Preface

The University of Pennsylvania Working Papers in Linguistics (PWPL) is an occasional series published by the Penn Linguistics Club, the graduate student organization of the Linguistics Department of the University of Pennsylvania. The series has included volumes of previously unpublished work, or work in progress, by linguists with an ongoing affiliation with the Department, as well as volumes of papers from the NWAVE conference and the Penn Linguistics Colloquium. The current PWPL series editors are Jim Alexander, Alexis Dimitriadis, Na-­‐Rae Han, Elsi Kaiser, Michelle Minnick Fox, Christine Moisset, and Alexander Williams

Preface

The University of Pennsylvania Working Papers in Linguistics (PWPL) is an occasional series published by the Penn Linguistics Club, the graduate student organization of the Linguistics Department of the University of Pennsylvania. The series has included volumes of previously unpublished work, or work in progress, by linguists with an ongoing affiliation with the Department, as well as volumes of papers from the NWAVE conference and the Penn Linguistics Colloquium. The current PWPL series editors are Jim Alexander, Alexis Dimitriadis, Na-­‐Rae Han, Elsi Kaiser, Michelle Minnick Fox, Christine Moisset, and Alexander Williams

Preface

The University of Pennsylvania Working Papers in Linguistics (PWPL) is an occasional series published by the Penn Linguistics Club, the graduate student organization of the Linguistics Department of the University of Pennsylvania. The series has included volumes of previously unpublished work, or work in progress, by linguists with an ongoing affiliation with the Department, as well as volumes of papers from the NWAVE conference and the Penn Linguistics Colloquium. This volume presents a cross-­‐section of current work in linguistics at the University of Pennsylvania. On behalf of both the editors and the authors whose work appears in this volume, we wish to thank the reviewers of these papers for their important contribution

Preface

The University of Pennsylvania Working Papers in Linguistics (PWPL) is an occasional series published by the Penn Linguistics Club, the graduate student organization of the Linguistics Department of the University of Pennsylvania. The series has included volumes of previously unpublished work, or work in progress, by linguists with an ongoing affiliation with the Department, as well as volumes of papers from the NWAVE conference and the Penn Linguistics Colloquium. This volume presents a cross-­‐section of current work in linguistics at the University of Pennsylvania. On behalf of both the editors and the authors whose work appears in this volume, we wish to thank the reviewers of these papers for their important contribution

Preface

The University of Pennsylvania Working Papers in Linguistics (PWPL) is an occasional series published by the Penn Linguistics Club, the graduate student organization of the Linguistics Department of the University of Pennsylvania. The series has included volumes of previously unpublished work, or work in progress, by linguists with an ongoing affiliation with the Department, as well as volumes of papers from the NWAVE conference and the Penn Linguistics Colloquium. The current PWPL series editors are Jim Alexander, Alexis Dimitriadis, Na-­‐Rae Han, Elsi Kaiser, Michelle Minnick Fox, Christine Moisset, and Alexander Williams

Preface

The University of Pennsylvania Working Papers in Linguistics (PWPL) is an occasional series published by the Penn Linguistics Club, the graduate student organization of the Linguistics Department of the University of Pennsylvania. The series has included volumes of previously unpublished work, or work in progress, by linguists with an ongoing affiliation with the Department, as well as volumes of papers from the NWAVE conference and the Penn Linguistics Colloquium. The current PWPL series editors are Jim Alexander, Alexis Dimitriadis, Na-­‐Rae Han, Elsi Kaiser, Michelle Minnick Fox, Christine Moisset, and Alexander Williams

Submicroscopic Deletions at 13q32.1 Cause Congenital Microcoria.

International audienceCongenital microcoria (MCOR) is a rare autosomal-dominant disorder characterized by inability of the iris to dilate owing to absence of dilator pupillae muscle. So far, a dozen MCOR-affected families have been reported worldwide. By using whole-genome oligonucleotide array CGH, we have identified deletions at 13q32.1 segregating with MCOR in six families originating from France, Japan, and Mexico. Breakpoint sequence analyses showed nonrecurrent deletions in 5/6 families. The deletions varied from 35 kbp to 80 kbp in size, but invariably encompassed or interrupted only two genes: TGDS encoding the TDP-glucose 4,6-dehydratase and GPR180 encoding the G protein-coupled receptor 180, also known as intimal thickness-related receptor (ITR). Unlike TGDS which has no known function in muscle cells, GPR180 is involved in the regulation of smooth muscle cell growth. The identification of a null GPR180 mutation segregating over two generations with iridocorneal angle dysgenesis, which can be regarded as a MCOR endophenotype, is consistent with the view that deletions of this gene, with or without the loss of elements regulating the expression of neighboring genes, are the cause of MCOR

DMTs and Covid-19 severity in MS: a pooled analysis from Italy and France

We evaluated the effect of DMTs on Covid-19 severity in patients with MS, with a pooled-analysis of two large cohorts from Italy and France. The association of baseline characteristics and DMTs with Covid-19 severity was assessed by multivariate ordinal-logistic models and pooled by a fixed-effect meta-analysis. 1066 patients with MS from Italy and 721 from France were included. In the multivariate model, anti-CD20 therapies were significantly associated (OR = 2.05, 95%CI = 1.39–3.02, p < 0.001) with Covid-19 severity, whereas interferon indicated a decreased risk (OR = 0.42, 95%CI = 0.18–0.99, p = 0.047). This pooled-analysis confirms an increased risk of severe Covid-19 in patients on anti-CD20 therapies and supports the protective role of interferon