%); P: 3/28 (11%); PM 2/28 (7%) (p = 0.049, Cram&eacute;r&rsquo;s V = 0.26 (medium effect). Post-hoc multiple comparisons revealed a significant reduction in NVR episodes and NRS scores between the PM group and control. Sedation scores did not differ among groups. Conclusion: In women undergoing CS under SA with a risk factor control strategy, combined propofol and metoclopramide reduce nausea and vomiting